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UniProtKB - P06133 (UD2B4_HUMAN)

Entry version 198 (02 Jun 2021)
Sequence version 2 (15 Dec 1998)
Previous versions | rss
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Protein

UDP-glucuronosyltransferase 2B4

Gene

UGT2B4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867).

Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867).

Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867).

2 Publications

Caution

UGT2B4 has been previously described as an enzyme named UGT2B11. However the name UGT2B11 has now been reused for another human protein (see AC O75310).Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Some kinetic parameters were assessed using commercial enzymes, which may represent a mix of both active and inactive protein forms, and therefore modify the kinetic values.2 Publications
  1. KM=4.77 µM for 17alpha-estradiol/epiestradiol (when assaying glucuronidation at position 17)1 Publication
  2. KM=57.8 µM for calcitriol (when assaying glucuronidation at position 25)1 Publication
  1. Vmax=135 pmol/min/mg enzyme for the formation of 17alpha-estradiol 17-O-(beta-D-glucuronate)1 Publication
  2. Vmax=17 pmol/min/mg enzyme for the formation of 17alpha-estradiol 17-O-(beta-D-glucuronate)1 Publication
  3. Vmax=3.8 pmol/min/mg enzyme for the formation of 16alpha,17beta-estriol 16-O-(beta-D-glucuronate)1 Publication
  4. Vmax=9.2 pmol/min/mg enzyme for the formation of 16beta,17beta-estriol 16-O-(beta-D-glucuronate)1 Publication
  5. Vmax=174 pmol/min/mg enzyme for the formation of 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate)1 Publication
  6. Vmax=4.3 pmol/min/mg enzyme for the formation of calcitriol 25-O-(beta-D-glucuronate)1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.4.1.17, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P06133

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156588, Glucuronidation

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GT1, Glycosyltransferase Family 1

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001708

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B41 Publication (EC:2.4.1.171 Publication)
Short name:
UDPGT 2B4
Short name:
UGT2B4
Alternative name(s):
HLUG25
Hyodeoxycholic acid-specific UDPGT
UDPGTh-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UGT2B4Imported
Synonyms:UGT2B11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12553, UGT2B4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600067, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P06133

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000156096.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei493 – 509HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		7363

Open Targets

More...OpenTargetsi		ENSG00000156096

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA360

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P06133, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL6196

Drug and drug target database

More...DrugBanki		DB00714, Apomorphine
DB08907, Canagliflozin
DB01136, Carvedilol
DB06119, Cenobamate
DB00318, Codeine
DB14635, Curcumin sulfate
DB06292, Dapagliflozin
DB09213, Dexibuprofen
DB00514, Dextromethorphan
DB00586, Diclofenac
DB00783, Estradiol
DB00712, Flurbiprofen
DB11796, Fostemsavir
DB06741, Gavestinel
DB01241, Gemfibrozil
DB01050, Ibuprofen
DB00555, Lamotrigine
DB00295, Morphine
DB00794, Primidone
DB00503, Ritonavir

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UGT2B4

Domain mapping of disease mutations (DMDM)

More...DMDMi		6175083

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23By similarityAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003602824 – 528UDP-glucuronosyltransferase 2B4Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi315N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P06133

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P06133

MaxQB - The MaxQuant DataBase

More...MaxQBi		P06133

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P06133

PeptideAtlas

More...PeptideAtlasi		P06133

PRoteomics IDEntifications database

More...PRIDEi		P06133

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		34076
51871 [P06133-1]
850

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P06133, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P06133

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P06133

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000156096, Expressed in intestine and 67 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P06133, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P06133, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000156096, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113210, 1 interactor

Protein interaction database and analysis system

More...IntActi		P06133, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000305221

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P06133, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P06133

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1192, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158332

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012949_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P06133

Identification of Orthologs from Complete Genome Data

More...OMAi		IYVLYFE

Database of Orthologous Groups

More...OrthoDBi		508327at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P06133

TreeFam database of animal gene trees

More...TreeFami		TF315472

Family and domain databases

Conserved Domains Database

More...CDDi		cd03784, GT1_Gtf-like, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002213, UDP_glucos_trans
IPR035595, UDP_glycos_trans_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00201, UDPGT, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00375, UDPGT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P06133-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSMKWTSALL LIQLSCYFSS GSCGKVLVWP TEFSHWMNIK TILDELVQRG 
        60         70         80         90        100
HEVTVLASSA SISFDPNSPS TLKFEVYPVS LTKTEFEDII KQLVKRWAEL 
       110        120        130        140        150
PKDTFWSYFS QVQEIMWTFN DILRKFCKDI VSNKKLMKKL QESRFDVVLA 
       160        170        180        190        200
DAVFPFGELL AELLKIPFVY SLRFSPGYAI EKHSGGLLFP PSYVPVVMSE 
       210        220        230        240        250
LSDQMTFIER VKNMIYVLYF EFWFQIFDMK KWDQFYSEVL GRPTTLSETM 
       260        270        280        290        300
AKADIWLIRN YWDFQFPHPL LPNVEFVGGL HCKPAKPLPK EMEEFVQSSG 
       310        320        330        340        350
ENGVVVFSLG SMVSNTSEER ANVIASALAK IPQKVLWRFD GNKPDTLGLN 
       360        370        380        390        400
TRLYKWIPQN DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGVPLFADQP 
       410        420        430        440        450
DNIAHMKAKG AAVSLDFHTM SSTDLLNALK TVINDPLYKE NAMKLSRIHH 
       460        470        480        490        500
DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA HDLTWFQYHS LDVTGFLLAC 
       510        520 
VATVIFIITK CLFCVWKFVR TGKKGKRD
Length:528
Mass (Da):60,513
Last modified:December 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B45E6769971A078
GO
Isoform 2 (identifier: P06133-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MSMKWTSALLLIQL → MFFALLHVSSTNGL
     15-150: Missing.

Show »
Length:392
Mass (Da):44,593
Checksum:i86803DC78D6790A6
GO
Isoform 3 (identifier: P06133-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     364-369: GHPKTR → DIKRML
     370-528: Missing.

Show »
Length:369
Mass (Da):42,723
Checksum:i0590B6A6B4D29FCE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RGY0D6RGY0_HUMAN
UDP-glucuronosyltransferase 2B4
UGT2B4
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQJ2A0A1W2PQJ2_HUMAN
UDP-glucuronosyltransferase 2B4
UGT2B4
369Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti171 – 172SL → RP in CAA68415 (PubMed:3109396).Curated2
Sequence conflicti291 – 293EME → KWK in AAC32272 (Ref. 4) Curated3
Sequence conflicti309L → V in AAS47487 (Ref. 6) 1 Publication1
Sequence conflicti354Y → H in AAS47487 (Ref. 6) 1 Publication1
Sequence conflicti382 – 387EAIYHG → KAISPR in CAA68415 (PubMed:3109396).Curated6

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06071340K → N1 PublicationCorresponds to variant dbSNP:rs41299974EnsemblClinVar.1
Natural variantiVAR_06071478P → T1 PublicationCorresponds to variant dbSNP:rs41299976Ensembl.1
Natural variantiVAR_06071580S → P1 PublicationCorresponds to variant dbSNP:rs41299978EnsemblClinVar.1
Natural variantiVAR_011328109F → L1 Publication1
Natural variantiVAR_060716277V → I1 PublicationCorresponds to variant dbSNP:rs41300004Ensembl.1
Natural variantiVAR_011329396F → L1 PublicationCorresponds to variant dbSNP:rs72552707Ensembl.1
Natural variantiVAR_007712458D → E2 PublicationsCorresponds to variant dbSNP:rs13119049Ensembl.1
Natural variantiVAR_060717511C → R1 PublicationCorresponds to variant dbSNP:rs41298245Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0566791 – 14MSMKW…LLIQL → MFFALLHVSSTNGL in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_05668015 – 150Missing in isoform 2. 1 PublicationAdd BLAST136
Alternative sequenceiVSP_056869364 – 369GHPKTR → DIKRML in isoform 3. 1 Publication6
Alternative sequenceiVSP_056870370 – 528Missing in isoform 3. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y00317 mRNA Translation: CAA68415.1
AF064200 mRNA Translation: AAC95002.1
AJ005162 mRNA Translation: CAA06396.1
AF081793 mRNA Translation: AAC32272.1
AF135416 Genomic DNA Translation: AAF78145.1
AY529122 mRNA Translation: AAS47487.1
DQ520733 Genomic DNA Translation: ABF47107.1
AK292748 mRNA Translation: BAF85437.1
AK300084 mRNA Translation: BAG61887.1
AC093829 Genomic DNA No translation available.
AC108078 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05591.1
BC026264 mRNA Translation: AAH26264.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43234.1 [P06133-1]
CCDS75137.1 [P06133-3]

Protein sequence database of the Protein Information Resource

More...PIRi		JN0619

NCBI Reference Sequences

More...RefSeqi		NP_001284544.1, NM_001297615.1 [P06133-3]
NP_001284545.1, NM_001297616.1 [P06133-2]
NP_066962.2, NM_021139.2 [P06133-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000305107; ENSP00000305221; ENSG00000156096 [P06133-1]
ENST00000512583; ENSP00000421290; ENSG00000156096 [P06133-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7363

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7363

UCSC genome browser

More...UCSCi		uc003hek.4, human [P06133-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00317 mRNA Translation: CAA68415.1
AF064200 mRNA Translation: AAC95002.1
AJ005162 mRNA Translation: CAA06396.1
AF081793 mRNA Translation: AAC32272.1
AF135416 Genomic DNA Translation: AAF78145.1
AY529122 mRNA Translation: AAS47487.1
DQ520733 Genomic DNA Translation: ABF47107.1
AK292748 mRNA Translation: BAF85437.1
AK300084 mRNA Translation: BAG61887.1
AC093829 Genomic DNA No translation available.
AC108078 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05591.1
BC026264 mRNA Translation: AAH26264.1
CCDSiCCDS43234.1 [P06133-1]
CCDS75137.1 [P06133-3]
PIRiJN0619
RefSeqiNP_001284544.1, NM_001297615.1 [P06133-3]
NP_001284545.1, NM_001297616.1 [P06133-2]
NP_066962.2, NM_021139.2 [P06133-1]

3D structure databases

SMRiP06133
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi113210, 1 interactor
IntActiP06133, 2 interactors
STRINGi9606.ENSP00000305221

Chemistry databases

ChEMBLiCHEMBL6196
DrugBankiDB00714, Apomorphine
DB08907, Canagliflozin
DB01136, Carvedilol
DB06119, Cenobamate
DB00318, Codeine
DB14635, Curcumin sulfate
DB06292, Dapagliflozin
DB09213, Dexibuprofen
DB00514, Dextromethorphan
DB00586, Diclofenac
DB00783, Estradiol
DB00712, Flurbiprofen
DB11796, Fostemsavir
DB06741, Gavestinel
DB01241, Gemfibrozil
DB01050, Ibuprofen
DB00555, Lamotrigine
DB00295, Morphine
DB00794, Primidone
DB00503, Ritonavir
SwissLipidsiSLP:000001708

Protein family/group databases

CAZyiGT1, Glycosyltransferase Family 1

PTM databases

GlyGeniP06133, 1 site
iPTMnetiP06133
PhosphoSitePlusiP06133

Genetic variation databases

BioMutaiUGT2B4
DMDMi6175083

Proteomic databases

jPOSTiP06133
MassIVEiP06133
MaxQBiP06133
PaxDbiP06133
PeptideAtlasiP06133
PRIDEiP06133
ProteomicsDBi34076
51871 [P06133-1]
850

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24236, 195 antibodies

The DNASU plasmid repository

More...DNASUi		7363

Genome annotation databases

EnsembliENST00000305107; ENSP00000305221; ENSG00000156096 [P06133-1]
ENST00000512583; ENSP00000421290; ENSG00000156096 [P06133-3]
GeneIDi7363
KEGGihsa:7363
UCSCiuc003hek.4, human [P06133-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7363
DisGeNETi7363

GeneCards: human genes, protein and diseases

More...GeneCardsi		UGT2B4
HGNCiHGNC:12553, UGT2B4
HPAiENSG00000156096, Tissue enriched (liver)
MIMi600067, gene
neXtProtiNX_P06133
OpenTargetsiENSG00000156096
PharmGKBiPA360
VEuPathDBiHostDB:ENSG00000156096.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1192, Eukaryota
GeneTreeiENSGT00940000158332
HOGENOMiCLU_012949_5_1_1
InParanoidiP06133
OMAiIYVLYFE
OrthoDBi508327at2759
PhylomeDBiP06133
TreeFamiTF315472

Enzyme and pathway databases

BRENDAi2.4.1.17, 2681
PathwayCommonsiP06133
ReactomeiR-HSA-156588, Glucuronidation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7363, 3 hits in 984 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		UGT2B4, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		UGT2B4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7363
PharosiP06133, Tbio

Protein Ontology

More...PROi		PR:P06133
RNActiP06133, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000156096, Expressed in intestine and 67 other tissues
ExpressionAtlasiP06133, baseline and differential
GenevisibleiP06133, HS

Family and domain databases

CDDicd03784, GT1_Gtf-like, 1 hit
InterProiView protein in InterPro
IPR002213, UDP_glucos_trans
IPR035595, UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201, UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375, UDPGT, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUD2B4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06133
Secondary accession number(s): A6NCP7
, B4DT75, G5E9X8, O60731, O60867, O75614, P36538, Q1HBF9, Q6QQX7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: December 15, 1998
Last modified: June 2, 2021
This is version 198 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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