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UniProtKB - P06396 (GELS_HUMAN)

Entry version 233 (18 Sep 2019)
Sequence version 1 (01 Jan 1988)
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Protein

Gelsolin

Gene

GSN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi471Calcium 1; via carbonyl oxygen1
Metal bindingi472Calcium 11
Metal bindingi502Calcium 11
Metal bindingi551Calcium 1; via carbonyl oxygen1
Metal bindingi591Calcium 21
Metal bindingi591Calcium 2; via carbonyl oxygen1
Metal bindingi592Calcium 21
Metal bindingi614Calcium 21
Metal bindingi696Calcium 3; via carbonyl oxygen1
Metal bindingi697Calcium 31
Metal bindingi719Calcium 31

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin capping, Actin-binding
Biological processCilium biogenesis/degradation
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-977225 Amyloid fiber formation

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P06396

SIGNOR Signaling Network Open Resource

More...SIGNORi		P06396

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gelsolin
Alternative name(s):
AGEL
Actin-depolymerizing factor
Short name:
ADF
Brevin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GSN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4620 GSN

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		137350 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P06396

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, Cytoplasm, Cytoskeleton, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Amyloidosis 5 (AMYL5)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hereditary generalized amyloidosis due to gelsolin amyloid deposition. It is typically characterized by cranial neuropathy and lattice corneal dystrophy. Most patients have modest involvement of internal organs, but severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_007718214D → N in AMYL5. 2 PublicationsCorresponds to variant dbSNP:rs121909715EnsemblClinVar.1
Natural variantiVAR_007719214D → Y in AMYL5. 1 PublicationCorresponds to variant dbSNP:rs121909715EnsemblClinVar.1

Keywords - Diseasei

Amyloidosis, Corneal dystrophy, Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		2934

MalaCards human disease database

More...MalaCardsi		GSN
MIMi105120 phenotype

Open Targets

More...OpenTargetsi		ENSG00000148180

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		85448 AGel amyloidosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29011

Chemistry databases

Drug and drug target database

More...DrugBanki		DB09130 Copper
DB02621 Latrunculin A
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GSN

Domain mapping of disease mutations (DMDM)

More...DMDMi		121116

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Add BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003638528 – 782GelsolinAdd BLAST755

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei86Phosphotyrosine; by SRC; in vitro1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi215 ↔ 228In isoform 12 Publications
Modified residuei409Phosphotyrosine; by SRC; in vitro1 Publication1
Modified residuei465Phosphotyrosine; by SRC1 Publication1
Modified residuei584N6-acetyllysineBy similarity1
Modified residuei603Phosphotyrosine; by SRC; in vitro1 Publication1
Modified residuei651Phosphotyrosine; by SRC; in vitro1 Publication1
Modified residuei742PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids.1 Publication

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		non-CPTAC-1126
non-CPTAC-1127

Encyclopedia of Proteome Dynamics

More...EPDi		P06396

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P06396

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P06396

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P06396

PeptideAtlas

More...PeptideAtlasi		P06396

PRoteomics IDEntifications database

More...PRIDEi		P06396

ProteomicsDB human proteome resource

More...ProteomicsDBi		12635 [P06396-3]
25596
51897 [P06396-1]
51898 [P06396-2]
51899 [P06396-3]

2D gel databases

USC-OGP 2-DE database

More...OGPi		P06396

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P06396

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P06396

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P06396

Miscellaneous databases

CutDB - Proteolytic event database

More...PMAP-CutDBi		P06396

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000148180 Expressed in 243 organ(s), highest expression level in adipose tissue of abdominal region

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P06396 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P06396 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB010823
CAB016728
CAB036009
HPA054026

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to actin and to fibronectin.

Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X.

Interacts with the inactive form of EIF2AK2/PKR (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		109189, 108 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P06396

Database of interacting proteins

More...DIPi		DIP-2196N

Protein interaction database and analysis system

More...IntActi		P06396, 80 interactors

Molecular INTeraction database

More...MINTi		P06396

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362924

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1782
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P06396

Database of comparative protein structure models

More...ModBasei		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P06396

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati76 – 126Gelsolin-like 1Add BLAST51
Repeati198 – 238Gelsolin-like 2Add BLAST41
Repeati314 – 356Gelsolin-like 3Add BLAST43
Repeati453 – 504Gelsolin-like 4Add BLAST52
Repeati576 – 616Gelsolin-like 5Add BLAST41
Repeati679 – 721Gelsolin-like 6Add BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni53 – 176Actin-severingSequence analysisAdd BLAST124
Regioni123 – 126Actin-actin interfilament contact point4
Regioni162 – 169Polyphosphoinositide bindingBy similarity8
Regioni188 – 196Polyphosphoinositide bindingBy similarity9
Regioni434 – 782Actin-binding, Ca-sensitiveSequence analysisAdd BLAST349

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the villin/gelsolin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0443 Eukaryota
ENOG410XR0A LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155591

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000233630

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P06396

KEGG Orthology (KO)

More...KOi		K05768

Identification of Orthologs from Complete Genome Data

More...OMAi		EWPQTPD

Database of Orthologous Groups

More...OrthoDBi		1376537at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P06396

TreeFam database of animal gene trees

More...TreeFami		TF313468

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.20.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR030004 Gelsolin
IPR007123 Gelsolin-like_dom
IPR007122 Villin/Gelsolin

The PANTHER Classification System

More...PANTHERi		PTHR11977 PTHR11977, 1 hit
PTHR11977:SF29 PTHR11977:SF29, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00626 Gelsolin, 6 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00597 GELSOLIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00262 GEL, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P06396-1) [UniParc]FASTAAdd to basket
Also known as: Secreted, Plasma

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPHRPAPAL LCALSLALCA LSLPVRAATA SRGASQAGAP QGRVPEARPN 
        60         70         80         90        100
SMVVEHPEFL KAGKEPGLQI WRVEKFDLVP VPTNLYGDFF TGDAYVILKT 
       110        120        130        140        150
VQLRNGNLQY DLHYWLGNEC SQDESGAAAI FTVQLDDYLN GRAVQHREVQ 
       160        170        180        190        200
GFESATFLGY FKSGLKYKKG GVASGFKHVV PNEVVVQRLF QVKGRRVVRA 
       210        220        230        240        250
TEVPVSWESF NNGDCFILDL GNNIHQWCGS NSNRYERLKA TQVSKGIRDN 
       260        270        280        290        300
ERSGRARVHV SEEGTEPEAM LQVLGPKPAL PAGTEDTAKE DAANRKLAKL 
       310        320        330        340        350
YKVSNGAGTM SVSLVADENP FAQGALKSED CFILDHGKDG KIFVWKGKQA 
       360        370        380        390        400
NTEERKAALK TASDFITKMD YPKQTQVSVL PEGGETPLFK QFFKNWRDPD 
       410        420        430        440        450
QTDGLGLSYL SSHIANVERV PFDAATLHTS TAMAAQHGMD DDGTGQKQIW 
       460        470        480        490        500
RIEGSNKVPV DPATYGQFYG GDSYIILYNY RHGGRQGQII YNWQGAQSTQ 
       510        520        530        540        550
DEVAASAILT AQLDEELGGT PVQSRVVQGK EPAHLMSLFG GKPMIIYKGG 
       560        570        580        590        600
TSREGGQTAP ASTRLFQVRA NSAGATRAVE VLPKAGALNS NDAFVLKTPS 
       610        620        630        640        650
AAYLWVGTGA SEAEKTGAQE LLRVLRAQPV QVAEGSEPDG FWEALGGKAA 
       660        670        680        690        700
YRTSPRLKDK KMDAHPPRLF ACSNKIGRFV IEEVPGELMQ EDLATDDVML 
       710        720        730        740        750
LDTWDQVFVW VGKDSQEEEK TEALTSAKRY IETDPANRDR RTPITVVKQG 
       760        770        780 
FEPPSFVGWF LGWDDDYWSV DPLDRAMAEL AA
Length:782
Mass (Da):85,698
Last modified:January 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8CEBC52257A160F7
GO
Isoform 2 (identifier: P06396-2) [UniParc]FASTAAdd to basket
Also known as: Cytoplasmic

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.

Show »
Length:731
Mass (Da):80,641
Checksum:i0C5C30CE497A0684
GO
Isoform 3 (identifier: P06396-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: MAPHRPAPALLCALSLALCALSLPVRAATASRGASQAGAPQGRVPEAR → MEKLFCCF

Show »
Length:742
Mass (Da):81,941
Checksum:iCA633F2D7DFF84DA
GO
Isoform 4 (identifier: P06396-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: MAPHRPAPALLCALSLALCALSLPVRAATASRGASQAGAPQGRVPEAR → MPLCT

Note: No experimental confirmation available.
Show »
Length:739
Mass (Da):81,485
Checksum:i61A735296139EB27
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MS51A0A0A0MS51_HUMAN
Gelsolin
GSN
748Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MT01A0A0A0MT01_HUMAN
Gelsolin
GSN
767Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0I0Q5T0I0_HUMAN
Gelsolin
GSN
260Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0H8Q5T0H8_HUMAN
Gelsolin
GSN
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQL8A0A0U1RQL8_HUMAN
Gelsolin
GSN
232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti294N → D in BAH13037 (PubMed:14702039).Curated1
Sequence conflicti419R → W in BAH13037 (PubMed:14702039).Curated1
Sequence conflicti603Y → H in BAH13037 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03633722S → L in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_024690129A → T. Corresponds to variant dbSNP:rs2230287EnsemblClinVar.1
Natural variantiVAR_036338201T → I in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_007718214D → N in AMYL5. 2 PublicationsCorresponds to variant dbSNP:rs121909715EnsemblClinVar.1
Natural variantiVAR_007719214D → Y in AMYL5. 1 PublicationCorresponds to variant dbSNP:rs121909715EnsemblClinVar.1
Natural variantiVAR_061982231N → D. Corresponds to variant dbSNP:rs11550199Ensembl.1
Natural variantiVAR_036339611S → N in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_033958668R → L. Corresponds to variant dbSNP:rs9696578Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0189591 – 51Missing in isoform 2. 2 PublicationsAdd BLAST51
Alternative sequenceiVSP_0428791 – 48MAPHR…VPEAR → MEKLFCCF in isoform 3. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_0547911 – 48MAPHR…VPEAR → MPLCT in isoform 4. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X04412 mRNA Translation: CAA28000.1
AK096280 mRNA Translation: BAG53247.1
AK125819 mRNA Translation: BAG54252.1
AK295572 mRNA Translation: BAH12109.1
AK299453 mRNA Translation: BAH13037.1
AK315494 mRNA Translation: BAG37878.1
AL137068 Genomic DNA No translation available.
AL513122 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87489.1
CH471090 Genomic DNA Translation: EAW87490.1
CH471090 Genomic DNA Translation: EAW87491.1
BC017491 mRNA Translation: AAH17491.1
BC026033 mRNA Translation: AAH26033.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS48011.1 [P06396-3]
CCDS65118.1 [P06396-4]
CCDS6828.1 [P06396-1]
CCDS6829.1 [P06396-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A03011 FAHUP

NCBI Reference Sequences

More...RefSeqi		NP_000168.1, NM_000177.4 [P06396-1]
NP_001121134.1, NM_001127662.1 [P06396-2]
NP_001121135.2, NM_001127663.1
NP_001121136.1, NM_001127664.1 [P06396-2]
NP_001121137.1, NM_001127665.1 [P06396-2]
NP_001121138.1, NM_001127666.1 [P06396-3]
NP_001121139.1, NM_001127667.1 [P06396-3]
NP_001244958.1, NM_001258029.1
NP_001244959.1, NM_001258030.1 [P06396-4]
NP_937895.1, NM_198252.2 [P06396-2]
XP_005252000.1, XM_005251943.1
XP_005252001.1, XM_005251944.1 [P06396-3]
XP_005252002.1, XM_005251945.3
XP_006717142.1, XM_006717079.1
XP_011516888.1, XM_011518586.1
XP_011516889.1, XM_011518587.2
XP_011516890.1, XM_011518588.2
XP_011516891.1, XM_011518589.2
XP_011516892.1, XM_011518590.2
XP_011516893.1, XM_011518591.2
XP_011516894.1, XM_011518592.1
XP_011516895.1, XM_011518593.1 [P06396-2]
XP_016870135.1, XM_017014646.1
XP_016870136.1, XM_017014647.1
XP_016870137.1, XM_017014648.1 [P06396-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373808; ENSP00000362914; ENSG00000148180 [P06396-3]
ENST00000373818; ENSP00000362924; ENSG00000148180 [P06396-1]
ENST00000373823; ENSP00000362929; ENSG00000148180 [P06396-2]
ENST00000545652; ENSP00000445823; ENSG00000148180 [P06396-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2934

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2934

UCSC genome browser

More...UCSCi		uc004ble.1 human [P06396-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Gelsolin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04412 mRNA Translation: CAA28000.1
AK096280 mRNA Translation: BAG53247.1
AK125819 mRNA Translation: BAG54252.1
AK295572 mRNA Translation: BAH12109.1
AK299453 mRNA Translation: BAH13037.1
AK315494 mRNA Translation: BAG37878.1
AL137068 Genomic DNA No translation available.
AL513122 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87489.1
CH471090 Genomic DNA Translation: EAW87490.1
CH471090 Genomic DNA Translation: EAW87491.1
BC017491 mRNA Translation: AAH17491.1
BC026033 mRNA Translation: AAH26033.1
CCDSiCCDS48011.1 [P06396-3]
CCDS65118.1 [P06396-4]
CCDS6828.1 [P06396-1]
CCDS6829.1 [P06396-2]
PIRiA03011 FAHUP
RefSeqiNP_000168.1, NM_000177.4 [P06396-1]
NP_001121134.1, NM_001127662.1 [P06396-2]
NP_001121135.2, NM_001127663.1
NP_001121136.1, NM_001127664.1 [P06396-2]
NP_001121137.1, NM_001127665.1 [P06396-2]
NP_001121138.1, NM_001127666.1 [P06396-3]
NP_001121139.1, NM_001127667.1 [P06396-3]
NP_001244958.1, NM_001258029.1
NP_001244959.1, NM_001258030.1 [P06396-4]
NP_937895.1, NM_198252.2 [P06396-2]
XP_005252000.1, XM_005251943.1
XP_005252001.1, XM_005251944.1 [P06396-3]
XP_005252002.1, XM_005251945.3
XP_006717142.1, XM_006717079.1
XP_011516888.1, XM_011518586.1
XP_011516889.1, XM_011518587.2
XP_011516890.1, XM_011518588.2
XP_011516891.1, XM_011518589.2
XP_011516892.1, XM_011518590.2
XP_011516893.1, XM_011518591.2
XP_011516894.1, XM_011518592.1
XP_011516895.1, XM_011518593.1 [P06396-2]
XP_016870135.1, XM_017014646.1
XP_016870136.1, XM_017014647.1
XP_016870137.1, XM_017014648.1 [P06396-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C0FX-ray2.40S53-176[»]
1C0GX-ray2.00S53-176[»]
1D4XX-ray1.75G52-177[»]
1DEJX-ray2.40S53-176[»]
1EQYX-ray2.30S52-176[»]
1ESVX-ray2.00S52-176[»]
1H1VX-ray3.00G439-769[»]
1KCQX-ray1.65A185-288[»]
1MDUX-ray2.20A/D52-176[»]
1NLVX-ray1.80G52-176[»]
1NM1X-ray1.80G52-176[»]
1NMDX-ray1.90G52-176[»]
1P8XX-ray2.00A/B/C439-782[»]
1P8ZX-ray2.60G52-187[»]
1SOLNMR-A177-196[»]
1T44X-ray2.00G55-179[»]
1YAGX-ray1.90G52-176[»]
1YVNX-ray2.10G52-176[»]
2FF3X-ray2.00A52-179[»]
2FF6X-ray2.05G52-179[»]
2FH1X-ray1.55A/B/C439-782[»]
2FH2X-ray2.50A/B/C439-782[»]
2FH3X-ray2.87A/B/C439-782[»]
2FH4X-ray3.00A/B/C439-782[»]
3A5LX-ray2.40S53-176[»]
3A5MX-ray2.40S53-176[»]
3A5NX-ray2.36S53-176[»]
3A5OX-ray2.40S53-176[»]
3CI5X-ray1.70G52-176[»]
3CIPX-ray1.60G52-176[»]
3CJBX-ray3.21G52-176[»]
3CJCX-ray3.90G52-176[»]
3FFKX-ray3.00A/D52-426[»]
3FFNX-ray3.00A/B1-782[»]
3TU5X-ray3.00B53-174[»]
4PKGX-ray1.80G52-176[»]
4PKHX-ray2.15B/E/G/J52-176[»]
B/E/G/J196-260[»]
4PKIX-ray2.30G52-176[»]
4S10X-ray2.61C/D186-288[»]
4Z94X-ray2.40G52-176[»]
5DD2X-ray2.60A/G55-188[»]
5FAEX-ray1.70A178-293[»]
5FAFX-ray1.05A178-293[»]
5H3MNMR-A55-187[»]
5H3NNMR-A55-187[»]
5O2ZX-ray1.70A/B178-293[»]
5UBOX-ray2.39S52-178[»]
5ZZ0X-ray2.63A/G55-188[»]
6H1FX-ray1.90B178-293[»]
6JCOX-ray2.88A/B56-782[»]
6JEGX-ray2.98A/B54-782[»]
6JEHX-ray2.95A/B56-782[»]
SMRiP06396
ModBaseiSearch...

Protein-protein interaction databases

BioGridi109189, 108 interactors
CORUMiP06396
DIPiDIP-2196N
IntActiP06396, 80 interactors
MINTiP06396
STRINGi9606.ENSP00000362924

Chemistry databases

DrugBankiDB09130 Copper
DB02621 Latrunculin A
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

PTM databases

iPTMnetiP06396
PhosphoSitePlusiP06396
SwissPalmiP06396

Polymorphism and mutation databases

BioMutaiGSN
DMDMi121116

2D gel databases

OGPiP06396

Proteomic databases

CPTACinon-CPTAC-1126
non-CPTAC-1127
EPDiP06396
jPOSTiP06396
MassIVEiP06396
PaxDbiP06396
PeptideAtlasiP06396
PRIDEiP06396
ProteomicsDBi12635 [P06396-3]
25596
51897 [P06396-1]
51898 [P06396-2]
51899 [P06396-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P06396

The DNASU plasmid repository

More...DNASUi		2934
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373808; ENSP00000362914; ENSG00000148180 [P06396-3]
ENST00000373818; ENSP00000362924; ENSG00000148180 [P06396-1]
ENST00000373823; ENSP00000362929; ENSG00000148180 [P06396-2]
ENST00000545652; ENSP00000445823; ENSG00000148180 [P06396-4]
GeneIDi2934
KEGGihsa:2934
UCSCiuc004ble.1 human [P06396-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2934
DisGeNETi2934

GeneCards: human genes, protein and diseases

More...GeneCardsi		GSN
HGNCiHGNC:4620 GSN
HPAiCAB010823
CAB016728
CAB036009
HPA054026
MalaCardsiGSN
MIMi105120 phenotype
137350 gene
neXtProtiNX_P06396
OpenTargetsiENSG00000148180
Orphaneti85448 AGel amyloidosis
PharmGKBiPA29011

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0443 Eukaryota
ENOG410XR0A LUCA
GeneTreeiENSGT00940000155591
HOGENOMiHOG000233630
InParanoidiP06396
KOiK05768
OMAiEWPQTPD
OrthoDBi1376537at2759
PhylomeDBiP06396
TreeFamiTF313468

Enzyme and pathway databases

ReactomeiR-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-977225 Amyloid fiber formation
SABIO-RKiP06396
SIGNORiP06396

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GSN human
EvolutionaryTraceiP06396

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Gelsolin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2934

Pharos

More...Pharosi		P06396
PMAP-CutDBiP06396

Protein Ontology

More...PROi		PR:P06396

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000148180 Expressed in 243 organ(s), highest expression level in adipose tissue of abdominal region
ExpressionAtlasiP06396 baseline and differential
GenevisibleiP06396 HS

Family and domain databases

Gene3Di3.40.20.10, 6 hits
InterProiView protein in InterPro
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR030004 Gelsolin
IPR007123 Gelsolin-like_dom
IPR007122 Villin/Gelsolin
PANTHERiPTHR11977 PTHR11977, 1 hit
PTHR11977:SF29 PTHR11977:SF29, 1 hit
PfamiView protein in Pfam
PF00626 Gelsolin, 6 hits
PRINTSiPR00597 GELSOLIN
SMARTiView protein in SMART
SM00262 GEL, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGELS_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06396
Secondary accession number(s): A2A418
, A8MUD1, A8MYN7, B7Z373, B7Z5V1, F5H1A8, Q5T0I2, Q8WVV7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: September 18, 2019
This is version 233 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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