Tyrosine-protein kinase Fyn

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• alpha-tubulin binding Source: ARUK-UCL
• ATP binding Source: UniProtKB-KW
• CD4 receptor binding Source: Ensembl
• CD8 receptor binding Source: Ensembl
• disordered domain specific binding Source: CAFA <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 9351809
• enzyme binding Source: ARUK-UCLInferred from physical interactionⁱ
  • 27525436
• ephrin receptor binding Source: UniProtKBInferred from physical interactionⁱ
  • 10498895
• growth factor receptor binding Source: UniProtKBInferred from physical interactionⁱ
  • 16479011
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • 14993658
  • 27001024
• ion channel binding Source: Ensembl
• metal ion binding Source: UniProtKB-KW
• non-membrane spanning protein tyrosine kinase activity Source: GO_Central
• peptide hormone receptor binding Source: Ensembl
• phosphatidylinositol 3-kinase binding Source: Ensembl
• phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: Reactome
• protein tyrosine kinase activity Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 16979591
• Ras guanyl-nucleotide exchange factor activity Source: Reactome
• tau protein binding Source: ARUK-UCL
• T cell receptor binding Source: Ensembl
• type 5 metabotropic glutamate receptor binding Source: ARUK-UCL

GO - Biological processⁱ

• activated T cell proliferation Source: Ensembl
• adaptive immune response Source: UniProtKB-KW
• axon guidance Source: Reactome
• blood coagulation Source: Reactome
• calcium ion transport Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 7822789
• cell differentiation Source: GO_Central
• cell migration Source: GO_Central
• cellular response to glycine Source: ARUK-UCL <p>Inferred from Sequence or Structural Similarity <br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • 17526495
• cellular response to L-glutamate Source: ARUK-UCLInferred from sequence or structural similarityⁱ
  • 17526495
• cellular response to peptide hormone stimulus Source: Ensembl
• cellular response to platelet-derived growth factor stimulus Source: Ensembl
• cellular response to transforming growth factor beta stimulus Source: Ensembl
• central nervous system development Source: GO_Central
• cytokine-mediated signaling pathway Source: Reactome
• dendrite morphogenesis Source: Ensembl
• dendritic spine maintenance Source: ARUK-UCL <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 25707991
• detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
• ephrin receptor signaling pathway Source: Reactome
• Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
• feeding behavior Source: ProtIncTraceable author statementⁱ
  • 8264796
• forebrain development Source: Ensembl
• heart process Source: ARUK-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 27525436
• innate immune response Source: GO_Central
• intracellular signal transduction Source: ProtIncTraceable author statementⁱ
  • 1361685
• learning Source: ProtIncTraceable author statementⁱ
  • 1361685
• leukocyte migration Source: Reactome
• MAPK cascade Source: Reactome
• negative regulation of dendritic spine maintenance Source: ARUK-UCL
• negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
• negative regulation of gene expression Source: Ensembl
• negative regulation of hydrogen peroxide biosynthetic process Source: ARUK-UCLInferred from sequence or structural similarityⁱ
  • 27525436
• negative regulation of neuron apoptotic process Source: Ensembl
• negative regulation of oxidative stress-induced cell death Source: ARUK-UCLInferred from sequence or structural similarityⁱ
  • 27525436
• negative regulation of protein catabolic process Source: Ensembl
• negative regulation of protein ubiquitination Source: Ensembl
• neuron migration Source: Ensembl
• peptidyl-tyrosine autophosphorylation Source: GO_Central
• peptidyl-tyrosine phosphorylation Source: UniProtKBInferred from mutant phenotypeⁱ
  • 16979591
• platelet activation Source: Reactome
• positive regulation of cysteine-type endopeptidase activity Source: ARUK-UCLInferred from sequence or structural similarityⁱ
  • 17526495
• positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
• positive regulation of neuron death Source: ARUK-UCL
• positive regulation of neuron projection development Source: Ensembl
• positive regulation of non-membrane spanning protein tyrosine kinase activity Source: Reactome
• positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
• positive regulation of protein kinase B signaling Source: Reactome
• positive regulation of protein localization to membrane Source: ARUK-UCLTraceable author statementⁱ
  • 28386764
• positive regulation of protein localization to nucleus Source: Ensembl
• positive regulation of protein targeting to membrane Source: ARUK-UCL
• positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
• protein phosphorylation Source: ARUK-UCLTraceable author statementⁱ
  • 25707991
• regulation of apoptotic process Source: GO_Central
• regulation of calcium ion import across plasma membrane Source: ARUK-UCL
• regulation of cell proliferation Source: GO_Central
• regulation of cell shape Source: ARUK-UCL
• regulation of defense response to virus by virus Source: Reactome
• regulation of glutamate receptor signaling pathway Source: ARUK-UCL
• regulation of peptidyl-tyrosine phosphorylation Source: ARUK-UCL
• response to amyloid-beta Source: ARUK-UCL
• response to ethanol Source: Ensembl
• response to hydrogen peroxide Source: ARUK-UCLInferred from sequence or structural similarityⁱ
  • 27525436
• response to singlet oxygen Source: ARUK-UCLInferred from sequence or structural similarityⁱ
  • 27525436
• stimulatory C-type lectin receptor signaling pathway Source: Reactome
• T cell activation Source: GO_Central
• T cell costimulation Source: Reactome
• T cell receptor signaling pathway Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 7722293
• transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
• vascular endothelial growth factor receptor signaling pathway Source: Reactome

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• alpha-tubulin binding Source: ARUK-UCL
• CD4 receptor binding Source: Ensembl
• CD8 receptor binding Source: Ensembl
• disordered domain specific binding Source: CAFAInferred from physical interactionⁱ
  • 9351809
• enzyme binding Source: ARUK-UCLInferred from physical interactionⁱ
  • 27525436
• ephrin receptor binding Source: UniProtKBInferred from physical interactionⁱ
  • 10498895
• growth factor receptor binding Source: UniProtKBInferred from physical interactionⁱ
  • 16479011
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • 14993658
  • 27001024
• ion channel binding Source: Ensembl
• peptide hormone receptor binding Source: Ensembl
• phosphatidylinositol 3-kinase binding Source: Ensembl
• Ras guanyl-nucleotide exchange factor activity Source: Reactome
• tau protein binding Source: ARUK-UCL
• T cell receptor binding Source: Ensembl
• type 5 metabotropic glutamate receptor binding Source: ARUK-UCL

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 3 described isoforms and 13 potential isoforms that are <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>computationally mapped.ⁱShow all

        10         20         30         40         50
MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY 
        60         70         80         90        100
NNFHAAGGQG LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD 
       110        120        130        140        150
LSFHKGEKFQ ILNSSEGDWW EARSLTTGET GYIPSNYVAP VDSIQAEEWY 
       160        170        180        190        200
FGKLGRKDAE RQLLSFGNPR GTFLIRESET TKGAYSLSIR DWDDMKGDHV 
       210        220        230        240        250
KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC RLVVPCHKGM 
       260        270        280        290        300
PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT 
       310        320        330        340        350
LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL 
       360        370        380        390        400
LDFLKDGEGR ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN 
       410        420        430        440        450
GLICKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 
       460        470        480        490        500
SFGILLTELV TKGRVPYPGM NNREVLEQVE RGYRMPCPQD CPISLHELMI 
       510        520        530 
HCWKKDPEER PTFEYLQSFL EDYFTATEPQ YQPGENL               

        10         20         30         40         50
MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY 
        60         70         80         90        100
NNFHAAGGQG LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD 
       110        120        130        140        150
LSFHKGEKFQ ILNSSEGDWW EARSLTTGET GYIPSNYVAP VDSIQAEEWY 
       160        170        180        190        200
FGKLGRKDAE RQLLSFGNPR GTFLIRESET TKGAYSLSIR DWDDMKGDHV 
       210        220        230        240        250
KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSEKADGLCF NLTVIASSCT 
       260        270        280        290        300
PQTSGLAKDA WEVARRSLCL EKKLGQGCFA EVWLGTWNGN TKVAIKTLKP 
       310        320        330        340        350
GTMSPESFLE EAQIMKKLKH DKLVQLYAVV SEEPIYIVTE YMNKGSLLDF 
       360        370        380        390        400
LKDGEGRALK LPNLVDMAAQ VAAGMAYIER MNYIHRDLRS ANILVGNGLI 
       410        420        430        440        450
CKIADFGLAR LIEDNEYTAR QGAKFPIKWT APEAALYGRF TIKSDVWSFG 
       460        470        480        490        500
ILLTELVTKG RVPYPGMNNR EVLEQVERGY RMPCPQDCPI SLHELMIHCW 
       510        520        530 
KKDPEERPTF EYLQSFLEDY FTATEPQYQP GENL                  

        10         20         30         40         50
MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY 
        60         70         80         90        100
NNFHAAGGQG LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD 
       110        120        130        140        150
LSFHKGEKFQ ILNSSEGDWW EARSLTTGET GYIPSNYVAP VDSIQAEEWY 
       160        170        180        190        200
FGKLGRKDAE RQLLSFGNPR GTFLIRESET TKGAYSLSIR DWDDMKGDHV 
       210        220        230        240        250
KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSGTWNGNTK VAIKTLKPGT 
       260        270        280        290        300
MSPESFLEEA QIMKKLKHDK LVQLYAVVSE EPIYIVTEYM NKGSLLDFLK 
       310        320        330        340        350
DGEGRALKLP NLVDMAAQVA AGMAYIERMN YIHRDLRSAN ILVGNGLICK 
       360        370        380        390        400
IADFGLARLI EDNEYTARQG AKFPIKWTAP EAALYGRFTI KSDVWSFGIL 
       410        420        430        440        450
LTELVTKGRV PYPGMNNREV LEQVERGYRM PCPQDCPISL HELMIHCWKK 
       460        470        480 
DPEERPTFEY LQSFLEDYFT ATEPQYQPGE NL                    

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ