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Entry version 186 (03 Jul 2019)
Sequence version 2 (30 Nov 2010)
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Protein

T-cell surface glycoprotein CD5

Gene

CD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a receptor in regulating T-cell proliferation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P06127

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
T-cell surface glycoprotein CD5
Alternative name(s):
Lymphocyte antigen T1/Leu-1
CD_antigen: CD5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD5
Synonyms:LEU1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1685 CD5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
153340 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P06127

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 372ExtracellularSequence analysisAdd BLAST348
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei373 – 402HelicalSequence analysisAdd BLAST30
Topological domaini403 – 495CytoplasmicSequence analysisAdd BLAST93

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
921

Open Targets

More...
OpenTargetsi
ENSG00000110448

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26224

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3712888

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CD5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104090

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Add BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003322225 – 495T-cell surface glycoprotein CD5Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi44 ↔ 86PROSITE-ProRule annotation1 Publication
Disulfide bondi60 ↔ 125PROSITE-ProRule annotation1 Publication
Disulfide bondi81 ↔ 132PROSITE-ProRule annotation1 Publication
Disulfide bondi107 ↔ 117PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi201 ↔ 267PROSITE-ProRule annotation
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi244 ↔ 250PROSITE-ProRule annotation
Disulfide bondi285 ↔ 321PROSITE-ProRule annotation1 Publication
Disulfide bondi301 ↔ 360PROSITE-ProRule annotation1 Publication
Disulfide bondi316 ↔ 367PROSITE-ProRule annotation1 Publication
Disulfide bondi342 ↔ 350PROSITE-ProRule annotation1 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei439PhosphoserineCombined sources1
Modified residuei453PhosphotyrosineCombined sources1
Modified residuei460PhosphoserineCombined sources1
Modified residuei483PhosphoserineCombined sources1
Modified residuei485PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P06127

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P06127

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P06127

PeptideAtlas

More...
PeptideAtlasi
P06127

PRoteomics IDEntifications database

More...
PRIDEi
P06127

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51869

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
589

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P06127

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P06127

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P06127

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P06127

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110448 Expressed in 101 organ(s), highest expression level in leukocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P06127 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P06127 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB015392
CAB020308
HPA043416
HPA060839

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CD72/LYB-2.

Interacts with PTPN6/SHP-1 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107359, 14 interactors

Database of interacting proteins

More...
DIPi
DIP-21N

Protein interaction database and analysis system

More...
IntActi
P06127, 4 interactors

Molecular INTeraction database

More...
MINTi
P06127

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000342681

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1495
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P06127

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P06127

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 133SRCR 1PROSITE-ProRule annotationAdd BLAST99
Domaini159 – 268SRCR 2PROSITE-ProRule annotationAdd BLAST110
Domaini276 – 368SRCR 3PROSITE-ProRule annotationAdd BLAST93

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ3D Eukaryota
ENOG4111C54 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017536

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111490

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P06127

KEGG Orthology (KO)

More...
KOi
K06455

Identification of Orthologs from Complete Genome Data

More...
OMAi
FHRNHTA

Database of Orthologous Groups

More...
OrthoDBi
1017770at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P06127

TreeFam database of animal gene trees

More...
TreeFami
TF329295

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.250.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR003566 Tcell_CD5

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00530 SRCR, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00258 SPERACTRCPTR
PR01409 TCELLCD5

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00202 SR, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56487 SSF56487, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50287 SRCR_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P06127-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPMGSLQPLA TLYLLGMLVA SCLGRLSWYD PDFQARLTRS NSKCQGQLEV
60 70 80 90 100
YLKDGWHMVC SQSWGRSSKQ WEDPSQASKV CQRLNCGVPL SLGPFLVTYT
110 120 130 140 150
PQSSIICYGQ LGSFSNCSHS RNDMCHSLGL TCLEPQKTTP PTTRPPPTTT
160 170 180 190 200
PEPTAPPRLQ LVAQSGGQHC AGVVEFYSGS LGGTISYEAQ DKTQDLENFL
210 220 230 240 250
CNNLQCGSFL KHLPETEAGR AQDPGEPREH QPLPIQWKIQ NSSCTSLEHC
260 270 280 290 300
FRKIKPQKSG RVLALLCSGF QPKVQSRLVG GSSICEGTVE VRQGAQWAAL
310 320 330 340 350
CDSSSARSSL RWEEVCREQQ CGSVNSYRVL DAGDPTSRGL FCPHQKLSQC
360 370 380 390 400
HELWERNSYC KKVFVTCQDP NPAGLAAGTV ASIILALVLL VVLLVVCGPL
410 420 430 440 450
AYKKLVKKFR QKKQRQWIGP TGMNQNMSFH RNHTATVRSH AENPTASHVD
460 470 480 490
NEYSQPPRNS HLSAYPALEG ALHRSSMQPD NSSDSDYDLH GAQRL
Length:495
Mass (Da):54,578
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9131AEC9683EE1D3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GYK3F5GYK3_HUMAN
T-cell surface glycoprotein CD5
CD5
165Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti289V → E in BAF85387 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020411224P → L1 PublicationCorresponds to variant dbSNP:rs2241002Ensembl.1
Natural variantiVAR_024649461H → RCombined sources5 PublicationsCorresponds to variant dbSNP:rs637186Ensembl.1
Natural variantiVAR_058203471A → V4 PublicationsCorresponds to variant dbSNP:rs2229177Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X04391 mRNA Translation: CAA27979.1
X89405
, AJ237927, AJ237928, AJ237929, AJ237930, AJ237931, AJ237932 Genomic DNA Translation: CAA61584.2
EF064752 Genomic DNA Translation: ABK41935.1
AK292698 mRNA Translation: BAF85387.1
AP000437 Genomic DNA No translation available.
BC027901 mRNA Translation: AAH27901.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8000.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A26396

NCBI Reference Sequences

More...
RefSeqi
NP_001333385.1, NM_001346456.1
NP_055022.2, NM_014207.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000347785; ENSP00000342681; ENSG00000110448

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
921

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:921

UCSC genome browser

More...
UCSCi
uc009ynk.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04391 mRNA Translation: CAA27979.1
X89405
, AJ237927, AJ237928, AJ237929, AJ237930, AJ237931, AJ237932 Genomic DNA Translation: CAA61584.2
EF064752 Genomic DNA Translation: ABK41935.1
AK292698 mRNA Translation: BAF85387.1
AP000437 Genomic DNA No translation available.
BC027901 mRNA Translation: AAH27901.1
CCDSiCCDS8000.1
PIRiA26396
RefSeqiNP_001333385.1, NM_001346456.1
NP_055022.2, NM_014207.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JA4X-ray2.21A270-369[»]
2JOPNMR-A25-134[»]
2JP0NMR-A25-134[»]
2OTTX-ray2.50X/Y276-368[»]
SMRiP06127
ModBaseiSearch...

Protein-protein interaction databases

BioGridi107359, 14 interactors
DIPiDIP-21N
IntActiP06127, 4 interactors
MINTiP06127
STRINGi9606.ENSP00000342681

Chemistry databases

ChEMBLiCHEMBL3712888

PTM databases

GlyConnecti589
iPTMnetiP06127
PhosphoSitePlusiP06127
SwissPalmiP06127
UniCarbKBiP06127

Polymorphism and mutation databases

BioMutaiCD5
DMDMi313104090

Proteomic databases

jPOSTiP06127
MaxQBiP06127
PaxDbiP06127
PeptideAtlasiP06127
PRIDEiP06127
ProteomicsDBi51869

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P06127

The DNASU plasmid repository

More...
DNASUi
921
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000347785; ENSP00000342681; ENSG00000110448
GeneIDi921
KEGGihsa:921
UCSCiuc009ynk.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
921
DisGeNETi921

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CD5

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0009680
HGNCiHGNC:1685 CD5
HPAiCAB015392
CAB020308
HPA043416
HPA060839
MIMi153340 gene
neXtProtiNX_P06127
OpenTargetsiENSG00000110448
PharmGKBiPA26224

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJ3D Eukaryota
ENOG4111C54 LUCA
GeneTreeiENSGT00390000017536
HOGENOMiHOG000111490
InParanoidiP06127
KOiK06455
OMAiFHRNHTA
OrthoDBi1017770at2759
PhylomeDBiP06127
TreeFamiTF329295

Enzyme and pathway databases

SIGNORiP06127

Miscellaneous databases

EvolutionaryTraceiP06127

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CD5_(protein)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
921

Protein Ontology

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PROi
PR:P06127

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000110448 Expressed in 101 organ(s), highest expression level in leukocyte
ExpressionAtlasiP06127 baseline and differential
GenevisibleiP06127 HS

Family and domain databases

Gene3Di3.10.250.10, 2 hits
InterProiView protein in InterPro
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR003566 Tcell_CD5
PfamiView protein in Pfam
PF00530 SRCR, 1 hit
PRINTSiPR00258 SPERACTRCPTR
PR01409 TCELLCD5
SMARTiView protein in SMART
SM00202 SR, 2 hits
SUPFAMiSSF56487 SSF56487, 2 hits
PROSITEiView protein in PROSITE
PS50287 SRCR_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06127
Secondary accession number(s): A0N0P4, A8K9I3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 30, 2010
Last modified: July 3, 2019
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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