UniProtKB - P06136 (FTSQ_ECOLI)
Cell division protein FtsQ
ftsQ
Functioni
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.
UniRule annotation2 PublicationsGO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- cell division Source: EcoliWiki
- division septum assembly Source: EcoliWiki
- FtsZ-dependent cytokinesis Source: EcoCyc
Keywordsi
Biological process | Cell cycle, Cell division |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10342-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division protein FtsQUniRule annotation |
Gene namesi | Name:ftsQUniRule annotation Ordered Locus Names:b0093, JW0091 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane UniRule annotation8 Publications; Single-pass type II membrane protein UniRule annotation8 Publications
Note: Localizes to the division septum. Localization requires FtsZ, FtsA, ZipA and FtsK, but not FtsL, FtsI and FtsN. Insertion into the membrane requires YidC and the Sec translocase.
Plasma Membrane
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Other locations
- cell division site Source: EcoCyc
- FtsQBL complex Source: ComplexPortal
- integral component of membrane Source: EcoliWiki
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 27 | CytoplasmicUniRule annotationAdd BLAST | 27 | |
Transmembranei | 28 – 48 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 49 – 276 | PeriplasmicUniRule annotationAdd BLAST | 228 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 29 | L → R: No change in activity. Correctly assembled, interacts with FtsB and FtsL, but fails to localize efficiently to the cell division site; when associated with R-32. Does not insert into the membrane and lack of activity; when associated with R-32 and P-38. 1 Publication | 1 | |
Mutagenesisi | 32 | L → R: No change in activity. Correctly assembled, interacts with FtsB and FtsL, but fails to localize efficiently to the cell division site; when associated with R-29. Does not insert into the membrane and lack of activity; when associated with R-29 and P-38. 1 Publication | 1 | |
Mutagenesisi | 38 | V → P: No change in activity. Does not insert into the membrane and lack of activity; when associated with R-29 and R-32. 1 Publication | 1 | |
Mutagenesisi | 91 | D → K or Q: Does not affect localization. 1 Publication | 1 | |
Mutagenesisi | 113 | K → D: Impairs localization. 1 Publication | 1 | |
Mutagenesisi | 125 | E → K: Impairs localization. 1 Publication | 1 | |
Mutagenesisi | 237 | D → N: Localizes to mid-cell, but is unable to form a functional complex with FtsL/FtsB. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000160580 | 1 – 276 | Cell division protein FtsQAdd BLAST | 276 |
Proteomic databases
PaxDbi | P06136 |
PRIDEi | P06136 |
Expressioni
Inductioni
Interactioni
Subunit structurei
Part of a complex composed of FtsB, FtsL and FtsQ. The complex can be formed before its localization to the division site. This tripartite complex can be divided further into a subcomplex of FtsB and FtsL, which forms in the absence of FtsQ.
Interacts with FtsA, FtsK, FtsL, FtsB, FtsW, FtsI, FtsN, FtsX and YmgF.
UniRule annotation4 PublicationsBinary interactionsi
P06136
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 4261112, 336 interactors 849224, 4 interactors |
ComplexPortali | CPX-3099, FtsQBL complex |
DIPi | DIP-9706N |
IntActi | P06136, 19 interactors |
MINTi | P06136 |
STRINGi | 511145.b0093 |
Structurei
Secondary structure
3D structure databases
SMRi | P06136 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06136 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 55 – 126 | POTRAPROSITE-ProRule annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 255 – 276 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 261 – 276 | Polar residuesSequence analysisAdd BLAST | 16 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG1589, Bacteria |
HOGENOMi | CLU_064041_2_1_6 |
InParanoidi | P06136 |
PhylomeDBi | P06136 |
Family and domain databases
Gene3Di | 3.40.50.11690, 1 hit |
HAMAPi | MF_00911, FtsQ_subfam, 1 hit |
InterProi | View protein in InterPro IPR005548, Cell_div_FtsQ/DivIB_C IPR026579, FtsQ IPR045335, FtsQ_C_sf IPR034746, POTRA IPR013685, POTRA_FtsQ_type |
PANTHERi | PTHR35851, PTHR35851, 1 hit |
Pfami | View protein in Pfam PF03799, FtsQ, 1 hit PF08478, POTRA_1, 1 hit |
PROSITEi | View protein in PROSITE PS51779, POTRA, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSQAALNTRN SEEEVSSRRN NGTRLAGILF LLTVLTTVLV SGWVVLGWME
60 70 80 90 100
DAQRLPLSKL VLTGERHYTR NDDIRQSILA LGEPGTFMTQ DVNIIQTQIE
110 120 130 140 150
QRLPWIKQVS VRKQWPDELK IHLVEYVPIA RWNDQHMVDA EGNTFSVPPE
160 170 180 190 200
RTSKQVLPML YGPEGSANEV LQGYREMGQM LAKDRFTLKE AAMTARRSWQ
210 220 230 240 250
LTLNNDIKLN LGRGDTMKRL ARFVELYPVL QQQAQTDGKR ISYVDLRYDS
260 270
GAAVGWAPLP PEESTQQQNQ AQAEQQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14029 Genomic DNA Translation: AAA23673.1 K02668 Genomic DNA Translation: AAA23816.1 X55034 Genomic DNA Translation: CAA38870.1 U00096 Genomic DNA Translation: AAC73204.1 AP009048 Genomic DNA Translation: BAB96661.1 |
PIRi | S10852, CEECQ |
RefSeqi | NP_414635.1, NC_000913.3 WP_000075748.1, NZ_SSZK01000004.1 |
Genome annotation databases
EnsemblBacteriai | AAC73204; AAC73204; b0093 BAB96661; BAB96661; BAB96661 |
GeneIDi | 944823 |
KEGGi | ecj:JW0091 eco:b0093 |
PATRICi | fig|1411691.4.peg.2187 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14029 Genomic DNA Translation: AAA23673.1 K02668 Genomic DNA Translation: AAA23816.1 X55034 Genomic DNA Translation: CAA38870.1 U00096 Genomic DNA Translation: AAC73204.1 AP009048 Genomic DNA Translation: BAB96661.1 |
PIRi | S10852, CEECQ |
RefSeqi | NP_414635.1, NC_000913.3 WP_000075748.1, NZ_SSZK01000004.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2VH1 | X-ray | 2.70 | A/B | 58-276 | [»] | |
4UE4 | electron microscopy | 7.00 | B | 29-50 | [»] | |
4V6M | electron microscopy | 7.10 | Z | 22-103 | [»] | |
5Z2W | X-ray | 3.00 | A | 53-261 | [»] | |
6H9N | X-ray | 2.60 | A | 57-276 | [»] | |
6H9O | X-ray | 2.80 | A/C | 57-276 | [»] | |
SMRi | P06136 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4261112, 336 interactors 849224, 4 interactors |
ComplexPortali | CPX-3099, FtsQBL complex |
DIPi | DIP-9706N |
IntActi | P06136, 19 interactors |
MINTi | P06136 |
STRINGi | 511145.b0093 |
Proteomic databases
PaxDbi | P06136 |
PRIDEi | P06136 |
Genome annotation databases
EnsemblBacteriai | AAC73204; AAC73204; b0093 BAB96661; BAB96661; BAB96661 |
GeneIDi | 944823 |
KEGGi | ecj:JW0091 eco:b0093 |
PATRICi | fig|1411691.4.peg.2187 |
Organism-specific databases
EchoBASEi | EB0338 |
Phylogenomic databases
eggNOGi | COG1589, Bacteria |
HOGENOMi | CLU_064041_2_1_6 |
InParanoidi | P06136 |
PhylomeDBi | P06136 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG10342-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P06136 |
PROi | PR:P06136 |
Family and domain databases
Gene3Di | 3.40.50.11690, 1 hit |
HAMAPi | MF_00911, FtsQ_subfam, 1 hit |
InterProi | View protein in InterPro IPR005548, Cell_div_FtsQ/DivIB_C IPR026579, FtsQ IPR045335, FtsQ_C_sf IPR034746, POTRA IPR013685, POTRA_FtsQ_type |
PANTHERi | PTHR35851, PTHR35851, 1 hit |
Pfami | View protein in Pfam PF03799, FtsQ, 1 hit PF08478, POTRA_1, 1 hit |
PROSITEi | View protein in PROSITE PS51779, POTRA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FTSQ_ECOLI | |
Accessioni | P06136Primary (citable) accession number: P06136 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | January 1, 1988 | |
Last modified: | February 23, 2022 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families