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Entry version 209 (18 Sep 2019)
Sequence version 1 (01 Aug 1988)
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Protein

Cholinesterase

Gene

BCHE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by mercury. Inhibited by Tabun. Tabun forms a covalent adduct with Ser-226 that becomes irreversible upon aging.3 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=18.0 µM for butyrylthiocholine (at 25 degrees Celsius)1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei110TacrineCombined sources1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei226Acyl-ester intermediatePROSITE-ProRule annotation1 Publication1
    Active sitei353Charge relay system1 Publication1
    Active sitei466Charge relay system1 Publication1
    Binding sitei466Tacrine; via carbonyl oxygenCombined sources1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Serine esterase
    LigandSialic acid

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.1.1.8 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-112311 Neurotransmitter clearance
    R-HSA-1483191 Synthesis of PC
    R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    P06276

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    P06276

    Protein family/group databases

    ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

    More...
    ESTHERi
    human-BCHE BCHE

    MEROPS protease database

    More...
    MEROPSi
    S09.980

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Cholinesterase (EC:3.1.1.8)
    Alternative name(s):
    Acylcholine acylhydrolase
    Butyrylcholine esterase
    Choline esterase II
    Pseudocholinesterase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:BCHE
    Synonyms:CHE1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:983 BCHE

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    177400 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P06276

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Butyrylcholinesterase deficiency (BCHED)24 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionAn autosomal recessive metabolic condition characterized by increased sensitivity to certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium. BCHED results in slower hydrolysis of these drugs and, consequently, a prolonged neuromuscular block, leading to apnea. The duration of the prolonged apnea varies significantly depending on the extent of the enzyme deficiency.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04001132Missing in BCHED. 1 Publication1
    Natural variantiVAR_04001252T → M in BCHED. 1 PublicationCorresponds to variant dbSNP:rs56309853EnsemblClinVar.1
    Natural variantiVAR_04001356F → I in BCHED. 1 PublicationCorresponds to variant dbSNP:rs531738678Ensembl.1
    Natural variantiVAR_04001461Y → C in BCHED; enzymatically inactive in the plasma. 1 PublicationCorresponds to variant dbSNP:rs116097205EnsemblClinVar.1
    Natural variantiVAR_07273062A → V in BCHED; reduced enzyme activity with butyrylthiocholine as substrate; inactive with butyrylthiocholine as substrate in the presence of G-98; 2-fold lower affinity for butyrylthiocholine; 10-fold lower affinity for butyrylthiocholine in the presence of G-98. 1 PublicationCorresponds to variant dbSNP:rs1553778274EnsemblClinVar.1
    Natural variantiVAR_04001565P → S in BCHED; seems to cause reduced expression of the protein. 1 PublicationCorresponds to variant dbSNP:rs148170012Ensembl.1
    Natural variantiVAR_00236098D → G in BCHED; atypical form; reduced enzyme activity with butyrylthiocholine as substrate; inactive with butyrylthiocholine as substrate in the presence of V-62; 2-fold lower affinity for butyrylthiocholine; 10-fold lower affinity for butyrylthiocholine in the presence of V-62 or at homozygosity. 6 PublicationsCorresponds to variant dbSNP:rs1799807EnsemblClinVar.1
    Natural variantiVAR_04001698D → H in BCHED. 1 Publication1
    Natural variantiVAR_072095103G → R in BCHED; reduced enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs979653503EnsemblClinVar.1
    Natural variantiVAR_072096118E → D in BCHED; the mutant undergoes rapid degradation. 2 Publications1
    Natural variantiVAR_040017124N → Y in BCHED. 1 PublicationCorresponds to variant dbSNP:rs1339128583Ensembl.1
    Natural variantiVAR_040018128P → S in BCHED. 1 PublicationCorresponds to variant dbSNP:rs3732880EnsemblClinVar.1
    Natural variantiVAR_040019143G → D in BCHED. 1 PublicationCorresponds to variant dbSNP:rs201820739EnsemblClinVar.1
    Natural variantiVAR_040020153L → F in BCHED; seems to cause reduced expression of the protein. 1 PublicationCorresponds to variant dbSNP:rs747598704EnsemblClinVar.1
    Natural variantiVAR_040021156Y → C in BCHED. 1 PublicationCorresponds to variant dbSNP:rs121918558EnsemblClinVar.1
    Natural variantiVAR_040022170V → M in BCHED; allele H variant. 1 PublicationCorresponds to variant dbSNP:rs527843566Ensembl.1
    Natural variantiVAR_040023198D → E in BCHED; seems to cause reduced expression of the protein. 1 PublicationCorresponds to variant dbSNP:rs781368801Ensembl.1
    Natural variantiVAR_040024226S → G in BCHED; enzymatically inactive in the plasma. 1 PublicationCorresponds to variant dbSNP:rs370077923Ensembl.1
    Natural variantiVAR_040025227A → V in BCHED. 1 Publication1
    Natural variantiVAR_040026229A → T in BCHED; enzymatically inactive in the plasma. 1 Publication1
    Natural variantiVAR_072098232V → D in BCHED. 1 Publication1
    Natural variantiVAR_040027271T → M in BCHED; allele fluoride-1. 2 PublicationsCorresponds to variant dbSNP:rs28933389EnsemblClinVar.1
    Natural variantiVAR_040028278T → P in BCHED. 2 PublicationsCorresponds to variant dbSNP:rs892642457Ensembl.1
    Natural variantiVAR_040030295K → R in BCHED. 1 PublicationCorresponds to variant dbSNP:rs115624085EnsemblClinVar.1
    Natural variantiVAR_040031335L → P in BCHED; expressed at very low level. 1 PublicationCorresponds to variant dbSNP:rs104893684EnsemblClinVar.1
    Natural variantiVAR_040032356A → D in BCHED. 1 PublicationCorresponds to variant dbSNP:rs770337031EnsemblClinVar.1
    Natural variantiVAR_002362358L → I in BCHED; BChE variant form; fluoride-resistant. 4 PublicationsCorresponds to variant dbSNP:rs121918557EnsemblClinVar.1
    Natural variantiVAR_072100361G → C in BCHED; results in 20% of activity compared to wild-type. 1 Publication1
    Natural variantiVAR_040033393G → R in BCHED. 4 PublicationsCorresponds to variant dbSNP:rs115129687EnsemblClinVar.1
    Natural variantiVAR_040034414R → C in BCHED. 2 PublicationsCorresponds to variant dbSNP:rs745364489EnsemblClinVar.1
    Natural variantiVAR_040035418G → V in BCHED; allele fluoride-2. 1 PublicationCorresponds to variant dbSNP:rs28933390EnsemblClinVar.1
    Natural variantiVAR_040036446F → S in BCHED. 2 Publications1
    Natural variantiVAR_040037488E → K in BCHED. 1 PublicationCorresponds to variant dbSNP:rs200998515Ensembl.1
    Natural variantiVAR_040038499W → R in BCHED; seems to cause reduced expression of the protein. 1 Publication1
    Natural variantiVAR_040039502F → L in BCHED. 1 PublicationCorresponds to variant dbSNP:rs769316835EnsemblClinVar.1
    Natural variantiVAR_040040525E → V in BCHED; allele J variant. 1 PublicationCorresponds to variant dbSNP:rs121918556EnsemblClinVar.1
    Natural variantiVAR_040041543R → C in BCHED. 3 PublicationsCorresponds to variant dbSNP:rs199660374EnsemblClinVar.1
    Natural variantiVAR_040042546Q → L in BCHED; seems to cause reduced expression of the protein. 1 Publication1
    Natural variantiVAR_002364567A → T in BCHED; allele K variant; with reduced enzyme activity. 4 PublicationsCorresponds to variant dbSNP:rs1803274EnsemblClinVar.1

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    590

    MalaCards human disease database

    More...
    MalaCardsi
    BCHE
    MIMi617936 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000114200

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    132 Butyrylcholinesterase deficiency
    413693 Curariform drugs toxicity

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA25294

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL1914

    Drug and drug target database

    More...
    DrugBanki
    DB08200 (1R)-menthyl hexyl phosphonate group
    DB08201 (1S)-menthyl hexyl phosphonate group
    DB03814 2-(N-Morpholino)-Ethanesulfonic Acid
    DB07940 9-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE
    DB03672 9-N-Phenylmethylamino-Tacrine
    DB08897 Aclidinium
    DB01122 Ambenonium
    DB06692 Aprotinin
    DB01408 Bambuterol
    DB11148 Butamben
    DB03568 Butyric Acid
    DB04250 Butyrylthiocholine
    DB06774 Capsaicin
    DB01161 Chloroprocaine
    DB00856 Chlorphenesin
    DB00477 Chlorpromazine
    DB00122 Choline
    DB14006 Choline salicylate
    DB00527 Cinchocaine
    DB00515 Cisplatin
    DB04920 Clevidipine
    DB00907 Cocaine
    DB00979 Cyclopentolate
    DB01245 Decamethonium
    DB00944 Demecarium
    DB11397 Dichlorvos
    DB00711 Diethylcarbamazine
    DB02811 Diethylphosphono Group
    DB00449 Dipivefrin
    DB07681 DODECANESULFONATE ION
    DB01135 Doxacurium
    DB01395 Drospirenone
    DB01525 Ecgonine
    DB01057 Echothiophate
    DB01010 Edrophonium
    DB01364 Ephedrine
    DB03822 Ethyl Dihydrogen Phosphate
    DB08658 ETHYL HYDROGEN DIETHYLAMIDOPHOSPHATE
    DB00674 Galantamine
    DB06756 Glycine betaine
    DB00941 Hexafluronium
    DB00762 Irinotecan
    DB00677 Isoflurophate
    DB01221 Ketamine
    DB00772 Malathion
    DB00888 Mechlorethamine
    DB00358 Mefloquine
    DB02845 Methylphosphinic Acid
    DB08893 Mirabegron
    DB01226 Mivacurium
    DB09205 Moxisylyte
    DB01400 Neostigmine
    DB00585 Nizatidine
    DB00892 Oxybuprocaine
    DB01337 Pancuronium
    DB00082 Pegvisomant
    DB00183 Pentagastrin
    DB00790 Perindopril
    DB04892 Phenserine
    DB03976 Phosphorylisopropane
    DB01338 Pipecuronium
    DB00733 Pralidoxime
    DB01035 Procainamide
    DB00721 Procaine
    DB00392 Profenamine
    DB09288 Propacetamol
    DB00545 Pyridostigmine
    DB00178 Ramipril
    DB00863 Ranitidine
    DB05386 Regramostim
    DB00989 Rivastigmine
    DB05875 Sar9, Met (O2)11-Substance P
    DB00202 Succinylcholine
    DB00391 Sulpiride
    DB00382 Tacrine
    DB00871 Terbutaline
    DB04572 Thiotepa
    DB14031 Tretamine
    DB00620 Triamcinolone
    DB00508 Triflupromazine
    DB01116 Trimethaphan
    DB01199 Tubocurarine

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    2471

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    BCHE

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    116353

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 282 PublicationsAdd BLAST28
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000861329 – 602CholinesteraseAdd BLAST574

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi45N-linked (GlcNAc...) (complex) asparagine2 Publications1
    Glycosylationi85N-linked (GlcNAc...) (complex) asparagine9 Publications1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi93 ↔ 120
    Glycosylationi134N-linked (GlcNAc...) (complex) asparagine9 Publications1
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei226Phosphoserine1 Publication1
    Glycosylationi269N-linked (GlcNAc...) (complex) asparagine6 Publications1
    Disulfide bondi280 ↔ 291
    Glycosylationi284N-linked (GlcNAc...) (complex) asparagine6 Publications1
    Glycosylationi369N-linked (GlcNAc...) (complex) asparagine9 Publications1
    Disulfide bondi428 ↔ 547
    Glycosylationi483N-linked (GlcNAc...) (complex) asparagine2 Publications1
    Glycosylationi509N-linked (GlcNAc...) asparagine3 Publications1
    Glycosylationi513N-linked (GlcNAc...) asparagine7 Publications1
    Glycosylationi514N-linked (GlcNAc...) asparagine3 Publications1
    Disulfide bondi599Interchain

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    N-glycosylated. No other PTM detected (PubMed:20946535). The major N-glycan structures are of the complex diantennary type with 1 and 2 N-acetylneuraminic acid molecules (Neu5Ac) making up approximately 33% and 47% of the total N-glycans, respectively. Only low amounts of fucosylated diantennary N-glycans are detected (approximately 2%). Triantennary N-glycans with or without fucose amount to approximately 13%, whereas 5% of the total N-glycans are of the oligomannosidic or hybrid type.12 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    The CPTAC Assay portal

    More...
    CPTACi
    non-CPTAC-2645

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P06276

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P06276

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P06276

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P06276

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P06276

    PeptideAtlas

    More...
    PeptideAtlasi
    P06276

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P06276

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    51880

    PTM databases

    GlyConnect protein glycosylation platform

    More...
    GlyConnecti
    1109

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P06276

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P06276

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Detected in blood plasma (at protein level). Present in most cells except erythrocytes.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000114200 Expressed in 182 organ(s), highest expression level in parietal pleura

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P06276 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P06276 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA001560

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homotetramer; disulfide-linked. Dimer of dimers.

    8 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself8EBI-7936069,EBI-7936069

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    107064, 40 interactors

    Database of interacting proteins

    More...
    DIPi
    DIP-46476N

    Protein interaction database and analysis system

    More...
    IntActi
    P06276, 28 interactors

    Molecular INTeraction database

    More...
    MINTi
    P06276

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000264381

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P06276

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1602
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P06276

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P06276

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni144 – 145Substrate binding2

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG4389 Eukaryota
    COG2272 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000157023

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P06276

    KEGG Orthology (KO)

    More...
    KOi
    K01050

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    FPGSEMW

    Database of Orthologous Groups

    More...
    OrthoDBi
    1226324at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P06276

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF315470

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.50.1820, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR029058 AB_hydrolase
    IPR014788 AChE_tetra
    IPR002018 CarbesteraseB
    IPR019826 Carboxylesterase_B_AS
    IPR019819 Carboxylesterase_B_CS
    IPR000997 Cholinesterase

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF08674 AChE_tetra, 1 hit
    PF00135 COesterase, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00878 CHOLNESTRASE

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53474 SSF53474, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00122 CARBOXYLESTERASE_B_1, 1 hit
    PS00941 CARBOXYLESTERASE_B_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

    P06276-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MHSKVTIICI RFLFWFLLLC MLIGKSHTED DIIIATKNGK VRGMNLTVFG
    60 70 80 90 100
    GTVTAFLGIP YAQPPLGRLR FKKPQSLTKW SDIWNATKYA NSCCQNIDQS
    110 120 130 140 150
    FPGFHGSEMW NPNTDLSEDC LYLNVWIPAP KPKNATVLIW IYGGGFQTGT
    160 170 180 190 200
    SSLHVYDGKF LARVERVIVV SMNYRVGALG FLALPGNPEA PGNMGLFDQQ
    210 220 230 240 250
    LALQWVQKNI AAFGGNPKSV TLFGESAGAA SVSLHLLSPG SHSLFTRAIL
    260 270 280 290 300
    QSGSFNAPWA VTSLYEARNR TLNLAKLTGC SRENETEIIK CLRNKDPQEI
    310 320 330 340 350
    LLNEAFVVPY GTPLSVNFGP TVDGDFLTDM PDILLELGQF KKTQILVGVN
    360 370 380 390 400
    KDEGTAFLVY GAPGFSKDNN SIITRKEFQE GLKIFFPGVS EFGKESILFH
    410 420 430 440 450
    YTDWVDDQRP ENYREALGDV VGDYNFICPA LEFTKKFSEW GNNAFFYYFE
    460 470 480 490 500
    HRSSKLPWPE WMGVMHGYEI EFVFGLPLER RDNYTKAEEI LSRSIVKRWA
    510 520 530 540 550
    NFAKYGNPNE TQNNSTSWPV FKSTEQKYLT LNTESTRIMT KLRAQQCRFW
    560 570 580 590 600
    TSFFPKVLEM TGNIDEAEWE WKAGFHRWNN YMMDWKNQFN DYTSKKESCV

    GL
    Length:602
    Mass (Da):68,418
    Last modified:August 1, 1988 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC9836409D9057F27
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    F8WEX7F8WEX7_HUMAN
    Carboxylic ester hydrolase
    BCHE
    525Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8WF14F8WF14_HUMAN
    Carboxylic ester hydrolase
    BCHE
    562Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0Y885H0Y885_HUMAN
    Cholinesterase
    BCHE
    132Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H7C4Y0H7C4Y0_HUMAN
    Cholinesterase
    BCHE
    120Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_04001132Missing in BCHED. 1 Publication1
    Natural variantiVAR_07209440K → R Rare polymorphism; does not affect enzymatic activity. 1 PublicationCorresponds to variant dbSNP:rs116047990Ensembl.1
    Natural variantiVAR_04001252T → M in BCHED. 1 PublicationCorresponds to variant dbSNP:rs56309853EnsemblClinVar.1
    Natural variantiVAR_04001356F → I in BCHED. 1 PublicationCorresponds to variant dbSNP:rs531738678Ensembl.1
    Natural variantiVAR_04001461Y → C in BCHED; enzymatically inactive in the plasma. 1 PublicationCorresponds to variant dbSNP:rs116097205EnsemblClinVar.1
    Natural variantiVAR_07273062A → V in BCHED; reduced enzyme activity with butyrylthiocholine as substrate; inactive with butyrylthiocholine as substrate in the presence of G-98; 2-fold lower affinity for butyrylthiocholine; 10-fold lower affinity for butyrylthiocholine in the presence of G-98. 1 PublicationCorresponds to variant dbSNP:rs1553778274EnsemblClinVar.1
    Natural variantiVAR_04001565P → S in BCHED; seems to cause reduced expression of the protein. 1 PublicationCorresponds to variant dbSNP:rs148170012Ensembl.1
    Natural variantiVAR_00236098D → G in BCHED; atypical form; reduced enzyme activity with butyrylthiocholine as substrate; inactive with butyrylthiocholine as substrate in the presence of V-62; 2-fold lower affinity for butyrylthiocholine; 10-fold lower affinity for butyrylthiocholine in the presence of V-62 or at homozygosity. 6 PublicationsCorresponds to variant dbSNP:rs1799807EnsemblClinVar.1
    Natural variantiVAR_04001698D → H in BCHED. 1 Publication1
    Natural variantiVAR_072095103G → R in BCHED; reduced enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs979653503EnsemblClinVar.1
    Natural variantiVAR_072096118E → D in BCHED; the mutant undergoes rapid degradation. 2 Publications1
    Natural variantiVAR_040017124N → Y in BCHED. 1 PublicationCorresponds to variant dbSNP:rs1339128583Ensembl.1
    Natural variantiVAR_072097127I → M Rare polymorphism; does not affect enzyme activity. 2 PublicationsCorresponds to variant dbSNP:rs755600722Ensembl.1
    Natural variantiVAR_040018128P → S in BCHED. 1 PublicationCorresponds to variant dbSNP:rs3732880EnsemblClinVar.1
    Natural variantiVAR_040019143G → D in BCHED. 1 PublicationCorresponds to variant dbSNP:rs201820739EnsemblClinVar.1
    Natural variantiVAR_040020153L → F in BCHED; seems to cause reduced expression of the protein. 1 PublicationCorresponds to variant dbSNP:rs747598704EnsemblClinVar.1
    Natural variantiVAR_040021156Y → C in BCHED. 1 PublicationCorresponds to variant dbSNP:rs121918558EnsemblClinVar.1
    Natural variantiVAR_040022170V → M in BCHED; allele H variant. 1 PublicationCorresponds to variant dbSNP:rs527843566Ensembl.1
    Natural variantiVAR_040023198D → E in BCHED; seems to cause reduced expression of the protein. 1 PublicationCorresponds to variant dbSNP:rs781368801Ensembl.1
    Natural variantiVAR_040024226S → G in BCHED; enzymatically inactive in the plasma. 1 PublicationCorresponds to variant dbSNP:rs370077923Ensembl.1
    Natural variantiVAR_040025227A → V in BCHED. 1 Publication1
    Natural variantiVAR_040026229A → T in BCHED; enzymatically inactive in the plasma. 1 Publication1
    Natural variantiVAR_072098232V → D in BCHED. 1 Publication1
    Natural variantiVAR_040027271T → M in BCHED; allele fluoride-1. 2 PublicationsCorresponds to variant dbSNP:rs28933389EnsemblClinVar.1
    Natural variantiVAR_040028278T → P in BCHED. 2 PublicationsCorresponds to variant dbSNP:rs892642457Ensembl.1
    Natural variantiVAR_040029283E → D. Corresponds to variant dbSNP:rs16849700EnsemblClinVar.1
    Natural variantiVAR_040030295K → R in BCHED. 1 PublicationCorresponds to variant dbSNP:rs115624085EnsemblClinVar.1
    Natural variantiVAR_072099322V → M Rare polymorphism; does not affect enzymatic activity. 1 PublicationCorresponds to variant dbSNP:rs754644618Ensembl.1
    Natural variantiVAR_040031335L → P in BCHED; expressed at very low level. 1 PublicationCorresponds to variant dbSNP:rs104893684EnsemblClinVar.1
    Natural variantiVAR_040032356A → D in BCHED. 1 PublicationCorresponds to variant dbSNP:rs770337031EnsemblClinVar.1
    Natural variantiVAR_002362358L → I in BCHED; BChE variant form; fluoride-resistant. 4 PublicationsCorresponds to variant dbSNP:rs121918557EnsemblClinVar.1
    Natural variantiVAR_072100361G → C in BCHED; results in 20% of activity compared to wild-type. 1 Publication1
    Natural variantiVAR_040033393G → R in BCHED. 4 PublicationsCorresponds to variant dbSNP:rs115129687EnsemblClinVar.1
    Natural variantiVAR_040034414R → C in BCHED. 2 PublicationsCorresponds to variant dbSNP:rs745364489EnsemblClinVar.1
    Natural variantiVAR_040035418G → V in BCHED; allele fluoride-2. 1 PublicationCorresponds to variant dbSNP:rs28933390EnsemblClinVar.1
    Natural variantiVAR_040036446F → S in BCHED. 2 Publications1
    Natural variantiVAR_040037488E → K in BCHED. 1 PublicationCorresponds to variant dbSNP:rs200998515Ensembl.1
    Natural variantiVAR_072101498R → W Rare polymorphism; does not affect enzymatic activity. 1 PublicationCorresponds to variant dbSNP:rs115017300EnsemblClinVar.1
    Natural variantiVAR_040038499W → R in BCHED; seems to cause reduced expression of the protein. 1 Publication1
    Natural variantiVAR_040039502F → L in BCHED. 1 PublicationCorresponds to variant dbSNP:rs769316835EnsemblClinVar.1
    Natural variantiVAR_040040525E → V in BCHED; allele J variant. 1 PublicationCorresponds to variant dbSNP:rs121918556EnsemblClinVar.1
    Natural variantiVAR_040041543R → C in BCHED. 3 PublicationsCorresponds to variant dbSNP:rs199660374EnsemblClinVar.1
    Natural variantiVAR_040042546Q → L in BCHED; seems to cause reduced expression of the protein. 1 Publication1
    Natural variantiVAR_002364567A → T in BCHED; allele K variant; with reduced enzyme activity. 4 PublicationsCorresponds to variant dbSNP:rs1803274EnsemblClinVar.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    M32391, M32389, M32390 Genomic DNA Translation: AAA99296.1
    M16541 mRNA Translation: AAA98113.1
    M16474 mRNA Translation: AAA52015.1
    AK292063 mRNA Translation: BAF84752.1
    BC018141 mRNA Translation: AAH18141.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS3198.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A33769 ACHU

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_000046.1, NM_000055.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000264381; ENSP00000264381; ENSG00000114200

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    590

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:590

    UCSC genome browser

    More...
    UCSCi
    uc003fem.5 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    M32391, M32389, M32390 Genomic DNA Translation: AAA99296.1
    M16541 mRNA Translation: AAA98113.1
    M16474 mRNA Translation: AAA52015.1
    AK292063 mRNA Translation: BAF84752.1
    BC018141 mRNA Translation: AAH18141.1
    CCDSiCCDS3198.1
    PIRiA33769 ACHU
    RefSeqiNP_000046.1, NM_000055.3

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1EHOmodel-A30-560[»]
    1EHQmodel-A30-560[»]
    1KCJmodel-A30-560[»]
    1P0IX-ray2.00A29-557[»]
    1P0MX-ray2.38A29-557[»]
    1P0PX-ray2.30A29-557[»]
    1P0QX-ray2.43A29-557[»]
    1XLUX-ray2.20A29-557[»]
    1XLVX-ray2.25A29-557[»]
    1XLWX-ray2.10A29-557[»]
    2J4CX-ray2.75A29-557[»]
    2PM8X-ray2.80A/B29-602[»]
    2WIDX-ray2.30A29-557[»]
    2WIFX-ray2.25A29-557[»]
    2WIGX-ray2.15A29-557[»]
    2WIJX-ray2.10A29-557[»]
    2WIKX-ray2.10A29-557[»]
    2WILX-ray3.10A/B29-557[»]
    2WSLX-ray2.00A29-557[»]
    2XMBX-ray2.10A29-557[»]
    2XMCX-ray2.40A29-557[»]
    2XMDX-ray2.30A29-557[»]
    2XMGX-ray2.70A29-557[»]
    2XQFX-ray2.10A31-557[»]
    2XQGX-ray2.30A31-557[»]
    2XQIX-ray2.60A31-557[»]
    2XQJX-ray2.40A31-557[»]
    2XQKX-ray2.40A31-557[»]
    2Y1KX-ray2.50A29-557[»]
    3DJYX-ray2.10A29-557[»]
    3DKKX-ray2.31A29-557[»]
    3O9MX-ray2.98A/B29-602[»]
    4AQDX-ray2.50A/B29-557[»]
    4AXBX-ray2.40A31-557[»]
    4B0OX-ray2.35A29-557[»]
    4B0PX-ray2.50A29-557[»]
    4BBZX-ray2.70A29-557[»]
    4BDSX-ray2.10A29-557[»]
    4TPKX-ray2.70A/B1-602[»]
    4XIIX-ray2.70A/B29-572[»]
    5DYTX-ray2.55A/B28-557[»]
    5DYWX-ray2.50A/B28-557[»]
    5DYYX-ray2.65A/B28-557[»]
    5K5EX-ray2.80A/B29-557[»]
    5LKRX-ray2.52A/B29-602[»]
    5NN0X-ray2.10A29-557[»]
    6EMIX-ray2.48A/B29-557[»]
    6EP4X-ray2.30A29-557[»]
    6EQPX-ray2.35A29-557[»]
    6EQQX-ray2.40A29-557[»]
    6ESJX-ray2.98A/B29-557[»]
    6ESYX-ray2.80A/B29-557[»]
    6EULX-ray2.60A31-558[»]
    6EYFX-ray2.60A31-557[»]
    6EZ2X-ray2.70A/B31-557[»]
    6F7QX-ray2.60A/B29-557[»]
    6I0BX-ray2.38A29-557[»]
    6I0CX-ray2.67A29-557[»]
    6I2Telectron microscopy5.70A/B/C/D29-602[»]
    6QAAX-ray1.90A1-557[»]
    6QABX-ray2.49A1-557[»]
    6QACX-ray2.77A1-557[»]
    6QADX-ray2.50A1-557[»]
    6QAEX-ray2.49A1-557[»]
    SMRiP06276
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi107064, 40 interactors
    DIPiDIP-46476N
    IntActiP06276, 28 interactors
    MINTiP06276
    STRINGi9606.ENSP00000264381

    Chemistry databases

    BindingDBiP06276
    ChEMBLiCHEMBL1914
    DrugBankiDB08200 (1R)-menthyl hexyl phosphonate group
    DB08201 (1S)-menthyl hexyl phosphonate group
    DB03814 2-(N-Morpholino)-Ethanesulfonic Acid
    DB07940 9-(3-IODOBENZYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE
    DB03672 9-N-Phenylmethylamino-Tacrine
    DB08897 Aclidinium
    DB01122 Ambenonium
    DB06692 Aprotinin
    DB01408 Bambuterol
    DB11148 Butamben
    DB03568 Butyric Acid
    DB04250 Butyrylthiocholine
    DB06774 Capsaicin
    DB01161 Chloroprocaine
    DB00856 Chlorphenesin
    DB00477 Chlorpromazine
    DB00122 Choline
    DB14006 Choline salicylate
    DB00527 Cinchocaine
    DB00515 Cisplatin
    DB04920 Clevidipine
    DB00907 Cocaine
    DB00979 Cyclopentolate
    DB01245 Decamethonium
    DB00944 Demecarium
    DB11397 Dichlorvos
    DB00711 Diethylcarbamazine
    DB02811 Diethylphosphono Group
    DB00449 Dipivefrin
    DB07681 DODECANESULFONATE ION
    DB01135 Doxacurium
    DB01395 Drospirenone
    DB01525 Ecgonine
    DB01057 Echothiophate
    DB01010 Edrophonium
    DB01364 Ephedrine
    DB03822 Ethyl Dihydrogen Phosphate
    DB08658 ETHYL HYDROGEN DIETHYLAMIDOPHOSPHATE
    DB00674 Galantamine
    DB06756 Glycine betaine
    DB00941 Hexafluronium
    DB00762 Irinotecan
    DB00677 Isoflurophate
    DB01221 Ketamine
    DB00772 Malathion
    DB00888 Mechlorethamine
    DB00358 Mefloquine
    DB02845 Methylphosphinic Acid
    DB08893 Mirabegron
    DB01226 Mivacurium
    DB09205 Moxisylyte
    DB01400 Neostigmine
    DB00585 Nizatidine
    DB00892 Oxybuprocaine
    DB01337 Pancuronium
    DB00082 Pegvisomant
    DB00183 Pentagastrin
    DB00790 Perindopril
    DB04892 Phenserine
    DB03976 Phosphorylisopropane
    DB01338 Pipecuronium
    DB00733 Pralidoxime
    DB01035 Procainamide
    DB00721 Procaine
    DB00392 Profenamine
    DB09288 Propacetamol
    DB00545 Pyridostigmine
    DB00178 Ramipril
    DB00863 Ranitidine
    DB05386 Regramostim
    DB00989 Rivastigmine
    DB05875 Sar9, Met (O2)11-Substance P
    DB00202 Succinylcholine
    DB00391 Sulpiride
    DB00382 Tacrine
    DB00871 Terbutaline
    DB04572 Thiotepa
    DB14031 Tretamine
    DB00620 Triamcinolone
    DB00508 Triflupromazine
    DB01116 Trimethaphan
    DB01199 Tubocurarine

    DrugCentral

    More...
    DrugCentrali
    P06276
    GuidetoPHARMACOLOGYi2471

    Protein family/group databases

    ESTHERihuman-BCHE BCHE
    MEROPSiS09.980

    PTM databases

    GlyConnecti1109
    iPTMnetiP06276
    PhosphoSitePlusiP06276

    Polymorphism and mutation databases

    BioMutaiBCHE
    DMDMi116353

    Proteomic databases

    CPTACinon-CPTAC-2645
    EPDiP06276
    jPOSTiP06276
    MassIVEiP06276
    MaxQBiP06276
    PaxDbiP06276
    PeptideAtlasiP06276
    PRIDEiP06276
    ProteomicsDBi51880

    Protocols and materials databases

    ABCD curated depository of sequenced antibodies

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    ABCDi
    P06276

    The DNASU plasmid repository

    More...
    DNASUi
    590
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000264381; ENSP00000264381; ENSG00000114200
    GeneIDi590
    KEGGihsa:590
    UCSCiuc003fem.5 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    590
    DisGeNETi590

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    BCHE
    HGNCiHGNC:983 BCHE
    HPAiHPA001560
    MalaCardsiBCHE
    MIMi177400 gene
    617936 phenotype
    neXtProtiNX_P06276
    OpenTargetsiENSG00000114200
    Orphaneti132 Butyrylcholinesterase deficiency
    413693 Curariform drugs toxicity
    PharmGKBiPA25294

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG4389 Eukaryota
    COG2272 LUCA
    GeneTreeiENSGT00940000157023
    InParanoidiP06276
    KOiK01050
    OMAiFPGSEMW
    OrthoDBi1226324at2759
    PhylomeDBiP06276
    TreeFamiTF315470

    Enzyme and pathway databases

    BRENDAi3.1.1.8 2681
    ReactomeiR-HSA-112311 Neurotransmitter clearance
    R-HSA-1483191 Synthesis of PC
    R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin
    SABIO-RKiP06276
    SIGNORiP06276

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    BCHE human
    EvolutionaryTraceiP06276

    The Gene Wiki collection of pages on human genes and proteins

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    GeneWikii
    Butyrylcholinesterase

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    590

    Pharos

    More...
    Pharosi
    P06276

    Protein Ontology

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    PROi
    PR:P06276

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000114200 Expressed in 182 organ(s), highest expression level in parietal pleura
    ExpressionAtlasiP06276 baseline and differential
    GenevisibleiP06276 HS

    Family and domain databases

    Gene3Di3.40.50.1820, 1 hit
    InterProiView protein in InterPro
    IPR029058 AB_hydrolase
    IPR014788 AChE_tetra
    IPR002018 CarbesteraseB
    IPR019826 Carboxylesterase_B_AS
    IPR019819 Carboxylesterase_B_CS
    IPR000997 Cholinesterase
    PfamiView protein in Pfam
    PF08674 AChE_tetra, 1 hit
    PF00135 COesterase, 1 hit
    PRINTSiPR00878 CHOLNESTRASE
    SUPFAMiSSF53474 SSF53474, 1 hit
    PROSITEiView protein in PROSITE
    PS00122 CARBOXYLESTERASE_B_1, 1 hit
    PS00941 CARBOXYLESTERASE_B_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHLE_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06276
    Secondary accession number(s): A8K7P8
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: August 1, 1988
    Last modified: September 18, 2019
    This is version 209 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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