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Protein

Cholecystokinin

Gene

CCK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

GO - Molecular functioni

  • hormone activity Source: GO_Central
  • neuropeptide hormone activity Source: UniProtKB
  • peptide hormone receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiP06307

Names & Taxonomyi

Protein namesi
Recommended name:
Cholecystokinin
Short name:
CCK
Cleaved into the following 10 chains:
Cholecystokinin-58
Short name:
CCK58
Alternative name(s):
(1-49)-CCK58
Cholecystokinin-39
Short name:
CCK39
Cholecystokinin-33
Short name:
CCK33
Cholecystokinin-25
Short name:
CCK25
Cholecystokinin-18
Short name:
CCK18
Cholecystokinin-12
Short name:
CCK12
Cholecystokinin-8
Short name:
CCK8
Cholecystokinin-7
Short name:
CCK7
Cholecystokinin-5
Short name:
CCK5
Gene namesi
Name:CCK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000187094.11
HGNCiHGNC:1569 CCK
MIMi118440 gene
neXtProtiNX_P06307

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi97Y → F: Reduces the quantity of secreted CCK8 by 50%. 1 Publication1

Organism-specific databases

DisGeNETi885
OpenTargetsiENSG00000187094
PharmGKBiPA26141

Chemistry databases

ChEMBLiCHEMBL1649050

Polymorphism and mutation databases

BioMutaiCCK
DMDMi115945

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001053621 – 115CholecystokininAdd BLAST95
PropeptideiPRO_000001053721 – 44Add BLAST24
PeptideiPRO_000001053846 – 103Cholecystokinin-58Add BLAST58
PeptideiPRO_000030630446 – 94Cholecystokinin-58 desnonopeptideBy similarityAdd BLAST49
PeptideiPRO_000001053965 – 103Cholecystokinin-39Add BLAST39
PeptideiPRO_000001054071 – 103Cholecystokinin-33Add BLAST33
PeptideiPRO_000030630579 – 103Cholecystokinin-25By similarityAdd BLAST25
PeptideiPRO_000030630686 – 103Cholecystokinin-18By similarityAdd BLAST18
PeptideiPRO_000001054192 – 103Cholecystokinin-12Add BLAST12
PeptideiPRO_000001054296 – 103Cholecystokinin-88
PeptideiPRO_000030630797 – 103Cholecystokinin-7By similarity7
PeptideiPRO_000030630899 – 103Cholecystokinin-5By similarity5
PropeptideiPRO_0000010543107 – 1159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97Sulfotyrosine1 Publication1
Modified residuei103Phenylalanine amide1 Publication1
Modified residuei111SulfotyrosineBy similarity1
Modified residuei113SulfotyrosineBy similarity1

Post-translational modificationi

The precursor is cleaved by proteases to produce a number of active cholecystokinins.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Sulfation

Proteomic databases

PaxDbiP06307
PeptideAtlasiP06307
PRIDEiP06307
ProteomicsDBi51882

PTM databases

iPTMnetiP06307
PhosphoSitePlusiP06307

Miscellaneous databases

PMAP-CutDBiP06307

Expressioni

Gene expression databases

BgeeiENSG00000187094 Expressed in 111 organ(s), highest expression level in frontal pole
CleanExiHS_CCK
ExpressionAtlasiP06307 baseline and differential
GenevisibleiP06307 HS

Organism-specific databases

HPAiHPA045039
HPA069515

Interactioni

Subunit structurei

Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CCKBRP322392EBI-6624436,EBI-1753137

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107327, 2 interactors
IntActiP06307, 2 interactors
STRINGi9606.ENSP00000335657

Chemistry databases

BindingDBiP06307

Structurei

3D structure databases

ProteinModelPortaliP06307
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gastrin/cholecystokinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQ9 Eukaryota
ENOG411211F LUCA
GeneTreeiENSGT00390000003571
HOGENOMiHOG000073533
HOVERGENiHBG005806
InParanoidiP06307
KOiK05226
OMAiDGEPRAH
OrthoDBiEOG091G11B3
PhylomeDBiP06307
TreeFamiTF333419

Family and domain databases

InterProiView protein in InterPro
IPR015499 CCK-like
IPR001651 Gastrin/CCK
IPR013152 Gastrin/cholecystokinin_CS
PANTHERiPTHR10786 PTHR10786, 1 hit
PfamiView protein in Pfam
PF00918 Gastrin, 1 hit
PROSITEiView protein in PROSITE
PS00259 GASTRIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06307-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSGVCLCVL MAVLAAGALT QPVPPADPAG SGLQRAEEAP RRQLRVSQRT
60 70 80 90 100
DGESRAHLGA LLARYIQQAR KAPSGRMSIV KNLQNLDPSH RISDRDYMGW
110
MDFGRRSAEE YEYPS
Length:115
Mass (Da):12,669
Last modified:January 1, 1988 - v1
Checksum:i8A3EE6442FAEAF4B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01881832G → E1 PublicationCorresponds to variant dbSNP:rs11571848Ensembl.1
Natural variantiVAR_02445295R → W. Corresponds to variant dbSNP:rs3774395Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00354 Genomic DNA Translation: AAA53094.1
BT006991 mRNA Translation: AAP35637.1
AY514491 Genomic DNA Translation: AAR89908.1
BC008283 mRNA Translation: AAH08283.1
CCDSiCCDS2696.1
PIRiA01623 GMHUCP
RefSeqiNP_000720.1, NM_000729.5
NP_001167609.1, NM_001174138.2
UniGeneiHs.458426

Genome annotation databases

EnsembliENST00000334681; ENSP00000335657; ENSG00000187094
ENST00000396169; ENSP00000379472; ENSG00000187094
ENST00000434608; ENSP00000409124; ENSG00000187094
GeneIDi885
KEGGihsa:885

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

Cholecystokinin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00354 Genomic DNA Translation: AAA53094.1
BT006991 mRNA Translation: AAP35637.1
AY514491 Genomic DNA Translation: AAR89908.1
BC008283 mRNA Translation: AAH08283.1
CCDSiCCDS2696.1
PIRiA01623 GMHUCP
RefSeqiNP_000720.1, NM_000729.5
NP_001167609.1, NM_001174138.2
UniGeneiHs.458426

3D structure databases

ProteinModelPortaliP06307
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107327, 2 interactors
IntActiP06307, 2 interactors
STRINGi9606.ENSP00000335657

Chemistry databases

BindingDBiP06307
ChEMBLiCHEMBL1649050

PTM databases

iPTMnetiP06307
PhosphoSitePlusiP06307

Polymorphism and mutation databases

BioMutaiCCK
DMDMi115945

Proteomic databases

PaxDbiP06307
PeptideAtlasiP06307
PRIDEiP06307
ProteomicsDBi51882

Protocols and materials databases

DNASUi885
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334681; ENSP00000335657; ENSG00000187094
ENST00000396169; ENSP00000379472; ENSG00000187094
ENST00000434608; ENSP00000409124; ENSG00000187094
GeneIDi885
KEGGihsa:885

Organism-specific databases

CTDi885
DisGeNETi885
EuPathDBiHostDB:ENSG00000187094.11
GeneCardsiCCK
HGNCiHGNC:1569 CCK
HPAiHPA045039
HPA069515
MIMi118440 gene
neXtProtiNX_P06307
OpenTargetsiENSG00000187094
PharmGKBiPA26141
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXQ9 Eukaryota
ENOG411211F LUCA
GeneTreeiENSGT00390000003571
HOGENOMiHOG000073533
HOVERGENiHBG005806
InParanoidiP06307
KOiK05226
OMAiDGEPRAH
OrthoDBiEOG091G11B3
PhylomeDBiP06307
TreeFamiTF333419

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiP06307

Miscellaneous databases

ChiTaRSiCCK human
GeneWikiiCholecystokinin
GenomeRNAii885
PMAP-CutDBiP06307
PROiPR:P06307
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187094 Expressed in 111 organ(s), highest expression level in frontal pole
CleanExiHS_CCK
ExpressionAtlasiP06307 baseline and differential
GenevisibleiP06307 HS

Family and domain databases

InterProiView protein in InterPro
IPR015499 CCK-like
IPR001651 Gastrin/CCK
IPR013152 Gastrin/cholecystokinin_CS
PANTHERiPTHR10786 PTHR10786, 1 hit
PfamiView protein in Pfam
PF00918 Gastrin, 1 hit
PROSITEiView protein in PROSITE
PS00259 GASTRIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCKN_HUMAN
AccessioniPrimary (citable) accession number: P06307
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 7, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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