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Protein

Estrogen receptor

Gene

ESR1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Miscellaneous

In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone-receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi179 – 244Nuclear receptorPROSITE-ProRule annotationAdd BLAST66
Zinc fingeri179 – 199NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri215 – 239NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • DNA-binding transcription factor activity Source: InterPro
  • estrogen receptor activity Source: AgBase
  • Hsp90 protein binding Source: AgBase
  • sequence-specific DNA binding Source: InterPro
  • steroid binding Source: UniProtKB-KW
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandLipid-binding, Metal-binding, Steroid-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Estrogen receptor
Short name:
ER
Alternative name(s):
ER-alpha
Estradiol receptor
Nuclear receptor subfamily 3 group A member 1
Gene namesi
Name:ESR1
Synonyms:ESR, NR3A1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536251 – 589Estrogen receptorAdd BLAST589

Proteomic databases

PaxDbiP06212
PRIDEiP06212

Interactioni

Subunit structurei

Binds DNA as a homodimer. Can form a heterodimer with ER-beta.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021137

Structurei

3D structure databases

ProteinModelPortaliP06212
SMRiP06212
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini305 – 541NR LBDPROSITE-ProRule annotationAdd BLAST237

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 178Modulating (transactivation AF-1)Add BLAST178
Regioni245 – 304HingeAdd BLAST60
Regioni305 – 589Transactivation AF-2By similarityAdd BLAST285

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. The modulating domain, also known as A/B or AF-1 domain has a ligand-independent transactivation function. The C-terminus contains a ligand-dependent transactivation domain, also known as E/F or AF-2 domain which overlaps with the ligand binding domain. AF-1 and AF-2 activate transcription independently and synergistically and act in a promoter- and cell-specific manner (By similarity).By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri179 – 199NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri215 – 239NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
HOGENOMiHOG000233468
HOVERGENiHBG108344
InParanoidiP06212
KOiK08550
PhylomeDBiP06212

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR024178 Oest_rcpt/oest-rel_rcp
IPR001292 Oestr_rcpt
IPR024736 Oestrogen-typ_rcpt_final_C_dom
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF12743 ESR1_C, 1 hit
PF00104 Hormone_recep, 1 hit
PF02159 Oest_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF500101 ER-a, 1 hit
PIRSF002527 ER-like_NR, 1 hit
PRINTSiPR00543 OESTROGENR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P06212-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMTLHTKAS GVTLLHQIQG TELETLSRPQ LKIPLERSLS DMYVESNKTG
60 70 80 90 100
VFNYPEGATY DFGTTAPVYG STTLSYAPTS ESFGSSSLAG FHSLNNVPPS
110 120 130 140 150
PVVFLQTAPQ LSPFIHHHSQ QVPYYLENEQ GSFGMREAAP PAFYRPSSDN
160 170 180 190 200
RRHSIRERMS STNEKGSLSM ESTKETRYCA VCNDYASGYH YGVWSCEGCK
210 220 230 240 250
AFFKRSIQGH NDYMCPATNQ CTIDKNRRKS CQACRLRKCY EVGMMKGGIR
260 270 280 290 300
KDRRGGEMMK QKRQREEQDS RNGEASSTEL RAPTLWTSPL VVKHNKKNSP
310 320 330 340 350
ALSLTAEQMV SALLEAEPPI VYSEYDPNRP FNEASMMTLL TNLADRELVH
360 370 380 390 400
MINWAKRVPG FVDLTLHDQV HLLECAWLEI LMIGLVWRSM EHPGKLLFAP
410 420 430 440 450
NLLLDRNQGK CVEGMVEIFD MLLATAARFR MMNLQGEEFV CLKSIILLNS
460 470 480 490 500
GVYTFLSSTL KSLEERDYIH RVLDKITDTL IHLMAKSGLS LQQQHRRLAQ
510 520 530 540 550
LLLILSHIRH MSNKGMEHLY NMKCKNVVPL YDLLLEMLDA HRLHAPAARS
560 570 580
AAPMEEENRN QLTTAPASSH SLQSFYINSK EEESMQNTI
Length:589
Mass (Da):66,746
Last modified:January 1, 1988 - v1
Checksum:i1B092233C770A54B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257E → R (PubMed:2901032).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03805 mRNA Translation: CAA27433.1
PIRiA40914 QRCHE
RefSeqiNP_990514.1, NM_205183.2
UniGeneiGga.650

Genome annotation databases

GeneIDi396099
KEGGigga:396099

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03805 mRNA Translation: CAA27433.1
PIRiA40914 QRCHE
RefSeqiNP_990514.1, NM_205183.2
UniGeneiGga.650

3D structure databases

ProteinModelPortaliP06212
SMRiP06212
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021137

Proteomic databases

PaxDbiP06212
PRIDEiP06212

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396099
KEGGigga:396099

Organism-specific databases

CTDi2099

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
HOGENOMiHOG000233468
HOVERGENiHBG108344
InParanoidiP06212
KOiK08550
PhylomeDBiP06212

Miscellaneous databases

PROiPR:P06212

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR024178 Oest_rcpt/oest-rel_rcp
IPR001292 Oestr_rcpt
IPR024736 Oestrogen-typ_rcpt_final_C_dom
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF12743 ESR1_C, 1 hit
PF00104 Hormone_recep, 1 hit
PF02159 Oest_recep, 1 hit
PF00105 zf-C4, 1 hit
PIRSFiPIRSF500101 ER-a, 1 hit
PIRSF002527 ER-like_NR, 1 hit
PRINTSiPR00543 OESTROGENR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiESR1_CHICK
AccessioniPrimary (citable) accession number: P06212
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 7, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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