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UniProtKB - P06339 (HA15_MOUSE)
Protein
H-2 class I histocompatibility antigen, D-37 alpha chain
Gene
H2-T23
Organism
Mus musculus (Mouse)
Status
Functioni
Involved in the presentation of foreign antigens to the immune system.
GO - Molecular functioni
- 14-3-3 protein binding Source: MGI
- beta-2-microglobulin binding Source: MGI
- CD8 receptor binding Source: MGI
- identical protein binding Source: MGI
- MHC class I protein binding Source: MGI
- natural killer cell lectin-like receptor binding Source: MGI
- peptide antigen binding Source: MGI
- protein homodimerization activity Source: MGI
- signaling receptor binding Source: MGI
- TAP1 binding Source: MGI
- TAP2 binding Source: MGI
- T cell receptor binding Source: MGI
GO - Biological processi
- antigen processing and presentation of endogenous peptide antigen via MHC class Ib Source: GO_Central
- antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent Source: MGI
- antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
- inner ear development Source: MGI
- positive regulation of T cell mediated cytotoxicity Source: MGI
Keywordsi
Biological process | Immunity |
Enzyme and pathway databases
Reactomei | R-MMU-1236974, ER-Phagosome pathway R-MMU-1236977, Endosomal/Vacuolar pathway R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-2172127, DAP12 interactions R-MMU-2424491, DAP12 signaling R-MMU-6798695, Neutrophil degranulation R-MMU-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Names & Taxonomyi
Protein namesi | Recommended name: H-2 class I histocompatibility antigen, D-37 alpha chain |
Gene namesi | Name:H2-T23 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95957, H2-T23 |
VEuPathDBi | HostDB:ENSMUSG00000067212 |
Subcellular locationi
Other locations
Endoplasmic reticulum
- endoplasmic reticulum Source: MGI
- integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
Endosome
- early endosome Source: MGI
- early endosome membrane Source: MGI
Extracellular region or secreted
- extracellular space Source: GO_Central
Golgi apparatus
- cis-Golgi network membrane Source: MGI
- Golgi membrane Source: MGI
Lysosome
- lysosomal membrane Source: MGI
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- MHC class I protein complex Source: MGI
- MHC class Ib protein complex Source: MGI
- plasma membrane Source: MGI
Other locations
- cell surface Source: MGI
- phagocytic vesicle membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 304 | ExtracellularSequence analysisAdd BLAST | 284 | |
Transmembranei | 305 – 327 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 328 – 357 | CytoplasmicSequence analysisAdd BLAST | 30 |
Keywords - Cellular componenti
Membrane, MHC IPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000018927 | 21 – 357 | H-2 class I histocompatibility antigen, D-37 alpha chainAdd BLAST | 337 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 106 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 121 ↔ 184 | PROSITE-ProRule annotation | ||
Glycosylationi | 196 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 223 ↔ 279 | PROSITE-ProRule annotation | ||
Modified residuei | 347 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P06339 |
jPOSTi | P06339 |
PaxDbi | P06339 |
PRIDEi | P06339 |
ProteomicsDBi | 269673 |
PTM databases
GlyGeni | P06339, 2 sites |
iPTMneti | P06339 |
PhosphoSitePlusi | P06339 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000067212, Expressed in lymph node and 261 other tissues |
ExpressionAtlasi | P06339, baseline and differential |
Genevisiblei | P06339, MM |
Interactioni
Subunit structurei
Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).
GO - Molecular functioni
- 14-3-3 protein binding Source: MGI
- beta-2-microglobulin binding Source: MGI
- CD8 receptor binding Source: MGI
- identical protein binding Source: MGI
- MHC class I protein binding Source: MGI
- natural killer cell lectin-like receptor binding Source: MGI
- protein homodimerization activity Source: MGI
- signaling receptor binding Source: MGI
- TAP1 binding Source: MGI
- TAP2 binding Source: MGI
- T cell receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 200189, 1 interactor |
IntActi | P06339, 1 interactor |
STRINGi | 10090.ENSMUSP00000099739 |
Miscellaneous databases
RNActi | P06339, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P06339 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 205 – 293 | Ig-like C1-typeAdd BLAST | 89 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 21 – 110 | Alpha-1Add BLAST | 90 | |
Regioni | 111 – 202 | Alpha-2Add BLAST | 92 | |
Regioni | 203 – 294 | Alpha-3Add BLAST | 92 | |
Regioni | 295 – 304 | Connecting peptide | 10 |
Sequence similaritiesi
Belongs to the MHC class I family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RQEK, Eukaryota |
GeneTreei | ENSGT00980000198488 |
HOGENOMi | CLU_047501_1_1_1 |
InParanoidi | P06339 |
OMAi | QGPCVEW |
OrthoDBi | 1390181at2759 |
PhylomeDBi | P06339 |
TreeFami | TF336617 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog IPR001039, MHC_I_a_a1/a2 |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit |
PRINTSi | PR01638, MHCCLASSI |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P06339-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLFAHLLQL LVSATVPTQS SPHSLRYFTT AVSRPGLGEP RFIIVGYVDD
60 70 80 90 100
TQFVRFDSDA ENPRMEPRAR WIEQEGPEYW ERETWKARDM GRNFRVNLRT
110 120 130 140 150
LLGYYNQSND ESHTLQWMYG CDVGPDGRLL RGYCQEAYDG QDYISLNEDL
160 170 180 190 200
RSWTANDIAS QISKHKSEAV DEAHQQRAYL QGPCVEWLHR YLRLGNETLQ
210 220 230 240 250
RSDPPKAHVT HHPRSEDEVT LRCWALGFYP ADITLTWQLN GEELTQDMEL
260 270 280 290 300
VETRPAGDGT FQKWAAVVVP LGKEQYYTCH VYHEGLPEPL TLRWEPPPST
310 320 330 340 350
VSNMVIIAVL VVLGAVIILG AVVAFVMKRR RHIGVKGCYA HVLGSKSFQT
SDWPQKA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M11284 mRNA Translation: AAA39693.1 Y00629 Genomic DNA Translation: CAA68665.1 |
CCDSi | CCDS28715.1 |
PIRi | A02205, HLMS37 |
RefSeqi | NP_034528.1, NM_010398.3 |
Genome annotation databases
Ensembli | ENSMUST00000102678; ENSMUSP00000099739; ENSMUSG00000067212 |
GeneIDi | 15040 |
KEGGi | mmu:15040 |
UCSCi | uc008cjr.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M11284 mRNA Translation: AAA39693.1 Y00629 Genomic DNA Translation: CAA68665.1 |
CCDSi | CCDS28715.1 |
PIRi | A02205, HLMS37 |
RefSeqi | NP_034528.1, NM_010398.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3VJ6 | X-ray | 1.90 | A | 21-297 | [»] | |
SMRi | P06339 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 200189, 1 interactor |
IntActi | P06339, 1 interactor |
STRINGi | 10090.ENSMUSP00000099739 |
PTM databases
GlyGeni | P06339, 2 sites |
iPTMneti | P06339 |
PhosphoSitePlusi | P06339 |
Proteomic databases
EPDi | P06339 |
jPOSTi | P06339 |
PaxDbi | P06339 |
PRIDEi | P06339 |
ProteomicsDBi | 269673 |
Protocols and materials databases
DNASUi | 15040 |
Genome annotation databases
Ensembli | ENSMUST00000102678; ENSMUSP00000099739; ENSMUSG00000067212 |
GeneIDi | 15040 |
KEGGi | mmu:15040 |
UCSCi | uc008cjr.1, mouse |
Organism-specific databases
CTDi | 15040 |
MGIi | MGI:95957, H2-T23 |
VEuPathDBi | HostDB:ENSMUSG00000067212 |
Phylogenomic databases
eggNOGi | ENOG502RQEK, Eukaryota |
GeneTreei | ENSGT00980000198488 |
HOGENOMi | CLU_047501_1_1_1 |
InParanoidi | P06339 |
OMAi | QGPCVEW |
OrthoDBi | 1390181at2759 |
PhylomeDBi | P06339 |
TreeFami | TF336617 |
Enzyme and pathway databases
Reactomei | R-MMU-1236974, ER-Phagosome pathway R-MMU-1236977, Endosomal/Vacuolar pathway R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-2172127, DAP12 interactions R-MMU-2424491, DAP12 signaling R-MMU-6798695, Neutrophil degranulation R-MMU-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Miscellaneous databases
BioGRID-ORCSi | 15040, 6 hits in 67 CRISPR screens |
ChiTaRSi | H2-T23, mouse |
PROi | PR:P06339 |
RNActi | P06339, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000067212, Expressed in lymph node and 261 other tissues |
ExpressionAtlasi | P06339, baseline and differential |
Genevisiblei | P06339, MM |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog IPR001039, MHC_I_a_a1/a2 |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit |
PRINTSi | PR01638, MHCCLASSI |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HA15_MOUSE | |
Accessioni | P06339Primary (citable) accession number: P06339 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | January 1, 1988 | |
Last modified: | February 23, 2022 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families