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Entry version 254 (12 Aug 2020)
Sequence version 3 (23 Jan 2007)
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Protein

Tyrosine-protein kinase Fyn

Gene

FYN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity).By similarity20 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei299ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei390Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi277 – 285ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Transferase, Tyrosine-protein kinase
Biological processAdaptive immunity, Host-virus interaction, Immunity
LigandATP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.7.10.2, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P06241

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-114604, GPVI-mediated activation cascade
R-HSA-1227986, Signaling by ERBB2
R-HSA-1257604, PIP3 activates AKT signaling
R-HSA-1433557, Signaling by SCF-KIT
R-HSA-1433559, Regulation of KIT signaling
R-HSA-164944, Nef and signal transduction
R-HSA-202733, Cell surface interactions at the vascular wall
R-HSA-2029481, FCGR activation
R-HSA-210990, PECAM1 interactions
R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-2424491, DAP12 signaling
R-HSA-2682334, EPH-Ephrin signaling
R-HSA-2730905, Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-373753, Nephrin family interactions
R-HSA-375165, NCAM signaling for neurite out-growth
R-HSA-389356, CD28 co-stimulation
R-HSA-389357, CD28 dependent PI3K/Akt signaling
R-HSA-389359, CD28 dependent Vav1 pathway
R-HSA-389513, CTLA4 inhibitory signaling
R-HSA-3928662, EPHB-mediated forward signaling
R-HSA-3928663, EPHA-mediated growth cone collapse
R-HSA-3928664, Ephrin signaling
R-HSA-3928665, EPH-ephrin mediated repulsion of cells
R-HSA-399954, Sema3A PAK dependent Axon repulsion
R-HSA-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-399956, CRMPs in Sema3A signaling
R-HSA-418885, DCC mediated attractive signaling [P06241-1]
R-HSA-4420097, VEGFA-VEGFR2 Pathway
R-HSA-5621480, Dectin-2 family
R-HSA-5621575, CD209 (DC-SIGN) signaling
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-75892, Platelet Adhesion to exposed collagen
R-HSA-8866376, Reelin signalling pathway
R-HSA-9032500, Activated NTRK2 signals through FYN [P06241-1]
R-HSA-9032759, NTRK2 activates RAC1 [P06241-1]
R-HSA-912631, Regulation of signaling by CBL
R-HSA-9607240, FLT3 Signaling
R-HSA-9664323, FCGR3A-mediated IL10 synthesis
R-HSA-9664422, FCGR3A-mediated phagocytosis
R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P06241

SIGNOR Signaling Network Open Resource

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SIGNORi
P06241

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
P06241, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tyrosine-protein kinase Fyn (EC:2.7.10.2)
Alternative name(s):
Proto-oncogene Syn
Proto-oncogene c-Fyn
Src-like kinase
Short name:
SLK
p59-Fyn
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FYN
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000010810.17

Human Gene Nomenclature Database

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HGNCi
HGNC:4037, FYN

Online Mendelian Inheritance in Man (OMIM)

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MIMi
137025, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P06241

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

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DisGeNETi
2534

Open Targets

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OpenTargetsi
ENSG00000010810

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA28454

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P06241, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL1841

Drug and drug target database

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DrugBanki
DB01254, Dasatinib
DB12010, Fostamatinib
DB02078, Triglyme

DrugCentral

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DrugCentrali
P06241

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2026

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
FYN

Domain mapping of disease mutations (DMDM)

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DMDMi
125370

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000880992 – 537Tyrosine-protein kinase FynAdd BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1
Lipidationi3S-palmitoyl cysteineBy similarity1
Lipidationi6S-palmitoyl cysteineBy similarity1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12Phosphothreonine; by PKC1 Publication1
Modified residuei21PhosphoserineCombined sources1
Modified residuei26PhosphoserineCombined sources1
Modified residuei185PhosphotyrosineBy similarity1
Modified residuei420Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei531Phosphotyrosine; by CSKCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated at Tyr-420 (By similarity). Phosphorylation on the C-terminal tail at Tyr-531 by CSK maintains the enzyme in an inactive state (PubMed:1699196). PTPRC/CD45 dephosphorylates Tyr-531 leading to activation (PubMed:1533589). Ultraviolet B (UVB) strongly increase phosphorylation at Thr-12 and kinase activity, and promotes translocation from the cytoplasm to the nucleus (PubMed:15537652). Dephosphorylation at Tyr-420 by PTPN2 negatively regulates T-cell receptor signaling (PubMed:22080863). Phosphorylated at tyrosine residues, which can be enhanced by NTN1 (By similarity).By similarity5 Publications
Palmitoylation at Cys-3 and Cys-6 regulates subcellular location.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Palmitate, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-1792

Encyclopedia of Proteome Dynamics

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EPDi
P06241

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P06241

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P06241

MaxQB - The MaxQuant DataBase

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MaxQBi
P06241

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P06241

PeptideAtlas

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PeptideAtlasi
P06241

PRoteomics IDEntifications database

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PRIDEi
P06241

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
51877 [P06241-1]
51878 [P06241-2]
51879 [P06241-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P06241

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P06241

SwissPalm database of S-palmitoylation events

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SwissPalmi
P06241

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000010810, Expressed in corpus callosum and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P06241, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P06241, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000010810, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via its SH3 domain) with PIK3R1 and PRMT8.

Interacts with FYB1, PAG1, and SH2D1A.

Interacts with CD79A (tyrosine-phosphorylated form); the interaction increases FYN activity.

Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (By similarity).

Interacts with TOM1L1 (phosphorylated form).

Interacts with KDR (tyrosine phosphorylated).

Interacts (via SH3 domain) with KLHL2 (via N-terminus) (By similarity).

Interacts with SH2D1A and SLAMF1.

Interacts with ITCH; the interaction phosphorylates ITCH and negatively regulates its activity.

Interacts with FASLG.

Interacts with RUNX3.

Interacts with KIT.

Interacts with EPHA8; possible downstream effector of EPHA8 in regulation of cell adhesion.

Interacts with PTK2/FAK1; this interaction leads to PTK2/FAK1 phosphorylation and activation.

Interacts with CAV1; this interaction couples integrins to the Ras-ERK pathway.

Interacts with UNC119.

Interacts (via SH2 domain) with PTPRH (phosphorylated form) (By similarity).

Interacts with PTPRO (phosphorylated form) (By similarity).

Interacts with PTPRB (phosphorylated form) (By similarity).

Interacts with FYB2 (PubMed:27335501).

Interacts with DSCAM (By similarity).

Interacts with SKAP1 and FYB1; this interaction promotes the phosphorylation of CLNK (By similarity).

By similarity14 Publications

(Microbial infection) Interacts (via its SH3 domain) with hepatitis E virus/HEV protein ORF3.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P06241
With#Exp.IntAct
ABL2 [P42684]2EBI-515315,EBI-1102694
ADAM10 [O14672]2EBI-515315,EBI-1536151
ADAM15 [Q13444]2EBI-515315,EBI-77818
ARHGAP32 [A7KAX9]4EBI-515315,EBI-308663
ARHGAP33 [O14559]2EBI-515315,EBI-1210010
ASAP1 [Q9ULH1]3EBI-515315,EBI-346622
BCAR1 [P56945]4EBI-515315,EBI-702093
CD2AP [Q9Y5K6]2EBI-515315,EBI-298152
CDC37 [Q16543]3EBI-515315,EBI-295634
EFS [O43281]4EBI-515315,EBI-718488
ERBB2 [P04626]2EBI-515315,EBI-641062
FASLG [P48023]2EBI-515315,EBI-495538
FLT3 [P36888]2EBI-515315,EBI-3946257
FN1 - isoform 7 [P02751-7]2EBI-515315,EBI-7133890
FYB1 [O15117]4EBI-515315,EBI-1753267
itself3EBI-515315,EBI-515315
GP6 [Q9HCN6]2EBI-515315,EBI-515278
GP6 - isoform 1 [Q9HCN6-1]2EBI-515315,EBI-15816577
HSP90AB1 [P08238]4EBI-515315,EBI-352572
HTR6 [P50406]7EBI-515315,EBI-1182222
KHDRBS1 [Q07666]7EBI-515315,EBI-1364
MAP4K1 [Q92918]2EBI-515315,EBI-881
MAPT [P10636]3EBI-515315,EBI-366182
MAPT - isoform Fetal-tau [P10636-2]2EBI-515315,EBI-7796412
MAPT - isoform Tau-C [P10636-5]2EBI-515315,EBI-21313635
MAPT - isoform Tau-D [P10636-6]3EBI-515315,EBI-7796455
MAPT - isoform Tau-F [P10636-8]9EBI-515315,EBI-366233
MED28 [Q9H204]6EBI-515315,EBI-514199
NCKIPSD [Q9NZQ3]2EBI-515315,EBI-745080
NELFB [Q8WX92]2EBI-515315,EBI-347721
PAG1 [Q9NWQ8]5EBI-515315,EBI-2828115
PDCD6IP [Q8WUM4]6EBI-515315,EBI-310624
PDGFRB [P09619]3EBI-515315,EBI-641237
PRICKLE3 [O43900]2EBI-515315,EBI-1751761
PRKCD [Q05655]5EBI-515315,EBI-704279
PRKCQ [Q04759]7EBI-515315,EBI-374762
PTK2B [Q14289]4EBI-515315,EBI-298640
RAPGEF1 [Q13905]2EBI-515315,EBI-976876
SRC [P12931]3EBI-515315,EBI-621482
WBP11 [Q9Y2W2]3EBI-515315,EBI-714455
Grm5 - isoform 1 [P31424-2] from Rattus norvegicus.2EBI-515315,EBI-8830305
Slamf7 [Q8BHK6] from Mus musculus.2EBI-515315,EBI-11463802
O92972 from Hepatitis C virus genotype 1b (strain HC-J4).2EBI-515315,EBI-710506
P27958 from Hepatitis C virus genotype 1a (isolate H).4EBI-515315,EBI-706378
Q9WMX2 from Hepatitis C virus genotype 1b (isolate Con1).2EBI-515315,EBI-710918
Isoform 3 [P06241-3]
With#Exp.IntAct
BAG4 [O95429]3EBI-10691738,EBI-2949658
BCAR1 [P56945]3EBI-10691738,EBI-702093
CBLB [Q13191]4EBI-10691738,EBI-744027
DLGAP4 - isoform 2 [Q9Y2H0-1]3EBI-10691738,EBI-12000556
DTX3 [Q8N9I9]4EBI-10691738,EBI-2340258
EFS - isoform Efs2 [O43281-2]5EBI-10691738,EBI-11525448
ERRFI1 [Q9UJM3]3EBI-10691738,EBI-2941912
FAM90A1 [Q86YD7]3EBI-10691738,EBI-6658203
MEOX2 [Q6FHY5]3EBI-10691738,EBI-16439278

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
108810, 211 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P06241

Database of interacting proteins

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DIPi
DIP-33876N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P06241

Protein interaction database and analysis system

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IntActi
P06241, 392 interactors

Molecular INTeraction database

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MINTi
P06241

STRING: functional protein association networks

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STRINGi
9606.ENSP00000346671

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P06241

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P06241, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1537
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P06241

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P06241

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini82 – 143SH3PROSITE-ProRule annotationAdd BLAST62
Domaini149 – 246SH2PROSITE-ProRule annotationAdd BLAST98
Domaini271 – 524Protein kinasePROSITE-ProRule annotationAdd BLAST254

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0197, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155462

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_7_2_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P06241

KEGG Orthology (KO)

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KOi
K05703

Identification of Orthologs from Complete Genome Data

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OMAi
XWYFGKL

Database of Orthologous Groups

More...
OrthoDBi
539311at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P06241

TreeFam database of animal gene trees

More...
TreeFami
TF351634

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12006, SH3_Fyn_Yrk, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035750, Fyn/Yrk_SH3
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07714, Pkinase_Tyr, 1 hit
PF00017, SH2, 1 hit
PF00018, SH3_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00401, SH2DOMAIN
PR00452, SH3DOMAIN
PR00109, TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00252, SH2, 1 hit
SM00326, SH3, 1 hit
SM00219, TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044, SSF50044, 1 hit
SSF55550, SSF55550, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit
PS50001, SH2, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P06241-1) [UniParc]FASTAAdd to basket
Also known as: B

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY
60 70 80 90 100
NNFHAAGGQG LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD
110 120 130 140 150
LSFHKGEKFQ ILNSSEGDWW EARSLTTGET GYIPSNYVAP VDSIQAEEWY
160 170 180 190 200
FGKLGRKDAE RQLLSFGNPR GTFLIRESET TKGAYSLSIR DWDDMKGDHV
210 220 230 240 250
KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC RLVVPCHKGM
260 270 280 290 300
PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT
310 320 330 340 350
LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL
360 370 380 390 400
LDFLKDGEGR ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN
410 420 430 440 450
GLICKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW
460 470 480 490 500
SFGILLTELV TKGRVPYPGM NNREVLEQVE RGYRMPCPQD CPISLHELMI
510 520 530
HCWKKDPEER PTFEYLQSFL EDYFTATEPQ YQPGENL
Length:537
Mass (Da):60,762
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A1E443A4B5A0977
GO
Isoform 2 (identifier: P06241-2) [UniParc]FASTAAdd to basket
Also known as: T

The sequence of this isoform differs from the canonical sequence as follows:
     234-287: RAAGLCCRLV...GNGQFGEVWM → KADGLCFNLT...GQGCFAEVWL

Show »
Length:534
Mass (Da):60,141
Checksum:iFA082D40A24C2802
GO
Isoform 3 (identifier: P06241-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-287: Missing.

Show »
Length:482
Mass (Da):54,513
Checksum:i055C3965AC5A9135
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RIX5E5RIX5_HUMAN
Tyrosine-protein kinase Fyn
FYN
186Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFS5E5RFS5_HUMAN
Tyrosine-protein kinase Fyn
FYN
232Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RH71E5RH71_HUMAN
Tyrosine-protein kinase Fyn
FYN
175Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGT0E5RGT0_HUMAN
Tyrosine-protein kinase Fyn
FYN
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFM0E5RFM0_HUMAN
Tyrosine-protein kinase Fyn
FYN
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI25E5RI25_HUMAN
Tyrosine-protein kinase Fyn
FYN
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGM6E5RGM6_HUMAN
Tyrosine-protein kinase Fyn
FYN
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFM4E5RFM4_HUMAN
Tyrosine-protein kinase Fyn
FYN
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHF7E5RHF7_HUMAN
Tyrosine-protein kinase Fyn
FYN
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RK23E5RK23_HUMAN
Tyrosine-protein kinase Fyn
FYN
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti184A → S in AAA36615 (PubMed:3099169).Curated1
Sequence conflicti437A → R in AAA36615 (PubMed:3099169).Curated1
Sequence conflicti437A → R in AAB33113 (PubMed:7822789).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_041704243V → L in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041705410G → R in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_014661445I → F. Corresponds to variant dbSNP:rs1801121Ensembl.1
Natural variantiVAR_041706506D → E1 PublicationCorresponds to variant dbSNP:rs28763975Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024108233 – 287Missing in isoform 3. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_024110234 – 287RAAGL…GEVWM → KADGLCFNLTVIASSCTPQT SGLAKDAWEVARRSLCLEKK LGQGCFAEVWL in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M14676 mRNA Translation: AAA36615.1
M14333 mRNA Translation: AAC08285.1
S74774 mRNA Translation: AAB33113.2
AB451293 mRNA Translation: BAG70107.1
AB451426 mRNA Translation: BAG70240.1
Z97989 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48278.1
CH471051 Genomic DNA Translation: EAW48279.1
CH471051 Genomic DNA Translation: EAW48281.1
CH471051 Genomic DNA Translation: EAW48282.1
CH471051 Genomic DNA Translation: EAW48283.1
BC032496 mRNA Translation: AAH32496.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5094.1 [P06241-1]
CCDS5095.1 [P06241-2]
CCDS5096.1 [P06241-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
A24314, TVHUSY

NCBI Reference Sequences

More...
RefSeqi
NP_002028.1, NM_002037.5 [P06241-1]
NP_694592.1, NM_153047.3 [P06241-2]
NP_694593.1, NM_153048.3 [P06241-3]
XP_005266947.1, XM_005266890.3
XP_005266949.1, XM_005266892.3 [P06241-3]
XP_016866139.1, XM_017010650.1 [P06241-1]
XP_016866140.1, XM_017010651.1 [P06241-1]
XP_016866141.1, XM_017010652.1 [P06241-1]
XP_016866142.1, XM_017010653.1 [P06241-1]
XP_016866143.1, XM_017010654.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000229471; ENSP00000229471; ENSG00000010810 [P06241-3]
ENST00000354650; ENSP00000346671; ENSG00000010810 [P06241-1]
ENST00000368667; ENSP00000357656; ENSG00000010810 [P06241-1]
ENST00000368678; ENSP00000357667; ENSG00000010810 [P06241-2]
ENST00000368682; ENSP00000357671; ENSG00000010810 [P06241-2]
ENST00000538466; ENSP00000440646; ENSG00000010810 [P06241-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2534

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2534

UCSC genome browser

More...
UCSCi
uc003pvh.3, human [P06241-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14676 mRNA Translation: AAA36615.1
M14333 mRNA Translation: AAC08285.1
S74774 mRNA Translation: AAB33113.2
AB451293 mRNA Translation: BAG70107.1
AB451426 mRNA Translation: BAG70240.1
Z97989 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48278.1
CH471051 Genomic DNA Translation: EAW48279.1
CH471051 Genomic DNA Translation: EAW48281.1
CH471051 Genomic DNA Translation: EAW48282.1
CH471051 Genomic DNA Translation: EAW48283.1
BC032496 mRNA Translation: AAH32496.1
CCDSiCCDS5094.1 [P06241-1]
CCDS5095.1 [P06241-2]
CCDS5096.1 [P06241-3]
PIRiA24314, TVHUSY
RefSeqiNP_002028.1, NM_002037.5 [P06241-1]
NP_694592.1, NM_153047.3 [P06241-2]
NP_694593.1, NM_153048.3 [P06241-3]
XP_005266947.1, XM_005266890.3
XP_005266949.1, XM_005266892.3 [P06241-3]
XP_016866139.1, XM_017010650.1 [P06241-1]
XP_016866140.1, XM_017010651.1 [P06241-1]
XP_016866141.1, XM_017010652.1 [P06241-1]
XP_016866142.1, XM_017010653.1 [P06241-1]
XP_016866143.1, XM_017010654.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A0NNMR-B80-148[»]
1AOTNMR-F143-248[»]
1AOUNMR-F143-248[»]
1AVZX-ray3.00C85-141[»]
1AZGNMR-B82-148[»]
1EFNX-ray2.50A/C86-143[»]
1FYNX-ray2.30A81-142[»]
1G83X-ray2.60A/B82-246[»]
1M27X-ray2.50C84-144[»]
1NYFNMR-A82-148[»]
1NYGNMR-A82-148[»]
1SHFX-ray1.90A/B84-142[»]
1ZBJNMR-A84-142[»]
2DQ7X-ray2.80X261-537[»]
2MQINMR-A148-248[»]
2MRJNMR-A148-248[»]
2MRKNMR-A149-248[»]
B528-537[»]
3H0FX-ray2.61A73-142[»]
3H0HX-ray1.76A73-142[»]
3H0IX-ray2.20A/B73-142[»]
3UA6X-ray1.85A/B81-143[»]
3UA7X-ray1.50A/B/C/D81-143[»]
4D8DX-ray2.52A/C84-141[»]
4EIKX-ray1.60A81-143[»]
4U17X-ray1.99A/B/C148-248[»]
4U1PX-ray1.40A148-248[»]
4ZNXX-ray2.10A/B/C/D84-141[»]
5ZAUNMR-A85-141[»]
6EDFX-ray1.40A83-146[»]
6IPYX-ray1.34A82-144[»]
6IPZX-ray1.58Z82-144[»]
SMRiP06241
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108810, 211 interactors
CORUMiP06241
DIPiDIP-33876N
ELMiP06241
IntActiP06241, 392 interactors
MINTiP06241
STRINGi9606.ENSP00000346671

Chemistry databases

BindingDBiP06241
ChEMBLiCHEMBL1841
DrugBankiDB01254, Dasatinib
DB12010, Fostamatinib
DB02078, Triglyme
DrugCentraliP06241
GuidetoPHARMACOLOGYi2026

Protein family/group databases

MoonDBiP06241, Predicted

PTM databases

iPTMnetiP06241
PhosphoSitePlusiP06241
SwissPalmiP06241

Polymorphism and mutation databases

BioMutaiFYN
DMDMi125370

Proteomic databases

CPTACiCPTAC-1792
EPDiP06241
jPOSTiP06241
MassIVEiP06241
MaxQBiP06241
PaxDbiP06241
PeptideAtlasiP06241
PRIDEiP06241
ProteomicsDBi51877 [P06241-1]
51878 [P06241-2]
51879 [P06241-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P06241, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3559, 985 antibodies

The DNASU plasmid repository

More...
DNASUi
2534

Genome annotation databases

EnsembliENST00000229471; ENSP00000229471; ENSG00000010810 [P06241-3]
ENST00000354650; ENSP00000346671; ENSG00000010810 [P06241-1]
ENST00000368667; ENSP00000357656; ENSG00000010810 [P06241-1]
ENST00000368678; ENSP00000357667; ENSG00000010810 [P06241-2]
ENST00000368682; ENSP00000357671; ENSG00000010810 [P06241-2]
ENST00000538466; ENSP00000440646; ENSG00000010810 [P06241-2]
GeneIDi2534
KEGGihsa:2534
UCSCiuc003pvh.3, human [P06241-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2534
DisGeNETi2534
EuPathDBiHostDB:ENSG00000010810.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FYN
HGNCiHGNC:4037, FYN
HPAiENSG00000010810, Low tissue specificity
MIMi137025, gene
neXtProtiNX_P06241
OpenTargetsiENSG00000010810
PharmGKBiPA28454

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0197, Eukaryota
GeneTreeiENSGT00940000155462
HOGENOMiCLU_000288_7_2_1
InParanoidiP06241
KOiK05703
OMAiXWYFGKL
OrthoDBi539311at2759
PhylomeDBiP06241
TreeFamiTF351634

Enzyme and pathway databases

BRENDAi2.7.10.2, 2681
PathwayCommonsiP06241
ReactomeiR-HSA-114604, GPVI-mediated activation cascade
R-HSA-1227986, Signaling by ERBB2
R-HSA-1257604, PIP3 activates AKT signaling
R-HSA-1433557, Signaling by SCF-KIT
R-HSA-1433559, Regulation of KIT signaling
R-HSA-164944, Nef and signal transduction
R-HSA-202733, Cell surface interactions at the vascular wall
R-HSA-2029481, FCGR activation
R-HSA-210990, PECAM1 interactions
R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-2424491, DAP12 signaling
R-HSA-2682334, EPH-Ephrin signaling
R-HSA-2730905, Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-373753, Nephrin family interactions
R-HSA-375165, NCAM signaling for neurite out-growth
R-HSA-389356, CD28 co-stimulation
R-HSA-389357, CD28 dependent PI3K/Akt signaling
R-HSA-389359, CD28 dependent Vav1 pathway
R-HSA-389513, CTLA4 inhibitory signaling
R-HSA-3928662, EPHB-mediated forward signaling
R-HSA-3928663, EPHA-mediated growth cone collapse
R-HSA-3928664, Ephrin signaling
R-HSA-3928665, EPH-ephrin mediated repulsion of cells
R-HSA-399954, Sema3A PAK dependent Axon repulsion
R-HSA-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-399956, CRMPs in Sema3A signaling
R-HSA-418885, DCC mediated attractive signaling [P06241-1]
R-HSA-4420097, VEGFA-VEGFR2 Pathway
R-HSA-5621480, Dectin-2 family
R-HSA-5621575, CD209 (DC-SIGN) signaling
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-75892, Platelet Adhesion to exposed collagen
R-HSA-8866376, Reelin signalling pathway
R-HSA-9032500, Activated NTRK2 signals through FYN [P06241-1]
R-HSA-9032759, NTRK2 activates RAC1 [P06241-1]
R-HSA-912631, Regulation of signaling by CBL
R-HSA-9607240, FLT3 Signaling
R-HSA-9664323, FCGR3A-mediated IL10 synthesis
R-HSA-9664422, FCGR3A-mediated phagocytosis
R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkiP06241
SIGNORiP06241

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
2534, 4 hits in 901 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FYN, human
EvolutionaryTraceiP06241

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FYN

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2534
PharosiP06241, Tclin

Protein Ontology

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PROi
PR:P06241
RNActiP06241, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000010810, Expressed in corpus callosum and 243 other tissues
ExpressionAtlasiP06241, baseline and differential
GenevisibleiP06241, HS

Family and domain databases

CDDicd12006, SH3_Fyn_Yrk, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR035750, Fyn/Yrk_SH3
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR000980, SH2
IPR036860, SH2_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714, Pkinase_Tyr, 1 hit
PF00017, SH2, 1 hit
PF00018, SH3_1, 1 hit
PRINTSiPR00401, SH2DOMAIN
PR00452, SH3DOMAIN
PR00109, TYRKINASE
SMARTiView protein in SMART
SM00252, SH2, 1 hit
SM00326, SH3, 1 hit
SM00219, TyrKc, 1 hit
SUPFAMiSSF50044, SSF50044, 1 hit
SSF55550, SSF55550, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit
PS50001, SH2, 1 hit
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFYN_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06241
Secondary accession number(s): B5BU57
, E1P557, H0UI48, Q16248, Q5R3A6, Q5R3A7, Q8N5D7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: August 12, 2020
This is version 254 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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