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Protein

H-2 class II histocompatibility antigen, A-K beta chain

Gene

H2-Ab1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • peptide antigen binding Source: MGI
  • protein heterodimerization activity Source: MGI

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, A-K beta chain
Gene namesi
Name:H2-Ab1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:103070 H2-Ab1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 224ExtracellularSequence analysisAdd BLAST197
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 263CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Add BLAST27
ChainiPRO_000001899628 – 263H-2 class II histocompatibility antigen, A-K beta chainAdd BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 104
Glycosylationi46N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi143 ↔ 199

Post-translational modificationi

Ubiquitinated in immature dendritic cells leading to down-regulation of MHC class II.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP06343
PRIDEiP06343

PTM databases

iPTMnetiP06343

Expressioni

Gene expression databases

CleanExiMM_H2-AB1

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-6134N
IntActiP06343, 1 interactor
MINTiP06343

Structurei

Secondary structure

1263
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP06343
SMRiP06343
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06343

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 211Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 120Beta-1Add BLAST93
Regioni121 – 214Beta-2Add BLAST94
Regioni215 – 224Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012730

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P06343-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALQIPSLLL LAAVVVLTVL SSPGTEGGNS ERHFVHQFQP FCYFTNGTQR
60 70 80 90 100
IRLVIRYIYN REEYVRFDSD VGEYRAVTEL GRPDAEYWNK QYLERTRAEL
110 120 130 140 150
DTVCRHNYEK TETPTSLRRL EQPSVVISLS RTEALNHHNT LVCSVTDFYP
160 170 180 190 200
AKIKVRWFRN GQEETVGVSS TQLIRNGDWT FQVLVMLEMT PRRGEVYTCH
210 220 230 240 250
VEHPSLKSPI TVEWRAQSES ARSKMLSGIG GCVLGVIFLG LGLFIRHRSQ
260
KGPRGPPPAG LLQ
Length:263
Mass (Da):29,967
Last modified:January 1, 1988 - v1
Checksum:i48F8FB38370EADF8
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P14483HB2A_MOUSE
H-2 class II histocompatibility ant...
H2-Ab1 H2-iabeta
265Annotation score:
P01921HB2D_MOUSE
H-2 class II histocompatibility ant...
H2-Ab1
265Annotation score:
P06342HB2Q_MOUSE
H-2 class II histocompatibility ant...
H2-Ab1
265Annotation score:
P06346HB2F_MOUSE
H-2 class II histocompatibility ant...
H2-Ab1
252Annotation score:
P06345HB2S_MOUSE
H-2 class II histocompatibility ant...
H2-Ab1
263Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36H → Y in AAA57291 (PubMed:3692165).Curated1
Sequence conflicti55I → T in AAA57291 (PubMed:3692165).Curated1
Sequence conflicti64 – 65YV → FM in AAA57291 (PubMed:3692165).Curated2
Sequence conflicti85A → V in AAA57291 (PubMed:3692165).Curated1
Sequence conflicti90K → S in AAA57291 (PubMed:3692165).Curated1
Sequence conflicti114P → H in AAA57291 (PubMed:3692165).Curated1
Sequence conflicti120L → F in AAA57291 (PubMed:3692165).Curated1
Sequence conflicti124S → N in AAA57291 (PubMed:3692165).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13538 mRNA Translation: AAA39632.1
M27456 Genomic DNA Translation: AAA57291.1
PIRiA02238 HLMSBK
I68208
PL0285
PL0286
UniGeneiMm.254067

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13538 mRNA Translation: AAA39632.1
M27456 Genomic DNA Translation: AAA57291.1
PIRiA02238 HLMSBK
I68208
PL0285
PL0286
UniGeneiMm.254067

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D9KX-ray3.20D/H30-216[»]
1IAKX-ray1.90B34-216[»]
1JL4X-ray4.30B34-216[»]
ProteinModelPortaliP06343
SMRiP06343
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6134N
IntActiP06343, 1 interactor
MINTiP06343

PTM databases

iPTMnetiP06343

Proteomic databases

MaxQBiP06343
PRIDEiP06343

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:103070 H2-Ab1

Phylogenomic databases

HOVERGENiHBG012730

Miscellaneous databases

ChiTaRSiH2-Ab1 mouse
EvolutionaryTraceiP06343
SOURCEiSearch...

Gene expression databases

CleanExiMM_H2-AB1

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHB2K_MOUSE
AccessioniPrimary (citable) accession number: P06343
Secondary accession number(s): Q31137
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: September 12, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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