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Protein

H-2 class II histocompatibility antigen, A-F beta chain

Gene

H2-Ab1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • peptide antigen binding Source: MGI
  • protein heterodimerization activity Source: MGI

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, A-F beta chain
Gene namesi
Name:H2-Ab1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:103070 H2-Ab1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 213ExtracellularSequence analysisAdd BLAST197
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 252CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 16By similarityAdd BLAST›16
ChainiPRO_000001899517 – 252H-2 class II histocompatibility antigen, A-F beta chainAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 93PROSITE-ProRule annotation
Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi132 ↔ 188PROSITE-ProRule annotation

Post-translational modificationi

Ubiquitinated in immature dendritic cells leading to down-regulation of MHC class II.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP06346
PRIDEiP06346

Expressioni

Gene expression databases

CleanExiMM_H2-AB1

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

MINTiP06346

Structurei

3D structure databases

ProteinModelPortaliP06346
SMRiP06346
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 200Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni17 – 109Beta-1Add BLAST93
Regioni110 – 203Beta-2Add BLAST94
Regioni204 – 213Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012730

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P06346-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
AAVVVLMVLS SPGTEGGNSE RHFVSQFKGE CYFTNGTQRI RSVDRYIYNR
60 70 80 90 100
EEYLRFDSDV GEYRAVTELG RSDAEYYNKQ YLERTRAELD TVCRHNYEGV
110 120 130 140 150
ETPTSLRRLE QPNVVISLSR TEALNHHNTL VCSVTDFYPA KIKVRWFRNG
160 170 180 190 200
QEETVGVSST QLIRNGDWTF QVLVMLEMAP RRGEVYTCHV EHPSLKSPIT
210 220 230 240 250
VEWRAQSESA RSKMLSGIGG CVLGVIFLGL GLFIRYRSQK GPRGPPPAGL

LQ
Length:252
Mass (Da):28,602
Last modified:January 1, 1988 - v1
Checksum:iE9D91C8A213E629B
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P14483HB2A_MOUSE
H-2 class II histocompatibility ant...
H2-Ab1 H2-iabeta
265Annotation score:
P06343HB2K_MOUSE
H-2 class II histocompatibility ant...
H2-Ab1
263Annotation score:
P01921HB2D_MOUSE
H-2 class II histocompatibility ant...
H2-Ab1
265Annotation score:
P06342HB2Q_MOUSE
H-2 class II histocompatibility ant...
H2-Ab1
265Annotation score:
P06345HB2S_MOUSE
H-2 class II histocompatibility ant...
H2-Ab1
263Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13541 mRNA Translation: AAA39629.1
PIRiA02241 HLMSBF
UniGeneiMm.254067

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13541 mRNA Translation: AAA39629.1
PIRiA02241 HLMSBF
UniGeneiMm.254067

3D structure databases

ProteinModelPortaliP06346
SMRiP06346
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiP06346

Proteomic databases

MaxQBiP06346
PRIDEiP06346

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:103070 H2-Ab1

Phylogenomic databases

HOVERGENiHBG012730

Miscellaneous databases

ChiTaRSiH2-Ab1 mouse
SOURCEiSearch...

Gene expression databases

CleanExiMM_H2-AB1

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHB2F_MOUSE
AccessioniPrimary (citable) accession number: P06346
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: September 12, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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