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Protein

Cell division control protein 7

Gene

CDC7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase. Needed for the initiation of DNA synthesis during mitosis as well as for synaptonemal complex formation and commitment to recombination during meiosis. Required for HTA1-HTB1 locus transcription repression.1 Publication

Miscellaneous

Present with 1600 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei76ATPPROSITE-ProRule annotation1
Active sitei163Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi39 – 47ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: SGD

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division, Meiosis, Mitosis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29446-MONOMER
BRENDAi2.7.11.1 984
ReactomeiR-SCE-68962 Activation of the pre-replicative complex

Protein family/group databases

MoonDBiP06243 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 7 (EC:2.7.11.1)
Gene namesi
Name:CDC7
Synonyms:OAF2
Ordered Locus Names:YDL017W
ORF Names:D2855
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

SGDiS000002175 CDC7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857661 – 507Cell division control protein 7Add BLAST507

Proteomic databases

MaxQBiP06243
PaxDbiP06243
PRIDEiP06243

PTM databases

iPTMnetiP06243

Interactioni

Subunit structurei

Associates with DBF4 and ORC2.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi32038, 456 interactors
ComplexPortaliCPX-867 DBF4-dependent CDC7 kinase complex
DIPiDIP-1235N
IntActiP06243, 80 interactors
MINTiP06243
STRINGi4932.YDL017W

Structurei

3D structure databases

ProteinModelPortaliP06243
SMRiP06243
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 469Protein kinasePROSITE-ProRule annotationAdd BLAST437

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000075011
HOGENOMiHOG000193450
InParanoidiP06243
KOiK02214
OMAiFYRDLPI
OrthoDBiEOG092C2IG9

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P06243-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSKTKNIDD IPPEIKEEMI QLYHDLPGIE NEYKLIDKIG EGTFSSVYKA
60 70 80 90 100
KDITGKITKK FASHFWNYGS NYVALKKIYV TSSPQRIYNE LNLLYIMTGS
110 120 130 140 150
SRVAPLCDAK RVRDQVIAVL PYYPHEEFRT FYRDLPIKGI KKYIWELLRA
160 170 180 190 200
LKFVHSKGII HRDIKPTNFL FNLELGRGVL VDFGLAEAQM DYKSMISSQN
210 220 230 240 250
DYDNYANTNH DGGYSMRNHE QFCPCIMRNQ YSPNSHNQTP PMVTIQNGKV
260 270 280 290 300
VHLNNVNGVD LTKGYPKNET RRIKRANRAG TRGFRAPEVL MKCGAQSTKI
310 320 330 340 350
DIWSVGVILL SLLGRRFPMF QSLDDADSLL ELCTIFGWKE LRKCAALHGL
360 370 380 390 400
GFEASGLIWD KPNGYSNGLK EFVYDLLNKE CTIGTFPEYS VAFETFGFLQ
410 420 430 440 450
QELHDRMSIE PQLPDPKTNM DAVDAYELKK YQEEIWSDHY WCFQVLEQCF
460 470 480 490 500
EMDPQKRSSA EDLLKTPFFN ELNENTYLLD GESTDEDDVV SSSEADLLDK

DVLLISE
Length:507
Mass (Da):58,320
Last modified:November 1, 1995 - v2
Checksum:iB74BA9144D0EC39F
GO

Sequence cautioni

The sequence CAA32370 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12624 Genomic DNA Translation: AAA34485.1
Z48432 Genomic DNA Translation: CAA88342.1
Z74065 Genomic DNA Translation: CAA98574.1
X14164 Genomic DNA Translation: CAA32369.1
X14164 Genomic DNA Translation: CAA32370.1 Different initiation.
X15362 Genomic DNA Translation: CAA33420.1
BK006938 Genomic DNA Translation: DAA11833.1
PIRiA25228
RefSeqiNP_010267.3, NM_001180076.3

Genome annotation databases

EnsemblFungiiYDL017W; YDL017W; YDL017W
GeneIDi851545
KEGGisce:YDL017W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12624 Genomic DNA Translation: AAA34485.1
Z48432 Genomic DNA Translation: CAA88342.1
Z74065 Genomic DNA Translation: CAA98574.1
X14164 Genomic DNA Translation: CAA32369.1
X14164 Genomic DNA Translation: CAA32370.1 Different initiation.
X15362 Genomic DNA Translation: CAA33420.1
BK006938 Genomic DNA Translation: DAA11833.1
PIRiA25228
RefSeqiNP_010267.3, NM_001180076.3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5T2SX-ray2.40B/D480-491[»]
ProteinModelPortaliP06243
SMRiP06243
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32038, 456 interactors
ComplexPortaliCPX-867 DBF4-dependent CDC7 kinase complex
DIPiDIP-1235N
IntActiP06243, 80 interactors
MINTiP06243
STRINGi4932.YDL017W

Protein family/group databases

MoonDBiP06243 Predicted

PTM databases

iPTMnetiP06243

Proteomic databases

MaxQBiP06243
PaxDbiP06243
PRIDEiP06243

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDL017W; YDL017W; YDL017W
GeneIDi851545
KEGGisce:YDL017W

Organism-specific databases

SGDiS000002175 CDC7

Phylogenomic databases

GeneTreeiENSGT00550000075011
HOGENOMiHOG000193450
InParanoidiP06243
KOiK02214
OMAiFYRDLPI
OrthoDBiEOG092C2IG9

Enzyme and pathway databases

BioCyciYEAST:G3O-29446-MONOMER
BRENDAi2.7.11.1 984
ReactomeiR-SCE-68962 Activation of the pre-replicative complex

Miscellaneous databases

PROiPR:P06243

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDC7_YEAST
AccessioniPrimary (citable) accession number: P06243
Secondary accession number(s): D6VRX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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Main funding by: National Institutes of Health

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