UniProtKB - P06239 (LCK_HUMAN)
Tyrosine-protein kinase Lck
LCK
Functioni
Catalytic activityi
- EC:2.7.10.2PROSITE-ProRule annotation
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 273 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 364 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 251 – 259 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATPase binding Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- CD4 receptor binding Source: UniProtKB
- CD8 receptor binding Source: UniProtKB
- identical protein binding Source: IntAct
- non-membrane spanning protein tyrosine kinase activity Source: GO_Central
- phosphatidylinositol 3-kinase binding Source: UniProtKB
- phosphotyrosine residue binding Source: CAFA
- protein C-terminus binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- protein phosphatase binding Source: UniProtKB
- protein serine/threonine phosphatase activity Source: UniProtKB
- protein tyrosine kinase activity Source: UniProtKB
- SH2 domain binding Source: UniProtKB
- signaling receptor binding Source: GO_Central
- T cell receptor binding Source: CAFA
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- B cell receptor signaling pathway Source: GO_Central
- cell differentiation Source: GO_Central
- cellular zinc ion homeostasis Source: UniProtKB
- hemopoiesis Source: UniProtKB
- innate immune response Source: GO_Central
- leukocyte migration Source: Reactome
- peptidyl-tyrosine autophosphorylation Source: GO_Central
- peptidyl-tyrosine phosphorylation Source: CAFA
- platelet activation Source: Reactome
- positive regulation of heterotypic cell-cell adhesion Source: BHF-UCL
- positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
- positive regulation of leukocyte cell-cell adhesion Source: BHF-UCL
- positive regulation of protein kinase B signaling Source: Reactome
- positive regulation of T cell activation Source: UniProtKB
- positive regulation of T cell receptor signaling pathway Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- regulation of cell population proliferation Source: GO_Central
- regulation of defense response to virus by virus Source: Reactome
- regulation of lymphocyte activation Source: UniProtKB
- release of sequestered calcium ion into cytosol Source: UniProtKB
- response to drug Source: UniProtKB
- T cell costimulation Source: Reactome
- T cell differentiation Source: UniProtKB
- T cell receptor signaling pathway Source: Reactome
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinase |
Biological process | Host-virus interaction |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P06239 |
Reactomei | R-HSA-114604, GPVI-mediated activation cascade R-HSA-1257604, PIP3 activates AKT signaling R-HSA-1433557, Signaling by SCF-KIT R-HSA-1433559, Regulation of KIT signaling R-HSA-164944, Nef and signal transduction R-HSA-167590, Nef Mediated CD4 Down-regulation R-HSA-202424, Downstream TCR signaling R-HSA-202427, Phosphorylation of CD3 and TCR zeta chains R-HSA-202430, Translocation of ZAP-70 to Immunological synapse R-HSA-202433, Generation of second messenger molecules R-HSA-210990, PECAM1 interactions R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2424491, DAP12 signaling R-HSA-389356, CD28 co-stimulation R-HSA-389357, CD28 dependent PI3K/Akt signaling R-HSA-389359, CD28 dependent Vav1 pathway R-HSA-389513, CTLA4 inhibitory signaling R-HSA-389948, PD-1 signaling R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-9020558, Interleukin-2 signaling R-HSA-9670439, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants |
SignaLinki | P06239 |
SIGNORi | P06239 |
Names & Taxonomyi
Protein namesi | Recommended name: Tyrosine-protein kinase Lck (EC:2.7.10.2)Alternative name(s): Leukocyte C-terminal Src kinase Short name: LSK Lymphocyte cell-specific protein-tyrosine kinase Protein YT16 Proto-oncogene Lck T cell-specific protein-tyrosine kinase p56-LCK |
Gene namesi | Name:LCK |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6524, LCK |
MIMi | 153390, gene |
neXtProti | NX_P06239 |
VEuPathDBi | HostDB:ENSG00000182866.16 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Lipid-anchor 2 Publications; Cytoplasmic side 2 Publications
Cytosol
- cytosol 2 Publications
Note: Present in lipid rafts in an inactive form.1 Publication
Cytoskeleton
- pericentriolar material Source: UniProtKB
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: GO_Central
- immunological synapse Source: MGI
- plasma membrane Source: BHF-UCL
Other locations
- membrane raft Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Involvement in diseasei
Immunodeficiency 22 (IMD22)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071291 | 341 | L → P in IMD22. 1 PublicationCorresponds to variant dbSNP:rs587777335EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 59 | S → E: Allows interaction with SQSTM1. 1 Publication | 1 | |
Mutagenesisi | 154 | R → K: No effect on interaction with SQSTM1. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, Proto-oncogeneOrganism-specific databases
DisGeNETi | 3932 |
MalaCardsi | LCK |
MIMi | 615758, phenotype |
OpenTargetsi | ENSG00000182866 |
Orphaneti | 280142, Severe combined immunodeficiency due to LCK deficiency |
PharmGKBi | PA30307 |
Miscellaneous databases
Pharosi | P06239, Tclin |
Chemistry databases
ChEMBLi | CHEMBL258 |
DrugBanki | DB03023, 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine DB07146, 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE DB06925, 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE DB07297, 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE DB01830, AP-22408 DB01254, Dasatinib DB12010, Fostamatinib DB08056, N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine DB08057, N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine DB08055, N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine DB09079, Nintedanib DB04395, Phosphoaminophosphonic Acid-Adenylate Ester DB08901, Ponatinib DB02010, Staurosporine DB15035, Zanubrutinib DB04003, {4-[(2S)-2-Acetamido-3-({(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl}amino)-3-oxopropyl]-2-phosphonophenoxy}acetic acid |
DrugCentrali | P06239 |
GuidetoPHARMACOLOGYi | 2053 |
Genetic variation databases
BioMutai | LCK |
DMDMi | 125474 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed | |||
ChainiPRO_0000088124 | 2 – 509 | Tyrosine-protein kinase LckAdd BLAST | 508 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycineBy similarity | 1 | |
Lipidationi | 3 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 5 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 102 | PhosphoserineCombined sources | 1 | |
Modified residuei | 159 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 162 | PhosphoserineCombined sources | 1 | |
Modified residuei | 192 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 194 | PhosphoserineCombined sources | 1 | |
Modified residuei | 394 | Phosphotyrosine; by autocatalysis1 Publication | 1 | |
Modified residuei | 505 | Phosphotyrosine; by CSKCombined sources3 Publications | 1 |
Post-translational modificationi
Keywords - PTMi
Lipoprotein, Myristate, Palmitate, PhosphoproteinProteomic databases
CPTACi | CPTAC-1775 CPTAC-929 |
EPDi | P06239 |
jPOSTi | P06239 |
MassIVEi | P06239 |
MaxQBi | P06239 |
PaxDbi | P06239 |
PeptideAtlasi | P06239 |
PRIDEi | P06239 |
ProteomicsDBi | 51874 [P06239-1] 51875 [P06239-2] 51876 [P06239-3] |
PTM databases
iPTMneti | P06239 |
PhosphoSitePlusi | P06239 |
SwissPalmi | P06239 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000182866, Expressed in thymus and 162 other tissues |
ExpressionAtlasi | P06239, baseline and differential |
Genevisiblei | P06239, HS |
Organism-specific databases
HPAi | ENSG00000182866, Group enriched (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Binds to the cytoplasmic domain of cell surface receptors, such as AXL, CD2, CD4, CD5, CD8, CD44, CD45 and CD122. Also binds to effector molecules, such as PI4K, VAV1, RASA1, FYB1 and to other protein kinases including CDK1, RAF1, ZAP70 and SYK. Binds to phosphatidylinositol 3'-kinase (PI3K) from T-lymphocytes through its SH3 domain and to the tyrosine phosphorylated form of KHDRBS1/p70 through its SH2 domain. This interaction inhibits its tyrosine-kinase activity.
Interacts with SQSTM1.
Interacts with phosphorylated LIME1.
Interacts with CBLB and PTPRH.
Interacts with RUNX3.
Forms a signaling complex with EPHA1, PTK2B AND PI3-KINASE; upon activation by EFNA1 which may regulate T-lymphocyte migration. Associates with ZAP70 and RHOH; these interactions allow LCK-mediated RHOH and CD3 subunit phosphorylation in the presence of functional ZAP70.
Interacts with UNC119; this interaction plays a crucial role in activation of LCK.
Interacts with CEACAM1 (via cytoplasmic domain); mediates CEACAM1 phosphorylation resulting in PTPN6 recruitment that dephosphorylates TCR stimulation-induced CD247 and ZAP70 (PubMed:18424730).
Interacts with CD160.
11 Publications(Microbial infection) Interacts with herpes simplex virus 1 UL46; this interaction activates LCK.
1 Publication(Microbial infection) Interacts with HIV-1 Nef through its SH3 domain.
1 PublicationBinary interactionsi
Hide detailsP06239
Isoform 3 [P06239-3]
GO - Molecular functioni
- ATPase binding Source: UniProtKB
- CD4 receptor binding Source: UniProtKB
- CD8 receptor binding Source: UniProtKB
- identical protein binding Source: IntAct
- phosphatidylinositol 3-kinase binding Source: UniProtKB
- phosphotyrosine residue binding Source: CAFA
- protein C-terminus binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- protein phosphatase binding Source: UniProtKB
- SH2 domain binding Source: UniProtKB
- signaling receptor binding Source: GO_Central
- T cell receptor binding Source: CAFA
Protein-protein interaction databases
BioGRIDi | 110124, 187 interactors |
CORUMi | P06239 |
DIPi | DIP-553N |
ELMi | P06239 |
IntActi | P06239, 169 interactors |
MINTi | P06239 |
STRINGi | 9606.ENSP00000337825 |
Chemistry databases
BindingDBi | P06239 |
Miscellaneous databases
RNActi | P06239, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P06239 |
SMRi | P06239 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06239 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 61 – 121 | SH3PROSITE-ProRule annotationAdd BLAST | 61 | |
Domaini | 127 – 224 | SH2PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 245 – 498 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 254 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 72 | Interactions with CD4 and CD8By similarityAdd BLAST | 71 | |
Regioni | 154 – 242 | Interaction with PTPRH1 PublicationAdd BLAST | 89 |
Domaini
Sequence similaritiesi
Keywords - Domaini
SH2 domain, SH3 domainPhylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000161163 |
HOGENOMi | CLU_000288_7_2_1 |
InParanoidi | P06239 |
OMAi | ICEHCNY |
OrthoDBi | 539311at2759 |
PhylomeDBi | P06239 |
TreeFami | TF351634 |
Family and domain databases
CDDi | cd10362, SH2_Src_Lck, 1 hit cd12005, SH3_Lck, 1 hit |
DisProti | DP01580 |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR035850, Lck_SH2 IPR035749, Lck_SH3 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT
60 70 80 90 100
YEGSNPPASP LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQSGEWWKA
110 120 130 140 150
QSLTTGQEGF IPFNFVAKAN SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS
160 170 180 190 200
FLIRESESTA GSFSLSVRDF DQNQGEVVKH YKIRNLDNGG FYISPRITFP
210 220 230 240 250
GLHELVRHYT NASDGLCTRL SRPCQTQKPQ KPWWEDEWEV PRETLKLVER
260 270 280 290 300
LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHQRL
310 320 330 340 350
VRLYAVVTQE PIYIITEYME NGSLVDFLKT PSGIKLTINK LLDMAAQIAE
360 370 380 390 400
GMAFIEERNY IHRDLRAANI LVSDTLSCKI ADFGLARLIE DNEYTAREGA
410 420 430 440 450
KFPIKWTAPE AINYGTFTIK SDVWSFGILL TEIVTHGRIP YPGMTNPEVI
460 470 480 490 500
QNLERGYRMV RPDNCPEELY QLMRLCWKER PEDRPTFDYL RSVLEDFFTA
TEGQYQPQP
The sequence of this isoform differs from the canonical sequence as follows:
348-363: IAEGMAFIEERNYIHR → VRRLGRGAGQGNRPVT
364-509: Missing.
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ573B4 | Q573B4_HUMAN | Tyrosine-protein kinase | LCK | 516 | Annotation score: | ||
E9PJ92 | E9PJ92_HUMAN | Tyrosine-protein kinase | LCK | 319 | Annotation score: | ||
E9PKQ8 | E9PKQ8_HUMAN | Tyrosine-protein kinase Lck | LCK | 200 | Annotation score: | ||
E9PQ10 | E9PQ10_HUMAN | Tyrosine-protein kinase Lck | LCK | 149 | Annotation score: | ||
E9PI33 | E9PI33_HUMAN | Tyrosine-protein kinase Lck | LCK | 167 | Annotation score: | ||
E9PAP0 | E9PAP0_HUMAN | Tyrosine-protein kinase Lck | LCK | 285 | Annotation score: | ||
F8W6B9 | F8W6B9_HUMAN | Tyrosine-protein kinase Lck | LCK | 137 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 29 | P → R in AAA59502 (PubMed:3265417).Curated | 1 | |
Sequence conflicti | 35 | T → R in AAA59502 (PubMed:3265417).Curated | 1 | |
Sequence conflicti | 87 | Q → P in CAA31884 (PubMed:3265417).Curated | 1 | |
Sequence conflicti | 87 | Q → P in AAA59502 (PubMed:3265417).Curated | 1 | |
Sequence conflicti | 206 – 211 | VRHYTN → ASAITPI in CAA28691 (PubMed:3493153).Curated | 6 | |
Sequence conflicti | 254 | G → A in AAA59502 (PubMed:3265417).Curated | 1 | |
Sequence conflicti | 258 – 267 | EVWMGYYNGH → RCGWGTTTGT in CAA28691 (PubMed:3493153).Curated | 10 | |
Sequence conflicti | 282 – 286 | PDAFL → AGRLP in CAA28691 (PubMed:3493153).Curated | 5 | |
Sequence conflicti | 375 | T → A in CAA28165 (PubMed:3489486).Curated | 1 | |
Sequence conflicti | 472 | L → H in CAA29667 (PubMed:2835736).Curated | 1 | |
Sequence conflicti | 504 – 509 | QYQPQP → STA in CAA28691 (PubMed:3493153).Curated | 6 |
Mass spectrometryi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013463 | 28 | V → L Found in leukemia. 1 Publication | 1 | |
Natural variantiVAR_051697 | 201 | G → S. Corresponds to variant dbSNP:rs11567841EnsemblClinVar. | 1 | |
Natural variantiVAR_013464 | 232 | P → PQKP in leukemia. | 1 | |
Natural variantiVAR_071291 | 341 | L → P in IMD22. 1 PublicationCorresponds to variant dbSNP:rs587777335EnsemblClinVar. | 1 | |
Natural variantiVAR_013465 | 353 | A → V Found in leukemia. 1 Publication | 1 | |
Natural variantiVAR_013466 | 447 | P → L Found in leukemia. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016049 | 321 | N → NDTLLDSQLEEKGLGASPWG NLGQQLLLLPT in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_005000 | 348 – 363 | IAEGM…NYIHR → VRRLGRGAGQGNRPVT in isoform Short. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_005001 | 364 – 509 | Missing in isoform Short. 1 PublicationAdd BLAST | 146 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X05027 mRNA Translation: CAA28691.1 X13529 mRNA Translation: CAA31884.1 M36881 mRNA Translation: AAA59502.1 X14055, X14053, X14054 Genomic DNA Translation: CAA32211.1 U07236 mRNA Translation: AAA18225.1 U23852 mRNA Translation: AAC50287.1 BN000073 Genomic DNA Translation: CAD55807.1 AL121991 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07543.1 CH471059 Genomic DNA Translation: EAX07546.1 BC013200 mRNA Translation: AAH13200.1 M21510 Genomic DNA Translation: AAA59501.1 Different termination. M26692 Genomic DNA Translation: AAA59503.1 AF228313 mRNA Translation: AAF34794.1 X06369 mRNA Translation: CAA29667.1 X04476 mRNA Translation: CAA28165.1 |
CCDSi | CCDS359.1 [P06239-1] |
PIRi | JQ0152, OKHULK |
RefSeqi | NP_001036236.1, NM_001042771.2 [P06239-1] NP_005347.3, NM_005356.4 [P06239-1] |
Genome annotation databases
Ensembli | ENST00000333070; ENSP00000328213; ENSG00000182866 [P06239-3] ENST00000336890; ENSP00000337825; ENSG00000182866 [P06239-1] ENST00000619559; ENSP00000477713; ENSG00000182866 [P06239-1] |
GeneIDi | 3932 |
KEGGi | hsa:3932 |
UCSCi | uc001bux.3, human [P06239-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Wikipedia Lck entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X05027 mRNA Translation: CAA28691.1 X13529 mRNA Translation: CAA31884.1 M36881 mRNA Translation: AAA59502.1 X14055, X14053, X14054 Genomic DNA Translation: CAA32211.1 U07236 mRNA Translation: AAA18225.1 U23852 mRNA Translation: AAC50287.1 BN000073 Genomic DNA Translation: CAD55807.1 AL121991 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07543.1 CH471059 Genomic DNA Translation: EAX07546.1 BC013200 mRNA Translation: AAH13200.1 M21510 Genomic DNA Translation: AAA59501.1 Different termination. M26692 Genomic DNA Translation: AAA59503.1 AF228313 mRNA Translation: AAF34794.1 X06369 mRNA Translation: CAA29667.1 X04476 mRNA Translation: CAA28165.1 |
CCDSi | CCDS359.1 [P06239-1] |
PIRi | JQ0152, OKHULK |
RefSeqi | NP_001036236.1, NM_001042771.2 [P06239-1] NP_005347.3, NM_005356.4 [P06239-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BHF | X-ray | 1.80 | A | 119-226 | [»] | |
1BHH | X-ray | 1.90 | A | 119-226 | [»] | |
B | 124-226 | [»] | ||||
1CWD | X-ray | 2.25 | L | 127-222 | [»] | |
1CWE | X-ray | 2.30 | A/C | 127-222 | [»] | |
1FBZ | X-ray | 2.40 | A/B | 123-226 | [»] | |
1H92 | NMR | - | A | 59-120 | [»] | |
1IJR | X-ray | 2.20 | A | 124-226 | [»] | |
1KIK | NMR | - | A | 64-120 | [»] | |
1LCJ | X-ray | 1.80 | A | 119-226 | [»] | |
1LCK | X-ray | 2.50 | A | 53-226 | [»] | |
B | 502-509 | [»] | ||||
1LKK | X-ray | 1.00 | A | 122-226 | [»] | |
1LKL | X-ray | 1.80 | A | 123-226 | [»] | |
1Q68 | NMR | - | B | 7-35 | [»] | |
1Q69 | NMR | - | B | 7-35 | [»] | |
1QPC | X-ray | 1.60 | A | 231-509 | [»] | |
1QPD | X-ray | 2.00 | A | 231-509 | [»] | |
1QPE | X-ray | 2.00 | A | 231-509 | [»] | |
1QPJ | X-ray | 2.20 | A | 231-509 | [»] | |
1X27 | X-ray | 2.70 | A/B/C/D/E/F | 64-226 | [»] | |
2IIM | X-ray | 1.00 | A | 59-119 | [»] | |
2OF2 | X-ray | 2.00 | A | 231-501 | [»] | |
2OF4 | X-ray | 2.70 | A | 231-501 | [»] | |
2OFU | X-ray | 2.00 | A | 229-501 | [»] | |
2OFV | X-ray | 2.00 | A/B | 232-498 | [»] | |
2OG8 | X-ray | 2.30 | A/B | 237-499 | [»] | |
2PL0 | X-ray | 2.80 | A | 225-509 | [»] | |
2ZM1 | X-ray | 2.10 | A | 225-509 | [»] | |
2ZM4 | X-ray | 2.70 | A | 225-509 | [»] | |
2ZYB | X-ray | 2.55 | A | 225-509 | [»] | |
3AC1 | X-ray | 1.99 | A | 225-509 | [»] | |
3AC2 | X-ray | 2.10 | A | 225-509 | [»] | |
3AC3 | X-ray | 2.55 | A | 225-509 | [»] | |
3AC4 | X-ray | 2.70 | A | 225-509 | [»] | |
3AC5 | X-ray | 2.50 | A | 225-509 | [»] | |
3AC8 | X-ray | 2.30 | A | 225-509 | [»] | |
3ACJ | X-ray | 2.20 | A | 225-509 | [»] | |
3ACK | X-ray | 2.60 | A | 225-509 | [»] | |
3AD4 | X-ray | 2.20 | A | 225-509 | [»] | |
3AD5 | X-ray | 2.00 | A | 225-509 | [»] | |
3AD6 | X-ray | 2.15 | A | 225-509 | [»] | |
3B2W | X-ray | 2.30 | A | 226-502 | [»] | |
3BRH | X-ray | 2.20 | C/D | 391-397 | [»] | |
3BYM | X-ray | 2.00 | A | 230-501 | [»] | |
3BYO | X-ray | 2.00 | A | 231-501 | [»] | |
3BYS | X-ray | 2.20 | A | 225-501 | [»] | |
3BYU | X-ray | 2.30 | A | 225-501 | [»] | |
3KMM | X-ray | 2.80 | A | 229-509 | [»] | |
3KXZ | X-ray | 2.37 | A | 225-509 | [»] | |
3LCK | X-ray | 1.70 | A | 231-501 | [»] | |
3MPM | X-ray | 1.95 | A | 237-501 | [»] | |
4C3F | X-ray | 1.72 | A | 237-501 | [»] | |
4D8K | X-ray | 2.36 | A | 53-226 | [»] | |
5MTM | X-ray | 2.40 | A | 118-231 | [»] | |
5MTN | X-ray | 2.85 | A | 118-231 | [»] | |
6H6A | X-ray | 2.00 | E/H/K | 2-11 | [»] | |
6PDJ | X-ray | 1.81 | A | 225-509 | [»] | |
BMRBi | P06239 | |||||
SMRi | P06239 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110124, 187 interactors |
CORUMi | P06239 |
DIPi | DIP-553N |
ELMi | P06239 |
IntActi | P06239, 169 interactors |
MINTi | P06239 |
STRINGi | 9606.ENSP00000337825 |
Chemistry databases
BindingDBi | P06239 |
ChEMBLi | CHEMBL258 |
DrugBanki | DB03023, 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine DB07146, 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE DB06925, 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE DB07297, 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE DB01830, AP-22408 DB01254, Dasatinib DB12010, Fostamatinib DB08056, N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine DB08057, N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine DB08055, N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine DB09079, Nintedanib DB04395, Phosphoaminophosphonic Acid-Adenylate Ester DB08901, Ponatinib DB02010, Staurosporine DB15035, Zanubrutinib DB04003, {4-[(2S)-2-Acetamido-3-({(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl}amino)-3-oxopropyl]-2-phosphonophenoxy}acetic acid |
DrugCentrali | P06239 |
GuidetoPHARMACOLOGYi | 2053 |
PTM databases
iPTMneti | P06239 |
PhosphoSitePlusi | P06239 |
SwissPalmi | P06239 |
Genetic variation databases
BioMutai | LCK |
DMDMi | 125474 |
Proteomic databases
CPTACi | CPTAC-1775 CPTAC-929 |
EPDi | P06239 |
jPOSTi | P06239 |
MassIVEi | P06239 |
MaxQBi | P06239 |
PaxDbi | P06239 |
PeptideAtlasi | P06239 |
PRIDEi | P06239 |
ProteomicsDBi | 51874 [P06239-1] 51875 [P06239-2] 51876 [P06239-3] |
Protocols and materials databases
ABCDi | P06239, 2 sequenced antibodies |
Antibodypediai | 735, 1646 antibodies |
DNASUi | 3932 |
Genome annotation databases
Ensembli | ENST00000333070; ENSP00000328213; ENSG00000182866 [P06239-3] ENST00000336890; ENSP00000337825; ENSG00000182866 [P06239-1] ENST00000619559; ENSP00000477713; ENSG00000182866 [P06239-1] |
GeneIDi | 3932 |
KEGGi | hsa:3932 |
UCSCi | uc001bux.3, human [P06239-1] |
Organism-specific databases
CTDi | 3932 |
DisGeNETi | 3932 |
GeneCardsi | LCK |
HGNCi | HGNC:6524, LCK |
HPAi | ENSG00000182866, Group enriched (blood, lymphoid tissue) |
MalaCardsi | LCK |
MIMi | 153390, gene 615758, phenotype |
neXtProti | NX_P06239 |
OpenTargetsi | ENSG00000182866 |
Orphaneti | 280142, Severe combined immunodeficiency due to LCK deficiency |
PharmGKBi | PA30307 |
VEuPathDBi | HostDB:ENSG00000182866.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0197, Eukaryota |
GeneTreei | ENSGT00940000161163 |
HOGENOMi | CLU_000288_7_2_1 |
InParanoidi | P06239 |
OMAi | ICEHCNY |
OrthoDBi | 539311at2759 |
PhylomeDBi | P06239 |
TreeFami | TF351634 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P06239 |
Reactomei | R-HSA-114604, GPVI-mediated activation cascade R-HSA-1257604, PIP3 activates AKT signaling R-HSA-1433557, Signaling by SCF-KIT R-HSA-1433559, Regulation of KIT signaling R-HSA-164944, Nef and signal transduction R-HSA-167590, Nef Mediated CD4 Down-regulation R-HSA-202424, Downstream TCR signaling R-HSA-202427, Phosphorylation of CD3 and TCR zeta chains R-HSA-202430, Translocation of ZAP-70 to Immunological synapse R-HSA-202433, Generation of second messenger molecules R-HSA-210990, PECAM1 interactions R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2424491, DAP12 signaling R-HSA-389356, CD28 co-stimulation R-HSA-389357, CD28 dependent PI3K/Akt signaling R-HSA-389359, CD28 dependent Vav1 pathway R-HSA-389513, CTLA4 inhibitory signaling R-HSA-389948, PD-1 signaling R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-9020558, Interleukin-2 signaling R-HSA-9670439, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants |
SignaLinki | P06239 |
SIGNORi | P06239 |
Miscellaneous databases
BioGRID-ORCSi | 3932, 10 hits in 901 CRISPR screens |
ChiTaRSi | LCK, human |
EvolutionaryTracei | P06239 |
GeneWikii | Lck |
GenomeRNAii | 3932 |
Pharosi | P06239, Tclin |
PROi | PR:P06239 |
RNActi | P06239, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182866, Expressed in thymus and 162 other tissues |
ExpressionAtlasi | P06239, baseline and differential |
Genevisiblei | P06239, HS |
Family and domain databases
CDDi | cd10362, SH2_Src_Lck, 1 hit cd12005, SH3_Lck, 1 hit |
DisProti | DP01580 |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR035850, Lck_SH2 IPR035749, Lck_SH3 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07714, PK_Tyr_Ser-Thr, 1 hit PF00017, SH2, 1 hit PF00018, SH3_1, 1 hit |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 1 hit SM00219, TyrKc, 1 hit |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS50001, SH2, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LCK_HUMAN | |
Accessioni | P06239Primary (citable) accession number: P06239 Secondary accession number(s): D3DPP8 Q9NYT8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 263 of the entry and version 6 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families