UniProtKB - P06241 (FYN_HUMAN)
Tyrosine-protein kinase Fyn
FYN
Functioni
Catalytic activityi
- EC:2.7.10.2PROSITE-ProRule annotation
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 299 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 390 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 277 – 285 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- alpha-tubulin binding Source: ARUK-UCL
- ATP binding Source: UniProtKB-KW
- CD4 receptor binding Source: Ensembl
- CD8 receptor binding Source: Ensembl
- disordered domain specific binding Source: CAFA
- enzyme binding Source: ARUK-UCL
- ephrin receptor binding Source: UniProtKB
- growth factor receptor binding Source: UniProtKB
- identical protein binding Source: IntAct
- ion channel binding Source: Ensembl
- metal ion binding Source: UniProtKB-KW
- non-membrane spanning protein tyrosine kinase activity Source: GO_Central
- peptide hormone receptor binding Source: Ensembl
- phosphatidylinositol 3-kinase binding Source: Ensembl
- protein tyrosine kinase activity Source: UniProtKB
- signaling receptor binding Source: GO_Central
- tau protein binding Source: ARUK-UCL
- tau-protein kinase activity Source: ARUK-UCL
- T cell receptor binding Source: Ensembl
- type 5 metabotropic glutamate receptor binding Source: ARUK-UCL
GO - Biological processi
- activated T cell proliferation Source: Ensembl
- adaptive immune response Source: UniProtKB-KW
- axon guidance Source: Reactome
- blood coagulation Source: Reactome
- calcium ion transport Source: UniProtKB
- cell differentiation Source: GO_Central
- cellular response to amyloid-beta Source: ARUK-UCL
- cellular response to glycine Source: ARUK-UCL
- cellular response to L-glutamate Source: ARUK-UCL
- cellular response to peptide hormone stimulus Source: Ensembl
- cellular response to platelet-derived growth factor stimulus Source: Ensembl
- cellular response to transforming growth factor beta stimulus Source: Ensembl
- cytokine-mediated signaling pathway Source: Reactome
- dendrite morphogenesis Source: Ensembl
- dendritic spine maintenance Source: ARUK-UCL
- detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
- ephrin receptor signaling pathway Source: Reactome
- Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
- feeding behavior Source: ProtInc
- forebrain development Source: Ensembl
- heart process Source: ARUK-UCL
- innate immune response Source: GO_Central
- intracellular signal transduction Source: ProtInc
- learning Source: ProtInc
- leukocyte migration Source: Reactome
- MAPK cascade Source: Reactome
- modulation of chemical synaptic transmission Source: Ensembl
- negative regulation of dendritic spine maintenance Source: ARUK-UCL
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
- negative regulation of gene expression Source: Ensembl
- negative regulation of hydrogen peroxide biosynthetic process Source: ARUK-UCL
- negative regulation of neuron apoptotic process Source: Ensembl
- negative regulation of oxidative stress-induced cell death Source: ARUK-UCL
- negative regulation of protein catabolic process Source: Ensembl
- negative regulation of protein ubiquitination Source: Ensembl
- neuron migration Source: Ensembl
- peptidyl-tyrosine autophosphorylation Source: GO_Central
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- platelet activation Source: Reactome
- positive regulation of cysteine-type endopeptidase activity Source: ARUK-UCL
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
- positive regulation of neuron death Source: ARUK-UCL
- positive regulation of neuron projection development Source: Ensembl
- positive regulation of non-membrane spanning protein tyrosine kinase activity Source: Reactome
- positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
- positive regulation of protein kinase B signaling Source: Reactome
- positive regulation of protein localization to membrane Source: ARUK-UCL
- positive regulation of protein localization to nucleus Source: Ensembl
- positive regulation of protein targeting to membrane Source: ARUK-UCL
- positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
- protein phosphorylation Source: ARUK-UCL
- regulation of calcium ion import across plasma membrane Source: ARUK-UCL
- regulation of cell population proliferation Source: GO_Central
- regulation of cell shape Source: ARUK-UCL
- regulation of defense response to virus by virus Source: Reactome
- regulation of glutamate receptor signaling pathway Source: ARUK-UCL
- regulation of peptidyl-tyrosine phosphorylation Source: ARUK-UCL
- response to amyloid-beta Source: ARUK-UCL
- response to drug Source: Ensembl
- response to ethanol Source: Ensembl
- response to hydrogen peroxide Source: ARUK-UCL
- response to singlet oxygen Source: ARUK-UCL
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
- T cell costimulation Source: Reactome
- T cell receptor signaling pathway Source: UniProtKB
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
- vascular endothelial growth factor receptor signaling pathway Source: Reactome
Keywordsi
Molecular function | Developmental protein, Kinase, Transferase, Tyrosine-protein kinase |
Biological process | Adaptive immunity, Host-virus interaction, Immunity |
Ligand | ATP-binding, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P06241 |
Reactomei | R-HSA-114604, GPVI-mediated activation cascade R-HSA-1227986, Signaling by ERBB2 R-HSA-1257604, PIP3 activates AKT signaling R-HSA-1433557, Signaling by SCF-KIT R-HSA-1433559, Regulation of KIT signaling R-HSA-164944, Nef and signal transduction R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-2029481, FCGR activation R-HSA-210990, PECAM1 interactions R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2424491, DAP12 signaling R-HSA-2682334, EPH-Ephrin signaling R-HSA-2730905, Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-373753, Nephrin family interactions R-HSA-375165, NCAM signaling for neurite out-growth R-HSA-389356, CD28 co-stimulation R-HSA-389357, CD28 dependent PI3K/Akt signaling R-HSA-389359, CD28 dependent Vav1 pathway R-HSA-389513, CTLA4 inhibitory signaling R-HSA-3928662, EPHB-mediated forward signaling R-HSA-3928663, EPHA-mediated growth cone collapse R-HSA-3928664, Ephrin signaling R-HSA-3928665, EPH-ephrin mediated repulsion of cells R-HSA-399954, Sema3A PAK dependent Axon repulsion R-HSA-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399956, CRMPs in Sema3A signaling R-HSA-418885, DCC mediated attractive signaling [P06241-1] R-HSA-4420097, VEGFA-VEGFR2 Pathway R-HSA-5621480, Dectin-2 family R-HSA-5621575, CD209 (DC-SIGN) signaling R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-75892, Platelet Adhesion to exposed collagen R-HSA-8866376, Reelin signalling pathway R-HSA-9032500, Activated NTRK2 signals through FYN [P06241-1] R-HSA-9032759, NTRK2 activates RAC1 [P06241-1] R-HSA-912631, Regulation of signaling by CBL R-HSA-9607240, FLT3 Signaling R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-9664422, FCGR3A-mediated phagocytosis R-HSA-9670439, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
SignaLinki | P06241 |
SIGNORi | P06241 |
Protein family/group databases
MoonDBi | P06241, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Tyrosine-protein kinase Fyn (EC:2.7.10.2)Alternative name(s): Proto-oncogene Syn Proto-oncogene c-Fyn Src-like kinase Short name: SLK p59-Fyn |
Gene namesi | Name:FYN |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4037, FYN |
MIMi | 137025, gene |
neXtProti | NX_P06241 |
VEuPathDBi | HostDB:ENSG00000010810.17 |
Subcellular locationi
Plasma membrane
Nucleus
Other locations
Note: Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking.
Cytoskeleton
- actin filament Source: Ensembl
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- perinuclear endoplasmic reticulum Source: ARUK-UCL
Endosome
- endosome Source: HGNC-UCL
Mitochondrion
- mitochondrion Source: ARUK-UCL
Nucleus
- nucleus Source: ARUK-UCL
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: GO_Central
- plasma membrane Source: BHF-UCL
Other locations
- cell body Source: ARUK-UCL
- dendrite Source: ParkinsonsUK-UCL
- glial cell projection Source: ARUK-UCL
- glutamatergic synapse Source: Ensembl
- membrane raft Source: ARUK-UCL
- perinuclear region of cytoplasm Source: ARUK-UCL
- postsynaptic density Source: ARUK-UCL
- postsynaptic density, intracellular component Source: Ensembl
- Schaffer collateral - CA1 synapse Source: Ensembl
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 2534 |
OpenTargetsi | ENSG00000010810 |
PharmGKBi | PA28454 |
Miscellaneous databases
Pharosi | P06241, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1841 |
DrugBanki | DB01254, Dasatinib DB12010, Fostamatinib DB02078, Triglyme |
DrugCentrali | P06241 |
GuidetoPHARMACOLOGYi | 2026 |
Genetic variation databases
BioMutai | FYN |
DMDMi | 125370 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed | |||
ChainiPRO_0000088099 | 2 – 537 | Tyrosine-protein kinase FynAdd BLAST | 536 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycine1 Publication | 1 | |
Lipidationi | 3 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 6 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 12 | Phosphothreonine; by PKC1 Publication | 1 | |
Modified residuei | 21 | PhosphoserineCombined sources | 1 | |
Modified residuei | 26 | PhosphoserineCombined sources | 1 | |
Modified residuei | 185 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 420 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 531 | Phosphotyrosine; by CSKCombined sources1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Lipoprotein, Myristate, Palmitate, PhosphoproteinProteomic databases
CPTACi | CPTAC-1792 |
EPDi | P06241 |
jPOSTi | P06241 |
MassIVEi | P06241 |
MaxQBi | P06241 |
PaxDbi | P06241 |
PeptideAtlasi | P06241 |
PRIDEi | P06241 |
ProteomicsDBi | 51877 [P06241-1] 51878 [P06241-2] 51879 [P06241-3] |
PTM databases
iPTMneti | P06241 |
PhosphoSitePlusi | P06241 |
SwissPalmi | P06241 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000010810, Expressed in corpus callosum and 243 other tissues |
ExpressionAtlasi | P06241, baseline and differential |
Genevisiblei | P06241, HS |
Organism-specific databases
HPAi | ENSG00000010810, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via its SH3 domain) with PIK3R1 and PRMT8.
Interacts with FYB1, PAG1, and SH2D1A.
Interacts with CD79A (tyrosine-phosphorylated form); the interaction increases FYN activity.
Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (By similarity).
Interacts with TOM1L1 (phosphorylated form).
Interacts with KDR (tyrosine phosphorylated).
Interacts (via SH3 domain) with KLHL2 (via N-terminus) (By similarity).
Interacts with SH2D1A and SLAMF1.
Interacts with ITCH; the interaction phosphorylates ITCH and negatively regulates its activity.
Interacts with FASLG.
Interacts with RUNX3.
Interacts with KIT.
Interacts with EPHA8; possible downstream effector of EPHA8 in regulation of cell adhesion.
Interacts with PTK2/FAK1; this interaction leads to PTK2/FAK1 phosphorylation and activation.
Interacts with CAV1; this interaction couples integrins to the Ras-ERK pathway.
Interacts with UNC119.
Interacts (via SH2 domain) with PTPRH (phosphorylated form) (By similarity).
Interacts with PTPRO (phosphorylated form) (By similarity).
Interacts with PTPRB (phosphorylated form) (By similarity).
Interacts with FYB2 (PubMed:27335501).
Interacts with DSCAM (By similarity).
Interacts with SKAP1 and FYB1; this interaction promotes the phosphorylation of CLNK (By similarity).
By similarity14 Publications(Microbial infection) Interacts (via its SH3 domain) with hepatitis E virus/HEV protein ORF3.
1 PublicationBinary interactionsi
P06241
Isoform 3 [P06241-3]
GO - Molecular functioni
- alpha-tubulin binding Source: ARUK-UCL
- CD4 receptor binding Source: Ensembl
- CD8 receptor binding Source: Ensembl
- disordered domain specific binding Source: CAFA
- enzyme binding Source: ARUK-UCL
- ephrin receptor binding Source: UniProtKB
- growth factor receptor binding Source: UniProtKB
- identical protein binding Source: IntAct
- ion channel binding Source: Ensembl
- peptide hormone receptor binding Source: Ensembl
- phosphatidylinositol 3-kinase binding Source: Ensembl
- signaling receptor binding Source: GO_Central
- tau protein binding Source: ARUK-UCL
- T cell receptor binding Source: Ensembl
- type 5 metabotropic glutamate receptor binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 108810, 274 interactors |
CORUMi | P06241 |
DIPi | DIP-33876N |
ELMi | P06241 |
IntActi | P06241, 427 interactors |
MINTi | P06241 |
STRINGi | 9606.ENSP00000346671 |
Chemistry databases
BindingDBi | P06241 |
Miscellaneous databases
RNActi | P06241, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P06241 |
SMRi | P06241 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06241 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 82 – 143 | SH3PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 149 – 246 | SH2PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 271 – 524 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 254 |
Sequence similaritiesi
Keywords - Domaini
SH2 domain, SH3 domainPhylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000155462 |
HOGENOMi | CLU_000288_7_2_1 |
InParanoidi | P06241 |
OMAi | XWYFGKL |
OrthoDBi | 539311at2759 |
PhylomeDBi | P06241 |
TreeFami | TF351634 |
Family and domain databases
CDDi | cd12006, SH3_Fyn_Yrk, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035750, Fyn/Yrk_SH3 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY
60 70 80 90 100
NNFHAAGGQG LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD
110 120 130 140 150
LSFHKGEKFQ ILNSSEGDWW EARSLTTGET GYIPSNYVAP VDSIQAEEWY
160 170 180 190 200
FGKLGRKDAE RQLLSFGNPR GTFLIRESET TKGAYSLSIR DWDDMKGDHV
210 220 230 240 250
KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC RLVVPCHKGM
260 270 280 290 300
PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT
310 320 330 340 350
LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL
360 370 380 390 400
LDFLKDGEGR ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN
410 420 430 440 450
GLICKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW
460 470 480 490 500
SFGILLTELV TKGRVPYPGM NNREVLEQVE RGYRMPCPQD CPISLHELMI
510 520 530
HCWKKDPEER PTFEYLQSFL EDYFTATEPQ YQPGENL
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RFS5 | E5RFS5_HUMAN | Tyrosine-protein kinase Fyn | FYN | 232 | Annotation score: | ||
E5RIX5 | E5RIX5_HUMAN | Tyrosine-protein kinase Fyn | FYN | 186 | Annotation score: | ||
E5RH71 | E5RH71_HUMAN | Tyrosine-protein kinase Fyn | FYN | 175 | Annotation score: | ||
E5RFM0 | E5RFM0_HUMAN | Tyrosine-protein kinase Fyn | FYN | 152 | Annotation score: | ||
E5RGT0 | E5RGT0_HUMAN | Tyrosine-protein kinase Fyn | FYN | 153 | Annotation score: | ||
E5RGM6 | E5RGM6_HUMAN | Tyrosine-protein kinase Fyn | FYN | 139 | Annotation score: | ||
E5RI25 | E5RI25_HUMAN | Tyrosine-protein kinase Fyn | FYN | 145 | Annotation score: | ||
E5RFM4 | E5RFM4_HUMAN | Tyrosine-protein kinase Fyn | FYN | 116 | Annotation score: | ||
E5RHF7 | E5RHF7_HUMAN | Tyrosine-protein kinase Fyn | FYN | 118 | Annotation score: | ||
E5RK23 | E5RK23_HUMAN | Tyrosine-protein kinase Fyn | FYN | 106 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 184 | A → S in AAA36615 (PubMed:3099169).Curated | 1 | |
Sequence conflicti | 437 | A → R in AAA36615 (PubMed:3099169).Curated | 1 | |
Sequence conflicti | 437 | A → R in AAB33113 (PubMed:7822789).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041704 | 243 | V → L in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041705 | 410 | G → R in a metastatic melanoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_014661 | 445 | I → F. Corresponds to variant dbSNP:rs1801121Ensembl. | 1 | |
Natural variantiVAR_041706 | 506 | D → E1 PublicationCorresponds to variant dbSNP:rs28763975EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024108 | 233 – 287 | Missing in isoform 3. 1 PublicationAdd BLAST | 55 | |
Alternative sequenceiVSP_024110 | 234 – 287 | RAAGL…GEVWM → KADGLCFNLTVIASSCTPQT SGLAKDAWEVARRSLCLEKK LGQGCFAEVWL in isoform 2. 1 PublicationAdd BLAST | 54 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000229471; ENSP00000229471; ENSG00000010810 [P06241-3] ENST00000354650; ENSP00000346671; ENSG00000010810 [P06241-1] ENST00000368667; ENSP00000357656; ENSG00000010810 [P06241-1] ENST00000368678; ENSP00000357667; ENSG00000010810 [P06241-2] ENST00000368682; ENSP00000357671; ENSG00000010810 [P06241-2] ENST00000538466; ENSP00000440646; ENSG00000010810 [P06241-2] |
GeneIDi | 2534 |
KEGGi | hsa:2534 |
UCSCi | uc003pvh.3, human [P06241-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1A0N | NMR | - | B | 80-148 | [»] | |
1AOT | NMR | - | F | 143-248 | [»] | |
1AOU | NMR | - | F | 143-248 | [»] | |
1AVZ | X-ray | 3.00 | C | 85-141 | [»] | |
1AZG | NMR | - | B | 82-148 | [»] | |
1EFN | X-ray | 2.50 | A/C | 86-143 | [»] | |
1FYN | X-ray | 2.30 | A | 81-142 | [»] | |
1G83 | X-ray | 2.60 | A/B | 82-246 | [»] | |
1M27 | X-ray | 2.50 | C | 84-144 | [»] | |
1NYF | NMR | - | A | 82-148 | [»] | |
1NYG | NMR | - | A | 82-148 | [»] | |
1SHF | X-ray | 1.90 | A/B | 84-142 | [»] | |
1ZBJ | NMR | - | A | 84-142 | [»] | |
2DQ7 | X-ray | 2.80 | X | 261-537 | [»] | |
2MQI | NMR | - | A | 148-248 | [»] | |
2MRJ | NMR | - | A | 148-248 | [»] | |
2MRK | NMR | - | A | 149-248 | [»] | |
B | 528-537 | [»] | ||||
3H0F | X-ray | 2.61 | A | 73-142 | [»] | |
3H0H | X-ray | 1.76 | A | 73-142 | [»] | |
3H0I | X-ray | 2.20 | A/B | 73-142 | [»] | |
3UA6 | X-ray | 1.85 | A/B | 81-143 | [»] | |
3UA7 | X-ray | 1.50 | A/B/C/D | 81-143 | [»] | |
4D8D | X-ray | 2.52 | A/C | 84-141 | [»] | |
4EIK | X-ray | 1.60 | A | 81-143 | [»] | |
4U17 | X-ray | 1.99 | A/B/C | 148-248 | [»] | |
4U1P | X-ray | 1.40 | A | 148-248 | [»] | |
4ZNX | X-ray | 2.10 | A/B/C/D | 84-141 | [»] | |
5ZAU | NMR | - | A | 85-141 | [»] | |
6EDF | X-ray | 1.40 | A | 83-146 | [»] | |
6IPY | X-ray | 1.34 | A | 82-144 | [»] | |
6IPZ | X-ray | 1.58 | Z | 82-144 | [»] | |
BMRBi | P06241 | |||||
SMRi | P06241 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108810, 274 interactors |
CORUMi | P06241 |
DIPi | DIP-33876N |
ELMi | P06241 |
IntActi | P06241, 427 interactors |
MINTi | P06241 |
STRINGi | 9606.ENSP00000346671 |
Chemistry databases
BindingDBi | P06241 |
ChEMBLi | CHEMBL1841 |
DrugBanki | DB01254, Dasatinib DB12010, Fostamatinib DB02078, Triglyme |
DrugCentrali | P06241 |
GuidetoPHARMACOLOGYi | 2026 |
Protein family/group databases
MoonDBi | P06241, Predicted |
PTM databases
iPTMneti | P06241 |
PhosphoSitePlusi | P06241 |
SwissPalmi | P06241 |
Genetic variation databases
BioMutai | FYN |
DMDMi | 125370 |
Proteomic databases
CPTACi | CPTAC-1792 |
EPDi | P06241 |
jPOSTi | P06241 |
MassIVEi | P06241 |
MaxQBi | P06241 |
PaxDbi | P06241 |
PeptideAtlasi | P06241 |
PRIDEi | P06241 |
ProteomicsDBi | 51877 [P06241-1] 51878 [P06241-2] 51879 [P06241-3] |
Protocols and materials databases
ABCDi | P06241, 2 sequenced antibodies |
Antibodypediai | 3559, 985 antibodies |
DNASUi | 2534 |
Genome annotation databases
Ensembli | ENST00000229471; ENSP00000229471; ENSG00000010810 [P06241-3] ENST00000354650; ENSP00000346671; ENSG00000010810 [P06241-1] ENST00000368667; ENSP00000357656; ENSG00000010810 [P06241-1] ENST00000368678; ENSP00000357667; ENSG00000010810 [P06241-2] ENST00000368682; ENSP00000357671; ENSG00000010810 [P06241-2] ENST00000538466; ENSP00000440646; ENSG00000010810 [P06241-2] |
GeneIDi | 2534 |
KEGGi | hsa:2534 |
UCSCi | uc003pvh.3, human [P06241-1] |
Organism-specific databases
CTDi | 2534 |
DisGeNETi | 2534 |
GeneCardsi | FYN |
HGNCi | HGNC:4037, FYN |
HPAi | ENSG00000010810, Low tissue specificity |
MIMi | 137025, gene |
neXtProti | NX_P06241 |
OpenTargetsi | ENSG00000010810 |
PharmGKBi | PA28454 |
VEuPathDBi | HostDB:ENSG00000010810.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000155462 |
HOGENOMi | CLU_000288_7_2_1 |
InParanoidi | P06241 |
OMAi | XWYFGKL |
OrthoDBi | 539311at2759 |
PhylomeDBi | P06241 |
TreeFami | TF351634 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P06241 |
Reactomei | R-HSA-114604, GPVI-mediated activation cascade R-HSA-1227986, Signaling by ERBB2 R-HSA-1257604, PIP3 activates AKT signaling R-HSA-1433557, Signaling by SCF-KIT R-HSA-1433559, Regulation of KIT signaling R-HSA-164944, Nef and signal transduction R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-2029481, FCGR activation R-HSA-210990, PECAM1 interactions R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2424491, DAP12 signaling R-HSA-2682334, EPH-Ephrin signaling R-HSA-2730905, Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-373753, Nephrin family interactions R-HSA-375165, NCAM signaling for neurite out-growth R-HSA-389356, CD28 co-stimulation R-HSA-389357, CD28 dependent PI3K/Akt signaling R-HSA-389359, CD28 dependent Vav1 pathway R-HSA-389513, CTLA4 inhibitory signaling R-HSA-3928662, EPHB-mediated forward signaling R-HSA-3928663, EPHA-mediated growth cone collapse R-HSA-3928664, Ephrin signaling R-HSA-3928665, EPH-ephrin mediated repulsion of cells R-HSA-399954, Sema3A PAK dependent Axon repulsion R-HSA-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399956, CRMPs in Sema3A signaling R-HSA-418885, DCC mediated attractive signaling [P06241-1] R-HSA-4420097, VEGFA-VEGFR2 Pathway R-HSA-5621480, Dectin-2 family R-HSA-5621575, CD209 (DC-SIGN) signaling R-HSA-5673001, RAF/MAP kinase cascade R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-75892, Platelet Adhesion to exposed collagen R-HSA-8866376, Reelin signalling pathway R-HSA-9032500, Activated NTRK2 signals through FYN [P06241-1] R-HSA-9032759, NTRK2 activates RAC1 [P06241-1] R-HSA-912631, Regulation of signaling by CBL R-HSA-9607240, FLT3 Signaling R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-9664422, FCGR3A-mediated phagocytosis R-HSA-9670439, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
SignaLinki | P06241 |
SIGNORi | P06241 |
Miscellaneous databases
BioGRID-ORCSi | 2534, 4 hits in 901 CRISPR screens |
ChiTaRSi | FYN, human |
EvolutionaryTracei | P06241 |
GeneWikii | FYN |
GenomeRNAii | 2534 |
Pharosi | P06241, Tclin |
PROi | PR:P06241 |
RNActi | P06241, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000010810, Expressed in corpus callosum and 243 other tissues |
ExpressionAtlasi | P06241, baseline and differential |
Genevisiblei | P06241, HS |
Family and domain databases
CDDi | cd12006, SH3_Fyn_Yrk, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035750, Fyn/Yrk_SH3 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FYN_HUMAN | |
Accessioni | P06241Primary (citable) accession number: P06241 Secondary accession number(s): B5BU57 Q8N5D7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 257 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families