CCK

Functionⁱ

This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

GO - Molecular functionⁱ

hormone activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neuropeptide hormone activity
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 15374756
peptide hormone receptor binding
Source: GO_Central
Inferred from physical interactionⁱ
- 7681836

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
axonogenesis
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 15152034
digestion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
eating behavior
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 15374756
G protein-coupled receptor signaling pathway Source: Reactome
memory Source: Ensembl
negative regulation of appetite Source: Ensembl
negative regulation of behavioral fear response Source: Ensembl
negative regulation of eating behavior Source: Ensembl
neuron migration
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 15152034
positive regulation of behavioral fear response Source: Ensembl
positive regulation of cell proliferation Source: Ensembl
positive regulation of glutamate secretion Source: Ensembl
positive regulation of mitochondrial depolarization Source: Ensembl
positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
positive regulation of protein oligomerization Source: Ensembl
positive regulation of sensory perception of pain Source: Ensembl
protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
release of cytochrome c from mitochondria Source: Ensembl
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 10320330
visual learning Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hormone

Molecular function

Hormone

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events
SIGNORⁱ	P06307

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cholecystokinin Short name: CCK Cleaved into the following 10 chains: Cholecystokinin-58 Short name: CCK58 Cholecystokinin-58 desnonopeptide Alternative name(s): (1-49)-CCK58 Cholecystokinin-39 Short name: CCK39 Cholecystokinin-33 Short name: CCK33 Cholecystokinin-25 Short name: CCK25 Cholecystokinin-18 Short name: CCK18 Cholecystokinin-12 Short name: CCK12 Cholecystokinin-8 Short name: CCK8 Cholecystokinin-7 Short name: CCK7 Cholecystokinin-5 Short name: CCK5
Gene namesⁱ	Name:CCK
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000187094.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1569 CCK
MIMⁱ	118440 gene
neXtProtⁱ	NX_P06307

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	97	Y → F: Reduces the quantity of secreted CCK8 by 50%. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	885
Open Targets More...OpenTargetsⁱ	ENSG00000187094
PharmGKBⁱ	PA26141

Chemistry databases

ChEMBLⁱ	CHEMBL1649050

ChEMBLⁱ

CHEMBL1649050

Polymorphism and mutation databases

BioMutaⁱ	CCK
DMDMⁱ	115945

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 20	Add BLAST	20
ChainⁱPRO_0000010536	21 – 115	CholecystokininAdd BLAST	95
PropeptideⁱPRO_0000010537	21 – 44	Add BLAST	24
PeptideⁱPRO_0000010538	46 – 103	Cholecystokinin-58Add BLAST	58
PeptideⁱPRO_0000306304	46 – 94	Cholecystokinin-58 desnonopeptideBy similarityAdd BLAST	49
PeptideⁱPRO_0000010539	65 – 103	Cholecystokinin-39Add BLAST	39
PeptideⁱPRO_0000010540	71 – 103	Cholecystokinin-33Add BLAST	33
PeptideⁱPRO_0000306305	79 – 103	Cholecystokinin-25By similarityAdd BLAST	25
PeptideⁱPRO_0000306306	86 – 103	Cholecystokinin-18By similarityAdd BLAST	18
PeptideⁱPRO_0000010541	92 – 103	Cholecystokinin-12Add BLAST	12
PeptideⁱPRO_0000010542	96 – 103	Cholecystokinin-8	8
PeptideⁱPRO_0000306307	97 – 103	Cholecystokinin-7By similarity	7
PeptideⁱPRO_0000306308	99 – 103	Cholecystokinin-5By similarity	5
PropeptideⁱPRO_0000010543	107 – 115		9

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	97	Sulfotyrosine1 Publication	1
Modified residueⁱ	103	Phenylalanine amide1 Publication	1
Modified residueⁱ	111	SulfotyrosineBy similarity	1
Modified residueⁱ	113	SulfotyrosineBy similarity	1

Post-translational modificationⁱ

The precursor is cleaved by proteases to produce a number of active cholecystokinins.

Keywords - PTMⁱ

Amidation, Cleavage on pair of basic residues, Sulfation

Proteomic databases

PaxDbⁱ	P06307
PeptideAtlas More...PeptideAtlasⁱ	P06307
PRIDEⁱ	P06307
ProteomicsDBⁱ	51882

PTM databases

iPTMnetⁱ	P06307
PhosphoSitePlusⁱ	P06307

Miscellaneous databases

PMAP-CutDBⁱ	P06307

PMAP-CutDBⁱ

P06307

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000187094 Expressed in 111 organ(s), highest expression level in frontal pole
CleanExⁱ	HS_CCK
ExpressionAtlasⁱ	P06307 baseline and differential
Genevisibleⁱ	P06307 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045039 HPA069515

HPAⁱ

HPA045039
HPA069515

Interactionⁱ

Subunit structureⁱ

Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CCKBR	P32239	2	EBI-6624436,EBI-1753137

With

Entry

#Exp.

IntAct

Notes

CCKBR

P32239

2

EBI-6624436,EBI-1753137

GO - Molecular functionⁱ

hormone activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neuropeptide hormone activity
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 15374756
peptide hormone receptor binding
Source: GO_Central
Inferred from physical interactionⁱ
- 7681836

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107327, 2 interactors
IntActⁱ	P06307, 2 interactors
STRINGⁱ	9606.ENSP00000335657

Chemistry databases

BindingDBⁱ

P06307

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P06307
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the gastrin/cholecystokinin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IXQ9 Eukaryota ENOG411211F LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003571
HOGENOMⁱ	HOG000073533
HOVERGENⁱ	HBG005806
InParanoidⁱ	P06307
KEGG Orthology (KO) More...KOⁱ	K05226
OMAⁱ	DGEPRAH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G11B3
PhylomeDBⁱ	P06307
TreeFamⁱ	TF333419

Family and domain databases

InterProⁱ	View protein in InterPro IPR015499 CCK-like IPR001651 Gastrin/CCK IPR013152 Gastrin/cholecystokinin_CS
PANTHERⁱ	PTHR10786 PTHR10786, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00918 Gastrin, 1 hit
PROSITEⁱ	View protein in PROSITE PS00259 GASTRIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P06307-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNSGVCLCVL MAVLAAGALT QPVPPADPAG SGLQRAEEAP RRQLRVSQRT 
        60         70         80         90        100
DGESRAHLGA LLARYIQQAR KAPSGRMSIV KNLQNLDPSH RISDRDYMGW 
       110 
MDFGRRSAEE YEYPS

Length:115

Mass (Da):12,669

Last modified:January 1, 1988 - v1

Checksum:ⁱ8A3EE6442FAEAF4B

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_018818	32	G → E1 PublicationCorresponds to variant dbSNP:rs11571848Ensembl.		1
Natural variantⁱVAR_024452	95	R → W. Corresponds to variant dbSNP:rs3774395Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L00354 Genomic DNA Translation: AAA53094.1 BT006991 mRNA Translation: AAP35637.1 AY514491 Genomic DNA Translation: AAR89908.1 BC008283 mRNA Translation: AAH08283.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2696.1
PIRⁱ	A01623 GMHUCP
NCBI Reference Sequences More...RefSeqⁱ	NP_000720.1, NM_000729.5 NP_001167609.1, NM_001174138.2
UniGeneⁱ	Hs.458426

Genome annotation databases

Ensemblⁱ	ENST00000334681; ENSP00000335657; ENSG00000187094 ENST00000396169; ENSP00000379472; ENSG00000187094 ENST00000434608; ENSP00000409124; ENSG00000187094
GeneIDⁱ	885
KEGGⁱ	hsa:885

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P06307	CCK protein (Fragment)		HUMAN		115	UniRef100_P06307

Protein	Similar proteins		Species	Score	Length	Source
P06307	Cholecystokinin		MACFA		115	UniRef90_P06307
CCK protein (Fragment)		HUMAN		115
Uncharacterized protein		MANLE		119
Cholecystokinin		MACMU		115
Uncharacterized protein		CERAT		115
+20

Protein	Similar proteins		Species	Score	Length	Source
P06307	Cholecystokinin		RAT		115	UniRef50_P01355
Cholecystokinin		MOUSE		115
Cholecystokinins		CANLF		58
Cholecystokinin		MACFA		115
Cholecystokinin		BOVIN		115
+63

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Wikipedia

Cholecystokinin entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L00354 Genomic DNA Translation: AAA53094.1 BT006991 mRNA Translation: AAP35637.1 AY514491 Genomic DNA Translation: AAR89908.1 BC008283 mRNA Translation: AAH08283.1
CCDSⁱ	CCDS2696.1
PIRⁱ	A01623 GMHUCP
RefSeqⁱ	NP_000720.1, NM_000729.5 NP_001167609.1, NM_001174138.2
UniGeneⁱ	Hs.458426

3D structure databases

ProteinModelPortalⁱ	P06307
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107327, 2 interactors
IntActⁱ	P06307, 2 interactors
STRINGⁱ	9606.ENSP00000335657

Chemistry databases

BindingDBⁱ	P06307
ChEMBLⁱ	CHEMBL1649050

PTM databases

iPTMnetⁱ	P06307
PhosphoSitePlusⁱ	P06307

Polymorphism and mutation databases

BioMutaⁱ	CCK
DMDMⁱ	115945

Proteomic databases

PaxDbⁱ	P06307
PeptideAtlasⁱ	P06307
PRIDEⁱ	P06307
ProteomicsDBⁱ	51882

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	885
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000334681; ENSP00000335657; ENSG00000187094 ENST00000396169; ENSP00000379472; ENSG00000187094 ENST00000434608; ENSP00000409124; ENSG00000187094
GeneIDⁱ	885
KEGGⁱ	hsa:885

Organism-specific databases

CTDⁱ	885
DisGeNETⁱ	885
EuPathDBⁱ	HostDB:ENSG00000187094.11
GeneCardsⁱ	CCK
HGNCⁱ	HGNC:1569 CCK
HPAⁱ	HPA045039 HPA069515
MIMⁱ	118440 gene
neXtProtⁱ	NX_P06307
OpenTargetsⁱ	ENSG00000187094
PharmGKBⁱ	PA26141
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IXQ9 Eukaryota ENOG411211F LUCA
GeneTreeⁱ	ENSGT00390000003571
HOGENOMⁱ	HOG000073533
HOVERGENⁱ	HBG005806
InParanoidⁱ	P06307
KOⁱ	K05226
OMAⁱ	DGEPRAH
OrthoDBⁱ	EOG091G11B3
PhylomeDBⁱ	P06307
TreeFamⁱ	TF333419

Enzyme and pathway databases

Reactomeⁱ	R-HSA-375276 Peptide ligand-binding receptors R-HSA-416476 G alpha (q) signalling events
SIGNORⁱ	P06307

Miscellaneous databases

ChiTaRSⁱ	CCK human
GeneWikiⁱ	Cholecystokinin
GenomeRNAiⁱ	885
PMAP-CutDBⁱ	P06307
Protein Ontology More...PROⁱ	PR:P06307
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000187094 Expressed in 111 organ(s), highest expression level in frontal pole
CleanExⁱ	HS_CCK
ExpressionAtlasⁱ	P06307 baseline and differential
Genevisibleⁱ	P06307 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR015499 CCK-like IPR001651 Gastrin/CCK IPR013152 Gastrin/cholecystokinin_CS
PANTHERⁱ	PTHR10786 PTHR10786, 1 hit
Pfamⁱ	View protein in Pfam PF00918 Gastrin, 1 hit
PROSITEⁱ	View protein in PROSITE PS00259 GASTRIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCKN_HUMAN
Accessionⁱ	P06307Primary (citable) accession number: P06307
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
	Last sequence update:	January 1, 1988
	Last modified:	November 7, 2018
	This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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Help

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Supporting data

UniProtKB - P06307 (CCKN_HUMAN)

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Cholecystokinin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ