Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HLA class II histocompatibility antigen, DO alpha chain

Gene

HLA-DOA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • MHC class II protein complex binding Source: UniProtKB
  • MHC class II receptor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2132295 MHC class II antigen presentation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P06340

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DO alpha chain
Alternative name(s):
MHC DN-alpha
MHC DZ alpha
MHC class II antigen DOA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HLA-DOA
Synonyms:HLA-DNA, HLA-DZA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000204252.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4936 HLA-DOA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
142930 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P06340

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 217ExtracellularSequence analysisAdd BLAST192
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei218 – 240HelicalSequence analysisAdd BLAST23
Topological domaini241 – 250CytoplasmicSequence analysis10

Keywords - Cellular componenti

Endosome, Lysosome, Membrane, MHC II

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3111

Open Targets

More...
OpenTargetsi
ENSG00000204252

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35060

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HLA-DOA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
122210

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001896226 – 250HLA class II histocompatibility antigen, DO alpha chainAdd BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi133 ↔ 189PROSITE-ProRule annotation
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P06340

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P06340

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P06340

PeptideAtlas

More...
PeptideAtlasi
P06340

PRoteomics IDEntifications database

More...
PRIDEi
P06340

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51896

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P06340

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P06340

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204252 Expressed in 192 organ(s), highest expression level in amniotic fluid

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P06340 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P06340 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045038

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha chain (DOA) and a beta chain (DOB). Forms a heterotetrameric complex with an HLA-DM molecule during intracellular transport in endosomal/lysosomal compartments in B-cells.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
RELQ048643EBI-10194851,EBI-307352

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109356, 3 interactors

Database of interacting proteins

More...
DIPi
DIP-60116N

Protein interaction database and analysis system

More...
IntActi
P06340, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000229829

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1250
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I0PX-ray3.20C/G27-207[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P06340

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P06340

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini113 – 205Ig-like C1-typeAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni26 – 110Alpha-1Add BLAST85
Regioni111 – 204Alpha-2Add BLAST94
Regioni205 – 217Connecting peptideAdd BLAST13

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IM01 Eukaryota
ENOG4111C4S LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162112

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006862

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P06340

KEGG Orthology (KO)

More...
KOi
K06752

Identification of Orthologs from Complete Genome Data

More...
OMAi
ASGQFTH

Database of Orthologous Groups

More...
OrthoDBi
1132781at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P06340

TreeFam database of animal gene trees

More...
TreeFami
TF333797

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.10.320.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P06340-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRAGLVLG FHTLMTLLSP QEAGATKADH MGSYGPAFYQ SYGASGQFTH
60 70 80 90 100
EFDEEQLFSV DLKKSEAVWR LPEFGDFARF DPQGGLAGIA AIKAHLDILV
110 120 130 140 150
ERSNRSRAIN VPPRVTVLPK SRVELGQPNI LICIVDNIFP PVINITWLRN
160 170 180 190 200
GQTVTEGVAQ TSFYSQPDHL FRKFHYLPFV PSAEDVYDCQ VEHWGLDAPL
210 220 230 240 250
LRHWELQVPI PPPDAMETLV CALGLAIGLV GFLVGTVLII MGTYVSSVPR
Length:250
Mass (Da):27,599
Last modified:January 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA9482197A02AC85
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6WU08F6WU08_HUMAN
HLA class II histocompatibility ant...
HLA-DOA
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9P4A0A140T9P4_HUMAN
HLA class II histocompatibility ant...
HLA-DOA
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9J7A0A140T9J7_HUMAN
HLA class II histocompatibility ant...
HLA-DOA
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T8X4A0A140T8X4_HUMAN
HLA class II histocompatibility ant...
HLA-DOA
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9G1A0A140T9G1_HUMAN
HLA class II histocompatibility ant...
HLA-DOA
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9F9A0A140T9F9_HUMAN
HLA class II histocompatibility ant...
HLA-DOA
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9G3A0A140T9G3_HUMAN
HLA class II histocompatibility ant...
HLA-DOA
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The following alleles of DOA are known: DOA*01:01, DOA*01:02 and DOA*01:03. The sequence shown is that of DOA*01:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05812699L → V in allele DOA*01:03. Corresponds to variant dbSNP:rs41542323Ensembl.1
Natural variantiVAR_058127105R → C in allele DOA*01:02. Corresponds to variant dbSNP:rs11575906Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X02882 Genomic DNA Translation: CAA26635.1
M26039 mRNA Translation: AAA59716.1
M31525 mRNA Translation: AAA60075.1
AY947479 mRNA Translation: AAX49509.1
AY947480 mRNA Translation: AAX49510.1
AY947481 mRNA Translation: AAX49511.1
AK290714 mRNA Translation: BAF83403.1
AK313551 mRNA Translation: BAG36327.1
Z81310 Genomic DNA Translation: CAB03594.1
AL662845 Genomic DNA No translation available.
AL645931 Genomic DNA No translation available.
AL805913 Genomic DNA No translation available.
BX005422 Genomic DNA No translation available.
CR759829 Genomic DNA No translation available.
CR936909 Genomic DNA No translation available.
CR759795 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03668.1
BC013183 mRNA Translation: AAH13183.1
AB005991 Genomic DNA Translation: BAA81787.1
AB005992 Genomic DNA Translation: BAA81788.1
AB005993 Genomic DNA Translation: BAA81789.1
AB005994 Genomic DNA Translation: BAA81790.1
AB005995 Genomic DNA Translation: BAA81791.1
AB005996 Genomic DNA Translation: BAA81792.1
AB005997 Genomic DNA Translation: BAA81793.1
AB005998 Genomic DNA Translation: BAA81794.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4763.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A02216 HLHUDZ

NCBI Reference Sequences

More...
RefSeqi
NP_002110.1, NM_002119.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.631991

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000229829; ENSP00000229829; ENSG00000204252
ENST00000383226; ENSP00000372713; ENSG00000206292
ENST00000426070; ENSP00000401504; ENSG00000231558
ENST00000426685; ENSP00000397945; ENSG00000232957
ENST00000434335; ENSP00000416448; ENSG00000232962
ENST00000438987; ENSP00000395737; ENSG00000230141
ENST00000452598; ENSP00000398819; ENSG00000235744

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3111

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3111

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02882 Genomic DNA Translation: CAA26635.1
M26039 mRNA Translation: AAA59716.1
M31525 mRNA Translation: AAA60075.1
AY947479 mRNA Translation: AAX49509.1
AY947480 mRNA Translation: AAX49510.1
AY947481 mRNA Translation: AAX49511.1
AK290714 mRNA Translation: BAF83403.1
AK313551 mRNA Translation: BAG36327.1
Z81310 Genomic DNA Translation: CAB03594.1
AL662845 Genomic DNA No translation available.
AL645931 Genomic DNA No translation available.
AL805913 Genomic DNA No translation available.
BX005422 Genomic DNA No translation available.
CR759829 Genomic DNA No translation available.
CR936909 Genomic DNA No translation available.
CR759795 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03668.1
BC013183 mRNA Translation: AAH13183.1
AB005991 Genomic DNA Translation: BAA81787.1
AB005992 Genomic DNA Translation: BAA81788.1
AB005993 Genomic DNA Translation: BAA81789.1
AB005994 Genomic DNA Translation: BAA81790.1
AB005995 Genomic DNA Translation: BAA81791.1
AB005996 Genomic DNA Translation: BAA81792.1
AB005997 Genomic DNA Translation: BAA81793.1
AB005998 Genomic DNA Translation: BAA81794.1
CCDSiCCDS4763.1
PIRiA02216 HLHUDZ
RefSeqiNP_002110.1, NM_002119.3
UniGeneiHs.631991

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I0PX-ray3.20C/G27-207[»]
ProteinModelPortaliP06340
SMRiP06340
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109356, 3 interactors
DIPiDIP-60116N
IntActiP06340, 4 interactors
STRINGi9606.ENSP00000229829

PTM databases

iPTMnetiP06340
PhosphoSitePlusiP06340

Polymorphism and mutation databases

BioMutaiHLA-DOA
DMDMi122210

Proteomic databases

EPDiP06340
jPOSTiP06340
PaxDbiP06340
PeptideAtlasiP06340
PRIDEiP06340
ProteomicsDBi51896

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3111
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229829; ENSP00000229829; ENSG00000204252
ENST00000383226; ENSP00000372713; ENSG00000206292
ENST00000426070; ENSP00000401504; ENSG00000231558
ENST00000426685; ENSP00000397945; ENSG00000232957
ENST00000434335; ENSP00000416448; ENSG00000232962
ENST00000438987; ENSP00000395737; ENSG00000230141
ENST00000452598; ENSP00000398819; ENSG00000235744
GeneIDi3111
KEGGihsa:3111

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3111
DisGeNETi3111
EuPathDBiHostDB:ENSG00000204252.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HLA-DOA
HGNCiHGNC:4936 HLA-DOA
HPAiHPA045038
MIMi142930 gene
neXtProtiNX_P06340
OpenTargetsiENSG00000204252
PharmGKBiPA35060

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IM01 Eukaryota
ENOG4111C4S LUCA
GeneTreeiENSGT00940000162112
HOVERGENiHBG006862
InParanoidiP06340
KOiK06752
OMAiASGQFTH
OrthoDBi1132781at2759
PhylomeDBiP06340
TreeFamiTF333797

Enzyme and pathway databases

ReactomeiR-HSA-2132295 MHC class II antigen presentation
SIGNORiP06340

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HLA-DOA human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
HLA-DOA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3111

Protein Ontology

More...
PROi
PR:P06340

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204252 Expressed in 192 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiP06340 baseline and differential
GenevisibleiP06340 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDOA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06340
Secondary accession number(s): Q58HU0
, Q58HU1, Q5STC7, Q9TQC6, Q9TQC7, Q9TQC8, Q9TQC9, Q9TQD0, Q9TQD1, Q9TQD2, Q9TQD3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: January 16, 2019
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again