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Protein

H-2 class I histocompatibility antigen, D-37 alpha chain

Gene

H2-T23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-MMU-1236974 ER-Phagosome pathway
R-MMU-1236977 Endosomal/Vacuolar pathway
R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-6798695 Neutrophil degranulation
R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class I histocompatibility antigen, D-37 alpha chain
Gene namesi
Name:H2-T23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95957 H2-T23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 304ExtracellularSequence analysisAdd BLAST284
Transmembranei305 – 327HelicalSequence analysisAdd BLAST23
Topological domaini328 – 357CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001892721 – 357H-2 class I histocompatibility antigen, D-37 alpha chainAdd BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi121 ↔ 184PROSITE-ProRule annotation
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi223 ↔ 279PROSITE-ProRule annotation
Modified residuei347PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP06339
PaxDbiP06339
PRIDEiP06339

PTM databases

iPTMnetiP06339
PhosphoSitePlusiP06339

Expressioni

Gene expression databases

BgeeiENSMUSG00000067212 Expressed in 235 organ(s), highest expression level in lymph node
CleanExiMM_H2-T23
ExpressionAtlasiP06339 baseline and differential
GenevisibleiP06339 MM

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099739

Structurei

Secondary structure

1357
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP06339
SMRiP06339
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini205 – 293Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 110Alpha-1Add BLAST90
Regioni111 – 202Alpha-2Add BLAST92
Regioni203 – 294Alpha-3Add BLAST92
Regioni295 – 304Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
GeneTreeiENSGT00760000118960
HOGENOMiHOG000296917
HOVERGENiHBG016709
InParanoidiP06339
KOiK06751
OMAiEPRARWI
OrthoDBiEOG091G09OH
PhylomeDBiP06339
TreeFamiTF336617

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06339-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLFAHLLQL LVSATVPTQS SPHSLRYFTT AVSRPGLGEP RFIIVGYVDD
60 70 80 90 100
TQFVRFDSDA ENPRMEPRAR WIEQEGPEYW ERETWKARDM GRNFRVNLRT
110 120 130 140 150
LLGYYNQSND ESHTLQWMYG CDVGPDGRLL RGYCQEAYDG QDYISLNEDL
160 170 180 190 200
RSWTANDIAS QISKHKSEAV DEAHQQRAYL QGPCVEWLHR YLRLGNETLQ
210 220 230 240 250
RSDPPKAHVT HHPRSEDEVT LRCWALGFYP ADITLTWQLN GEELTQDMEL
260 270 280 290 300
VETRPAGDGT FQKWAAVVVP LGKEQYYTCH VYHEGLPEPL TLRWEPPPST
310 320 330 340 350
VSNMVIIAVL VVLGAVIILG AVVAFVMKRR RHIGVKGCYA HVLGSKSFQT

SDWPQKA
Length:357
Mass (Da):40,875
Last modified:January 1, 1988 - v1
Checksum:i62139862B099D411
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11284 mRNA Translation: AAA39693.1
Y00629 Genomic DNA Translation: CAA68665.1
CCDSiCCDS28715.1
PIRiA02205 HLMS37
RefSeqiNP_034528.1, NM_010398.3
UniGeneiMm.439648
Mm.441651

Genome annotation databases

EnsembliENSMUST00000102678; ENSMUSP00000099739; ENSMUSG00000067212
GeneIDi15040
KEGGimmu:15040
UCSCiuc008cjr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11284 mRNA Translation: AAA39693.1
Y00629 Genomic DNA Translation: CAA68665.1
CCDSiCCDS28715.1
PIRiA02205 HLMS37
RefSeqiNP_034528.1, NM_010398.3
UniGeneiMm.439648
Mm.441651

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VJ6X-ray1.90A21-297[»]
ProteinModelPortaliP06339
SMRiP06339
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099739

PTM databases

iPTMnetiP06339
PhosphoSitePlusiP06339

Proteomic databases

EPDiP06339
PaxDbiP06339
PRIDEiP06339

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102678; ENSMUSP00000099739; ENSMUSG00000067212
GeneIDi15040
KEGGimmu:15040
UCSCiuc008cjr.1 mouse

Organism-specific databases

CTDi15040
MGIiMGI:95957 H2-T23

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
GeneTreeiENSGT00760000118960
HOGENOMiHOG000296917
HOVERGENiHBG016709
InParanoidiP06339
KOiK06751
OMAiEPRARWI
OrthoDBiEOG091G09OH
PhylomeDBiP06339
TreeFamiTF336617

Enzyme and pathway databases

ReactomeiR-MMU-1236974 ER-Phagosome pathway
R-MMU-1236977 Endosomal/Vacuolar pathway
R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-6798695 Neutrophil degranulation
R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

PROiPR:P06339
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000067212 Expressed in 235 organ(s), highest expression level in lymph node
CleanExiMM_H2-T23
ExpressionAtlasiP06339 baseline and differential
GenevisibleiP06339 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHA15_MOUSE
AccessioniPrimary (citable) accession number: P06339
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 7, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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