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UniProtKB - P06307 (CCKN_HUMAN)

Entry version 178 (02 Jun 2021)
Sequence version 1 (01 Jan 1988)
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Protein

Cholecystokinin

Gene

CCK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P06307

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-375276, Peptide ligand-binding receptors
R-HSA-416476, G alpha (q) signalling events

SIGNOR Signaling Network Open Resource

More...SIGNORi		P06307

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cholecystokinin
Short name:
CCK
Cleaved into the following 10 chains:
Cholecystokinin-58
Short name:
CCK58
Cholecystokinin-58 desnonopeptide
Alternative name(s):
(1-49)-CCK58
Cholecystokinin-39
Short name:
CCK39
Cholecystokinin-33
Short name:
CCK33
Cholecystokinin-25
Short name:
CCK25
Cholecystokinin-18
Short name:
CCK18
Cholecystokinin-12
Short name:
CCK12
Cholecystokinin-8
Short name:
CCK8
Cholecystokinin-7
Short name:
CCK7
Cholecystokinin-5
Short name:
CCK5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCK
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1569, CCK

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		118440, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P06307

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000187094.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi97Y → F: Reduces the quantity of secreted CCK8 by 50%. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		885

Open Targets

More...OpenTargetsi		ENSG00000187094

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26141

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P06307, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1649050

Drug and drug target database

More...DrugBanki		DB13729, Camostat

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCK

Domain mapping of disease mutations (DMDM)

More...DMDMi		115945

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Add BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001053621 – 115CholecystokininAdd BLAST95
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001053721 – 44Add BLAST24
<p>This subsection of the 'PTM / Processing' section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000001053846 – 103Cholecystokinin-58Add BLAST58
PeptideiPRO_000030630446 – 94Cholecystokinin-58 desnonopeptideBy similarityAdd BLAST49
PeptideiPRO_000001053965 – 103Cholecystokinin-39Add BLAST39
PeptideiPRO_000001054071 – 103Cholecystokinin-33Add BLAST33
PeptideiPRO_000030630579 – 103Cholecystokinin-25By similarityAdd BLAST25
PeptideiPRO_000030630686 – 103Cholecystokinin-18By similarityAdd BLAST18
PeptideiPRO_000001054192 – 103Cholecystokinin-12Add BLAST12
PeptideiPRO_000001054296 – 103Cholecystokinin-88
PeptideiPRO_000030630797 – 103Cholecystokinin-7By similarity7
PeptideiPRO_000030630899 – 103Cholecystokinin-5By similarity5
PropeptideiPRO_0000010543107 – 1159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei97Sulfotyrosine1 Publication1
Modified residuei103Phenylalanine amide1 Publication1
Modified residuei111SulfotyrosineBy similarity1
Modified residuei113SulfotyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The precursor is cleaved by proteases to produce a number of active cholecystokinins.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Sulfation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P06307

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P06307

PeptideAtlas

More...PeptideAtlasi		P06307

PRoteomics IDEntifications database

More...PRIDEi		P06307

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51882

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P06307

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P06307

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000187094, Expressed in frontal pole and 131 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P06307, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P06307, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000187094, Group enriched (brain, intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P06307
With#Exp.IntAct
ADAL - isoform 2 [Q6DHV7-2]3EBI-6624398,EBI-18899653
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-6624398,EBI-10173507
ANKEF1 [Q9NU02]3EBI-6624398,EBI-8464238
ARL6IP4 - isoform 4 [Q66PJ3-4]3EBI-6624398,EBI-5280499
ASCL4 [Q6XD76]3EBI-6624398,EBI-10254793
ATG12 [C1IDX9]3EBI-6624398,EBI-25836940
BRWD1 - isoform D [Q9NSI6-4]3EBI-6624398,EBI-10693038
CBX4 - isoform 2 [O00257-3]3EBI-6624398,EBI-4392727
CFAP100 - isoform 2 [Q494V2-2]3EBI-6624398,EBI-11953200
CHMP7 [Q8WUX9]3EBI-6624398,EBI-749253
CIAO2B [Q9Y3D0]3EBI-6624398,EBI-744045
CITED1 [Q99966]3EBI-6624398,EBI-2624951
EPM2A - isoform 6 [O95278-6]3EBI-6624398,EBI-25836908
ESRP1 - isoform 3 [Q6NXG1-3]3EBI-6624398,EBI-21567429
FYN [P06241]3EBI-6624398,EBI-515315
GABPB1 - isoform 3 [Q06547-3]3EBI-6624398,EBI-9088619
H2AP [O75409]3EBI-6624398,EBI-6447217
H3-5 [Q6NXT2]3EBI-6624398,EBI-2868501
HCCS [P53701]3EBI-6624398,EBI-10763431
HELLS - isoform 6 [Q9NRZ9-6]3EBI-6624398,EBI-12003732
JPT1 [Q9UK76]3EBI-6624398,EBI-720411
KRT222 [Q8N1A0]3EBI-6624398,EBI-8473062
LGALS9C [Q6DKI2]3EBI-6624398,EBI-9088829
LHX5 [Q9H2C1]3EBI-6624398,EBI-25835523
LPAL2 [Q16609]3EBI-6624398,EBI-10238012
MCFD2 [Q8NI22]3EBI-6624398,EBI-2689785
MYC [P01106]3EBI-6624398,EBI-447544
NAGK - isoform 2 [Q9UJ70-2]3EBI-6624398,EBI-11526455
NFYB [P25208]3EBI-6624398,EBI-389728
NUP43 [Q8NFH3]3EBI-6624398,EBI-1059321
NUP54 [Q7Z3B4]3EBI-6624398,EBI-741048
PPARA [Q07869]3EBI-6624398,EBI-78615
PPBP [P02775]3EBI-6624398,EBI-718973
PPP1R21 - isoform 5 [Q6ZMI0-5]3EBI-6624398,EBI-25835994
PRPH2 [P23942]3EBI-6624398,EBI-25836834
PTPN4 [P29074]3EBI-6624398,EBI-710431
REEP6 - isoform 2 [Q96HR9-2]3EBI-6624398,EBI-14065960
RELA [Q04206]3EBI-6624398,EBI-73886
RGR - isoform 3 [P47804-3]3EBI-6624398,EBI-25834767
RHEB [Q15382]3EBI-6624398,EBI-1055287
RPS4X [P62701]3EBI-6624398,EBI-354303
RUSC1-AS1 [Q66K80]3EBI-6624398,EBI-10248967
SH3BP5L [Q7L8J4]3EBI-6624398,EBI-747389
SLFN12 [Q8IYM2]3EBI-6624398,EBI-2822550
SPRY4 [Q9C004]3EBI-6624398,EBI-354861
SPRYD7 - isoform 2 [Q5W111-2]3EBI-6624398,EBI-12408727
SPSB1 [Q96BD6]3EBI-6624398,EBI-2659201
SYMPK - isoform 2 [Q92797-2]3EBI-6624398,EBI-21560407
UBE2G1 [P62253]3EBI-6624398,EBI-2340619
UBQLN2 [Q9UHD9]3EBI-6624398,EBI-947187
VPS54 - isoform 4 [Q9P1Q0-4]3EBI-6624398,EBI-25835297
WBP1L [Q9NX94]3EBI-6624398,EBI-10316321
ZBTB8OS - isoform 2 [Q8IWT0-2]3EBI-6624398,EBI-12956041
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-6624398,EBI-14104088
ZNF333 - isoform 2 [Q96JL9-2]3EBI-6624398,EBI-25835852
Cholecystokinin-8 (PRO_0000010542)
With#Exp.IntAct
CCKBR [P32239]2EBI-6624436,EBI-1753137

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107327, 3 interactors

Protein interaction database and analysis system

More...IntActi		P06307, 56 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000379472

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P06307

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P06307, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 52DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi38 – 52Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the gastrin/cholecystokinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S472, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003571

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_169783_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P06307

Identification of Orthologs from Complete Genome Data

More...OMAi		DGEPRAH

Database of Orthologous Groups

More...OrthoDBi		1524113at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P06307

TreeFam database of animal gene trees

More...TreeFami		TF333419

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015499, CCK-like
IPR001651, Gastrin/CCK
IPR013152, Gastrin/cholecystokinin_CS

The PANTHER Classification System

More...PANTHERi		PTHR10786, PTHR10786, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00918, Gastrin, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00259, GASTRIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P06307-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSGVCLCVL MAVLAAGALT QPVPPADPAG SGLQRAEEAP RRQLRVSQRT 
        60         70         80         90        100
DGESRAHLGA LLARYIQQAR KAPSGRMSIV KNLQNLDPSH RISDRDYMGW 
       110 
MDFGRRSAEE YEYPS
Length:115
Mass (Da):12,669
Last modified:January 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A3EE6442FAEAF4B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01881832G → E1 PublicationCorresponds to variant dbSNP:rs11571848Ensembl.1
Natural variantiVAR_02445295R → W. Corresponds to variant dbSNP:rs3774395Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L00354 Genomic DNA Translation: AAA53094.1
BT006991 mRNA Translation: AAP35637.1
AY514491 Genomic DNA Translation: AAR89908.1
BC008283 mRNA Translation: AAH08283.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2696.1

Protein sequence database of the Protein Information Resource

More...PIRi		A01623, GMHUCP

NCBI Reference Sequences

More...RefSeqi		NP_000720.1, NM_000729.5
NP_001167609.1, NM_001174138.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000334681; ENSP00000335657; ENSG00000187094
ENST00000396169; ENSP00000379472; ENSG00000187094
ENST00000434608; ENSP00000409124; ENSG00000187094

Database of genes from NCBI RefSeq genomes

More...GeneIDi		885

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:885

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Wikipedia

Cholecystokinin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00354 Genomic DNA Translation: AAA53094.1
BT006991 mRNA Translation: AAP35637.1
AY514491 Genomic DNA Translation: AAR89908.1
BC008283 mRNA Translation: AAH08283.1
CCDSiCCDS2696.1
PIRiA01623, GMHUCP
RefSeqiNP_000720.1, NM_000729.5
NP_001167609.1, NM_001174138.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi107327, 3 interactors
IntActiP06307, 56 interactors
STRINGi9606.ENSP00000379472

Chemistry databases

BindingDBiP06307
ChEMBLiCHEMBL1649050
DrugBankiDB13729, Camostat

PTM databases

iPTMnetiP06307
PhosphoSitePlusiP06307

Genetic variation databases

BioMutaiCCK
DMDMi115945

Proteomic databases

MassIVEiP06307
PaxDbiP06307
PeptideAtlasiP06307
PRIDEiP06307
ProteomicsDBi51882

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29187, 267 antibodies

The DNASU plasmid repository

More...DNASUi		885

Genome annotation databases

EnsembliENST00000334681; ENSP00000335657; ENSG00000187094
ENST00000396169; ENSP00000379472; ENSG00000187094
ENST00000434608; ENSP00000409124; ENSG00000187094
GeneIDi885
KEGGihsa:885

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		885
DisGeNETi885

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCK
HGNCiHGNC:1569, CCK
HPAiENSG00000187094, Group enriched (brain, intestine)
MIMi118440, gene
neXtProtiNX_P06307
OpenTargetsiENSG00000187094
PharmGKBiPA26141
VEuPathDBiHostDB:ENSG00000187094.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S472, Eukaryota
GeneTreeiENSGT00390000003571
HOGENOMiCLU_169783_0_0_1
InParanoidiP06307
OMAiDGEPRAH
OrthoDBi1524113at2759
PhylomeDBiP06307
TreeFamiTF333419

Enzyme and pathway databases

PathwayCommonsiP06307
ReactomeiR-HSA-375276, Peptide ligand-binding receptors
R-HSA-416476, G alpha (q) signalling events
SIGNORiP06307

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		885, 8 hits in 985 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CCK, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Cholecystokinin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		885
PharosiP06307, Tbio

Protein Ontology

More...PROi		PR:P06307
RNActiP06307, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000187094, Expressed in frontal pole and 131 other tissues
ExpressionAtlasiP06307, baseline and differential
GenevisibleiP06307, HS

Family and domain databases

InterProiView protein in InterPro
IPR015499, CCK-like
IPR001651, Gastrin/CCK
IPR013152, Gastrin/cholecystokinin_CS
PANTHERiPTHR10786, PTHR10786, 1 hit
PfamiView protein in Pfam
PF00918, Gastrin, 1 hit
PROSITEiView protein in PROSITE
PS00259, GASTRIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCKN_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06307
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: June 2, 2021
This is version 178 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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