UniProtKB - P06307 (CCKN_HUMAN)
Protein
Cholecystokinin
Gene
CCK
Organism
Homo sapiens (Human)
Status
Functioni
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
GO - Molecular functioni
- hormone activity Source: GO_Central
- neuropeptide hormone activity Source: UniProtKB
- peptide hormone receptor binding Source: GO_Central
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
- axonogenesis Source: UniProtKB
- digestion Source: GO_Central
- eating behavior Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: Reactome
- memory Source: Ensembl
- negative regulation of appetite Source: Ensembl
- negative regulation of behavioral fear response Source: Ensembl
- negative regulation of eating behavior Source: Ensembl
- neuron migration Source: UniProtKB
- positive regulation of behavioral fear response Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of glutamate secretion Source: Ensembl
- positive regulation of mitochondrial depolarization Source: Ensembl
- positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
- positive regulation of protein-containing complex assembly Source: Ensembl
- positive regulation of sensory perception of pain Source: Ensembl
- protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
- release of cytochrome c from mitochondria Source: Ensembl
- signal transduction Source: ProtInc
- visual learning Source: Ensembl
Keywordsi
Molecular function | Hormone |
Enzyme and pathway databases
PathwayCommonsi | P06307 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events |
SIGNORi | P06307 |
Names & Taxonomyi
Protein namesi | Recommended name: CholecystokininShort name: CCK Cleaved into the following 10 chains: Alternative name(s): (1-49)-CCK58 |
Gene namesi | Name:CCK |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000187094.11 |
HGNCi | HGNC:1569, CCK |
MIMi | 118440, gene |
neXtProti | NX_P06307 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Other locations
- axon Source: UniProtKB
- axon hillock Source: Ensembl
- axon initial segment Source: Ensembl
- dendrite Source: Ensembl
- perikaryon Source: Ensembl
- terminal bouton Source: Ensembl
Keywords - Cellular componenti
SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 97 | Y → F: Reduces the quantity of secreted CCK8 by 50%. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 885 |
OpenTargetsi | ENSG00000187094 |
PharmGKBi | PA26141 |
Miscellaneous databases
Pharosi | P06307, Tbio |
Chemistry databases
ChEMBLi | CHEMBL1649050 |
DrugBanki | DB13729, Camostat |
Polymorphism and mutation databases
BioMutai | CCK |
DMDMi | 115945 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Add BLAST | 20 | |
ChainiPRO_0000010536 | 21 – 115 | CholecystokininAdd BLAST | 95 | |
PropeptideiPRO_0000010537 | 21 – 44 | Add BLAST | 24 | |
PeptideiPRO_0000010538 | 46 – 103 | Cholecystokinin-58Add BLAST | 58 | |
PeptideiPRO_0000306304 | 46 – 94 | Cholecystokinin-58 desnonopeptideBy similarityAdd BLAST | 49 | |
PeptideiPRO_0000010539 | 65 – 103 | Cholecystokinin-39Add BLAST | 39 | |
PeptideiPRO_0000010540 | 71 – 103 | Cholecystokinin-33Add BLAST | 33 | |
PeptideiPRO_0000306305 | 79 – 103 | Cholecystokinin-25By similarityAdd BLAST | 25 | |
PeptideiPRO_0000306306 | 86 – 103 | Cholecystokinin-18By similarityAdd BLAST | 18 | |
PeptideiPRO_0000010541 | 92 – 103 | Cholecystokinin-12Add BLAST | 12 | |
PeptideiPRO_0000010542 | 96 – 103 | Cholecystokinin-8 | 8 | |
PeptideiPRO_0000306307 | 97 – 103 | Cholecystokinin-7By similarity | 7 | |
PeptideiPRO_0000306308 | 99 – 103 | Cholecystokinin-5By similarity | 5 | |
PropeptideiPRO_0000010543 | 107 – 115 | 9 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 97 | Sulfotyrosine1 Publication | 1 | |
Modified residuei | 103 | Phenylalanine amide1 Publication | 1 | |
Modified residuei | 111 | SulfotyrosineBy similarity | 1 | |
Modified residuei | 113 | SulfotyrosineBy similarity | 1 |
Post-translational modificationi
The precursor is cleaved by proteases to produce a number of active cholecystokinins.
Keywords - PTMi
Amidation, Cleavage on pair of basic residues, SulfationProteomic databases
MassIVEi | P06307 |
PaxDbi | P06307 |
PeptideAtlasi | P06307 |
PRIDEi | P06307 |
ProteomicsDBi | 51882 |
PTM databases
iPTMneti | P06307 |
PhosphoSitePlusi | P06307 |
Expressioni
Gene expression databases
Bgeei | ENSG00000187094, Expressed in frontal pole and 130 other tissues |
ExpressionAtlasi | P06307, baseline and differential |
Genevisiblei | P06307, HS |
Organism-specific databases
HPAi | ENSG00000187094, Group enriched (brain, intestine) |
Interactioni
Subunit structurei
Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain.
By similarityBinary interactionsi
Hide detailsP06307
With | #Exp. | IntAct |
---|---|---|
UBQLN2 [Q9UHD9] | 3 | EBI-6624398,EBI-947187 |
Cholecystokinin-8 (PRO_0000010542)
With | #Exp. | IntAct |
---|---|---|
CCKBR [P32239] | 2 | EBI-6624436,EBI-1753137 |
GO - Molecular functioni
- hormone activity Source: GO_Central
- neuropeptide hormone activity Source: UniProtKB
- peptide hormone receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 107327, 3 interactors |
IntActi | P06307, 2 interactors |
STRINGi | 9606.ENSP00000379472 |
Chemistry databases
BindingDBi | P06307 |
Miscellaneous databases
RNActi | P06307, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the gastrin/cholecystokinin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S472, Eukaryota |
GeneTreei | ENSGT00390000003571 |
HOGENOMi | CLU_169783_0_0_1 |
InParanoidi | P06307 |
OMAi | DGEPRAH |
OrthoDBi | 1524113at2759 |
PhylomeDBi | P06307 |
TreeFami | TF333419 |
Family and domain databases
InterProi | View protein in InterPro IPR015499, CCK-like IPR001651, Gastrin/CCK IPR013152, Gastrin/cholecystokinin_CS |
PANTHERi | PTHR10786, PTHR10786, 1 hit |
Pfami | View protein in Pfam PF00918, Gastrin, 1 hit |
PROSITEi | View protein in PROSITE PS00259, GASTRIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P06307-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSGVCLCVL MAVLAAGALT QPVPPADPAG SGLQRAEEAP RRQLRVSQRT
60 70 80 90 100
DGESRAHLGA LLARYIQQAR KAPSGRMSIV KNLQNLDPSH RISDRDYMGW
110
MDFGRRSAEE YEYPS
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018818 | 32 | G → E1 PublicationCorresponds to variant dbSNP:rs11571848Ensembl. | 1 | |
Natural variantiVAR_024452 | 95 | R → W. Corresponds to variant dbSNP:rs3774395Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L00354 Genomic DNA Translation: AAA53094.1 BT006991 mRNA Translation: AAP35637.1 AY514491 Genomic DNA Translation: AAR89908.1 BC008283 mRNA Translation: AAH08283.1 |
CCDSi | CCDS2696.1 |
PIRi | A01623, GMHUCP |
RefSeqi | NP_000720.1, NM_000729.5 NP_001167609.1, NM_001174138.2 |
Genome annotation databases
Ensembli | ENST00000334681; ENSP00000335657; ENSG00000187094 ENST00000396169; ENSP00000379472; ENSG00000187094 ENST00000434608; ENSP00000409124; ENSG00000187094 |
GeneIDi | 885 |
KEGGi | hsa:885 |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Wikipedia Cholecystokinin entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L00354 Genomic DNA Translation: AAA53094.1 BT006991 mRNA Translation: AAP35637.1 AY514491 Genomic DNA Translation: AAR89908.1 BC008283 mRNA Translation: AAH08283.1 |
CCDSi | CCDS2696.1 |
PIRi | A01623, GMHUCP |
RefSeqi | NP_000720.1, NM_000729.5 NP_001167609.1, NM_001174138.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 107327, 3 interactors |
IntActi | P06307, 2 interactors |
STRINGi | 9606.ENSP00000379472 |
Chemistry databases
BindingDBi | P06307 |
ChEMBLi | CHEMBL1649050 |
DrugBanki | DB13729, Camostat |
PTM databases
iPTMneti | P06307 |
PhosphoSitePlusi | P06307 |
Polymorphism and mutation databases
BioMutai | CCK |
DMDMi | 115945 |
Proteomic databases
MassIVEi | P06307 |
PaxDbi | P06307 |
PeptideAtlasi | P06307 |
PRIDEi | P06307 |
ProteomicsDBi | 51882 |
Protocols and materials databases
Antibodypediai | 29187, 259 antibodies |
DNASUi | 885 |
Genome annotation databases
Ensembli | ENST00000334681; ENSP00000335657; ENSG00000187094 ENST00000396169; ENSP00000379472; ENSG00000187094 ENST00000434608; ENSP00000409124; ENSG00000187094 |
GeneIDi | 885 |
KEGGi | hsa:885 |
Organism-specific databases
CTDi | 885 |
DisGeNETi | 885 |
EuPathDBi | HostDB:ENSG00000187094.11 |
GeneCardsi | CCK |
HGNCi | HGNC:1569, CCK |
HPAi | ENSG00000187094, Group enriched (brain, intestine) |
MIMi | 118440, gene |
neXtProti | NX_P06307 |
OpenTargetsi | ENSG00000187094 |
PharmGKBi | PA26141 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S472, Eukaryota |
GeneTreei | ENSGT00390000003571 |
HOGENOMi | CLU_169783_0_0_1 |
InParanoidi | P06307 |
OMAi | DGEPRAH |
OrthoDBi | 1524113at2759 |
PhylomeDBi | P06307 |
TreeFami | TF333419 |
Enzyme and pathway databases
PathwayCommonsi | P06307 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events |
SIGNORi | P06307 |
Miscellaneous databases
BioGRID-ORCSi | 885, 4 hits in 843 CRISPR screens |
ChiTaRSi | CCK, human |
GeneWikii | Cholecystokinin |
GenomeRNAii | 885 |
Pharosi | P06307, Tbio |
PROi | PR:P06307 |
RNActi | P06307, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000187094, Expressed in frontal pole and 130 other tissues |
ExpressionAtlasi | P06307, baseline and differential |
Genevisiblei | P06307, HS |
Family and domain databases
InterProi | View protein in InterPro IPR015499, CCK-like IPR001651, Gastrin/CCK IPR013152, Gastrin/cholecystokinin_CS |
PANTHERi | PTHR10786, PTHR10786, 1 hit |
Pfami | View protein in Pfam PF00918, Gastrin, 1 hit |
PROSITEi | View protein in PROSITE PS00259, GASTRIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCKN_HUMAN | |
Accessioni | P06307Primary (citable) accession number: P06307 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | January 1, 1988 | |
Last modified: | December 2, 2020 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations