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Protein

HLA class II histocompatibility antigen, DO alpha chain

Gene

HLA-DOA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

GO - Molecular functioni

  • MHC class II protein complex binding Source: UniProtKB
  • MHC class II receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-2132295 MHC class II antigen presentation
SIGNORiP06340

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DO alpha chain
Alternative name(s):
MHC DN-alpha
MHC DZ alpha
MHC class II antigen DOA
Gene namesi
Name:HLA-DOA
Synonyms:HLA-DNA, HLA-DZA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204252.12
HGNCiHGNC:4936 HLA-DOA
MIMi142930 gene
neXtProtiNX_P06340

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 217ExtracellularSequence analysisAdd BLAST192
Transmembranei218 – 240HelicalSequence analysisAdd BLAST23
Topological domaini241 – 250CytoplasmicSequence analysis10

Keywords - Cellular componenti

Endosome, Lysosome, Membrane, MHC II

Pathology & Biotechi

Organism-specific databases

DisGeNETi3111
OpenTargetsiENSG00000204252
PharmGKBiPA35060

Polymorphism and mutation databases

BioMutaiHLA-DOA
DMDMi122210

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001896226 – 250HLA class II histocompatibility antigen, DO alpha chainAdd BLAST225

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi133 ↔ 189PROSITE-ProRule annotation
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP06340
PaxDbiP06340
PeptideAtlasiP06340
PRIDEiP06340
ProteomicsDBi51896

PTM databases

iPTMnetiP06340
PhosphoSitePlusiP06340

Expressioni

Gene expression databases

BgeeiENSG00000204252
ExpressionAtlasiP06340 baseline and differential
GenevisibleiP06340 HS

Organism-specific databases

HPAiHPA045038

Interactioni

Subunit structurei

Heterodimer of an alpha chain (DOA) and a beta chain (DOB). Forms a heterotetrameric complex with an HLA-DM molecule during intracellular transport in endosomal/lysosomal compartments in B-cells.

Binary interactionsi

WithEntry#Exp.IntActNotes
RELQ048643EBI-10194851,EBI-307352

Protein-protein interaction databases

BioGridi109356, 3 interactors
DIPiDIP-60116N
IntActiP06340, 4 interactors
STRINGi9606.ENSP00000229829

Structurei

Secondary structure

1250
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 40Combined sources12
Helixi42 – 44Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Turni62 – 65Combined sources4
Beta strandi66 – 71Combined sources6
Helixi72 – 74Combined sources3
Beta strandi77 – 80Combined sources4
Helixi87 – 94Combined sources8
Helixi96 – 102Combined sources7
Beta strandi114 – 121Combined sources8
Beta strandi129 – 141Combined sources13
Beta strandi144 – 149Combined sources6
Beta strandi152 – 154Combined sources3
Beta strandi171 – 179Combined sources9
Beta strandi187 – 192Combined sources6
Beta strandi196 – 198Combined sources3
Beta strandi200 – 204Combined sources5

3D structure databases

ProteinModelPortaliP06340
SMRiP06340
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini113 – 205Ig-like C1-typeAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 110Alpha-1Add BLAST85
Regioni111 – 204Alpha-2Add BLAST94
Regioni205 – 217Connecting peptideAdd BLAST13

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IM01 Eukaryota
ENOG4111C4S LUCA
GeneTreeiENSGT00900000140882
HOVERGENiHBG006862
InParanoidiP06340
KOiK06752
OMAiDHMGSYG
OrthoDBiEOG093711AM
PhylomeDBiP06340
TreeFamiTF333797

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06340-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRAGLVLG FHTLMTLLSP QEAGATKADH MGSYGPAFYQ SYGASGQFTH
60 70 80 90 100
EFDEEQLFSV DLKKSEAVWR LPEFGDFARF DPQGGLAGIA AIKAHLDILV
110 120 130 140 150
ERSNRSRAIN VPPRVTVLPK SRVELGQPNI LICIVDNIFP PVINITWLRN
160 170 180 190 200
GQTVTEGVAQ TSFYSQPDHL FRKFHYLPFV PSAEDVYDCQ VEHWGLDAPL
210 220 230 240 250
LRHWELQVPI PPPDAMETLV CALGLAIGLV GFLVGTVLII MGTYVSSVPR
Length:250
Mass (Da):27,599
Last modified:January 1, 1988 - v1
Checksum:iFA9482197A02AC85
GO

Polymorphismi

The following alleles of DOA are known: DOA*01:01, DOA*01:02 and DOA*01:03. The sequence shown is that of DOA*01:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05812699L → V in allele DOA*01:03. Corresponds to variant dbSNP:rs41542323Ensembl.1
Natural variantiVAR_058127105R → C in allele DOA*01:02. Corresponds to variant dbSNP:rs11575906Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02882 Genomic DNA Translation: CAA26635.1
M26039 mRNA Translation: AAA59716.1
M31525 mRNA Translation: AAA60075.1
AY947479 mRNA Translation: AAX49509.1
AY947480 mRNA Translation: AAX49510.1
AY947481 mRNA Translation: AAX49511.1
AK290714 mRNA Translation: BAF83403.1
AK313551 mRNA Translation: BAG36327.1
Z81310 Genomic DNA Translation: CAB03594.1
AL662845 Genomic DNA No translation available.
AL645931 Genomic DNA No translation available.
AL805913 Genomic DNA No translation available.
BX005422 Genomic DNA No translation available.
CR759829 Genomic DNA No translation available.
CR936909 Genomic DNA No translation available.
CR759795 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03668.1
BC013183 mRNA Translation: AAH13183.1
AB005991 Genomic DNA Translation: BAA81787.1
AB005992 Genomic DNA Translation: BAA81788.1
AB005993 Genomic DNA Translation: BAA81789.1
AB005994 Genomic DNA Translation: BAA81790.1
AB005995 Genomic DNA Translation: BAA81791.1
AB005996 Genomic DNA Translation: BAA81792.1
AB005997 Genomic DNA Translation: BAA81793.1
AB005998 Genomic DNA Translation: BAA81794.1
CCDSiCCDS4763.1
PIRiA02216 HLHUDZ
RefSeqiNP_002110.1, NM_002119.3
UniGeneiHs.631991

Genome annotation databases

EnsembliENST00000229829; ENSP00000229829; ENSG00000204252
ENST00000383226; ENSP00000372713; ENSG00000206292
ENST00000426070; ENSP00000401504; ENSG00000231558
ENST00000426685; ENSP00000397945; ENSG00000232957
ENST00000434335; ENSP00000416448; ENSG00000232962
ENST00000438987; ENSP00000395737; ENSG00000230141
ENST00000452598; ENSP00000398819; ENSG00000235744
GeneIDi3111
KEGGihsa:3111

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDOA_HUMAN
AccessioniPrimary (citable) accession number: P06340
Secondary accession number(s): Q58HU0
, Q58HU1, Q5STC7, Q9TQC6, Q9TQC7, Q9TQC8, Q9TQC9, Q9TQD0, Q9TQD1, Q9TQD2, Q9TQD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: June 20, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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