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Protein

UDP-glucuronosyltransferase 2B4

Gene

UGT2B4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.

Caution

PubMed:8333863 thought that this was a new form (UGT2B11). The name UGT2B11 has now been reused for another human enzyme.Curated

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  • glucuronosyltransferase activity Source: BHF-UCL
  • UDP-glycosyltransferase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17 2681
ReactomeiR-HSA-156588 Glucuronidation

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Chemistry databases

SwissLipidsiSLP:000001708

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B4 (EC:2.4.1.17)
Short name:
UDPGT 2B4
Alternative name(s):
HLUG25
Hyodeoxycholic acid-specific UDPGT
UDPGTh-1
Gene namesi
Name:UGT2B4
Synonyms:UGT2B11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000156096.12
HGNCiHGNC:12553 UGT2B4
MIMi600067 gene
neXtProtiNX_P06133

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei493 – 509HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi7363
OpenTargetsiENSG00000156096
PharmGKBiPA360

Chemistry databases

ChEMBLiCHEMBL6196
DrugBankiDB08907 Canagliflozin
DB00318 Codeine
DB06292 Dapagliflozin
DB00712 Flurbiprofen
DB06741 Gavestinel
DB01050 Ibuprofen
DB00295 Morphine

Polymorphism and mutation databases

BioMutaiUGT2B4
DMDMi6175083

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000003602824 – 528UDP-glucuronosyltransferase 2B4Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi315N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP06133
PaxDbiP06133
PeptideAtlasiP06133
PRIDEiP06133
ProteomicsDBi51871

PTM databases

iPTMnetiP06133
PhosphoSitePlusiP06133

Expressioni

Gene expression databases

BgeeiENSG00000156096 Expressed in 53 organ(s), highest expression level in liver
CleanExiHS_UGT2B11
HS_UGT2B4
ExpressionAtlasiP06133 baseline and differential
GenevisibleiP06133 HS

Organism-specific databases

HPAiCAB033260
HPA045108

Interactioni

Protein-protein interaction databases

BioGridi113210, 1 interactor
IntActiP06133, 1 interactor
STRINGi9606.ENSP00000305221

Structurei

3D structure databases

ProteinModelPortaliP06133
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOGENOMiHOG000220831
HOVERGENiHBG004033
InParanoidiP06133
KOiK00699
OMAiRSQYIFV
OrthoDBiEOG091G06JC
PhylomeDBiP06133
TreeFamiTF315472

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P06133-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSMKWTSALL LIQLSCYFSS GSCGKVLVWP TEFSHWMNIK TILDELVQRG
60 70 80 90 100
HEVTVLASSA SISFDPNSPS TLKFEVYPVS LTKTEFEDII KQLVKRWAEL
110 120 130 140 150
PKDTFWSYFS QVQEIMWTFN DILRKFCKDI VSNKKLMKKL QESRFDVVLA
160 170 180 190 200
DAVFPFGELL AELLKIPFVY SLRFSPGYAI EKHSGGLLFP PSYVPVVMSE
210 220 230 240 250
LSDQMTFIER VKNMIYVLYF EFWFQIFDMK KWDQFYSEVL GRPTTLSETM
260 270 280 290 300
AKADIWLIRN YWDFQFPHPL LPNVEFVGGL HCKPAKPLPK EMEEFVQSSG
310 320 330 340 350
ENGVVVFSLG SMVSNTSEER ANVIASALAK IPQKVLWRFD GNKPDTLGLN
360 370 380 390 400
TRLYKWIPQN DLLGHPKTRA FITHGGANGI YEAIYHGIPM VGVPLFADQP
410 420 430 440 450
DNIAHMKAKG AAVSLDFHTM SSTDLLNALK TVINDPLYKE NAMKLSRIHH
460 470 480 490 500
DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA HDLTWFQYHS LDVTGFLLAC
510 520
VATVIFIITK CLFCVWKFVR TGKKGKRD
Length:528
Mass (Da):60,513
Last modified:December 15, 1998 - v2
Checksum:i6B45E6769971A078
GO
Isoform 2 (identifier: P06133-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MSMKWTSALLLIQL → MFFALLHVSSTNGL
     15-150: Missing.

Note: No experimental confirmation available.
Show »
Length:392
Mass (Da):44,593
Checksum:i86803DC78D6790A6
GO
Isoform 3 (identifier: P06133-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     364-369: GHPKTR → DIKRML
     370-528: Missing.

Note: No experimental confirmation available.
Show »
Length:369
Mass (Da):42,723
Checksum:i0590B6A6B4D29FCE
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RGY0D6RGY0_HUMAN
UDP-glucuronosyltransferase 2B4
UGT2B4
54Annotation score:
A0A1W2PQJ2A0A1W2PQJ2_HUMAN
UDP-glucuronosyltransferase 2B4
UGT2B4
369Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171 – 172SL → RP in CAA68415 (PubMed:3109396).Curated2
Sequence conflicti291 – 293EME → KWK in AAC32272 (Ref. 4) Curated3
Sequence conflicti309L → V in AAS47487 (Ref. 6) 1 Publication1
Sequence conflicti354Y → H in AAS47487 (Ref. 6) 1 Publication1
Sequence conflicti382 – 387EAIYHG → KAISPR in CAA68415 (PubMed:3109396).Curated6

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06071340K → N1 PublicationCorresponds to variant dbSNP:rs41299974Ensembl.1
Natural variantiVAR_06071478P → T1 PublicationCorresponds to variant dbSNP:rs41299976Ensembl.1
Natural variantiVAR_06071580S → P1 PublicationCorresponds to variant dbSNP:rs41299978Ensembl.1
Natural variantiVAR_011328109F → L1 Publication1
Natural variantiVAR_060716277V → I1 PublicationCorresponds to variant dbSNP:rs41300004Ensembl.1
Natural variantiVAR_011329396F → L1 PublicationCorresponds to variant dbSNP:rs72552707Ensembl.1
Natural variantiVAR_007712458D → E2 PublicationsCorresponds to variant dbSNP:rs13119049Ensembl.1
Natural variantiVAR_060717511C → R1 PublicationCorresponds to variant dbSNP:rs41298245Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0566791 – 14MSMKW…LLIQL → MFFALLHVSSTNGL in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_05668015 – 150Missing in isoform 2. 1 PublicationAdd BLAST136
Alternative sequenceiVSP_056869364 – 369GHPKTR → DIKRML in isoform 3. 1 Publication6
Alternative sequenceiVSP_056870370 – 528Missing in isoform 3. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00317 mRNA Translation: CAA68415.1
AF064200 mRNA Translation: AAC95002.1
AJ005162 mRNA Translation: CAA06396.1
AF081793 mRNA Translation: AAC32272.1
AF135416 Genomic DNA Translation: AAF78145.1
AY529122 mRNA Translation: AAS47487.1
DQ520733 Genomic DNA Translation: ABF47107.1
AK292748 mRNA Translation: BAF85437.1
AK300084 mRNA Translation: BAG61887.1
AC093829 Genomic DNA No translation available.
AC108078 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05591.1
BC026264 mRNA Translation: AAH26264.1
CCDSiCCDS43234.1 [P06133-1]
CCDS75137.1 [P06133-3]
PIRiJN0619
RefSeqiNP_001284544.1, NM_001297615.1 [P06133-3]
NP_001284545.1, NM_001297616.1 [P06133-2]
NP_066962.2, NM_021139.2 [P06133-1]
UniGeneiHs.285887

Genome annotation databases

EnsembliENST00000305107; ENSP00000305221; ENSG00000156096 [P06133-1]
ENST00000512583; ENSP00000421290; ENSG00000156096 [P06133-3]
GeneIDi7363
KEGGihsa:7363
UCSCiuc003hek.4 human [P06133-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00317 mRNA Translation: CAA68415.1
AF064200 mRNA Translation: AAC95002.1
AJ005162 mRNA Translation: CAA06396.1
AF081793 mRNA Translation: AAC32272.1
AF135416 Genomic DNA Translation: AAF78145.1
AY529122 mRNA Translation: AAS47487.1
DQ520733 Genomic DNA Translation: ABF47107.1
AK292748 mRNA Translation: BAF85437.1
AK300084 mRNA Translation: BAG61887.1
AC093829 Genomic DNA No translation available.
AC108078 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05591.1
BC026264 mRNA Translation: AAH26264.1
CCDSiCCDS43234.1 [P06133-1]
CCDS75137.1 [P06133-3]
PIRiJN0619
RefSeqiNP_001284544.1, NM_001297615.1 [P06133-3]
NP_001284545.1, NM_001297616.1 [P06133-2]
NP_066962.2, NM_021139.2 [P06133-1]
UniGeneiHs.285887

3D structure databases

ProteinModelPortaliP06133
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113210, 1 interactor
IntActiP06133, 1 interactor
STRINGi9606.ENSP00000305221

Chemistry databases

ChEMBLiCHEMBL6196
DrugBankiDB08907 Canagliflozin
DB00318 Codeine
DB06292 Dapagliflozin
DB00712 Flurbiprofen
DB06741 Gavestinel
DB01050 Ibuprofen
DB00295 Morphine
SwissLipidsiSLP:000001708

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

PTM databases

iPTMnetiP06133
PhosphoSitePlusiP06133

Polymorphism and mutation databases

BioMutaiUGT2B4
DMDMi6175083

Proteomic databases

MaxQBiP06133
PaxDbiP06133
PeptideAtlasiP06133
PRIDEiP06133
ProteomicsDBi51871

Protocols and materials databases

DNASUi7363
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305107; ENSP00000305221; ENSG00000156096 [P06133-1]
ENST00000512583; ENSP00000421290; ENSG00000156096 [P06133-3]
GeneIDi7363
KEGGihsa:7363
UCSCiuc003hek.4 human [P06133-1]

Organism-specific databases

CTDi7363
DisGeNETi7363
EuPathDBiHostDB:ENSG00000156096.12
GeneCardsiUGT2B4
HGNCiHGNC:12553 UGT2B4
HPAiCAB033260
HPA045108
MIMi600067 gene
neXtProtiNX_P06133
OpenTargetsiENSG00000156096
PharmGKBiPA360
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1192 Eukaryota
COG1819 LUCA
GeneTreeiENSGT00760000118949
HOGENOMiHOG000220831
HOVERGENiHBG004033
InParanoidiP06133
KOiK00699
OMAiRSQYIFV
OrthoDBiEOG091G06JC
PhylomeDBiP06133
TreeFamiTF315472

Enzyme and pathway databases

BRENDAi2.4.1.17 2681
ReactomeiR-HSA-156588 Glucuronidation

Miscellaneous databases

ChiTaRSiUGT2B4 human
GeneWikiiUGT2B4
GenomeRNAii7363
PROiPR:P06133
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156096 Expressed in 53 organ(s), highest expression level in liver
CleanExiHS_UGT2B11
HS_UGT2B4
ExpressionAtlasiP06133 baseline and differential
GenevisibleiP06133 HS

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUD2B4_HUMAN
AccessioniPrimary (citable) accession number: P06133
Secondary accession number(s): A6NCP7
, B4DT75, G5E9X8, O60731, O60867, O75614, P36538, Q1HBF9, Q6QQX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: December 15, 1998
Last modified: November 7, 2018
This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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