UniProtKB - P06396 (GELS_HUMAN)
Gelsolin
GSN
Functioni
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 471 | Calcium 1; via carbonyl oxygen | 1 | |
Metal bindingi | 472 | Calcium 1 | 1 | |
Metal bindingi | 502 | Calcium 1 | 1 | |
Metal bindingi | 551 | Calcium 1; via carbonyl oxygen | 1 | |
Metal bindingi | 591 | Calcium 2 | 1 | |
Metal bindingi | 591 | Calcium 2; via carbonyl oxygen | 1 | |
Metal bindingi | 592 | Calcium 2 | 1 | |
Metal bindingi | 614 | Calcium 2 | 1 | |
Metal bindingi | 696 | Calcium 3; via carbonyl oxygen | 1 | |
Metal bindingi | 697 | Calcium 3 | 1 | |
Metal bindingi | 719 | Calcium 3 | 1 |
GO - Molecular functioni
- actin binding Source: UniProtKB
- actin filament binding Source: GO_Central
- calcium ion binding Source: UniProtKB
- myosin II binding Source: UniProtKB
- phosphatidylinositol 3-kinase catalytic subunit binding Source: BHF-UCL
- phosphatidylinositol-4,5-bisphosphate binding Source: GO_Central
GO - Biological processi
- actin filament capping Source: UniProtKB
- actin filament depolymerization Source: BHF-UCL
- actin filament polymerization Source: UniProtKB
- actin filament reorganization Source: UniProtKB
- actin filament severing Source: UniProtKB
- actin nucleation Source: InterPro
- actin polymerization or depolymerization Source: GO_Central
- amyloid fibril formation Source: UniProtKB
- barbed-end actin filament capping Source: GO_Central
- cardiac muscle cell contraction Source: BHF-UCL
- cell projection assembly Source: GO_Central
- cellular response to interferon-gamma Source: Ensembl
- central nervous system development Source: GO_Central
- cilium assembly Source: UniProtKB
- hepatocyte apoptotic process Source: UniProtKB
- negative regulation of viral entry into host cell Source: UniProtKB
- phagocytosis, engulfment Source: UniProtKB
- positive regulation of actin nucleation Source: UniProtKB
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of keratinocyte apoptotic process Source: UniProtKB
- positive regulation of protein processing in phagocytic vesicle Source: UniProtKB
- protein destabilization Source: UniProtKB
- regulation of establishment of T cell polarity Source: UniProtKB
- regulation of plasma membrane raft polarization Source: UniProtKB
- regulation of podosome assembly Source: UniProtKB
- regulation of receptor clustering Source: UniProtKB
- relaxation of cardiac muscle Source: BHF-UCL
- renal protein absorption Source: UniProtKB
- response to muscle stretch Source: BHF-UCL
- sequestering of actin monomers Source: UniProtKB
- striated muscle atrophy Source: UniProtKB
Keywordsi
Molecular function | Actin capping, Actin-binding |
Biological process | Cilium biogenesis/degradation |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P06396 |
Reactomei | R-HSA-264870, Caspase-mediated cleavage of cytoskeletal proteins R-HSA-6798695, Neutrophil degranulation R-HSA-9662361, Sensory processing of sound by outer hair cells of the cochlea R-HSA-977225, Amyloid fiber formation |
SABIO-RKi | P06396 |
SignaLinki | P06396 |
SIGNORi | P06396 |
Names & Taxonomyi
Protein namesi | Recommended name: GelsolinAlternative name(s): AGEL Actin-depolymerizing factor Short name: ADF Brevin |
Gene namesi | Name:GSN |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4620, GSN |
MIMi | 137350, gene |
neXtProti | NX_P06396 |
VEuPathDBi | HostDB:ENSG00000148180 |
Subcellular locationi
Cytoskeleton
Extracellular region or secreted
Cytoskeleton
- actin cap Source: UniProtKB
- actin cytoskeleton Source: GO_Central
- cortical actin cytoskeleton Source: UniProtKB
- podosome Source: UniProtKB
Cytosol
- cytosol Source: UniProtKB
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
- extracellular region Source: UniProtKB
- extracellular space Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- ficolin-1-rich granule lumen Source: Reactome
- focal adhesion Source: UniProtKB
- lamellipodium Source: Ensembl
- phagocytic vesicle Source: Ensembl
- sarcoplasm Source: UniProtKB
- secretory granule lumen Source: Reactome
Keywords - Cellular componenti
Amyloid, Cytoplasm, Cytoskeleton, SecretedPathology & Biotechi
Involvement in diseasei
Amyloidosis 5 (AMYL5)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_007718 | 214 | D → N in AMYL5. 2 PublicationsCorresponds to variant dbSNP:rs121909715Ensembl. | 1 | |
Natural variantiVAR_007719 | 214 | D → Y in AMYL5. 1 PublicationCorresponds to variant dbSNP:rs121909715Ensembl. | 1 |
Keywords - Diseasei
Amyloidosis, Corneal dystrophy, Disease variantOrganism-specific databases
DisGeNETi | 2934 |
MalaCardsi | GSN |
MIMi | 105120, phenotype |
OpenTargetsi | ENSG00000148180 |
Orphaneti | 85448, AGel amyloidosis |
PharmGKBi | PA29011 |
Miscellaneous databases
Pharosi | P06396, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295700 |
DrugBanki | DB09130, Copper DB02621, Latrunculin A DB01593, Zinc DB14487, Zinc acetate |
Genetic variation databases
BioMutai | GSN |
DMDMi | 121116 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Add BLAST | 27 | |
ChainiPRO_0000036385 | 28 – 782 | GelsolinAdd BLAST | 755 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 86 | Phosphotyrosine; by SRC; in vitro1 Publication | 1 | |
Disulfide bondi | 215 ↔ 228 | In isoform 12 Publications | ||
Modified residuei | 409 | Phosphotyrosine; by SRC; in vitro1 Publication | 1 | |
Modified residuei | 465 | Phosphotyrosine; by SRC1 Publication | 1 | |
Modified residuei | 584 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 603 | Phosphotyrosine; by SRC; in vitro1 Publication | 1 | |
Modified residuei | 651 | Phosphotyrosine; by SRC; in vitro1 Publication | 1 | |
Modified residuei | 742 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Disulfide bond, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-1126 non-CPTAC-1127 |
EPDi | P06396 |
jPOSTi | P06396 |
MassIVEi | P06396 |
MaxQBi | P06396 |
PaxDbi | P06396 |
PeptideAtlasi | P06396 |
PRIDEi | P06396 |
ProteomicsDBi | 25596 51897 [P06396-1] 51898 [P06396-2] 51899 [P06396-3] |
2D gel databases
OGPi | P06396 |
PTM databases
GlyGeni | P06396, 9 sites, 4 O-linked glycans (9 sites) |
iPTMneti | P06396 |
MetOSitei | P06396 |
PhosphoSitePlusi | P06396 |
SwissPalmi | P06396 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000148180, Expressed in adipose tissue of abdominal region and 255 other tissues |
ExpressionAtlasi | P06396, baseline and differential |
Genevisiblei | P06396, HS |
Organism-specific databases
HPAi | ENSG00000148180, Low tissue specificity |
Interactioni
Subunit structurei
Binds to actin and to fibronectin.
Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X.
Interacts with the inactive form of EIF2AK2/PKR (By similarity).
By similarityBinary interactionsi
P06396
GO - Molecular functioni
- actin binding Source: UniProtKB
- actin filament binding Source: GO_Central
- myosin II binding Source: UniProtKB
- phosphatidylinositol 3-kinase catalytic subunit binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 109189, 163 interactors |
CORUMi | P06396 |
DIPi | DIP-2196N |
IntActi | P06396, 290 interactors |
MINTi | P06396 |
STRINGi | 9606.ENSP00000362924 |
Miscellaneous databases
RNActi | P06396, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P06396 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06396 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 76 – 126 | Gelsolin-like 1Add BLAST | 51 | |
Repeati | 198 – 238 | Gelsolin-like 2Add BLAST | 41 | |
Repeati | 314 – 356 | Gelsolin-like 3Add BLAST | 43 | |
Repeati | 453 – 504 | Gelsolin-like 4Add BLAST | 52 | |
Repeati | 576 – 616 | Gelsolin-like 5Add BLAST | 41 | |
Repeati | 679 – 721 | Gelsolin-like 6Add BLAST | 43 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 53 – 176 | Actin-severingSequence analysisAdd BLAST | 124 | |
Regioni | 123 – 126 | Actin-actin interfilament contact point | 4 | |
Regioni | 162 – 169 | Polyphosphoinositide bindingBy similarity | 8 | |
Regioni | 188 – 196 | Polyphosphoinositide bindingBy similarity | 9 | |
Regioni | 247 – 285 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 434 – 782 | Actin-binding, Ca-sensitiveSequence analysisAdd BLAST | 349 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 247 – 264 | Basic and acidic residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | KOG0443, Eukaryota |
GeneTreei | ENSGT00940000155591 |
HOGENOMi | CLU_002568_3_2_1 |
InParanoidi | P06396 |
OrthoDBi | 1376537at2759 |
PhylomeDBi | P06396 |
TreeFami | TF313468 |
Family and domain databases
Gene3Di | 3.40.20.10, 6 hits |
IDEALi | IID00265 |
InterProi | View protein in InterPro IPR029006, ADF-H/Gelsolin-like_dom_sf IPR030004, Gelsolin IPR007123, Gelsolin-like_dom IPR007122, Villin/Gelsolin |
PANTHERi | PTHR11977, PTHR11977, 1 hit PTHR11977:SF27, PTHR11977:SF27, 1 hit |
Pfami | View protein in Pfam PF00626, Gelsolin, 6 hits |
PRINTSi | PR00597, GELSOLIN |
SMARTi | View protein in SMART SM00262, GEL, 6 hits |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing and alternative initiation. AlignAdd to basketThis entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAPHRPAPAL LCALSLALCA LSLPVRAATA SRGASQAGAP QGRVPEARPN
60 70 80 90 100
SMVVEHPEFL KAGKEPGLQI WRVEKFDLVP VPTNLYGDFF TGDAYVILKT
110 120 130 140 150
VQLRNGNLQY DLHYWLGNEC SQDESGAAAI FTVQLDDYLN GRAVQHREVQ
160 170 180 190 200
GFESATFLGY FKSGLKYKKG GVASGFKHVV PNEVVVQRLF QVKGRRVVRA
210 220 230 240 250
TEVPVSWESF NNGDCFILDL GNNIHQWCGS NSNRYERLKA TQVSKGIRDN
260 270 280 290 300
ERSGRARVHV SEEGTEPEAM LQVLGPKPAL PAGTEDTAKE DAANRKLAKL
310 320 330 340 350
YKVSNGAGTM SVSLVADENP FAQGALKSED CFILDHGKDG KIFVWKGKQA
360 370 380 390 400
NTEERKAALK TASDFITKMD YPKQTQVSVL PEGGETPLFK QFFKNWRDPD
410 420 430 440 450
QTDGLGLSYL SSHIANVERV PFDAATLHTS TAMAAQHGMD DDGTGQKQIW
460 470 480 490 500
RIEGSNKVPV DPATYGQFYG GDSYIILYNY RHGGRQGQII YNWQGAQSTQ
510 520 530 540 550
DEVAASAILT AQLDEELGGT PVQSRVVQGK EPAHLMSLFG GKPMIIYKGG
560 570 580 590 600
TSREGGQTAP ASTRLFQVRA NSAGATRAVE VLPKAGALNS NDAFVLKTPS
610 620 630 640 650
AAYLWVGTGA SEAEKTGAQE LLRVLRAQPV QVAEGSEPDG FWEALGGKAA
660 670 680 690 700
YRTSPRLKDK KMDAHPPRLF ACSNKIGRFV IEEVPGELMQ EDLATDDVML
710 720 730 740 750
LDTWDQVFVW VGKDSQEEEK TEALTSAKRY IETDPANRDR RTPITVVKQG
760 770 780
FEPPSFVGWF LGWDDDYWSV DPLDRAMAEL AA
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5T0I0 | Q5T0I0_HUMAN | Macrophage-capping protein | GSN | 260 | Annotation score: | ||
A0A0U1RQL8 | A0A0U1RQL8_HUMAN | Macrophage-capping protein | GSN | 232 | Annotation score: | ||
A0A0A0MS51 | A0A0A0MS51_HUMAN | Actin-depolymerizing factor | GSN | 748 | Annotation score: | ||
A0A0A0MT01 | A0A0A0MT01_HUMAN | Actin-depolymerizing factor | GSN | 767 | Annotation score: | ||
Q5T0H8 | Q5T0H8_HUMAN | Gelsolin | GSN | 67 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 294 | N → D in BAH13037 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 419 | R → W in BAH13037 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 603 | Y → H in BAH13037 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036337 | 22 | S → L in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_024690 | 129 | A → T. Corresponds to variant dbSNP:rs2230287Ensembl. | 1 | |
Natural variantiVAR_036338 | 201 | T → I in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_007718 | 214 | D → N in AMYL5. 2 PublicationsCorresponds to variant dbSNP:rs121909715Ensembl. | 1 | |
Natural variantiVAR_007719 | 214 | D → Y in AMYL5. 1 PublicationCorresponds to variant dbSNP:rs121909715Ensembl. | 1 | |
Natural variantiVAR_061982 | 231 | N → D. Corresponds to variant dbSNP:rs11550199Ensembl. | 1 | |
Natural variantiVAR_036339 | 611 | S → N in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_033958 | 668 | R → L. Corresponds to variant dbSNP:rs9696578Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018959 | 1 – 51 | Missing in isoform 2. 2 PublicationsAdd BLAST | 51 | |
Alternative sequenceiVSP_042879 | 1 – 48 | MAPHR…VPEAR → MEKLFCCF in isoform 3. 1 PublicationAdd BLAST | 48 | |
Alternative sequenceiVSP_054791 | 1 – 48 | MAPHR…VPEAR → MPLCT in isoform 4. 1 PublicationAdd BLAST | 48 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000373808; ENSP00000362914; ENSG00000148180 [P06396-3] ENST00000373818; ENSP00000362924; ENSG00000148180 ENST00000373823; ENSP00000362929; ENSG00000148180 [P06396-2] ENST00000432226; ENSP00000404226; ENSG00000148180 [P06396-2] ENST00000545652; ENSP00000445823; ENSG00000148180 [P06396-4] |
GeneIDi | 2934 |
KEGGi | hsa:2934 |
MANE-Selecti | ENST00000432226.7; ENSP00000404226.2; NM_198252.3; NP_937895.1 [P06396-2] |
UCSCi | uc004ble.1, human [P06396-1] |
Keywords - Coding sequence diversityi
Alternative initiation, Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Gelsolin entry |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1C0F | X-ray | 2.40 | S | 53-176 | [»] | |
1C0G | X-ray | 2.00 | S | 53-176 | [»] | |
1D4X | X-ray | 1.75 | G | 52-177 | [»] | |
1DEJ | X-ray | 2.40 | S | 53-176 | [»] | |
1EQY | X-ray | 2.30 | S | 52-176 | [»] | |
1ESV | X-ray | 2.00 | S | 52-176 | [»] | |
1H1V | X-ray | 3.00 | G | 439-769 | [»] | |
1KCQ | X-ray | 1.65 | A | 185-288 | [»] | |
1MDU | X-ray | 2.20 | A/D | 52-176 | [»] | |
1NLV | X-ray | 1.80 | G | 52-176 | [»] | |
1NM1 | X-ray | 1.80 | G | 52-176 | [»] | |
1NMD | X-ray | 1.90 | G | 52-176 | [»] | |
1P8X | X-ray | 2.00 | A/B/C | 439-782 | [»] | |
1P8Z | X-ray | 2.60 | G | 52-187 | [»] | |
1SOL | NMR | - | A | 177-196 | [»] | |
1T44 | X-ray | 2.00 | G | 55-179 | [»] | |
1YAG | X-ray | 1.90 | G | 52-176 | [»] | |
1YVN | X-ray | 2.10 | G | 52-176 | [»] | |
2FF3 | X-ray | 2.00 | A | 52-179 | [»] | |
2FF6 | X-ray | 2.05 | G | 52-179 | [»] | |
2FH1 | X-ray | 1.55 | A/B/C | 439-782 | [»] | |
2FH2 | X-ray | 2.50 | A/B/C | 439-782 | [»] | |
2FH3 | X-ray | 2.87 | A/B/C | 439-782 | [»] | |
2FH4 | X-ray | 3.00 | A/B/C | 439-782 | [»] | |
3A5L | X-ray | 2.40 | S | 53-176 | [»] | |
3A5M | X-ray | 2.40 | S | 53-176 | [»] | |
3A5N | X-ray | 2.36 | S | 53-176 | [»] | |
3A5O | X-ray | 2.40 | S | 53-176 | [»] | |
3CI5 | X-ray | 1.70 | G | 52-176 | [»] | |
3CIP | X-ray | 1.60 | G | 52-176 | [»] | |
3CJB | X-ray | 3.21 | G | 52-176 | [»] | |
3CJC | X-ray | 3.90 | G | 52-176 | [»] | |
3FFK | X-ray | 3.00 | A/D | 52-426 | [»] | |
3FFN | X-ray | 3.00 | A/B | 1-782 | [»] | |
3TU5 | X-ray | 3.00 | B | 53-174 | [»] | |
4PKG | X-ray | 1.80 | G | 52-176 | [»] | |
4PKH | X-ray | 2.15 | B/E/G/J | 52-176 | [»] | |
B/E/G/J | 196-260 | [»] | ||||
4PKI | X-ray | 2.30 | G | 52-176 | [»] | |
4S10 | X-ray | 2.61 | C/D | 186-288 | [»] | |
4Z94 | X-ray | 2.40 | G | 52-176 | [»] | |
5DD2 | X-ray | 2.60 | A/G | 55-188 | [»] | |
5FAE | X-ray | 1.70 | A | 178-293 | [»] | |
5FAF | X-ray | 1.05 | A | 178-293 | [»] | |
5H3M | NMR | - | A | 55-187 | [»] | |
5H3N | NMR | - | A | 55-187 | [»] | |
5O2Z | X-ray | 1.70 | A/B | 178-293 | [»] | |
5UBO | X-ray | 2.39 | S | 52-178 | [»] | |
5ZZ0 | X-ray | 2.63 | A/G | 55-188 | [»] | |
6H1F | X-ray | 1.90 | B | 178-293 | [»] | |
6JCO | X-ray | 2.88 | A/B | 56-782 | [»] | |
6JEG | X-ray | 2.98 | A/B | 54-782 | [»] | |
6JEH | X-ray | 2.95 | A/B | 56-782 | [»] | |
6LJE | X-ray | 1.40 | A/B | 297-397 | [»] | |
6LJF | X-ray | 1.50 | A/B | 297-397 | [»] | |
6Q9R | X-ray | 2.73 | A/B | 28-782 | [»] | |
6Q9Z | X-ray | 3.80 | A/B | 28-782 | [»] | |
6QBF | X-ray | 3.50 | A/B | 28-782 | [»] | |
6QW3 | X-ray | 1.30 | A | 178-293 | [»] | |
SMRi | P06396 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109189, 163 interactors |
CORUMi | P06396 |
DIPi | DIP-2196N |
IntActi | P06396, 290 interactors |
MINTi | P06396 |
STRINGi | 9606.ENSP00000362924 |
Chemistry databases
ChEMBLi | CHEMBL4295700 |
DrugBanki | DB09130, Copper DB02621, Latrunculin A DB01593, Zinc DB14487, Zinc acetate |
PTM databases
GlyGeni | P06396, 9 sites, 4 O-linked glycans (9 sites) |
iPTMneti | P06396 |
MetOSitei | P06396 |
PhosphoSitePlusi | P06396 |
SwissPalmi | P06396 |
Genetic variation databases
BioMutai | GSN |
DMDMi | 121116 |
2D gel databases
OGPi | P06396 |
Proteomic databases
CPTACi | non-CPTAC-1126 non-CPTAC-1127 |
EPDi | P06396 |
jPOSTi | P06396 |
MassIVEi | P06396 |
MaxQBi | P06396 |
PaxDbi | P06396 |
PeptideAtlasi | P06396 |
PRIDEi | P06396 |
ProteomicsDBi | 25596 51897 [P06396-1] 51898 [P06396-2] 51899 [P06396-3] |
Protocols and materials databases
ABCDi | P06396, 5 sequenced antibodies |
Antibodypediai | 3387, 772 antibodies from 47 providers |
CPTCi | P06396, 4 antibodies |
DNASUi | 2934 |
Genome annotation databases
Ensembli | ENST00000373808; ENSP00000362914; ENSG00000148180 [P06396-3] ENST00000373818; ENSP00000362924; ENSG00000148180 ENST00000373823; ENSP00000362929; ENSG00000148180 [P06396-2] ENST00000432226; ENSP00000404226; ENSG00000148180 [P06396-2] ENST00000545652; ENSP00000445823; ENSG00000148180 [P06396-4] |
GeneIDi | 2934 |
KEGGi | hsa:2934 |
MANE-Selecti | ENST00000432226.7; ENSP00000404226.2; NM_198252.3; NP_937895.1 [P06396-2] |
UCSCi | uc004ble.1, human [P06396-1] |
Organism-specific databases
CTDi | 2934 |
DisGeNETi | 2934 |
GeneCardsi | GSN |
HGNCi | HGNC:4620, GSN |
HPAi | ENSG00000148180, Low tissue specificity |
MalaCardsi | GSN |
MIMi | 105120, phenotype 137350, gene |
neXtProti | NX_P06396 |
OpenTargetsi | ENSG00000148180 |
Orphaneti | 85448, AGel amyloidosis |
PharmGKBi | PA29011 |
VEuPathDBi | HostDB:ENSG00000148180 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0443, Eukaryota |
GeneTreei | ENSGT00940000155591 |
HOGENOMi | CLU_002568_3_2_1 |
InParanoidi | P06396 |
OrthoDBi | 1376537at2759 |
PhylomeDBi | P06396 |
TreeFami | TF313468 |
Enzyme and pathway databases
PathwayCommonsi | P06396 |
Reactomei | R-HSA-264870, Caspase-mediated cleavage of cytoskeletal proteins R-HSA-6798695, Neutrophil degranulation R-HSA-9662361, Sensory processing of sound by outer hair cells of the cochlea R-HSA-977225, Amyloid fiber formation |
SABIO-RKi | P06396 |
SignaLinki | P06396 |
SIGNORi | P06396 |
Miscellaneous databases
BioGRID-ORCSi | 2934, 6 hits in 1043 CRISPR screens |
ChiTaRSi | GSN, human |
EvolutionaryTracei | P06396 |
GeneWikii | Gelsolin |
GenomeRNAii | 2934 |
Pharosi | P06396, Tbio |
PROi | PR:P06396 |
RNActi | P06396, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000148180, Expressed in adipose tissue of abdominal region and 255 other tissues |
ExpressionAtlasi | P06396, baseline and differential |
Genevisiblei | P06396, HS |
Family and domain databases
Gene3Di | 3.40.20.10, 6 hits |
IDEALi | IID00265 |
InterProi | View protein in InterPro IPR029006, ADF-H/Gelsolin-like_dom_sf IPR030004, Gelsolin IPR007123, Gelsolin-like_dom IPR007122, Villin/Gelsolin |
PANTHERi | PTHR11977, PTHR11977, 1 hit PTHR11977:SF27, PTHR11977:SF27, 1 hit |
Pfami | View protein in Pfam PF00626, Gelsolin, 6 hits |
PRINTSi | PR00597, GELSOLIN |
SMARTi | View protein in SMART SM00262, GEL, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | GELS_HUMAN | |
Accessioni | P06396Primary (citable) accession number: P06396 Secondary accession number(s): A2A418 Q8WVV7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | January 1, 1988 | |
Last modified: | February 23, 2022 | |
This is version 247 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families