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Entry version 84 (02 Dec 2020)
Sequence version 1 (01 Jan 1988)
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Protein

DNA-directed RNA polymerase

Gene
N/A
Organism
Enterobacteria phage SP6 (Bacteriophage SP6)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase that catalyzes the transcription of viral genes.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei536By similarity1
Active sitei623By similarity1
Active sitei806By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription, Viral transcription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase (EC:2.7.7.61 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEnterobacteria phage SP6 (Bacteriophage SP6)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri194966 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesDuplodnaviriaHeunggongviraeUroviricotaCaudoviricetesCaudoviralesAutographiviridaeMolineuxvirinaeZindervirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiSalmonella typhimurium [TaxID: 90371]

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000877501 – 874DNA-directed RNA polymeraseAdd BLAST874

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.1320.10, 1 hit
1.10.287.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024075, DNA-dir_RNA_pol_helix_hairp_sf
IPR002092, DNA-dir_Rpol_phage-type
IPR043502, DNA/RNA_pol_sf
IPR037159, RNA_POL_N_sf
IPR029262, RPOL_N

The PANTHER Classification System

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PANTHERi
PTHR10102, PTHR10102, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00940, RNA_pol, 1 hit
PF14700, RPOL_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01311, RPOL_N, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00900, RNA_POL_PHAGE_1, 1 hit
PS00489, RNA_POL_PHAGE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P06221-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQDLHAIQLQ LEEEMFNGGI RRFEADQQRQ IAAGSESDTA WNRRLLSELI
60 70 80 90 100
APMAEGIQAY KEEYEGKKGR APRALAFLQC VENEVAAYIT MKVVMDMLNT
110 120 130 140 150
DATLQAIAMS VAERIEDQVR FSKLEGHAAK YFEKVKKSLK ASRTKSYRHA
160 170 180 190 200
HNVAVVAEKS VAEKDADFDR WEAWPKETQL QIGTTLLEIL EGSVFYNGEP
210 220 230 240 250
VFMRAMRTYG GKTIYYLQTS ESVGQWISAF KEHVAQLSPA YAPCVIPPRP
260 270 280 290 300
WRTPFNGGFH TEKVASRIRL VKGNREHVRK LTQKQMPKVY KAINALQNTQ
310 320 330 340 350
WQINKDVLAV IEEVIRLDLG YGVPSFKPLI DKENKPANPV PVEFQHLRGR
360 370 380 390 400
ELKEMLSPEQ WQQFINWKGE CARLYTAETK RGSKSAAVVR MVGQARKYSA
410 420 430 440 450
FESIYFVYAM DSRSRVYVQS STLSPQSNDL GKALLRFTEG RPVNGVEALK
460 470 480 490 500
WFCINGANLW GWDKKTFDVR VSNVLDEEFQ DMCRDIAADP LTFTQWAKAD
510 520 530 540 550
APYEFLAWCF EYAQYLDLVD EGRADEFRTH LPVHQDGSCS GIQHYSAMLR
560 570 580 590 600
DEVGAKAVNL KPSDAPQDIY GAVAQVVIKK NALYMDADDA TTFTSGSVTL
610 620 630 640 650
SGTELRAMAS AWDSIGITRS LTKKPVMTLP YGSTRLTCRE SVIDYIVDLE
660 670 680 690 700
EKEAQKAVAE GRTANKVHPF EDDRQDYLTP GAAYNYMTAL IWPSISEVVK
710 720 730 740 750
APIVAMKMIR QLARFAAKRN EGLMYTLPTG FILEQKIMAT EMLRVRTCLM
760 770 780 790 800
GDIKMSLQVE TDIVDEAAMM GAAAPNFVHG HDASHLILTV CELVDKGVTS
810 820 830 840 850
IAVIHDSFGT HADNTLTLRV ALKGQMVAMY IDGNALQKLL EEHEVRWMVD
860 870
TGIEVPEQGE FDLNEIMDSE YVFA
Length:874
Mass (Da):98,533
Last modified:January 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i207BD3F3CF9B501C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y00105 mRNA Translation: CAA68288.1

Protein sequence database of the Protein Information Resource

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PIRi
S07380

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00105 mRNA Translation: CAA68288.1
PIRiS07380

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.10.1320.10, 1 hit
1.10.287.260, 1 hit
InterProiView protein in InterPro
IPR024075, DNA-dir_RNA_pol_helix_hairp_sf
IPR002092, DNA-dir_Rpol_phage-type
IPR043502, DNA/RNA_pol_sf
IPR037159, RNA_POL_N_sf
IPR029262, RPOL_N
PANTHERiPTHR10102, PTHR10102, 1 hit
PfamiView protein in Pfam
PF00940, RNA_pol, 1 hit
PF14700, RPOL_N, 1 hit
SMARTiView protein in SMART
SM01311, RPOL_N, 1 hit
SUPFAMiSSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS00900, RNA_POL_PHAGE_1, 1 hit
PS00489, RNA_POL_PHAGE_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPOL_BPSP6
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06221
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: December 2, 2020
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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