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Entry version 158 (11 Dec 2019)
Sequence version 2 (12 Dec 2006)
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Protein

Alpha-2-macroglobulin

Gene

A2m

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processAcute phase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-114608 Platelet degranulation
R-RNO-140837 Intrinsic Pathway of Fibrin Clot Formation
R-RNO-1474228 Degradation of the extracellular matrix
R-RNO-194840 Rho GTPase cycle
R-RNO-8963896 HDL assembly

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I39.004

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-2-macroglobulin
Short name:
Alpha-2-M
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:A2m
Synonyms:A2m1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Rat genome database

More...
RGDi
2004 A2m

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Add BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000005828 – 1472Alpha-2-macroglobulinAdd BLAST1445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi52 ↔ 90By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi254 ↔ 302By similarity
Disulfide bondi272 ↔ 290By similarity
Disulfide bondi281Interchain (with C-434)By similarity
Glycosylationi399N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi434Interchain (with C-281)By similarity
Disulfide bondi473 ↔ 566By similarity
Disulfide bondi598 ↔ 769By similarity
Disulfide bondi647 ↔ 694By similarity
Glycosylationi651N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi772N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi819 ↔ 847By similarity
Disulfide bondi845 ↔ 881By similarity
Glycosylationi867N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi919 ↔ 1319By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki970 ↔ 973Isoglutamyl cysteine thioester (Cys-Gln)By similarity
Glycosylationi989N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1077 ↔ 1125By similarity
Disulfide bondi1350 ↔ 1465By similarity
Glycosylationi1364N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1422N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1426N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Thioester bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P06238

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P06238

PRoteomics IDEntifications database

More...
PRIDEi
P06238

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest constitutive expression in ovary. Low level in testis, uterus and non-acute phase liver. Protein found in plasma.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By inflammatory stimulus in liver. The level of this protein increases during acute phase, then decreases again.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000028896 Expressed in 8 organ(s), highest expression level in liver

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P06238 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer; disulfide-linked.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
246347, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000019346

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P06238

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni620 – 750Bait regionAdd BLAST131

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Bait region, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KCRI Eukaryota
ENOG410XQIV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154904

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220939

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P06238

KEGG Orthology (KO)

More...
KOi
K03910

Identification of Orthologs from Complete Genome Data

More...
OMAi
NPSNCFG

Database of Orthologous Groups

More...
OrthoDBi
354230at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P06238

TreeFam database of animal gene trees

More...
TreeFami
TF313285

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02897 A2M_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits
2.60.40.690, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011625 A2M_N_BRD
IPR041813 A2M_TED
IPR011626 Alpha-macroglobulin_TED
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR001599 Macroglobln_a2
IPR019742 MacrogloblnA2_CS
IPR002890 MG2
IPR041555 MG3
IPR040839 MG4
IPR008930 Terpenoid_cyclase/PrenylTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00207 A2M, 1 hit
PF07703 A2M_BRD, 1 hit
PF07677 A2M_recep, 1 hit
PF01835 MG2, 1 hit
PF17791 MG3, 1 hit
PF17789 MG4, 1 hit
PF07678 TED_complement, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00477 ALPHA_2_MACROGLOBULIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P06238-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKHRLRSLA LLPLLLRLLL LLLPTDASAP QKPIYMVMVP SLLHAGTPEK
60 70 80 90 100
ACFLFSHLNE TVAVRVSLES VRGNQSLFTD LVVDKDLFHC TSFTVPQSSS
110 120 130 140 150
DEVMFFTVQV KGATHEFRRR STVLVKKKES LVFAQTDKPI YKPGQTVRFR
160 170 180 190 200
VVSLDESFHP LNELIPLLYI QDPKNNRIAQ WQNFNLEGGL KQLSFPLSSE
210 220 230 240 250
PTQGSYKVVI RTESGRTVEH PFSVEEFVLP KFEVRVTVPE TITILEEEMN
260 270 280 290 300
VSVCGIYTYG KPVPGRVTVN ICRKYSNPSN CFGEESVAFC EKLSQQLDGR
310 320 330 340 350
GCFSQLVKTK SFQLKRQEYE MQLDVHAKIQ EEGTGVEETG KGLTKITRTI
360 370 380 390 400
TKLSFVNVDS HFRQGIPFVG QVLLVDGRGT PIPYETIFIG ADEANLYINT
410 420 430 440 450
TTDKHGLARF SINTDDIMGT SLTVRAKYKD SNACYGFRWL TEENVEAWHT
460 470 480 490 500
AYAVFSPSRS FLHLESLPDK LRCDQTLEVQ AHYILNGEAM QELKELVFYY
510 520 530 540 550
LMMAKGGIVR AGTHVLPLKQ GQMRGHFSIL ISMETDLAPV ARLVLYAILP
560 570 580 590 600
NGEVVGDTAK YEIENCLANK VDLVFRPNSG LPATRALLSV MASPQSLCGL
610 620 630 640 650
RAVDQSVLLM KPETELSASL IYDLLPVKDL TGFPQGADQR EEDTNGCVKQ
660 670 680 690 700
NDTYINGILY SPVQNTNEED MYGFLKDMGL KVFTNSNIRK PKVCERLRDN
710 720 730 740 750
KGIPAAYHLV SQSHMDAFLE SSESPTETRR SYFPETWIWD LVVVDSAGVA
760 770 780 790 800
EVEVTVPDTI TEWKAGAFCL SNDTGLGLSP VVQFQAFQPF FVELTMPYSV
810 820 830 840 850
IRGEAFTLKA TVLNYLPTCI RVAVQLEASP DFLAAPEEKE QRSHCICMNQ
860 870 880 890 900
RHTASWAVIP KSLGNVNFTV SAEALNSKEL CGNEVPVVPE QGKKDTIIKS
910 920 930 940 950
LLVEPEGLEN EVTFNSLLCP MGAEVSELIA LKLPSDVVEE SARASVTVLG
960 970 980 990 1000
DILGSAMQNT QDLLKMPYGC GEQNMVLFAP NIYVLDYLNE TQQLTQEIKT
1010 1020 1030 1040 1050
KAIAYLNTGY QRQLNYKHRD GSYSTFGDKP GRNHANTWLT AFVLKSFAQA
1060 1070 1080 1090 1100
RKYIFIDEVH ITQALLWLSQ QQKDNGCFRS SGSLLNNAMK GGVEDEVTLS
1110 1120 1130 1140 1150
AYITIALLEM SLPVTHPVVR NALFCLDTAW KSARGGAGGS HVYTKALLAY
1160 1170 1180 1190 1200
AFALAGNQDT KKEILKSLDE EAVKEEDSVH WTRPQKPSVS VALWYQPQAP
1210 1220 1230 1240 1250
SAEVEMTAYV LLAYLTTEPA PTQEDLTAAM LIVKWLTKQQ NSHGGFSSTQ
1260 1270 1280 1290 1300
DTVVALHALS KYGSATFTRA KKAAQVTIHS SGTFSTKFQV NNNNQLLLQR
1310 1320 1330 1340 1350
VTLPTVPGDY TVKVTGEGCV YLQTSLKYSV LPREEEFPFT VVVQTLPGTC
1360 1370 1380 1390 1400
EDPKAHTSFQ ISLNISYTGS RSESNMAIAD VKMVSGFIPL KPTVKMLERS
1410 1420 1430 1440 1450
VHVSRTEVSN NHVLIYLDKV SNQTVNLSFT VQQDIPIRDL KPAVVKVYDY
1460 1470
YEKDEFAVAK YSAPCSTDYG NA
Length:1,472
Mass (Da):163,785
Last modified:December 12, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFD63B8A4F6A2632
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti23L → V in CAA32164 (PubMed:2466233).Curated1
Sequence conflicti72R → H in AAA40636 (PubMed:2432068).Curated1
Sequence conflicti72R → H in CAA32164 (PubMed:2466233).Curated1
Sequence conflicti103V → L in AAA40636 (PubMed:2432068).Curated1
Sequence conflicti103V → L in CAA32164 (PubMed:2466233).Curated1
Sequence conflicti120R → Q in AAA40636 (PubMed:2432068).Curated1
Sequence conflicti120R → Q in CAA32164 (PubMed:2466233).Curated1
Sequence conflicti490M → L in AAA40638 (PubMed:2414291).Curated1
Sequence conflicti1025T → A in AAA40636 (PubMed:2432068).Curated1
Sequence conflicti1192A → G in AAA40636 (PubMed:2432068).Curated1
Sequence conflicti1200P → T in AAA40636 (PubMed:2432068).Curated1
Sequence conflicti1279H → R in AAA40636 (PubMed:2432068).Curated1
Sequence conflicti1340T → A in AAA40636 (PubMed:2432068).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J02635 mRNA Translation: AAA40636.1
BC098922 mRNA Translation: AAH98922.1
X13983, X13984, X13985 Genomic DNA Translation: CAA32164.1
M11792 mRNA Translation: AAA40637.1
M11793 mRNA Translation: AAA40638.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A26122

NCBI Reference Sequences

More...
RefSeqi
NP_036620.2, NM_012488.2
XP_003749876.1, XM_003749828.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000019346; ENSRNOP00000019346; ENSRNOG00000028896
ENSRNOT00000075799; ENSRNOP00000066130; ENSRNOG00000045772

Database of genes from NCBI RefSeq genomes

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GeneIDi
100911545
24153

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:100911545
rno:24153

UCSC genome browser

More...
UCSCi
RGD:2004 rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02635 mRNA Translation: AAA40636.1
BC098922 mRNA Translation: AAH98922.1
X13983, X13984, X13985 Genomic DNA Translation: CAA32164.1
M11792 mRNA Translation: AAA40637.1
M11793 mRNA Translation: AAA40638.1
PIRiA26122
RefSeqiNP_036620.2, NM_012488.2
XP_003749876.1, XM_003749828.2

3D structure databases

SMRiP06238
ModBaseiSearch...

Protein-protein interaction databases

BioGridi246347, 1 interactor
STRINGi10116.ENSRNOP00000019346

Protein family/group databases

MEROPSiI39.004

Proteomic databases

jPOSTiP06238
PaxDbiP06238
PRIDEiP06238

Genome annotation databases

EnsembliENSRNOT00000019346; ENSRNOP00000019346; ENSRNOG00000028896
ENSRNOT00000075799; ENSRNOP00000066130; ENSRNOG00000045772
GeneIDi100911545
24153
KEGGirno:100911545
rno:24153
UCSCiRGD:2004 rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2
RGDi2004 A2m

Phylogenomic databases

eggNOGiENOG410KCRI Eukaryota
ENOG410XQIV LUCA
GeneTreeiENSGT00940000154904
HOGENOMiHOG000220939
InParanoidiP06238
KOiK03910
OMAiNPSNCFG
OrthoDBi354230at2759
PhylomeDBiP06238
TreeFamiTF313285

Enzyme and pathway databases

ReactomeiR-RNO-114608 Platelet degranulation
R-RNO-140837 Intrinsic Pathway of Fibrin Clot Formation
R-RNO-1474228 Degradation of the extracellular matrix
R-RNO-194840 Rho GTPase cycle
R-RNO-8963896 HDL assembly

Miscellaneous databases

Protein Ontology

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PROi
PR:P06238

Gene expression databases

BgeeiENSRNOG00000028896 Expressed in 8 organ(s), highest expression level in liver
GenevisibleiP06238 RN

Family and domain databases

CDDicd02897 A2M_2, 1 hit
Gene3Di2.60.40.10, 2 hits
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011625 A2M_N_BRD
IPR041813 A2M_TED
IPR011626 Alpha-macroglobulin_TED
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR001599 Macroglobln_a2
IPR019742 MacrogloblnA2_CS
IPR002890 MG2
IPR041555 MG3
IPR040839 MG4
IPR008930 Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF00207 A2M, 1 hit
PF07703 A2M_BRD, 1 hit
PF07677 A2M_recep, 1 hit
PF01835 MG2, 1 hit
PF17791 MG3, 1 hit
PF17789 MG4, 1 hit
PF07678 TED_complement, 1 hit
SMARTiView protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit
SUPFAMiSSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00477 ALPHA_2_MACROGLOBULIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA2MG_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06238
Secondary accession number(s): Q4FZY3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: December 12, 2006
Last modified: December 11, 2019
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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