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Protein

Gelsolin

Gene

GSN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi471Calcium 1; via carbonyl oxygen1
Metal bindingi472Calcium 11
Metal bindingi502Calcium 11
Metal bindingi551Calcium 1; via carbonyl oxygen1
Metal bindingi591Calcium 21
Metal bindingi591Calcium 2; via carbonyl oxygen1
Metal bindingi592Calcium 21
Metal bindingi614Calcium 21
Metal bindingi696Calcium 3; via carbonyl oxygen1
Metal bindingi697Calcium 31
Metal bindingi719Calcium 31

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: UniProtKB
  • actin filament binding Source: InterPro
  • calcium ion binding Source: UniProtKB
  • myosin II binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin capping, Actin-binding
Biological processCilium biogenesis/degradation
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-977225 Amyloid fiber formation

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P06396

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P06396

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gelsolin
Alternative name(s):
AGEL
Actin-depolymerizing factor
Short name:
ADF
Brevin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GSN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000148180.17

Human Gene Nomenclature Database

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HGNCi
HGNC:4620 GSN

Online Mendelian Inheritance in Man (OMIM)

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MIMi
137350 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P06396

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, Cytoplasm, Cytoskeleton, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Amyloidosis 5 (AMYL5)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.
See also OMIM:105120
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_007718214D → N in AMYL5. 2 PublicationsCorresponds to variant dbSNP:rs121909715EnsemblClinVar.1
Natural variantiVAR_007719214D → Y in AMYL5. 1 PublicationCorresponds to variant dbSNP:rs121909715EnsemblClinVar.1

Keywords - Diseasei

Amyloidosis, Corneal dystrophy, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
2934

MalaCards human disease database

More...
MalaCardsi
GSN
MIMi105120 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000148180

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
85448 AGel amyloidosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA29011

Chemistry databases

Drug and drug target database

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DrugBanki
DB02621 Latrunculin A

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
GSN

Domain mapping of disease mutations (DMDM)

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DMDMi
121116

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Add BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003638528 – 782GelsolinAdd BLAST755

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei86Phosphotyrosine; by SRC; in vitro1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi215 ↔ 228In isoform 12 Publications
Modified residuei409Phosphotyrosine; by SRC; in vitro1 Publication1
Modified residuei465Phosphotyrosine; by SRC1 Publication1
Modified residuei584N6-acetyllysineBy similarity1
Modified residuei603Phosphotyrosine; by SRC; in vitro1 Publication1
Modified residuei651Phosphotyrosine; by SRC; in vitro1 Publication1
Modified residuei742PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids.1 Publication

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P06396

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P06396

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P06396

PeptideAtlas

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PeptideAtlasi
P06396

PRoteomics IDEntifications database

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PRIDEi
P06396

ProteomicsDB human proteome resource

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ProteomicsDBi
12635 [P06396-3]
51897
51898 [P06396-2]
51899 [P06396-3]

2D gel databases

USC-OGP 2-DE database

More...
OGPi
P06396

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P06396

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P06396

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P06396

Miscellaneous databases

CutDB - Proteolytic event database

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PMAP-CutDBi
P06396

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148180 Expressed in 243 organ(s), highest expression level in adipose tissue of abdominal region

CleanEx database of gene expression profiles

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CleanExi
HS_GSN

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P06396 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P06396 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB010823
CAB016728
CAB036009
HPA054026

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to actin and to fibronectin. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X. Interacts with the inactive form of EIF2AK2/PKR (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109189, 100 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P06396

Database of interacting proteins

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DIPi
DIP-2196N

Protein interaction database and analysis system

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IntActi
P06396, 58 interactors

Molecular INTeraction database

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MINTi
P06396

STRING: functional protein association networks

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STRINGi
9606.ENSP00000362924

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1782
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C0FX-ray2.40S53-176[»]
1C0GX-ray2.00S53-176[»]
1D4XX-ray1.75G52-177[»]
1DEJX-ray2.40S53-176[»]
1EQYX-ray2.30S52-176[»]
1ESVX-ray2.00S52-176[»]
1H1VX-ray3.00G439-769[»]
1KCQX-ray1.65A185-288[»]
1MDUX-ray2.20A/D52-176[»]
1NLVX-ray1.80G52-176[»]
1NM1X-ray1.80G52-176[»]
1NMDX-ray1.90G52-176[»]
1P8XX-ray2.00A/B/C439-782[»]
1P8ZX-ray2.60G52-187[»]
1SOLNMR-A177-196[»]
1T44X-ray2.00G55-179[»]
1YAGX-ray1.90G52-176[»]
1YVNX-ray2.10G52-176[»]
2FF3X-ray2.00A52-179[»]
2FF6X-ray2.05G52-179[»]
2FH1X-ray1.55A/B/C439-782[»]
2FH2X-ray2.50A/B/C439-782[»]
2FH3X-ray2.87A/B/C439-782[»]
2FH4X-ray3.00A/B/C439-782[»]
3A5LX-ray2.40S53-176[»]
3A5MX-ray2.40S53-176[»]
3A5NX-ray2.36S53-176[»]
3A5OX-ray2.40S53-176[»]
3CI5X-ray1.70G52-176[»]
3CIPX-ray1.60G52-176[»]
3CJBX-ray3.21G52-176[»]
3CJCX-ray3.90G52-176[»]
3FFKX-ray3.00A/D52-426[»]
3FFNX-ray3.00A/B1-782[»]
3TU5X-ray3.00B53-174[»]
4PKGX-ray1.80G52-176[»]
4PKHX-ray2.15B/E/G/J52-176[»]
B/E/G/J196-260[»]
4PKIX-ray2.30G52-176[»]
4S10X-ray2.61C/D186-288[»]
4Z94X-ray2.40G52-176[»]
5DD2X-ray2.60A/G55-188[»]
5FAEX-ray1.70A178-293[»]
5FAFX-ray1.05A178-293[»]
5H3MNMR-A55-187[»]
5H3NNMR-A55-187[»]
5O2ZX-ray1.70A/B178-293[»]
5UBOX-ray2.39S52-178[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P06396

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P06396

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P06396

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati76 – 126Gelsolin-like 1Add BLAST51
Repeati198 – 238Gelsolin-like 2Add BLAST41
Repeati314 – 356Gelsolin-like 3Add BLAST43
Repeati453 – 504Gelsolin-like 4Add BLAST52
Repeati576 – 616Gelsolin-like 5Add BLAST41
Repeati679 – 721Gelsolin-like 6Add BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni53 – 176Actin-severingSequence analysisAdd BLAST124
Regioni123 – 126Actin-actin interfilament contact point4
Regioni162 – 169Polyphosphoinositide bindingBy similarity8
Regioni188 – 196Polyphosphoinositide bindingBy similarity9
Regioni434 – 782Actin-binding, Ca-sensitiveSequence analysisAdd BLAST349

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0443 Eukaryota
ENOG410XR0A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155591

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000233630

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004183

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P06396

KEGG Orthology (KO)

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KOi
K05768

Identification of Orthologs from Complete Genome Data

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OMAi
EWPQTPD

Database of Orthologous Groups

More...
OrthoDBi
1376537at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P06396

TreeFam database of animal gene trees

More...
TreeFami
TF313468

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.20.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR030004 Gelsolin
IPR007123 Gelsolin-like_dom
IPR007122 Villin/Gelsolin

The PANTHER Classification System

More...
PANTHERi
PTHR11977 PTHR11977, 1 hit
PTHR11977:SF29 PTHR11977:SF29, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00626 Gelsolin, 6 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00597 GELSOLIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00262 GEL, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P06396-1) [UniParc]FASTAAdd to basket
Also known as: Secreted, Plasma

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPHRPAPAL LCALSLALCA LSLPVRAATA SRGASQAGAP QGRVPEARPN
60 70 80 90 100
SMVVEHPEFL KAGKEPGLQI WRVEKFDLVP VPTNLYGDFF TGDAYVILKT
110 120 130 140 150
VQLRNGNLQY DLHYWLGNEC SQDESGAAAI FTVQLDDYLN GRAVQHREVQ
160 170 180 190 200
GFESATFLGY FKSGLKYKKG GVASGFKHVV PNEVVVQRLF QVKGRRVVRA
210 220 230 240 250
TEVPVSWESF NNGDCFILDL GNNIHQWCGS NSNRYERLKA TQVSKGIRDN
260 270 280 290 300
ERSGRARVHV SEEGTEPEAM LQVLGPKPAL PAGTEDTAKE DAANRKLAKL
310 320 330 340 350
YKVSNGAGTM SVSLVADENP FAQGALKSED CFILDHGKDG KIFVWKGKQA
360 370 380 390 400
NTEERKAALK TASDFITKMD YPKQTQVSVL PEGGETPLFK QFFKNWRDPD
410 420 430 440 450
QTDGLGLSYL SSHIANVERV PFDAATLHTS TAMAAQHGMD DDGTGQKQIW
460 470 480 490 500
RIEGSNKVPV DPATYGQFYG GDSYIILYNY RHGGRQGQII YNWQGAQSTQ
510 520 530 540 550
DEVAASAILT AQLDEELGGT PVQSRVVQGK EPAHLMSLFG GKPMIIYKGG
560 570 580 590 600
TSREGGQTAP ASTRLFQVRA NSAGATRAVE VLPKAGALNS NDAFVLKTPS
610 620 630 640 650
AAYLWVGTGA SEAEKTGAQE LLRVLRAQPV QVAEGSEPDG FWEALGGKAA
660 670 680 690 700
YRTSPRLKDK KMDAHPPRLF ACSNKIGRFV IEEVPGELMQ EDLATDDVML
710 720 730 740 750
LDTWDQVFVW VGKDSQEEEK TEALTSAKRY IETDPANRDR RTPITVVKQG
760 770 780
FEPPSFVGWF LGWDDDYWSV DPLDRAMAEL AA
Length:782
Mass (Da):85,698
Last modified:January 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8CEBC52257A160F7
GO
Isoform 2 (identifier: P06396-2) [UniParc]FASTAAdd to basket
Also known as: Cytoplasmic

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.

Show »
Length:731
Mass (Da):80,641
Checksum:i0C5C30CE497A0684
GO
Isoform 3 (identifier: P06396-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: MAPHRPAPALLCALSLALCALSLPVRAATASRGASQAGAPQGRVPEAR → MEKLFCCF

Show »
Length:742
Mass (Da):81,941
Checksum:iCA633F2D7DFF84DA
GO
Isoform 4 (identifier: P06396-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: MAPHRPAPALLCALSLALCALSLPVRAATASRGASQAGAPQGRVPEAR → MPLCT

Note: No experimental confirmation available.
Show »
Length:739
Mass (Da):81,485
Checksum:i61A735296139EB27
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MS51A0A0A0MS51_HUMAN
Gelsolin
GSN
748Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MT01A0A0A0MT01_HUMAN
Gelsolin
GSN
767Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0I0Q5T0I0_HUMAN
Gelsolin
GSN
260Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0H8Q5T0H8_HUMAN
Gelsolin
GSN
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQL8A0A0U1RQL8_HUMAN
Gelsolin
GSN
232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti294N → D in BAH13037 (PubMed:14702039).Curated1
Sequence conflicti419R → W in BAH13037 (PubMed:14702039).Curated1
Sequence conflicti603Y → H in BAH13037 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03633722S → L in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_024690129A → T. Corresponds to variant dbSNP:rs2230287EnsemblClinVar.1
Natural variantiVAR_036338201T → I in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_007718214D → N in AMYL5. 2 PublicationsCorresponds to variant dbSNP:rs121909715EnsemblClinVar.1
Natural variantiVAR_007719214D → Y in AMYL5. 1 PublicationCorresponds to variant dbSNP:rs121909715EnsemblClinVar.1
Natural variantiVAR_061982231N → D. Corresponds to variant dbSNP:rs11550199Ensembl.1
Natural variantiVAR_036339611S → N in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_033958668R → L. Corresponds to variant dbSNP:rs9696578Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0189591 – 51Missing in isoform 2. 2 PublicationsAdd BLAST51
Alternative sequenceiVSP_0428791 – 48MAPHR…VPEAR → MEKLFCCF in isoform 3. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_0547911 – 48MAPHR…VPEAR → MPLCT in isoform 4. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X04412 mRNA Translation: CAA28000.1
AK096280 mRNA Translation: BAG53247.1
AK125819 mRNA Translation: BAG54252.1
AK295572 mRNA Translation: BAH12109.1
AK299453 mRNA Translation: BAH13037.1
AK315494 mRNA Translation: BAG37878.1
AL137068 Genomic DNA No translation available.
AL513122 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87489.1
CH471090 Genomic DNA Translation: EAW87490.1
CH471090 Genomic DNA Translation: EAW87491.1
BC017491 mRNA Translation: AAH17491.1
BC026033 mRNA Translation: AAH26033.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS48011.1 [P06396-3]
CCDS65118.1 [P06396-4]
CCDS6828.1 [P06396-1]
CCDS6829.1 [P06396-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A03011 FAHUP

NCBI Reference Sequences

More...
RefSeqi
NP_000168.1, NM_000177.4 [P06396-1]
NP_001121134.1, NM_001127662.1 [P06396-2]
NP_001121135.2, NM_001127663.1
NP_001121136.1, NM_001127664.1 [P06396-2]
NP_001121137.1, NM_001127665.1 [P06396-2]
NP_001121138.1, NM_001127666.1 [P06396-3]
NP_001121139.1, NM_001127667.1 [P06396-3]
NP_001244958.1, NM_001258029.1
NP_001244959.1, NM_001258030.1 [P06396-4]
NP_937895.1, NM_198252.2 [P06396-2]
XP_005252000.1, XM_005251943.1
XP_005252001.1, XM_005251944.1 [P06396-3]
XP_005252002.1, XM_005251945.3
XP_006717142.1, XM_006717079.1
XP_011516888.1, XM_011518586.1
XP_011516889.1, XM_011518587.2
XP_011516890.1, XM_011518588.2
XP_011516891.1, XM_011518589.2
XP_011516892.1, XM_011518590.2
XP_011516893.1, XM_011518591.2
XP_011516894.1, XM_011518592.1
XP_011516895.1, XM_011518593.1 [P06396-2]
XP_016870135.1, XM_017014646.1
XP_016870136.1, XM_017014647.1
XP_016870137.1, XM_017014648.1 [P06396-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.522373

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373808; ENSP00000362914; ENSG00000148180 [P06396-3]
ENST00000373818; ENSP00000362924; ENSG00000148180 [P06396-1]
ENST00000373823; ENSP00000362929; ENSG00000148180 [P06396-2]
ENST00000545652; ENSP00000445823; ENSG00000148180 [P06396-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2934

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2934

UCSC genome browser

More...
UCSCi
uc004ble.1 human [P06396-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Gelsolin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04412 mRNA Translation: CAA28000.1
AK096280 mRNA Translation: BAG53247.1
AK125819 mRNA Translation: BAG54252.1
AK295572 mRNA Translation: BAH12109.1
AK299453 mRNA Translation: BAH13037.1
AK315494 mRNA Translation: BAG37878.1
AL137068 Genomic DNA No translation available.
AL513122 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87489.1
CH471090 Genomic DNA Translation: EAW87490.1
CH471090 Genomic DNA Translation: EAW87491.1
BC017491 mRNA Translation: AAH17491.1
BC026033 mRNA Translation: AAH26033.1
CCDSiCCDS48011.1 [P06396-3]
CCDS65118.1 [P06396-4]
CCDS6828.1 [P06396-1]
CCDS6829.1 [P06396-2]
PIRiA03011 FAHUP
RefSeqiNP_000168.1, NM_000177.4 [P06396-1]
NP_001121134.1, NM_001127662.1 [P06396-2]
NP_001121135.2, NM_001127663.1
NP_001121136.1, NM_001127664.1 [P06396-2]
NP_001121137.1, NM_001127665.1 [P06396-2]
NP_001121138.1, NM_001127666.1 [P06396-3]
NP_001121139.1, NM_001127667.1 [P06396-3]
NP_001244958.1, NM_001258029.1
NP_001244959.1, NM_001258030.1 [P06396-4]
NP_937895.1, NM_198252.2 [P06396-2]
XP_005252000.1, XM_005251943.1
XP_005252001.1, XM_005251944.1 [P06396-3]
XP_005252002.1, XM_005251945.3
XP_006717142.1, XM_006717079.1
XP_011516888.1, XM_011518586.1
XP_011516889.1, XM_011518587.2
XP_011516890.1, XM_011518588.2
XP_011516891.1, XM_011518589.2
XP_011516892.1, XM_011518590.2
XP_011516893.1, XM_011518591.2
XP_011516894.1, XM_011518592.1
XP_011516895.1, XM_011518593.1 [P06396-2]
XP_016870135.1, XM_017014646.1
XP_016870136.1, XM_017014647.1
XP_016870137.1, XM_017014648.1 [P06396-3]
UniGeneiHs.522373

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C0FX-ray2.40S53-176[»]
1C0GX-ray2.00S53-176[»]
1D4XX-ray1.75G52-177[»]
1DEJX-ray2.40S53-176[»]
1EQYX-ray2.30S52-176[»]
1ESVX-ray2.00S52-176[»]
1H1VX-ray3.00G439-769[»]
1KCQX-ray1.65A185-288[»]
1MDUX-ray2.20A/D52-176[»]
1NLVX-ray1.80G52-176[»]
1NM1X-ray1.80G52-176[»]
1NMDX-ray1.90G52-176[»]
1P8XX-ray2.00A/B/C439-782[»]
1P8ZX-ray2.60G52-187[»]
1SOLNMR-A177-196[»]
1T44X-ray2.00G55-179[»]
1YAGX-ray1.90G52-176[»]
1YVNX-ray2.10G52-176[»]
2FF3X-ray2.00A52-179[»]
2FF6X-ray2.05G52-179[»]
2FH1X-ray1.55A/B/C439-782[»]
2FH2X-ray2.50A/B/C439-782[»]
2FH3X-ray2.87A/B/C439-782[»]
2FH4X-ray3.00A/B/C439-782[»]
3A5LX-ray2.40S53-176[»]
3A5MX-ray2.40S53-176[»]
3A5NX-ray2.36S53-176[»]
3A5OX-ray2.40S53-176[»]
3CI5X-ray1.70G52-176[»]
3CIPX-ray1.60G52-176[»]
3CJBX-ray3.21G52-176[»]
3CJCX-ray3.90G52-176[»]
3FFKX-ray3.00A/D52-426[»]
3FFNX-ray3.00A/B1-782[»]
3TU5X-ray3.00B53-174[»]
4PKGX-ray1.80G52-176[»]
4PKHX-ray2.15B/E/G/J52-176[»]
B/E/G/J196-260[»]
4PKIX-ray2.30G52-176[»]
4S10X-ray2.61C/D186-288[»]
4Z94X-ray2.40G52-176[»]
5DD2X-ray2.60A/G55-188[»]
5FAEX-ray1.70A178-293[»]
5FAFX-ray1.05A178-293[»]
5H3MNMR-A55-187[»]
5H3NNMR-A55-187[»]
5O2ZX-ray1.70A/B178-293[»]
5UBOX-ray2.39S52-178[»]
ProteinModelPortaliP06396
SMRiP06396
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109189, 100 interactors
CORUMiP06396
DIPiDIP-2196N
IntActiP06396, 58 interactors
MINTiP06396
STRINGi9606.ENSP00000362924

Chemistry databases

DrugBankiDB02621 Latrunculin A

PTM databases

iPTMnetiP06396
PhosphoSitePlusiP06396
SwissPalmiP06396

Polymorphism and mutation databases

BioMutaiGSN
DMDMi121116

2D gel databases

OGPiP06396

Proteomic databases

EPDiP06396
jPOSTiP06396
PaxDbiP06396
PeptideAtlasiP06396
PRIDEiP06396
ProteomicsDBi12635 [P06396-3]
51897
51898 [P06396-2]
51899 [P06396-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2934
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373808; ENSP00000362914; ENSG00000148180 [P06396-3]
ENST00000373818; ENSP00000362924; ENSG00000148180 [P06396-1]
ENST00000373823; ENSP00000362929; ENSG00000148180 [P06396-2]
ENST00000545652; ENSP00000445823; ENSG00000148180 [P06396-4]
GeneIDi2934
KEGGihsa:2934
UCSCiuc004ble.1 human [P06396-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2934
DisGeNETi2934
EuPathDBiHostDB:ENSG00000148180.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GSN
HGNCiHGNC:4620 GSN
HPAiCAB010823
CAB016728
CAB036009
HPA054026
MalaCardsiGSN
MIMi105120 phenotype
137350 gene
neXtProtiNX_P06396
OpenTargetsiENSG00000148180
Orphaneti85448 AGel amyloidosis
PharmGKBiPA29011

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0443 Eukaryota
ENOG410XR0A LUCA
GeneTreeiENSGT00940000155591
HOGENOMiHOG000233630
HOVERGENiHBG004183
InParanoidiP06396
KOiK05768
OMAiEWPQTPD
OrthoDBi1376537at2759
PhylomeDBiP06396
TreeFamiTF313468

Enzyme and pathway databases

ReactomeiR-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-977225 Amyloid fiber formation
SABIO-RKiP06396
SIGNORiP06396

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GSN human
EvolutionaryTraceiP06396

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Gelsolin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2934
PMAP-CutDBiP06396

Protein Ontology

More...
PROi
PR:P06396

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148180 Expressed in 243 organ(s), highest expression level in adipose tissue of abdominal region
CleanExiHS_GSN
ExpressionAtlasiP06396 baseline and differential
GenevisibleiP06396 HS

Family and domain databases

Gene3Di3.40.20.10, 6 hits
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR030004 Gelsolin
IPR007123 Gelsolin-like_dom
IPR007122 Villin/Gelsolin
PANTHERiPTHR11977 PTHR11977, 1 hit
PTHR11977:SF29 PTHR11977:SF29, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 6 hits
PRINTSiPR00597 GELSOLIN
SMARTiView protein in SMART
SM00262 GEL, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGELS_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06396
Secondary accession number(s): A2A418
, A8MUD1, A8MYN7, B7Z373, B7Z5V1, F5H1A8, Q5T0I2, Q8WVV7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: January 16, 2019
This is version 227 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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