FYN

Functionⁱ

Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.20 Publications

Catalytic activityⁱ

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Cofactorⁱ

Mn²⁺

Activity regulationⁱ

Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	299	ATPPROSITE-ProRule annotation		1
Active siteⁱ	390	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	277 – 285	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

alpha-tubulin binding Source: ARUK-UCL
ATP binding Source: UniProtKB-KW
CD4 receptor binding Source: Ensembl
CD8 receptor binding Source: Ensembl
disordered domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 9351809
enzyme binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 27525436
ephrin receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10498895
growth factor receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16479011
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 14993658
- 27001024
ion channel binding Source: Ensembl
metal ion binding Source: UniProtKB-KW
non-membrane spanning protein tyrosine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
peptide hormone receptor binding Source: Ensembl
phosphatidylinositol 3-kinase binding Source: Ensembl
phosphatidylinositol-4,5-bisphosphate 3-kinase activity Source: Reactome
protein tyrosine kinase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16979591
Ras guanyl-nucleotide exchange factor activity Source: Reactome
signaling receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
tau protein binding Source: ARUK-UCL
T cell receptor binding Source: Ensembl
type 5 metabotropic glutamate receptor binding Source: ARUK-UCL

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activated T cell proliferation Source: Ensembl
adaptive immune response Source: UniProtKB-KW
axon guidance Source: Reactome
blood coagulation Source: Reactome
calcium ion transport
Source: UniProtKB
Non-traceable author statementⁱ
- 7822789
cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to glycine
Source: ARUK-UCL
Inferred from sequence or structural similarityⁱ
- 17526495
cellular response to L-glutamate
Source: ARUK-UCL
Inferred from sequence or structural similarityⁱ
- 17526495
cellular response to peptide hormone stimulus Source: Ensembl
cellular response to platelet-derived growth factor stimulus Source: Ensembl
cellular response to transforming growth factor beta stimulus Source: Ensembl
cytokine-mediated signaling pathway Source: Reactome
dendrite morphogenesis Source: Ensembl
dendritic spine maintenance
Source: ARUK-UCL
Traceable author statementⁱ
- 25707991
detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
ephrin receptor signaling pathway Source: Reactome
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
feeding behavior
Source: ProtInc
Traceable author statementⁱ
- 8264796
forebrain development Source: Ensembl
heart process
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 27525436
intracellular signal transduction
Source: ProtInc
Traceable author statementⁱ
- 1361685
learning
Source: ProtInc
Traceable author statementⁱ
- 1361685
leukocyte migration Source: Reactome
MAPK cascade Source: Reactome
modulation of chemical synaptic transmission Source: Ensembl
negative regulation of dendritic spine maintenance Source: ARUK-UCL
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
negative regulation of gene expression Source: Ensembl
negative regulation of hydrogen peroxide biosynthetic process
Source: ARUK-UCL
Inferred from sequence or structural similarityⁱ
- 27525436
negative regulation of neuron apoptotic process Source: Ensembl
negative regulation of oxidative stress-induced cell death
Source: ARUK-UCL
Inferred from sequence or structural similarityⁱ
- 27525436
negative regulation of protein catabolic process Source: Ensembl
negative regulation of protein ubiquitination Source: Ensembl
neuron migration Source: Ensembl
peptidyl-tyrosine autophosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
peptidyl-tyrosine phosphorylation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16979591
platelet activation Source: Reactome
positive regulation of cysteine-type endopeptidase activity
Source: ARUK-UCL
Inferred from sequence or structural similarityⁱ
- 17526495
positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
positive regulation of neuron death Source: ARUK-UCL
positive regulation of neuron projection development Source: Ensembl
positive regulation of non-membrane spanning protein tyrosine kinase activity Source: Reactome
positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
positive regulation of protein kinase B signaling Source: Reactome
positive regulation of protein localization to membrane
Source: ARUK-UCL
Traceable author statementⁱ
- 28386764
positive regulation of protein localization to nucleus Source: Ensembl
positive regulation of protein targeting to membrane Source: ARUK-UCL
positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
protein phosphorylation
Source: ARUK-UCL
Traceable author statementⁱ
- 25707991
regulation of calcium ion import across plasma membrane Source: ARUK-UCL
regulation of cell shape Source: ARUK-UCL
regulation of defense response to virus by virus Source: Reactome
regulation of glutamate receptor signaling pathway Source: ARUK-UCL
regulation of peptidyl-tyrosine phosphorylation Source: ARUK-UCL
response to amyloid-beta Source: ARUK-UCL
response to ethanol Source: Ensembl
response to hydrogen peroxide
Source: ARUK-UCL
Inferred from sequence or structural similarityⁱ
- 27525436
response to singlet oxygen
Source: ARUK-UCL
Inferred from sequence or structural similarityⁱ
- 27525436
stimulatory C-type lectin receptor signaling pathway Source: Reactome
T cell costimulation Source: Reactome
T cell receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 7722293
transmembrane receptor protein tyrosine kinase signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
vascular endothelial growth factor receptor signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Kinase, Transferase, Tyrosine-protein kinase
Biological process	Adaptive immunity, Host-virus interaction, Immunity
Ligand	ATP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.10.2 2681
Reactomeⁱ	R-HSA-114604 GPVI-mediated activation cascade R-HSA-1227986 Signaling by ERBB2 R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1433557 Signaling by SCF-KIT R-HSA-1433559 Regulation of KIT signaling R-HSA-164944 Nef and signal transduction R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-2029481 FCGR activation R-HSA-210990 PECAM1 interactions R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2424491 DAP12 signaling R-HSA-2682334 EPH-Ephrin signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-373753 Nephrin family interactions R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-389356 CD28 co-stimulation R-HSA-389357 CD28 dependent PI3K/Akt signaling R-HSA-389359 CD28 dependent Vav1 pathway R-HSA-389513 CTLA4 inhibitory signaling R-HSA-3928662 EPHB-mediated forward signaling R-HSA-3928663 EPHA-mediated growth cone collapse R-HSA-3928664 Ephrin signaling R-HSA-3928665 EPH-ephrin mediated repulsion of cells R-HSA-399954 Sema3A PAK dependent Axon repulsion R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399956 CRMPs in Sema3A signaling R-HSA-418885 DCC mediated attractive signaling R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-5621480 Dectin-2 family R-HSA-5621575 CD209 (DC-SIGN) signaling R-HSA-5673001 RAF/MAP kinase cascade R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-75892 Platelet Adhesion to exposed collagen R-HSA-8866376 Reelin signalling pathway R-HSA-9032500 Activated NTRK2 signals through FYN R-HSA-9032759 NTRK2 activates RAC1 R-HSA-912631 Regulation of signaling by CBL R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkⁱ	P06241
SIGNORⁱ	P06241

Protein family/group databases

MoonDBⁱ	P06241 Predicted

MoonDBⁱ

P06241 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tyrosine-protein kinase Fyn (EC:2.7.10.2) Alternative name(s): Proto-oncogene Syn Proto-oncogene c-Fyn Src-like kinase Short name: SLK p59-Fyn
Gene namesⁱ	Name:FYN
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000010810.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4037 FYN
MIMⁱ	137025 gene
neXtProtⁱ	NX_P06241

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2534
Open Targets More...OpenTargetsⁱ	ENSG00000010810
PharmGKBⁱ	PA28454

Chemistry databases

ChEMBLⁱ	CHEMBL1841
Drug and drug target database More...DrugBankⁱ	DB02078 1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane DB01254 Dasatinib
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2026

Polymorphism and mutation databases

BioMutaⁱ	FYN
DMDMⁱ	125370

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed
ChainⁱPRO_0000088099	2 – 537	Tyrosine-protein kinase FynAdd BLAST		536

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Lipidationⁱ	2	N-myristoyl glycine1 Publication	1
Lipidationⁱ	3	S-palmitoyl cysteineBy similarity	1
Lipidationⁱ	6	S-palmitoyl cysteineBy similarity	1
Modified residueⁱ	12	Phosphothreonine; by PKC1 Publication	1
Modified residueⁱ	21	PhosphoserineCombined sources	1
Modified residueⁱ	26	PhosphoserineCombined sources	1
Modified residueⁱ	185	PhosphotyrosineBy similarity	1
Modified residueⁱ	420	Phosphotyrosine; by autocatalysisBy similarity	1
Modified residueⁱ	531	Phosphotyrosine; by CSKCombined sources1 Publication	1

Post-translational modificationⁱ

Autophosphorylated at Tyr-420. Phosphorylation on the C-terminal tail at Tyr-531 by CSK maintains the enzyme in an inactive state (By similarity). PTPRC/CD45 dephosphorylates Tyr-531 leading to activation. Ultraviolet B (UVB) strongly increase phosphorylation at Thr-12 and kinase activity, and promotes translocation from the cytoplasm to the nucleus. Dephosphorylation at Tyr-420 by PTPN2 negatively regulates T-cell receptor signaling.By similarity4 Publications

Palmitoylation at Cys-3 and Cys-6 regulates subcellular location.By similarity

Keywords - PTMⁱ

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

EPDⁱ	P06241
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P06241
PaxDbⁱ	P06241
PeptideAtlas More...PeptideAtlasⁱ	P06241
PRIDEⁱ	P06241
ProteomicsDBⁱ	51877 51878 [P06241-2] 51879 [P06241-3]

PTM databases

iPTMnetⁱ	P06241
PhosphoSitePlusⁱ	P06241
SwissPalmⁱ	P06241

Miscellaneous databases

PMAP-CutDBⁱ	P06241

PMAP-CutDBⁱ

P06241

Expressionⁱ

Tissue specificityⁱ

Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000010810 Expressed in 232 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_FYN
ExpressionAtlasⁱ	P06241 baseline and differential
Genevisibleⁱ	P06241 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB005034 CAB018387 HPA023887 HPA063770

HPAⁱ

CAB005034
CAB018387
HPA023887
HPA063770

Interactionⁱ

Subunit structureⁱ

Interacts (via its SH3 domain) with PIK3R1 and PRMT8. Interacts with FYB1, PAG1, and SH2D1A. Interacts with CD79A (tyrosine-phosphorylated form); the interaction increases FYN activity. Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (By similarity). Interacts with TOM1L1 (phosphorylated form). Interacts with KDR (tyrosine phosphorylated). Interacts (via SH3 domain) with KLHL2 (via N-terminus) (By similarity). Interacts with SH2D1A and SLAMF1. Interacts with ITCH; the interaction phosphorylates ITCH and negatively regulates its activity. Interacts with FASLG. Interacts with RUNX3. Interacts with KIT. Interacts with EPHA8; possible downstream effector of EPHA8 in regulation of cell adhesion. Interacts with PTK2/FAK1; this interaction leads to PTK2/FAK1 phosphorylation and activation. Interacts with CAV1; this interaction couples integrins to the Ras-ERK pathway. Interacts with UNC119. Interacts (via SH2 domain) with PTPRH (phosphorylated form) (By similarity). Interacts with PTPRO (phosphorylated form) (By similarity). Interacts with PTPRB (phosphorylated form) (By similarity). Interacts with FYB2 (PubMed:27335501).By similarity14 Publications

(Microbial infection) Interacts (via its SH3 domain) with hepatitis E virus/HEV protein ORF3.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		2	EBI-515315,EBI-515315
	O92972	2	EBI-515315,EBI-710506	From Hepatitis C virus genotype 1b (strain HC-J4).
	P27958	4	EBI-515315,EBI-706378	From Hepatitis C virus genotype 1a (isolate H).
	Q9WMX2	2	EBI-515315,EBI-710918	From Hepatitis C virus genotype 1b (isolate Con1).
ABL2	P42684	2	EBI-515315,EBI-1102694
ADAM15	Q13444	2	EBI-515315,EBI-77818
ARHGAP32	A7KAX9	4	EBI-515315,EBI-308663
ARHGAP33	O14559	2	EBI-515315,EBI-1210010
ASAP1	Q9ULH1	3	EBI-515315,EBI-346622
BCAR1	P56945	3	EBI-515315,EBI-702093
CBLB	Q13191	3	EBI-10691738,EBI-744027
EFS	O43281	3	EBI-515315,EBI-718488
ERBB2	P04626	2	EBI-515315,EBI-641062
FASLG	P48023	2	EBI-515315,EBI-495538
FN1	P02751-7	2	EBI-515315,EBI-7133890
FYB1	O15117	4	EBI-515315,EBI-1753267
GP6	Q9HCN6	2	EBI-515315,EBI-515278
GP6	Q9HCN6-1	2	EBI-515315,EBI-15816577
Grm5	P31424-2	2	EBI-515315,EBI-8830305	From a different organism.
HSP90AB1	P08238	2	EBI-515315,EBI-352572
HTR6	P50406	7	EBI-515315,EBI-1182222
KHDRBS1	Q07666	4	EBI-515315,EBI-1364
MAP4K1	Q92918	2	EBI-515315,EBI-881
MED28	Q9H204	6	EBI-515315,EBI-514199
NCKIPSD	Q9NZQ3	2	EBI-515315,EBI-745080
NELFB	Q8WX92	2	EBI-515315,EBI-347721
PAG1	Q9NWQ8	5	EBI-515315,EBI-2828115
PDCD6IP	Q8WUM4	6	EBI-515315,EBI-310624
PDGFRB	P09619	3	EBI-515315,EBI-641237
PRICKLE3	O43900	2	EBI-515315,EBI-1751761
PRKCD	Q05655	5	EBI-515315,EBI-704279
PRKCQ	Q04759	7	EBI-515315,EBI-374762
RAPGEF1	Q13905	2	EBI-515315,EBI-976876
Slamf7	Q8BHK6	2	EBI-515315,EBI-11463802	From Mus musculus.
WBP11	Q9Y2W2	3	EBI-515315,EBI-714455

GO - Molecular functionⁱ

alpha-tubulin binding Source: ARUK-UCL
CD4 receptor binding Source: Ensembl
CD8 receptor binding Source: Ensembl
disordered domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 9351809
enzyme binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 27525436
ephrin receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10498895
growth factor receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16479011
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 14993658
- 27001024
ion channel binding Source: Ensembl
peptide hormone receptor binding Source: Ensembl
phosphatidylinositol 3-kinase binding Source: Ensembl
Ras guanyl-nucleotide exchange factor activity Source: Reactome
signaling receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
tau protein binding Source: ARUK-UCL
T cell receptor binding Source: Ensembl
type 5 metabotropic glutamate receptor binding Source: ARUK-UCL

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108810, 189 interactors
CORUMⁱ	P06241
Database of interacting proteins More...DIPⁱ	DIP-33876N
ELMⁱ	P06241
IntActⁱ	P06241, 245 interactors
Molecular INTeraction database More...MINTⁱ	P06241
STRINGⁱ	9606.ENSP00000346671

Chemistry databases

BindingDBⁱ

P06241

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	87 – 91	Combined sources	5
Beta strandⁱ	96 – 100	Combined sources	5
Beta strandⁱ	108 – 113	Combined sources	6
Beta strandⁱ	115 – 124	Combined sources	10
Turnⁱ	125 – 127	Combined sources	3
Beta strandⁱ	130 – 134	Combined sources	5
Helixⁱ	135 – 137	Combined sources	3
Beta strandⁱ	138 – 141	Combined sources	4
Helixⁱ	144 – 146	Combined sources	3
Beta strandⁱ	147 – 150	Combined sources	4
Helixⁱ	156 – 163	Combined sources	8
Turnⁱ	165 – 167	Combined sources	3
Beta strandⁱ	172 – 177	Combined sources	6
Beta strandⁱ	179 – 181	Combined sources	3
Beta strandⁱ	185 – 193	Combined sources	9
Turnⁱ	194 – 196	Combined sources	3
Beta strandⁱ	197 – 207	Combined sources	11
Turnⁱ	209 – 211	Combined sources	3
Beta strandⁱ	213 – 216	Combined sources	4
Beta strandⁱ	219 – 223	Combined sources	5
Helixⁱ	224 – 233	Combined sources	10
Beta strandⁱ	238 – 240	Combined sources	3
Beta strandⁱ	263 – 265	Combined sources	3
Helixⁱ	268 – 270	Combined sources	3
Beta strandⁱ	271 – 278	Combined sources	8
Beta strandⁱ	285 – 290	Combined sources	6
Turnⁱ	291 – 293	Combined sources	3
Beta strandⁱ	294 – 299	Combined sources	6
Turnⁱ	303 – 305	Combined sources	3
Helixⁱ	308 – 318	Combined sources	11
Beta strandⁱ	329 – 333	Combined sources	5
Beta strandⁱ	335 – 337	Combined sources	3
Beta strandⁱ	339 – 343	Combined sources	5
Helixⁱ	350 – 354	Combined sources	5
Beta strandⁱ	355 – 357	Combined sources	3
Turnⁱ	358 – 360	Combined sources	3
Helixⁱ	364 – 383	Combined sources	20
Helixⁱ	393 – 395	Combined sources	3
Beta strandⁱ	396 – 399	Combined sources	4
Turnⁱ	400 – 402	Combined sources	3
Beta strandⁱ	403 – 406	Combined sources	4
Beta strandⁱ	416 – 418	Combined sources	3
Turnⁱ	430 – 432	Combined sources	3
Helixⁱ	435 – 438	Combined sources	4
Helixⁱ	445 – 460	Combined sources	16
Helixⁱ	472 – 481	Combined sources	10
Helixⁱ	496 – 502	Combined sources	7
Helixⁱ	507 – 509	Combined sources	3
Helixⁱ	513 – 521	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	P06241
SMRⁱ	P06241
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P06241

EvolutionaryTraceⁱ

P06241

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	82 – 143	SH3PROSITE-ProRule annotationAdd BLAST	62
Domainⁱ	149 – 246	SH2PROSITE-ProRule annotationAdd BLAST	98
Domainⁱ	271 – 524	Protein kinasePROSITE-ProRule annotationAdd BLAST	254

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGⁱ	KOG0197 Eukaryota COG0515 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118938
HOVERGENⁱ	HBG008761
InParanoidⁱ	P06241
KEGG Orthology (KO) More...KOⁱ	K05703
OMAⁱ	SHNSGYR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0D46
PhylomeDBⁱ	P06241
TreeFamⁱ	TF351634

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12006 SH3_Fyn_Yrk, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR035750 Fyn/Yrk_SH3 IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR000980 SH2 IPR036860 SH2_dom_sf IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07714 Pkinase_Tyr, 1 hit PF00017 SH2, 1 hit PF00018 SH3_1, 1 hit
PRINTSⁱ	PR00401 SH2DOMAIN PR00452 SH3DOMAIN PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit SM00326 SH3, 1 hit SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF50044 SSF50044, 1 hit SSF55550 SSF55550, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS50001 SH2, 1 hit PS50002 SH3, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 13 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P06241-1) [UniParc]FASTA Add to basket

Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY 
        60         70         80         90        100
NNFHAAGGQG LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD 
       110        120        130        140        150
LSFHKGEKFQ ILNSSEGDWW EARSLTTGET GYIPSNYVAP VDSIQAEEWY 
       160        170        180        190        200
FGKLGRKDAE RQLLSFGNPR GTFLIRESET TKGAYSLSIR DWDDMKGDHV 
       210        220        230        240        250
KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC RLVVPCHKGM 
       260        270        280        290        300
PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT 
       310        320        330        340        350
LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL 
       360        370        380        390        400
LDFLKDGEGR ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN 
       410        420        430        440        450
GLICKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 
       460        470        480        490        500
SFGILLTELV TKGRVPYPGM NNREVLEQVE RGYRMPCPQD CPISLHELMI 
       510        520        530 
HCWKKDPEER PTFEYLQSFL EDYFTATEPQ YQPGENL

Length:537

Mass (Da):60,762

Last modified:January 23, 2007 - v3

Checksum:ⁱ4A1E443A4B5A0977

GO

Isoform 2 (identifier: P06241-2) [UniParc]FASTA Add to basket

Also known as: T

The sequence of this isoform differs from the canonical sequence as follows:
234-287: RAAGLCCRLV...GNGQFGEVWM → KADGLCFNLT...GQGCFAEVWL

« Hide

        10         20         30         40         50
MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY 
        60         70         80         90        100
NNFHAAGGQG LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD 
       110        120        130        140        150
LSFHKGEKFQ ILNSSEGDWW EARSLTTGET GYIPSNYVAP VDSIQAEEWY 
       160        170        180        190        200
FGKLGRKDAE RQLLSFGNPR GTFLIRESET TKGAYSLSIR DWDDMKGDHV 
       210        220        230        240        250
KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSEKADGLCF NLTVIASSCT 
       260        270        280        290        300
PQTSGLAKDA WEVARRSLCL EKKLGQGCFA EVWLGTWNGN TKVAIKTLKP 
       310        320        330        340        350
GTMSPESFLE EAQIMKKLKH DKLVQLYAVV SEEPIYIVTE YMNKGSLLDF 
       360        370        380        390        400
LKDGEGRALK LPNLVDMAAQ VAAGMAYIER MNYIHRDLRS ANILVGNGLI 
       410        420        430        440        450
CKIADFGLAR LIEDNEYTAR QGAKFPIKWT APEAALYGRF TIKSDVWSFG 
       460        470        480        490        500
ILLTELVTKG RVPYPGMNNR EVLEQVERGY RMPCPQDCPI SLHELMIHCW 
       510        520        530 
KKDPEERPTF EYLQSFLEDY FTATEPQYQP GENL

Show »

Length:534

Mass (Da):60,141

Checksum:ⁱFA082D40A24C2802

GO

Isoform 3 (identifier: P06241-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
233-287: Missing.

« Hide

        10         20         30         40         50
MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY 
        60         70         80         90        100
NNFHAAGGQG LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD 
       110        120        130        140        150
LSFHKGEKFQ ILNSSEGDWW EARSLTTGET GYIPSNYVAP VDSIQAEEWY 
       160        170        180        190        200
FGKLGRKDAE RQLLSFGNPR GTFLIRESET TKGAYSLSIR DWDDMKGDHV 
       210        220        230        240        250
KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSGTWNGNTK VAIKTLKPGT 
       260        270        280        290        300
MSPESFLEEA QIMKKLKHDK LVQLYAVVSE EPIYIVTEYM NKGSLLDFLK 
       310        320        330        340        350
DGEGRALKLP NLVDMAAQVA AGMAYIERMN YIHRDLRSAN ILVGNGLICK 
       360        370        380        390        400
IADFGLARLI EDNEYTARQG AKFPIKWTAP EAALYGRFTI KSDVWSFGIL 
       410        420        430        440        450
LTELVTKGRV PYPGMNNREV LEQVERGYRM PCPQDCPISL HELMIHCWKK 
       460        470        480 
DPEERPTFEY LQSFLEDYFT ATEPQYQPGE NL

Note: No experimental confirmation available.

Show »

Length:482

Mass (Da):54,513

Checksum:ⁱ055C3965AC5A9135

GO

Computationally mapped potential isoform sequencesⁱ

There are 13 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	E5RFS5	E5RFS5_HUMAN	Tyrosine-protein kinase Fyn Tyrosine-protein kinase Fyn	FYN	232	Annotation score:
	E5RIX5	E5RIX5_HUMAN	Tyrosine-protein kinase Fyn Tyrosine-protein kinase Fyn	FYN	186	Annotation score:
	E5RH71	E5RH71_HUMAN	Tyrosine-protein kinase Fyn Tyrosine-protein kinase Fyn	FYN	175	Annotation score:
	E5RGT0	E5RGT0_HUMAN	Tyrosine-protein kinase Fyn Tyrosine-protein kinase Fyn	FYN	153	Annotation score:
	E5RFM0	E5RFM0_HUMAN	Tyrosine-protein kinase Fyn Tyrosine-protein kinase Fyn	FYN	152	Annotation score:
	E5RI25	E5RI25_HUMAN	Tyrosine-protein kinase Fyn Tyrosine-protein kinase Fyn	FYN	145	Annotation score:
	E5RGM6	E5RGM6_HUMAN	Tyrosine-protein kinase Fyn Tyrosine-protein kinase Fyn	FYN	139	Annotation score:
	E5RFM4	E5RFM4_HUMAN	Tyrosine-protein kinase Fyn Tyrosine-protein kinase Fyn	FYN	116	Annotation score:
	E5RHF7	E5RHF7_HUMAN	Tyrosine-protein kinase Fyn Tyrosine-protein kinase Fyn	FYN	118	Annotation score:
	E5RK23	E5RK23_HUMAN	Tyrosine-protein kinase Fyn Tyrosine-protein kinase Fyn	FYN	106	Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	184	A → S in AAA36615 (PubMed:3099169).Curated	1
Sequence conflictⁱ	437	A → R in AAA36615 (PubMed:3099169).Curated	1
Sequence conflictⁱ	437	A → R in AAB33113 (PubMed:7822789).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_041704	243	V → L in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_041705	410	G → R in a metastatic melanoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_014661	445	I → F. Corresponds to variant dbSNP:rs1801121Ensembl.	1
Natural variantⁱVAR_041706	506	D → E1 PublicationCorresponds to variant dbSNP:rs28763975Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_024108	233 – 287	Missing in isoform 3. 1 PublicationAdd BLAST		55
Alternative sequenceⁱVSP_024110	234 – 287	RAAGL…GEVWM → KADGLCFNLTVIASSCTPQT SGLAKDAWEVARRSLCLEKK LGQGCFAEVWL in isoform 2. 1 PublicationAdd BLAST		54

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14676 mRNA Translation: AAA36615.1 M14333 mRNA Translation: AAC08285.1 S74774 mRNA Translation: AAB33113.2 AB451293 mRNA Translation: BAG70107.1 AB451426 mRNA Translation: BAG70240.1 Z97989 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48278.1 CH471051 Genomic DNA Translation: EAW48279.1 CH471051 Genomic DNA Translation: EAW48281.1 CH471051 Genomic DNA Translation: EAW48282.1 CH471051 Genomic DNA Translation: EAW48283.1 BC032496 mRNA Translation: AAH32496.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5094.1 [P06241-1] CCDS5095.1 [P06241-2] CCDS5096.1 [P06241-3]
PIRⁱ	A24314 TVHUSY
NCBI Reference Sequences More...RefSeqⁱ	NP_002028.1, NM_002037.5 [P06241-1] NP_694592.1, NM_153047.3 [P06241-2] NP_694593.1, NM_153048.3 [P06241-3] XP_005266947.1, XM_005266890.3 [P06241-2] XP_005266949.1, XM_005266892.3 [P06241-3] XP_016866139.1, XM_017010650.1 [P06241-1] XP_016866140.1, XM_017010651.1 [P06241-1] XP_016866141.1, XM_017010652.1 [P06241-1] XP_016866142.1, XM_017010653.1 [P06241-1] XP_016866143.1, XM_017010654.1 [P06241-1]
UniGeneⁱ	Hs.390567 Hs.664520

Genome annotation databases

Ensemblⁱ	ENST00000229471; ENSP00000229471; ENSG00000010810 [P06241-3] ENST00000354650; ENSP00000346671; ENSG00000010810 [P06241-1] ENST00000368667; ENSP00000357656; ENSG00000010810 [P06241-1] ENST00000368678; ENSP00000357667; ENSG00000010810 [P06241-2] ENST00000368682; ENSP00000357671; ENSG00000010810 [P06241-2] ENST00000538466; ENSP00000440646; ENSG00000010810 [P06241-2]
GeneIDⁱ	2534
KEGGⁱ	hsa:2534
UCSC genome browser More...UCSCⁱ	uc003pvh.3 human [P06241-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P06241	Tyrosine-protein kinase		PANTR		537	UniRef100_P06241
Tyrosine-protein kinase		MACMU		537
Tyrosine-protein kinase		GORGO		537
Tyrosine-protein kinase		RHIBE		537
Tyrosine-protein kinase		RHIRO		537
+12
P06241-2	Tyrosine-protein kinase		PANTR		534	UniRef100_H2QTK7
Tyrosine-protein kinase		MACMU		534
Tyrosine-protein kinase		PONAB		534
Tyrosine-protein kinase		CERAT		534
Tyrosine-protein kinase		gibbon		534
+9
P06241-3	Tyrosine-protein kinase		PANTR		482	UniRef100_A0A2I3TUY5
Tyrosine-protein kinase		MACMU		482
Tyrosine-protein kinase		COLAP		482
Tyrosine-protein kinase		PONAB		482
Tyrosine-protein kinase		CERAT		482
+9

Protein	Similar proteins		Species	Score	Length	Source
P06241	Tyrosine-protein kinase fynb		DANRE		544	UniRef90_P06241
Tyrosine-protein kinase Fyn		RAT		537
Tyrosine-protein kinase Fyn		BOVIN		537
Tyrosine-protein kinase Fyn	)	MOUSE		537
Tyrosine-protein kinase Fyn		PIG		537
+318
P06241-3	Tyrosine-protein kinase		MOUSE		482	UniRef90_D3YZ57
Tyrosine-protein kinase		SALSA		485
Tyrosine-protein kinase		PANTR		482
Tyrosine-protein kinase		MACMU		482
Tyrosine-protein kinase		COLAP		482
+55

Protein	Similar proteins		Species	Score	Length	Source
P06241	Tyrosine-protein kinase fynb		DANRE		544	UniRef50_P06241
Tyrosine-protein kinase Fyn		RAT		537
Tyrosine-protein kinase Fyn		BOVIN		537
Tyrosine-protein kinase Fyn	)	MOUSE		537
Tyrosine-protein kinase Fyn		PIG		537
+805
P06241-3	Tyrosine-protein kinase		CERAT		496	UniRef50_A0A2K5P2G4
Uncharacterized protein		PAPAN		509
FGR proto-oncogene, Src family tyrosine kinase		GORGO		509
Uncharacterized protein		MACMU		509
Uncharacterized protein		MACFA		509
+129

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14676 mRNA Translation: AAA36615.1 M14333 mRNA Translation: AAC08285.1 S74774 mRNA Translation: AAB33113.2 AB451293 mRNA Translation: BAG70107.1 AB451426 mRNA Translation: BAG70240.1 Z97989 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48278.1 CH471051 Genomic DNA Translation: EAW48279.1 CH471051 Genomic DNA Translation: EAW48281.1 CH471051 Genomic DNA Translation: EAW48282.1 CH471051 Genomic DNA Translation: EAW48283.1 BC032496 mRNA Translation: AAH32496.1
CCDSⁱ	CCDS5094.1 [P06241-1] CCDS5095.1 [P06241-2] CCDS5096.1 [P06241-3]
PIRⁱ	A24314 TVHUSY
RefSeqⁱ	NP_002028.1, NM_002037.5 [P06241-1] NP_694592.1, NM_153047.3 [P06241-2] NP_694593.1, NM_153048.3 [P06241-3] XP_005266947.1, XM_005266890.3 [P06241-2] XP_005266949.1, XM_005266892.3 [P06241-3] XP_016866139.1, XM_017010650.1 [P06241-1] XP_016866140.1, XM_017010651.1 [P06241-1] XP_016866141.1, XM_017010652.1 [P06241-1] XP_016866142.1, XM_017010653.1 [P06241-1] XP_016866143.1, XM_017010654.1 [P06241-1]
UniGeneⁱ	Hs.390567 Hs.664520

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1A0N	NMR	-	B	80-148	[»]
	1AOT	NMR	-	F	143-248	[»]
	1AOU	NMR	-	F	143-248	[»]
	1AVZ	X-ray	3.00	C	85-141	[»]
	1AZG	NMR	-	B	82-148	[»]
	1EFN	X-ray	2.50	A/C	86-143	[»]
	1FYN	X-ray	2.30	A	81-142	[»]
	1G83	X-ray	2.60	A/B	82-246	[»]
	1M27	X-ray	2.50	C	84-144	[»]
	1NYF	NMR	-	A	82-148	[»]
	1NYG	NMR	-	A	82-148	[»]
	1SHF	X-ray	1.90	A/B	84-142	[»]
	1ZBJ	NMR	-	A	84-142	[»]
	2DQ7	X-ray	2.80	X	261-537	[»]
	2MQI	NMR	-	A	148-248	[»]
	2MRJ	NMR	-	A	148-248	[»]
	2MRK	NMR	-	A	149-248	[»]
				B	528-537	[»]
	3H0F	X-ray	2.61	A	73-142	[»]
	3H0H	X-ray	1.76	A	73-142	[»]
	3H0I	X-ray	2.20	A/B	73-142	[»]
	3UA6	X-ray	1.85	A/B	81-143	[»]
	3UA7	X-ray	1.50	A/B/C/D	81-143	[»]
	4D8D	X-ray	2.52	A/C	84-141	[»]
	4EIK	X-ray	1.60	A	81-143	[»]
	4U17	X-ray	1.99	A/B/C	148-248	[»]
	4U1P	X-ray	1.40	A	148-248	[»]
	4ZNX	X-ray	2.10	A/B/C/D	84-141	[»]
ProteinModelPortalⁱ	P06241
SMRⁱ	P06241
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108810, 189 interactors
CORUMⁱ	P06241
DIPⁱ	DIP-33876N
ELMⁱ	P06241
IntActⁱ	P06241, 245 interactors
MINTⁱ	P06241
STRINGⁱ	9606.ENSP00000346671

Chemistry databases

BindingDBⁱ	P06241
ChEMBLⁱ	CHEMBL1841
DrugBankⁱ	DB02078 1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane DB01254 Dasatinib
GuidetoPHARMACOLOGYⁱ	2026

Protein family/group databases

MoonDBⁱ	P06241 Predicted

MoonDBⁱ

P06241 Predicted

PTM databases

iPTMnetⁱ	P06241
PhosphoSitePlusⁱ	P06241
SwissPalmⁱ	P06241

Polymorphism and mutation databases

BioMutaⁱ	FYN
DMDMⁱ	125370

Proteomic databases

EPDⁱ	P06241
MaxQBⁱ	P06241
PaxDbⁱ	P06241
PeptideAtlasⁱ	P06241
PRIDEⁱ	P06241
ProteomicsDBⁱ	51877 51878 [P06241-2] 51879 [P06241-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2534
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000229471; ENSP00000229471; ENSG00000010810 [P06241-3] ENST00000354650; ENSP00000346671; ENSG00000010810 [P06241-1] ENST00000368667; ENSP00000357656; ENSG00000010810 [P06241-1] ENST00000368678; ENSP00000357667; ENSG00000010810 [P06241-2] ENST00000368682; ENSP00000357671; ENSG00000010810 [P06241-2] ENST00000538466; ENSP00000440646; ENSG00000010810 [P06241-2]
GeneIDⁱ	2534
KEGGⁱ	hsa:2534
UCSCⁱ	uc003pvh.3 human [P06241-1]

Organism-specific databases

CTDⁱ	2534
DisGeNETⁱ	2534
EuPathDBⁱ	HostDB:ENSG00000010810.17
GeneCardsⁱ	FYN
HGNCⁱ	HGNC:4037 FYN
HPAⁱ	CAB005034 CAB018387 HPA023887 HPA063770
MIMⁱ	137025 gene
neXtProtⁱ	NX_P06241
OpenTargetsⁱ	ENSG00000010810
PharmGKBⁱ	PA28454
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0197 Eukaryota COG0515 LUCA
GeneTreeⁱ	ENSGT00760000118938
HOVERGENⁱ	HBG008761
InParanoidⁱ	P06241
KOⁱ	K05703
OMAⁱ	SHNSGYR
OrthoDBⁱ	EOG091G0D46
PhylomeDBⁱ	P06241
TreeFamⁱ	TF351634

Enzyme and pathway databases

BRENDAⁱ	2.7.10.2 2681
Reactomeⁱ	R-HSA-114604 GPVI-mediated activation cascade R-HSA-1227986 Signaling by ERBB2 R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1433557 Signaling by SCF-KIT R-HSA-1433559 Regulation of KIT signaling R-HSA-164944 Nef and signal transduction R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-2029481 FCGR activation R-HSA-210990 PECAM1 interactions R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2424491 DAP12 signaling R-HSA-2682334 EPH-Ephrin signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-373753 Nephrin family interactions R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-389356 CD28 co-stimulation R-HSA-389357 CD28 dependent PI3K/Akt signaling R-HSA-389359 CD28 dependent Vav1 pathway R-HSA-389513 CTLA4 inhibitory signaling R-HSA-3928662 EPHB-mediated forward signaling R-HSA-3928663 EPHA-mediated growth cone collapse R-HSA-3928664 Ephrin signaling R-HSA-3928665 EPH-ephrin mediated repulsion of cells R-HSA-399954 Sema3A PAK dependent Axon repulsion R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion R-HSA-399956 CRMPs in Sema3A signaling R-HSA-418885 DCC mediated attractive signaling R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-5621480 Dectin-2 family R-HSA-5621575 CD209 (DC-SIGN) signaling R-HSA-5673001 RAF/MAP kinase cascade R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-75892 Platelet Adhesion to exposed collagen R-HSA-8866376 Reelin signalling pathway R-HSA-9032500 Activated NTRK2 signals through FYN R-HSA-9032759 NTRK2 activates RAC1 R-HSA-912631 Regulation of signaling by CBL R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkⁱ	P06241
SIGNORⁱ	P06241

Miscellaneous databases

ChiTaRSⁱ	FYN human
EvolutionaryTraceⁱ	P06241
GeneWikiⁱ	FYN
GenomeRNAiⁱ	2534
PMAP-CutDBⁱ	P06241
Protein Ontology More...PROⁱ	PR:P06241
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000010810 Expressed in 232 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_FYN
ExpressionAtlasⁱ	P06241 baseline and differential
Genevisibleⁱ	P06241 HS

Family and domain databases

CDDⁱ	cd12006 SH3_Fyn_Yrk, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR035750 Fyn/Yrk_SH3 IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR000980 SH2 IPR036860 SH2_dom_sf IPR036028 SH3-like_dom_sf IPR001452 SH3_domain IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom
Pfamⁱ	View protein in Pfam PF07714 Pkinase_Tyr, 1 hit PF00017 SH2, 1 hit PF00018 SH3_1, 1 hit
PRINTSⁱ	PR00401 SH2DOMAIN PR00452 SH3DOMAIN PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit SM00326 SH3, 1 hit SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF50044 SSF50044, 1 hit SSF55550 SSF55550, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS50001 SH2, 1 hit PS50002 SH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FYN_HUMAN
Accessionⁱ	P06241Primary (citable) accession number: P06241 Secondary accession number(s): B5BU57 Q8N5D7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 238 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - P06241 (FYN_HUMAN)

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Tyrosine-protein kinase Fyn

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Plasma membrane

Other locations

Cytoskeleton

Cytosol

Endoplasmic reticulum

Endosome

Mitochondrion

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ