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Protein

T-cell surface glycoprotein CD5

Gene

CD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a receptor in regulating T-cell proliferation.

GO - Molecular functioni

  • scavenger receptor activity Source: InterPro
  • signaling receptor activity Source: UniProtKB
  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

  • apoptotic signaling pathway Source: Ensembl
  • cell proliferation Source: UniProtKB
  • cell recognition Source: UniProtKB
  • T cell costimulation Source: Ensembl

Enzyme and pathway databases

SIGNORiP06127

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD5
Alternative name(s):
Lymphocyte antigen T1/Leu-1
CD_antigen: CD5
Gene namesi
Name:CD5
Synonyms:LEU1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110448.10
HGNCiHGNC:1685 CD5
MIMi153340 gene
neXtProtiNX_P06127

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 372ExtracellularSequence analysisAdd BLAST348
Transmembranei373 – 402HelicalSequence analysisAdd BLAST30
Topological domaini403 – 495CytoplasmicSequence analysisAdd BLAST93

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi921
OpenTargetsiENSG00000110448
PharmGKBiPA26224

Chemistry databases

ChEMBLiCHEMBL3712888

Polymorphism and mutation databases

BioMutaiCD5
DMDMi313104090

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000003322225 – 495T-cell surface glycoprotein CD5Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 86PROSITE-ProRule annotation1 Publication
Disulfide bondi60 ↔ 125PROSITE-ProRule annotation1 Publication
Disulfide bondi81 ↔ 132PROSITE-ProRule annotation1 Publication
Disulfide bondi107 ↔ 117PROSITE-ProRule annotation1 Publication
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi201 ↔ 267PROSITE-ProRule annotation
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi244 ↔ 250PROSITE-ProRule annotation
Disulfide bondi285 ↔ 321PROSITE-ProRule annotation1 Publication
Disulfide bondi301 ↔ 360PROSITE-ProRule annotation1 Publication
Disulfide bondi316 ↔ 367PROSITE-ProRule annotation1 Publication
Disulfide bondi342 ↔ 350PROSITE-ProRule annotation1 Publication
Modified residuei439PhosphoserineCombined sources1
Modified residuei453PhosphotyrosineCombined sources1
Modified residuei460PhosphoserineCombined sources1
Modified residuei483PhosphoserineCombined sources1
Modified residuei485PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP06127
PaxDbiP06127
PeptideAtlasiP06127
PRIDEiP06127
ProteomicsDBi51869

PTM databases

GlyConnecti589
iPTMnetiP06127
PhosphoSitePlusiP06127
SwissPalmiP06127
UniCarbKBiP06127

Expressioni

Gene expression databases

BgeeiENSG00000110448
CleanExiHS_CD5
ExpressionAtlasiP06127 baseline and differential
GenevisibleiP06127 HS

Organism-specific databases

HPAiCAB015392
CAB020308
HPA043416
HPA060839

Interactioni

Subunit structurei

Interacts with CD72/LYB-2. Interacts with PTPN6/SHP-1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi107359, 14 interactors
DIPiDIP-21N
IntActiP06127, 4 interactors
MINTiP06127
STRINGi9606.ENSP00000342681

Structurei

Secondary structure

1495
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi35 – 37Combined sources3
Beta strandi39 – 42Combined sources4
Beta strandi45 – 52Combined sources8
Beta strandi55 – 58Combined sources4
Helixi75 – 77Combined sources3
Helixi78 – 83Combined sources6
Beta strandi86 – 88Combined sources3
Beta strandi90 – 94Combined sources5
Turni101 – 103Combined sources3
Beta strandi104 – 110Combined sources7
Beta strandi117 – 119Combined sources3
Beta strandi122 – 124Combined sources3
Beta strandi126 – 132Combined sources7
Beta strandi275 – 280Combined sources6
Beta strandi286 – 295Combined sources10
Beta strandi298 – 301Combined sources4
Helixi310 – 318Combined sources9
Beta strandi323 – 331Combined sources9
Beta strandi339 – 341Combined sources3
Beta strandi344 – 346Combined sources3
Helixi347 – 349Combined sources3
Beta strandi354 – 356Combined sources3
Beta strandi362 – 367Combined sources6

3D structure databases

ProteinModelPortaliP06127
SMRiP06127
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06127

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 133SRCR 1PROSITE-ProRule annotationAdd BLAST99
Domaini159 – 268SRCR 2PROSITE-ProRule annotationAdd BLAST110
Domaini276 – 368SRCR 3PROSITE-ProRule annotationAdd BLAST93

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ3D Eukaryota
ENOG4111C54 LUCA
GeneTreeiENSGT00390000017536
HOGENOMiHOG000111490
HOVERGENiHBG005286
InParanoidiP06127
KOiK06455
OMAiMSFHRNH
OrthoDBiEOG091G0G5S
PhylomeDBiP06127
TreeFamiTF329295

Family and domain databases

Gene3Di3.10.250.10, 2 hits
InterProiView protein in InterPro
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR003566 Tcell_CD5
PfamiView protein in Pfam
PF00530 SRCR, 1 hit
PRINTSiPR00258 SPERACTRCPTR
PR01409 TCELLCD5
SMARTiView protein in SMART
SM00202 SR, 2 hits
SUPFAMiSSF56487 SSF56487, 2 hits
PROSITEiView protein in PROSITE
PS50287 SRCR_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06127-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMGSLQPLA TLYLLGMLVA SCLGRLSWYD PDFQARLTRS NSKCQGQLEV
60 70 80 90 100
YLKDGWHMVC SQSWGRSSKQ WEDPSQASKV CQRLNCGVPL SLGPFLVTYT
110 120 130 140 150
PQSSIICYGQ LGSFSNCSHS RNDMCHSLGL TCLEPQKTTP PTTRPPPTTT
160 170 180 190 200
PEPTAPPRLQ LVAQSGGQHC AGVVEFYSGS LGGTISYEAQ DKTQDLENFL
210 220 230 240 250
CNNLQCGSFL KHLPETEAGR AQDPGEPREH QPLPIQWKIQ NSSCTSLEHC
260 270 280 290 300
FRKIKPQKSG RVLALLCSGF QPKVQSRLVG GSSICEGTVE VRQGAQWAAL
310 320 330 340 350
CDSSSARSSL RWEEVCREQQ CGSVNSYRVL DAGDPTSRGL FCPHQKLSQC
360 370 380 390 400
HELWERNSYC KKVFVTCQDP NPAGLAAGTV ASIILALVLL VVLLVVCGPL
410 420 430 440 450
AYKKLVKKFR QKKQRQWIGP TGMNQNMSFH RNHTATVRSH AENPTASHVD
460 470 480 490
NEYSQPPRNS HLSAYPALEG ALHRSSMQPD NSSDSDYDLH GAQRL
Length:495
Mass (Da):54,578
Last modified:November 30, 2010 - v2
Checksum:i9131AEC9683EE1D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289V → E in BAF85387 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020411224P → L1 PublicationCorresponds to variant dbSNP:rs2241002Ensembl.1
Natural variantiVAR_024649461H → RCombined sources5 PublicationsCorresponds to variant dbSNP:rs637186Ensembl.1
Natural variantiVAR_058203471A → V4 PublicationsCorresponds to variant dbSNP:rs2229177Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04391 mRNA Translation: CAA27979.1
X89405
, AJ237927, AJ237928, AJ237929, AJ237930, AJ237931, AJ237932 Genomic DNA Translation: CAA61584.2
EF064752 Genomic DNA Translation: ABK41935.1
AK292698 mRNA Translation: BAF85387.1
AP000437 Genomic DNA No translation available.
BC027901 mRNA Translation: AAH27901.1
CCDSiCCDS8000.1
PIRiA26396
RefSeqiNP_001333385.1, NM_001346456.1
NP_055022.2, NM_014207.3
UniGeneiHs.58685

Genome annotation databases

EnsembliENST00000347785; ENSP00000342681; ENSG00000110448
GeneIDi921
KEGGihsa:921
UCSCiuc009ynk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCD5_HUMAN
AccessioniPrimary (citable) accession number: P06127
Secondary accession number(s): A0N0P4, A8K9I3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 30, 2010
Last modified: June 20, 2018
This is version 180 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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