H2-T23

Functionⁱ

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functionⁱ

beta-2-microglobulin binding Source: MGI
MHC class I protein binding Source: MGI
natural killer cell lectin-like receptor binding Source: MGI
peptide antigen binding Source: MGI
signaling receptor binding Source: MGI
T cell receptor binding Source: MGI

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response Source: MGI
antibacterial humoral response Source: MGI
antigen processing and presentation of endogenous peptide antigen via MHC class Ib Source: MGI
antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
Source: MGI
Inferred from direct assayⁱ
- "Ham-2 corrects the class I antigen-processing defect in RMA-S cells."
  Attaya M., Jameson S., Martinez C.K., Hermel E., Aldrich C., Forman J., Lindahl K.F., Bevan M.J., Monaco J.J.
  Nature 355:647-649(1992) [PubMed] [Europe PMC] [Abstract]
antigen processing and presentation of exogenous peptide antigen via MHC class Ib Source: MGI
antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
CD8-positive, alpha-beta T cell activation Source: MGI
defense response to Gram-positive bacterium Source: MGI
inner ear development
Source: MGI
Inferred from direct assayⁱ
- "Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly."
  Lu C.C., Appler J.M., Houseman E.A., Goodrich L.V.
  J Neurosci 31:10903-10918(2011) [PubMed] [Europe PMC] [Abstract]
natural killer cell tolerance induction Source: MGI
negative regulation of natural killer cell mediated cytotoxicity Source: MGI
positive regulation of antibody-dependent cellular cytotoxicity Source: MGI
positive regulation of CD8-positive, alpha-beta T cell activation Source: MGI
positive regulation of CD8-positive, alpha-beta T cell proliferation Source: MGI
positive regulation of immunoglobulin secretion Source: MGI
positive regulation of interleukin-13 production Source: MGI
positive regulation of interleukin-4 production Source: MGI
positive regulation of natural killer cell cytokine production Source: MGI
positive regulation of natural killer cell mediated cytotoxicity Source: MGI
positive regulation of natural killer cell mediated immunity Source: MGI
positive regulation of natural killer cell proliferation Source: MGI
positive regulation of T cell mediated cytotoxicity
Source: MGI
Inferred from direct assayⁱ
- "Ham-2 corrects the class I antigen-processing defect in RMA-S cells."
  Attaya M., Jameson S., Martinez C.K., Hermel E., Aldrich C., Forman J., Lindahl K.F., Bevan M.J., Monaco J.J.
  Nature 355:647-649(1992) [PubMed] [Europe PMC] [Abstract]
positive regulation of TRAIL production Source: MGI
positive regulation of tumor necrosis factor production Source: MGI
protection from natural killer cell mediated cytotoxicity Source: MGI
regulation of natural killer cell mediated immunity Source: MGI

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Immunity

Biological process

Immunity

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1236974, ER-Phagosome pathway R-MMU-1236977, Endosomal/Vacuolar pathway R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-2172127, DAP12 interactions R-MMU-2424491, DAP12 signaling R-MMU-6798695, Neutrophil degranulation R-MMU-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Reactomeⁱ

R-MMU-1236974, ER-Phagosome pathway
R-MMU-1236977, Endosomal/Vacuolar pathway
R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-2172127, DAP12 interactions
R-MMU-2424491, DAP12 signaling
R-MMU-6798695, Neutrophil degranulation
R-MMU-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: H-2 class I histocompatibility antigen, D-37 alpha chain
Gene namesⁱ	Name:H2-T23
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 17

Organism-specific databases

MGIⁱ	MGI:95957, H2-T23

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	21 – 304	ExtracellularSequence analysisAdd BLAST	284
Transmembraneⁱ	305 – 327	HelicalSequence analysisAdd BLAST	23
Topological domainⁱ	328 – 357	CytoplasmicSequence analysisAdd BLAST	30

Keywords - Cellular componentⁱ

Membrane, MHC I

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	Sequence analysisAdd BLAST		20
ChainⁱPRO_0000018927	21 – 357	H-2 class I histocompatibility antigen, D-37 alpha chainAdd BLAST		337

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	106	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	121 ↔ 184	PROSITE-ProRule annotation
Glycosylationⁱ	196	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	223 ↔ 279	PROSITE-ProRule annotation
Modified residueⁱ	347	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P06339
jPOSTⁱ	P06339
PaxDbⁱ	P06339
PRIDEⁱ	P06339

PTM databases

GlyGenⁱ	P06339, 2 sites
iPTMnetⁱ	P06339
PhosphoSitePlusⁱ	P06339

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000067212, Expressed in lymph node and 254 other tissues
ExpressionAtlasⁱ	P06339, baseline and differential
Genevisibleⁱ	P06339, MM

Interactionⁱ

Subunit structureⁱ

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

GO - Molecular functionⁱ

beta-2-microglobulin binding Source: MGI
MHC class I protein binding Source: MGI
natural killer cell lectin-like receptor binding Source: MGI
signaling receptor binding Source: MGI
T cell receptor binding Source: MGI

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	P06339, 1 interactor
STRINGⁱ	10090.ENSMUSP00000099739

Miscellaneous databases

RNActⁱ	P06339, protein

RNActⁱ

P06339, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	23 – 32	Combined sources	10
Beta strandⁱ	41 – 48	Combined sources	8
Beta strandⁱ	51 – 57	Combined sources	7
Beta strandⁱ	60 – 62	Combined sources	3
Beta strandⁱ	66 – 69	Combined sources	4
Helixⁱ	70 – 74	Combined sources	5
Helixⁱ	77 – 105	Combined sources	29
Beta strandⁱ	114 – 123	Combined sources	10
Beta strandⁱ	129 – 138	Combined sources	10
Beta strandⁱ	141 – 146	Combined sources	6
Beta strandⁱ	153 – 155	Combined sources	3
Helixⁱ	158 – 169	Combined sources	12
Helixⁱ	172 – 181	Combined sources	10
Helixⁱ	183 – 194	Combined sources	12
Helixⁱ	196 – 199	Combined sources	4
Beta strandⁱ	206 – 215	Combined sources	10
Beta strandⁱ	218 – 231	Combined sources	14
Beta strandⁱ	234 – 239	Combined sources	6
Beta strandⁱ	257 – 259	Combined sources	3
Beta strandⁱ	261 – 270	Combined sources	10
Helixⁱ	274 – 276	Combined sources	3
Beta strandⁱ	277 – 282	Combined sources	6
Beta strandⁱ	290 – 292	Combined sources	3

Show more details

3D structure databases

SMRⁱ	P06339
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	205 – 293	Ig-like C1-typeAdd BLAST		89

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	21 – 110	Alpha-1Add BLAST	90
Regionⁱ	111 – 202	Alpha-2Add BLAST	92
Regionⁱ	203 – 294	Alpha-3Add BLAST	92
Regionⁱ	295 – 304	Connecting peptide	10

Sequence similaritiesⁱ

Belongs to the MHC class I family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG502RQEK, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00990000203546
HOGENOMⁱ	CLU_047501_1_1_1
InParanoidⁱ	P06339
OMAⁱ	ETERWIT
Database of Orthologous Groups More...OrthoDBⁱ	1390181at2759
PhylomeDBⁱ	P06339
TreeFamⁱ	TF336617

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.30.500.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog IPR001039, MHC_I_a_a1/a2
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit
PRINTSⁱ	PR01638, MHCCLASSI
SMARTⁱ	View protein in SMART SM00407, IGc1, 1 hit
SUPFAMⁱ	SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P06339-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLLFAHLLQL LVSATVPTQS SPHSLRYFTT AVSRPGLGEP RFIIVGYVDD 
        60         70         80         90        100
TQFVRFDSDA ENPRMEPRAR WIEQEGPEYW ERETWKARDM GRNFRVNLRT 
       110        120        130        140        150
LLGYYNQSND ESHTLQWMYG CDVGPDGRLL RGYCQEAYDG QDYISLNEDL 
       160        170        180        190        200
RSWTANDIAS QISKHKSEAV DEAHQQRAYL QGPCVEWLHR YLRLGNETLQ 
       210        220        230        240        250
RSDPPKAHVT HHPRSEDEVT LRCWALGFYP ADITLTWQLN GEELTQDMEL 
       260        270        280        290        300
VETRPAGDGT FQKWAAVVVP LGKEQYYTCH VYHEGLPEPL TLRWEPPPST 
       310        320        330        340        350
VSNMVIIAVL VVLGAVIILG AVVAFVMKRR RHIGVKGCYA HVLGSKSFQT 

SDWPQKA

Length:357

Mass (Da):40,875

Last modified:January 1, 1988 - v1

Checksum:ⁱ62139862B099D411

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M11284 mRNA Translation: AAA39693.1 Y00629 Genomic DNA Translation: CAA68665.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS28715.1
PIRⁱ	A02205, HLMS37
NCBI Reference Sequences More...RefSeqⁱ	NP_034528.1, NM_010398.3

Genome annotation databases

Ensemblⁱ	ENSMUST00000102678; ENSMUSP00000099739; ENSMUSG00000067212
GeneIDⁱ	15040
KEGGⁱ	mmu:15040
UCSC genome browser More...UCSCⁱ	uc008cjr.1, mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P06339	Ig-like domain-containing protein		MOUSE		357	UniRef100_P06339
MHC class II antigen K (Fragment)		MOUSE		38
+1

Protein	Similar proteins		Species	Score	Length	Source
P06339	Ig-like domain-containing protein		MOUSE		357	UniRef90_P06339
MHC class II antigen K (Fragment)		MOUSE		38
MHC class Ib antigen Qa-1c		MOUSE		357
MHC class Ib antigen Qa-1d		MOUSE		357
MHC class II antigen K (Fragment)		MOUSE		38
+2

Protein	Similar proteins		Species	Score	Length	Source
P06339	H-2 class I histocompatibility antigen, D-D alpha chain	)	MOUSE		365	UniRef50_P06339
Class I histocompatibility antigen, Non-RT1.A alpha-1 chain		RAT		319
IGc1 domain-containing protein		ICTTR		318
H-2 class I histocompatibility antigen, D-37 alpha chain-like isoform X8		PERMB		361
MHC class I antigen (Fragment)		MACMU		273
+291

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M11284 mRNA Translation: AAA39693.1 Y00629 Genomic DNA Translation: CAA68665.1
CCDSⁱ	CCDS28715.1
PIRⁱ	A02205, HLMS37
RefSeqⁱ	NP_034528.1, NM_010398.3

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3VJ6	X-ray	1.90	A	21-297	[»]
SMRⁱ	P06339
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P06339, 1 interactor
STRINGⁱ	10090.ENSMUSP00000099739

PTM databases

GlyGenⁱ	P06339, 2 sites
iPTMnetⁱ	P06339
PhosphoSitePlusⁱ	P06339

Proteomic databases

EPDⁱ	P06339
jPOSTⁱ	P06339
PaxDbⁱ	P06339
PRIDEⁱ	P06339

Genome annotation databases

Ensemblⁱ	ENSMUST00000102678; ENSMUSP00000099739; ENSMUSG00000067212
GeneIDⁱ	15040
KEGGⁱ	mmu:15040
UCSCⁱ	uc008cjr.1, mouse

Organism-specific databases

CTDⁱ	15040
MGIⁱ	MGI:95957, H2-T23

Phylogenomic databases

eggNOGⁱ	ENOG502RQEK, Eukaryota
GeneTreeⁱ	ENSGT00990000203546
HOGENOMⁱ	CLU_047501_1_1_1
InParanoidⁱ	P06339
OMAⁱ	ETERWIT
OrthoDBⁱ	1390181at2759
PhylomeDBⁱ	P06339
TreeFamⁱ	TF336617

Enzyme and pathway databases

Reactomeⁱ	R-MMU-1236974, ER-Phagosome pathway R-MMU-1236977, Endosomal/Vacuolar pathway R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-2172127, DAP12 interactions R-MMU-2424491, DAP12 signaling R-MMU-6798695, Neutrophil degranulation R-MMU-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Reactomeⁱ

R-MMU-1236974, ER-Phagosome pathway
R-MMU-1236977, Endosomal/Vacuolar pathway
R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-2172127, DAP12 interactions
R-MMU-2424491, DAP12 signaling
R-MMU-6798695, Neutrophil degranulation
R-MMU-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

BioGRID-ORCSⁱ	15040, 2 hits in 21 CRISPR screens
ChiTaRSⁱ	H2-T23, mouse
Protein Ontology More...PROⁱ	PR:P06339
RNActⁱ	P06339, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000067212, Expressed in lymph node and 254 other tissues
ExpressionAtlasⁱ	P06339, baseline and differential
Genevisibleⁱ	P06339, MM

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.30.500.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog IPR001039, MHC_I_a_a1/a2
Pfamⁱ	View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit
PRINTSⁱ	PR01638, MHCCLASSI
SMARTⁱ	View protein in SMART SM00407, IGc1, 1 hit
SUPFAMⁱ	SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HA15_MOUSE
Accessionⁱ	P06339Primary (citable) accession number: P06339
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
	Last sequence update:	January 1, 1988
	Last modified:	December 2, 2020
	This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - P06339 (HA15_MOUSE)

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H-2 class I histocompatibility antigen, D-37 alpha chain

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Endoplasmic reticulum

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ