Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 224 (25 May 2022)
Sequence version 1 (01 Aug 1988)
Previous versions | rss
Add a publicationFeedback
Protein

Cholinesterase

Gene

BCHE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by mercury. Inhibited by Tabun. Tabun forms a covalent adduct with Ser-226 that becomes irreversible upon aging.3 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=18.0 µM for butyrylthiocholine (at 25 degrees Celsius)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei110Tacrine; inhibitorCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei226Acyl-ester intermediatePROSITE-ProRule annotation1 Publication1
Active sitei353Charge relay system1 Publication1
Active sitei466Charge relay system1 Publication1
Binding sitei466Tacrine; via carbonyl oxygen; inhibitorCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Serine esterase
LigandSialic acid

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.1.8, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P06276

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-112311, Neurotransmitter clearance
R-HSA-1483191, Synthesis of PC
R-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P06276

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P06276

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P06276

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
human-BCHE, BCHE

MEROPS protease database

More...
MEROPSi
S09.980

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cholinesterase (EC:3.1.1.8)
Alternative name(s):
Acylcholine acylhydrolase
Butyrylcholine esterase
Choline esterase II
Pseudocholinesterase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BCHE
Synonyms:CHE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:983, BCHE

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
177400, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P06276

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000114200

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Butyrylcholinesterase deficiency (BCHED)24 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive metabolic condition characterized by increased sensitivity to certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium. BCHED results in slower hydrolysis of these drugs and, consequently, a prolonged neuromuscular block, leading to apnea. The duration of the prolonged apnea varies significantly depending on the extent of the enzyme deficiency.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04001132Missing in BCHED. 1 Publication1
Natural variantiVAR_04001252T → M in BCHED. 1 PublicationCorresponds to variant dbSNP:rs56309853EnsemblClinVar.1
Natural variantiVAR_04001356F → I in BCHED. 1 PublicationCorresponds to variant dbSNP:rs531738678EnsemblClinVar.1
Natural variantiVAR_04001461Y → C in BCHED; enzymatically inactive in the plasma. 1 PublicationCorresponds to variant dbSNP:rs116097205EnsemblClinVar.1
Natural variantiVAR_07273062A → V in BCHED; reduced enzyme activity with butyrylthiocholine as substrate; inactive with butyrylthiocholine as substrate in the presence of G-98; 2-fold lower affinity for butyrylthiocholine; 10-fold lower affinity for butyrylthiocholine in the presence of G-98. 1 PublicationCorresponds to variant dbSNP:rs1553778274EnsemblClinVar.1
Natural variantiVAR_04001565P → S in BCHED; seems to cause reduced expression of the protein. 1 PublicationCorresponds to variant dbSNP:rs148170012Ensembl.1
Natural variantiVAR_00236098D → G in BCHED; atypical form; reduced enzyme activity with butyrylthiocholine as substrate; inactive with butyrylthiocholine as substrate in the presence of V-62; 2-fold lower affinity for butyrylthiocholine; 10-fold lower affinity for butyrylthiocholine in the presence of V-62 or at homozygosity. 6 PublicationsCorresponds to variant dbSNP:rs1799807EnsemblClinVar.1
Natural variantiVAR_04001698D → H in BCHED. 1 Publication1
Natural variantiVAR_072095103G → R in BCHED; reduced enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs979653503EnsemblClinVar.1
Natural variantiVAR_072096118E → D in BCHED; the mutant undergoes rapid degradation. 2 Publications1
Natural variantiVAR_040017124N → Y in BCHED. 1 PublicationCorresponds to variant dbSNP:rs1339128583Ensembl.1
Natural variantiVAR_040018128P → S in BCHED. 1 PublicationCorresponds to variant dbSNP:rs3732880EnsemblClinVar.1
Natural variantiVAR_040019143G → D in BCHED. 1 PublicationCorresponds to variant dbSNP:rs201820739EnsemblClinVar.1
Natural variantiVAR_040020153L → F in BCHED; seems to cause reduced expression of the protein. 1 PublicationCorresponds to variant dbSNP:rs747598704EnsemblClinVar.1
Natural variantiVAR_040021156Y → C in BCHED. 1 PublicationCorresponds to variant dbSNP:rs121918558EnsemblClinVar.1
Natural variantiVAR_040022170V → M in BCHED; allele H variant. 1 PublicationCorresponds to variant dbSNP:rs527843566EnsemblClinVar.1
Natural variantiVAR_040023198D → E in BCHED; seems to cause reduced expression of the protein. 1 PublicationCorresponds to variant dbSNP:rs781368801Ensembl.1
Natural variantiVAR_040024226S → G in BCHED; enzymatically inactive in the plasma. 1 PublicationCorresponds to variant dbSNP:rs370077923Ensembl.1
Natural variantiVAR_040025227A → V in BCHED. 1 Publication1
Natural variantiVAR_040026229A → T in BCHED; enzymatically inactive in the plasma. 1 Publication1
Natural variantiVAR_072098232V → D in BCHED. 1 Publication1
Natural variantiVAR_040027271T → M in BCHED; allele fluoride-1. 2 PublicationsCorresponds to variant dbSNP:rs28933389EnsemblClinVar.1
Natural variantiVAR_040028278T → P in BCHED. 2 PublicationsCorresponds to variant dbSNP:rs892642457Ensembl.1
Natural variantiVAR_040030295K → R in BCHED. 1 PublicationCorresponds to variant dbSNP:rs115624085EnsemblClinVar.1
Natural variantiVAR_040031335L → P in BCHED; expressed at very low level. 1 PublicationCorresponds to variant dbSNP:rs104893684EnsemblClinVar.1
Natural variantiVAR_040032356A → D in BCHED. 1 PublicationCorresponds to variant dbSNP:rs770337031EnsemblClinVar.1
Natural variantiVAR_002362358L → I in BCHED; BChE variant form; fluoride-resistant. 4 PublicationsCorresponds to variant dbSNP:rs121918557EnsemblClinVar.1
Natural variantiVAR_072100361G → C in BCHED; results in 20% of activity compared to wild-type. 1 Publication1
Natural variantiVAR_040033393G → R in BCHED. 4 PublicationsCorresponds to variant dbSNP:rs115129687EnsemblClinVar.1
Natural variantiVAR_040034414R → C in BCHED. 2 PublicationsCorresponds to variant dbSNP:rs745364489EnsemblClinVar.1
Natural variantiVAR_040035418G → V in BCHED; allele fluoride-2. 1 PublicationCorresponds to variant dbSNP:rs28933390EnsemblClinVar.1
Natural variantiVAR_040036446F → S in BCHED. 2 Publications1
Natural variantiVAR_040037488E → K in BCHED. 1 PublicationCorresponds to variant dbSNP:rs200998515EnsemblClinVar.1
Natural variantiVAR_040038499W → R in BCHED; seems to cause reduced expression of the protein. 1 Publication1
Natural variantiVAR_040039502F → L in BCHED. 1 PublicationCorresponds to variant dbSNP:rs769316835EnsemblClinVar.1
Natural variantiVAR_040040525E → V in BCHED; allele J variant. 1 PublicationCorresponds to variant dbSNP:rs121918556EnsemblClinVar.1
Natural variantiVAR_040041543R → C in BCHED. 3 PublicationsCorresponds to variant dbSNP:rs199660374EnsemblClinVar.1
Natural variantiVAR_040042546Q → L in BCHED; seems to cause reduced expression of the protein. 1 Publication1
Natural variantiVAR_002364567A → T in BCHED; allele K variant; with reduced enzyme activity. 4 PublicationsCorresponds to variant dbSNP:rs1803274EnsemblClinVar.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...
DisGeNETi
590

MalaCards human disease database

More...
MalaCardsi
BCHE
MIMi617936, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000114200

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
132, Butyrylcholinesterase deficiency
413693, Curariform drugs toxicity

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25294

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P06276, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1914

Drug and drug target database

More...
DrugBanki
DB08200, (1R)-menthyl hexyl phosphonate group
DB08201, (1S)-menthyl hexyl phosphonate group
DB03814, 2-(N-morpholino)ethanesulfonic acid
DB07940, 9-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE
DB03672, 9-N-Phenylmethylamino-Tacrine
DB08897, Aclidinium
DB01122, Ambenonium
DB06692, Aprotinin
DB01408, Bambuterol
DB00868, Benzonatate
DB06756, Betaine
DB11148, Butamben
DB03568, Butyric Acid
DB04250, Butyrylthiocholine
DB06774, Capsaicin
DB01161, Chloroprocaine
DB00856, Chlorphenesin
DB00477, Chlorpromazine
DB00122, Choline
DB14006, Choline salicylate
DB00527, Cinchocaine
DB00515, Cisplatin
DB04920, Clevidipine
DB00907, Cocaine
DB00979, Cyclopentolate
DB01245, Decamethonium
DB00944, Demecarium
DB11397, Dichlorvos
DB02811, Diethyl phosphonate
DB00711, Diethylcarbamazine
DB00449, Dipivefrin
DB07681, DODECANESULFONATE ION
DB00843, Donepezil
DB01135, Doxacurium
DB01057, Echothiophate
DB01010, Edrophonium
DB01364, Ephedrine
DB03822, Ethyl dihydrogen phosphate
DB08658, Ethyl hydrogen diethylamidophosphate
DB00674, Galantamine
DB00941, Hexafluronium
DB00762, Irinotecan
DB00677, Isoflurophate
DB01221, Ketamine
DB00772, Malathion
DB00888, Mechlorethamine
DB00358, Mefloquine
DB02845, Methylphosphinic Acid
DB08893, Mirabegron
DB01226, Mivacurium
DB09205, Moxisylyte
DB01400, Neostigmine
DB00585, Nizatidine
DB00892, Oxybuprocaine
DB01337, Pancuronium
DB00082, Pegvisomant
DB00183, Pentagastrin
DB00790, Perindopril
DB04892, Phenserine
DB03976, Phosphorylisopropane
DB01338, Pipecuronium
DB00733, Pralidoxime
DB01035, Procainamide
DB00721, Procaine
DB00392, Profenamine
DB09288, Propacetamol
DB00545, Pyridostigmine
DB00178, Ramipril
DB05386, Regramostim
DB00989, Rivastigmine
DB05875, Sar9, Met (O2)11-Substance P
DB00202, Succinylcholine
DB00391, Sulpiride
DB00382, Tacrine
DB00871, Terbutaline
DB04572, Thiotepa
DB14031, Tretamine
DB00620, Triamcinolone
DB00508, Triflupromazine
DB01116, Trimethaphan
DB01199, Tubocurarine

DrugCentral

More...
DrugCentrali
P06276

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2471

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BCHE

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116353

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 282 PublicationsAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000861329 – 602CholinesteraseAdd BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi45N-linked (GlcNAc...) (complex) asparagine2 Publications1
Glycosylationi85N-linked (GlcNAc...) (complex) asparagine9 Publications1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi93 ↔ 120
Glycosylationi134N-linked (GlcNAc...) (complex) asparagine9 Publications1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei226Phosphoserine1 Publication1
Glycosylationi269N-linked (GlcNAc...) (complex) asparagine6 Publications1
Disulfide bondi280 ↔ 291
Glycosylationi284N-linked (GlcNAc...) (complex) asparagine6 Publications1
Glycosylationi369N-linked (GlcNAc...) (complex) asparagine9 Publications1
Disulfide bondi428 ↔ 547
Glycosylationi483N-linked (GlcNAc...) (complex) asparagine2 Publications1
Glycosylationi509N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi513N-linked (GlcNAc...) asparagine7 Publications1
Glycosylationi514N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi599Interchain

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated. No other PTM detected (PubMed:20946535). The major N-glycan structures are of the complex diantennary type with 1 and 2 N-acetylneuraminic acid molecules (Neu5Ac) making up approximately 33% and 47% of the total N-glycans, respectively. Only low amounts of fucosylated diantennary N-glycans are detected (approximately 2%). Triantennary N-glycans with or without fucose amount to approximately 13%, whereas 5% of the total N-glycans are of the oligomannosidic or hybrid type.12 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-2645

Encyclopedia of Proteome Dynamics

More...
EPDi
P06276

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P06276

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P06276

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P06276

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P06276

PeptideAtlas

More...
PeptideAtlasi
P06276

PRoteomics IDEntifications database

More...
PRIDEi
P06276

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
51880

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1109, 12 N-Linked glycans (4 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P06276, 13 sites, 12 N-linked glycans (4 sites), 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P06276

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P06276

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in blood plasma (at protein level). Present in most cells except erythrocytes.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000114200, Expressed in parietal pleura and 198 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P06276, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P06276, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000114200, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer; disulfide-linked. Dimer of dimers.

8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
107064, 62 interactors

Database of interacting proteins

More...
DIPi
DIP-46476N

Protein interaction database and analysis system

More...
IntActi
P06276, 39 interactors

Molecular INTeraction database

More...
MINTi
P06276

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264381

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P06276

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P06276, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1602
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
P06276

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P06276

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P06276

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni144 – 145Substrate binding2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4389, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157023

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P06276

Identification of Orthologs from Complete Genome Data

More...
OMAi
EMRYICP

Database of Orthologous Groups

More...
OrthoDBi
754103at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P06276

TreeFam database of animal gene trees

More...
TreeFami
TF315470

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058, AB_hydrolase
IPR014788, AChE_tetra
IPR002018, CarbesteraseB
IPR019826, Carboxylesterase_B_AS
IPR019819, Carboxylesterase_B_CS
IPR000997, Cholinesterase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08674, AChE_tetra, 1 hit
PF00135, COesterase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00878, CHOLNESTRASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474, SSF53474, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00122, CARBOXYLESTERASE_B_1, 1 hit
PS00941, CARBOXYLESTERASE_B_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P06276-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHSKVTIICI RFLFWFLLLC MLIGKSHTED DIIIATKNGK VRGMNLTVFG
60 70 80 90 100
GTVTAFLGIP YAQPPLGRLR FKKPQSLTKW SDIWNATKYA NSCCQNIDQS
110 120 130 140 150
FPGFHGSEMW NPNTDLSEDC LYLNVWIPAP KPKNATVLIW IYGGGFQTGT
160 170 180 190 200
SSLHVYDGKF LARVERVIVV SMNYRVGALG FLALPGNPEA PGNMGLFDQQ
210 220 230 240 250
LALQWVQKNI AAFGGNPKSV TLFGESAGAA SVSLHLLSPG SHSLFTRAIL
260 270 280 290 300
QSGSFNAPWA VTSLYEARNR TLNLAKLTGC SRENETEIIK CLRNKDPQEI
310 320 330 340 350
LLNEAFVVPY GTPLSVNFGP TVDGDFLTDM PDILLELGQF KKTQILVGVN
360 370 380 390 400
KDEGTAFLVY GAPGFSKDNN SIITRKEFQE GLKIFFPGVS EFGKESILFH
410 420 430 440 450
YTDWVDDQRP ENYREALGDV VGDYNFICPA LEFTKKFSEW GNNAFFYYFE
460 470 480 490 500
HRSSKLPWPE WMGVMHGYEI EFVFGLPLER RDNYTKAEEI LSRSIVKRWA
510 520 530 540 550
NFAKYGNPNE TQNNSTSWPV FKSTEQKYLT LNTESTRIMT KLRAQQCRFW
560 570 580 590 600
TSFFPKVLEM TGNIDEAEWE WKAGFHRWNN YMMDWKNQFN DYTSKKESCV

GL
Length:602
Mass (Da):68,418
Last modified:August 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC9836409D9057F27
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WF14F8WF14_HUMAN
Carboxylic ester hydrolase
BCHE
562Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEX7F8WEX7_HUMAN
Carboxylic ester hydrolase
BCHE
525Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y885H0Y885_HUMAN
Cholinesterase
BCHE
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4Y0H7C4Y0_HUMAN
Cholinesterase
BCHE
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04001132Missing in BCHED. 1 Publication1
Natural variantiVAR_07209440K → R Does not affect enzymatic activity. 1 PublicationCorresponds to variant dbSNP:rs116047990Ensembl.1
Natural variantiVAR_04001252T → M in BCHED. 1 PublicationCorresponds to variant dbSNP:rs56309853EnsemblClinVar.1
Natural variantiVAR_04001356F → I in BCHED. 1 PublicationCorresponds to variant dbSNP:rs531738678EnsemblClinVar.1
Natural variantiVAR_04001461Y → C in BCHED; enzymatically inactive in the plasma. 1 PublicationCorresponds to variant dbSNP:rs116097205EnsemblClinVar.1
Natural variantiVAR_07273062A → V in BCHED; reduced enzyme activity with butyrylthiocholine as substrate; inactive with butyrylthiocholine as substrate in the presence of G-98; 2-fold lower affinity for butyrylthiocholine; 10-fold lower affinity for butyrylthiocholine in the presence of G-98. 1 PublicationCorresponds to variant dbSNP:rs1553778274EnsemblClinVar.1
Natural variantiVAR_04001565P → S in BCHED; seems to cause reduced expression of the protein. 1 PublicationCorresponds to variant dbSNP:rs148170012Ensembl.1
Natural variantiVAR_00236098D → G in BCHED; atypical form; reduced enzyme activity with butyrylthiocholine as substrate; inactive with butyrylthiocholine as substrate in the presence of V-62; 2-fold lower affinity for butyrylthiocholine; 10-fold lower affinity for butyrylthiocholine in the presence of V-62 or at homozygosity. 6 PublicationsCorresponds to variant dbSNP:rs1799807EnsemblClinVar.1
Natural variantiVAR_04001698D → H in BCHED. 1 Publication1
Natural variantiVAR_072095103G → R in BCHED; reduced enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs979653503EnsemblClinVar.1
Natural variantiVAR_072096118E → D in BCHED; the mutant undergoes rapid degradation. 2 Publications1
Natural variantiVAR_040017124N → Y in BCHED. 1 PublicationCorresponds to variant dbSNP:rs1339128583Ensembl.1
Natural variantiVAR_072097127I → M Does not affect enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs755600722Ensembl.1
Natural variantiVAR_040018128P → S in BCHED. 1 PublicationCorresponds to variant dbSNP:rs3732880EnsemblClinVar.1
Natural variantiVAR_040019143G → D in BCHED. 1 PublicationCorresponds to variant dbSNP:rs201820739EnsemblClinVar.1
Natural variantiVAR_040020153L → F in BCHED; seems to cause reduced expression of the protein. 1 PublicationCorresponds to variant dbSNP:rs747598704EnsemblClinVar.1
Natural variantiVAR_040021156Y → C in BCHED. 1 PublicationCorresponds to variant dbSNP:rs121918558EnsemblClinVar.1
Natural variantiVAR_040022170V → M in BCHED; allele H variant. 1 PublicationCorresponds to variant dbSNP:rs527843566EnsemblClinVar.1
Natural variantiVAR_040023198D → E in BCHED; seems to cause reduced expression of the protein. 1 PublicationCorresponds to variant dbSNP:rs781368801Ensembl.1
Natural variantiVAR_040024226S → G in BCHED; enzymatically inactive in the plasma. 1 PublicationCorresponds to variant dbSNP:rs370077923Ensembl.1
Natural variantiVAR_040025227A → V in BCHED. 1 Publication1
Natural variantiVAR_040026229A → T in BCHED; enzymatically inactive in the plasma. 1 Publication1
Natural variantiVAR_072098232V → D in BCHED. 1 Publication1
Natural variantiVAR_040027271T → M in BCHED; allele fluoride-1. 2 PublicationsCorresponds to variant dbSNP:rs28933389EnsemblClinVar.1
Natural variantiVAR_040028278T → P in BCHED. 2 PublicationsCorresponds to variant dbSNP:rs892642457Ensembl.1
Natural variantiVAR_040029283E → D. Corresponds to variant dbSNP:rs16849700EnsemblClinVar.1
Natural variantiVAR_040030295K → R in BCHED. 1 PublicationCorresponds to variant dbSNP:rs115624085EnsemblClinVar.1
Natural variantiVAR_072099322V → M Does not affect enzymatic activity. 1 PublicationCorresponds to variant dbSNP:rs754644618Ensembl.1
Natural variantiVAR_040031335L → P in BCHED; expressed at very low level. 1 PublicationCorresponds to variant dbSNP:rs104893684EnsemblClinVar.1
Natural variantiVAR_040032356A → D in BCHED. 1 PublicationCorresponds to variant dbSNP:rs770337031EnsemblClinVar.1
Natural variantiVAR_002362358L → I in BCHED; BChE variant form; fluoride-resistant. 4 PublicationsCorresponds to variant dbSNP:rs121918557EnsemblClinVar.1
Natural variantiVAR_072100361G → C in BCHED; results in 20% of activity compared to wild-type. 1 Publication1
Natural variantiVAR_040033393G → R in BCHED. 4 PublicationsCorresponds to variant dbSNP:rs115129687EnsemblClinVar.1
Natural variantiVAR_040034414R → C in BCHED. 2 PublicationsCorresponds to variant dbSNP:rs745364489EnsemblClinVar.1
Natural variantiVAR_040035418G → V in BCHED; allele fluoride-2. 1 PublicationCorresponds to variant dbSNP:rs28933390EnsemblClinVar.1
Natural variantiVAR_040036446F → S in BCHED. 2 Publications1
Natural variantiVAR_040037488E → K in BCHED. 1 PublicationCorresponds to variant dbSNP:rs200998515EnsemblClinVar.1
Natural variantiVAR_072101498R → W Does not affect enzymatic activity. 1 PublicationCorresponds to variant dbSNP:rs115017300EnsemblClinVar.1
Natural variantiVAR_040038499W → R in BCHED; seems to cause reduced expression of the protein. 1 Publication1
Natural variantiVAR_040039502F → L in BCHED. 1 PublicationCorresponds to variant dbSNP:rs769316835EnsemblClinVar.1
Natural variantiVAR_040040525E → V in BCHED; allele J variant. 1 PublicationCorresponds to variant dbSNP:rs121918556EnsemblClinVar.1
Natural variantiVAR_040041543R → C in BCHED. 3 PublicationsCorresponds to variant dbSNP:rs199660374EnsemblClinVar.1
Natural variantiVAR_040042546Q → L in BCHED; seems to cause reduced expression of the protein. 1 Publication1
Natural variantiVAR_002364567A → T in BCHED; allele K variant; with reduced enzyme activity. 4 PublicationsCorresponds to variant dbSNP:rs1803274EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M32391, M32389, M32390 Genomic DNA Translation: AAA99296.1
M16541 mRNA Translation: AAA98113.1
M16474 mRNA Translation: AAA52015.1
AK292063 mRNA Translation: BAF84752.1
BC018141 mRNA Translation: AAH18141.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3198.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A33769, ACHU

NCBI Reference Sequences

More...
RefSeqi
NP_000046.1, NM_000055.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264381.8; ENSP00000264381.3; ENSG00000114200.10

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
590

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:590

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...
MANE-Selecti
ENST00000264381.8; ENSP00000264381.3; NM_000055.4; NP_000046.1

UCSC genome browser

More...
UCSCi
uc003fem.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32391, M32389, M32390 Genomic DNA Translation: AAA99296.1
M16541 mRNA Translation: AAA98113.1
M16474 mRNA Translation: AAA52015.1
AK292063 mRNA Translation: BAF84752.1
BC018141 mRNA Translation: AAH18141.1
CCDSiCCDS3198.1
PIRiA33769, ACHU
RefSeqiNP_000046.1, NM_000055.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P0IX-ray2.00A29-557[»]
1P0MX-ray2.38A29-557[»]
1P0PX-ray2.30A29-557[»]
1P0QX-ray2.43A29-557[»]
1XLUX-ray2.20A29-557[»]
1XLVX-ray2.25A29-557[»]
1XLWX-ray2.10A29-557[»]
2J4CX-ray2.75A29-557[»]
2PM8X-ray2.80A/B29-602[»]
2WIDX-ray2.30A29-557[»]
2WIFX-ray2.25A29-557[»]
2WIGX-ray2.15A29-557[»]
2WIJX-ray2.10A29-557[»]
2WIKX-ray2.10A29-557[»]
2WILX-ray3.10A/B29-557[»]
2WSLX-ray2.00A29-557[»]
2XMBX-ray2.10A29-557[»]
2XMCX-ray2.40A29-557[»]
2XMDX-ray2.30A29-557[»]
2XMGX-ray2.70A29-557[»]
2XQFX-ray2.10A31-557[»]
2XQGX-ray2.30A31-557[»]
2XQIX-ray2.60A31-557[»]
2XQJX-ray2.40A31-557[»]
2XQKX-ray2.40A31-557[»]
2Y1KX-ray2.50A29-557[»]
3DJYX-ray2.10A29-557[»]
3DKKX-ray2.31A29-557[»]
3O9MX-ray2.98A/B29-602[»]
4AQDX-ray2.50A/B29-557[»]
4AXBX-ray2.40A31-557[»]
4B0OX-ray2.35A29-557[»]
4B0PX-ray2.50A29-557[»]
4BBZX-ray2.70A29-557[»]
4BDSX-ray2.10A29-557[»]
4TPKX-ray2.70A/B1-602[»]
4XIIX-ray2.70A/B29-572[»]
5DYTX-ray2.55A/B28-557[»]
5DYWX-ray2.50A/B28-557[»]
5DYYX-ray2.65A/B28-557[»]
5K5EX-ray2.80A/B29-557[»]
5LKRX-ray2.52A/B29-602[»]
5NN0X-ray2.10A29-557[»]
6EMIX-ray2.48A/B29-557[»]
6EP4X-ray2.30A29-557[»]
6EQPX-ray2.35A29-557[»]
6EQQX-ray2.40A29-557[»]
6ESJX-ray2.98A/B29-557[»]
6ESYX-ray2.80A/B29-557[»]
6EULX-ray2.60A31-558[»]
6EYFX-ray2.60A31-557[»]
6EZ2X-ray2.70A/B31-557[»]
6F7QX-ray2.60A/B29-557[»]
6I0BX-ray2.38A29-557[»]
6I0CX-ray2.67A29-557[»]
6I2Telectron microscopy5.70A/B/C/D29-602[»]
6QAAX-ray1.90A1-557[»]
6QABX-ray2.49A1-557[»]
6QACX-ray2.77A1-557[»]
6QADX-ray2.50A1-557[»]
6QAEX-ray2.49A1-557[»]
6R6VX-ray2.50A32-557[»]
6R6WX-ray2.47A32-557[»]
6RUAX-ray2.75A/B29-602[»]
6SAMX-ray2.50A29-557[»]
6T9PX-ray2.70A29-557[»]
6T9SX-ray2.70A29-557[»]
6XTAX-ray2.50A29-557[»]
6ZWIX-ray1.85A29-557[»]
7AIYX-ray2.94A/B1-602[»]
7AMZX-ray2.25A29-557[»]
7AWGX-ray2.00A29-557[»]
7AWHX-ray2.30A29-557[»]
7AWIX-ray2.30A29-557[»]
7BGCX-ray2.40A29-557[»]
AlphaFoldDBiP06276
SMRiP06276
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107064, 62 interactors
DIPiDIP-46476N
IntActiP06276, 39 interactors
MINTiP06276
STRINGi9606.ENSP00000264381

Chemistry databases

BindingDBiP06276
ChEMBLiCHEMBL1914
DrugBankiDB08200, (1R)-menthyl hexyl phosphonate group
DB08201, (1S)-menthyl hexyl phosphonate group
DB03814, 2-(N-morpholino)ethanesulfonic acid
DB07940, 9-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE
DB03672, 9-N-Phenylmethylamino-Tacrine
DB08897, Aclidinium
DB01122, Ambenonium
DB06692, Aprotinin
DB01408, Bambuterol
DB00868, Benzonatate
DB06756, Betaine
DB11148, Butamben
DB03568, Butyric Acid
DB04250, Butyrylthiocholine
DB06774, Capsaicin
DB01161, Chloroprocaine
DB00856, Chlorphenesin
DB00477, Chlorpromazine
DB00122, Choline
DB14006, Choline salicylate
DB00527, Cinchocaine
DB00515, Cisplatin
DB04920, Clevidipine
DB00907, Cocaine
DB00979, Cyclopentolate
DB01245, Decamethonium
DB00944, Demecarium
DB11397, Dichlorvos
DB02811, Diethyl phosphonate
DB00711, Diethylcarbamazine
DB00449, Dipivefrin
DB07681, DODECANESULFONATE ION
DB00843, Donepezil
DB01135, Doxacurium
DB01057, Echothiophate
DB01010, Edrophonium
DB01364, Ephedrine
DB03822, Ethyl dihydrogen phosphate
DB08658, Ethyl hydrogen diethylamidophosphate
DB00674, Galantamine
DB00941, Hexafluronium
DB00762, Irinotecan
DB00677, Isoflurophate
DB01221, Ketamine
DB00772, Malathion
DB00888, Mechlorethamine
DB00358, Mefloquine
DB02845, Methylphosphinic Acid
DB08893, Mirabegron
DB01226, Mivacurium
DB09205, Moxisylyte
DB01400, Neostigmine
DB00585, Nizatidine
DB00892, Oxybuprocaine
DB01337, Pancuronium
DB00082, Pegvisomant
DB00183, Pentagastrin
DB00790, Perindopril
DB04892, Phenserine
DB03976, Phosphorylisopropane
DB01338, Pipecuronium
DB00733, Pralidoxime
DB01035, Procainamide
DB00721, Procaine
DB00392, Profenamine
DB09288, Propacetamol
DB00545, Pyridostigmine
DB00178, Ramipril
DB05386, Regramostim
DB00989, Rivastigmine
DB05875, Sar9, Met (O2)11-Substance P
DB00202, Succinylcholine
DB00391, Sulpiride
DB00382, Tacrine
DB00871, Terbutaline
DB04572, Thiotepa
DB14031, Tretamine
DB00620, Triamcinolone
DB00508, Triflupromazine
DB01116, Trimethaphan
DB01199, Tubocurarine
DrugCentraliP06276
GuidetoPHARMACOLOGYi2471

Protein family/group databases

ESTHERihuman-BCHE, BCHE
MEROPSiS09.980

PTM databases

GlyConnecti1109, 12 N-Linked glycans (4 sites)
GlyGeniP06276, 13 sites, 12 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
iPTMnetiP06276
PhosphoSitePlusiP06276

Genetic variation databases

BioMutaiBCHE
DMDMi116353

Proteomic databases

CPTACinon-CPTAC-2645
EPDiP06276
jPOSTiP06276
MassIVEiP06276
MaxQBiP06276
PaxDbiP06276
PeptideAtlasiP06276
PRIDEiP06276
ProteomicsDBi51880

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P06276, 4 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
879, 447 antibodies from 40 providers

The DNASU plasmid repository

More...
DNASUi
590

Genome annotation databases

EnsembliENST00000264381.8; ENSP00000264381.3; ENSG00000114200.10
GeneIDi590
KEGGihsa:590
MANE-SelectiENST00000264381.8; ENSP00000264381.3; NM_000055.4; NP_000046.1
UCSCiuc003fem.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
590
DisGeNETi590

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BCHE
HGNCiHGNC:983, BCHE
HPAiENSG00000114200, Tissue enriched (liver)
MalaCardsiBCHE
MIMi177400, gene
617936, phenotype
neXtProtiNX_P06276
OpenTargetsiENSG00000114200
Orphaneti132, Butyrylcholinesterase deficiency
413693, Curariform drugs toxicity
PharmGKBiPA25294
VEuPathDBiHostDB:ENSG00000114200

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4389, Eukaryota
GeneTreeiENSGT00940000157023
InParanoidiP06276
OMAiEMRYICP
OrthoDBi754103at2759
PhylomeDBiP06276
TreeFamiTF315470

Enzyme and pathway databases

BRENDAi3.1.1.8, 2681
PathwayCommonsiP06276
ReactomeiR-HSA-112311, Neurotransmitter clearance
R-HSA-1483191, Synthesis of PC
R-HSA-422085, Synthesis, secretion, and deacylation of Ghrelin
SABIO-RKiP06276
SignaLinkiP06276
SIGNORiP06276

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
590, 14 hits in 1079 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BCHE, human
EvolutionaryTraceiP06276

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Butyrylcholinesterase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
590
PharosiP06276, Tclin

Protein Ontology

More...
PROi
PR:P06276
RNActiP06276, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000114200, Expressed in parietal pleura and 198 other tissues
ExpressionAtlasiP06276, baseline and differential
GenevisibleiP06276, HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR014788, AChE_tetra
IPR002018, CarbesteraseB
IPR019826, Carboxylesterase_B_AS
IPR019819, Carboxylesterase_B_CS
IPR000997, Cholinesterase
PfamiView protein in Pfam
PF08674, AChE_tetra, 1 hit
PF00135, COesterase, 1 hit
PRINTSiPR00878, CHOLNESTRASE
SUPFAMiSSF53474, SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122, CARBOXYLESTERASE_B_1, 1 hit
PS00941, CARBOXYLESTERASE_B_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHLE_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06276
Secondary accession number(s): A8K7P8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: August 1, 1988
Last modified: May 25, 2022
This is version 224 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again