UniProtKB - P06127 (CD5_HUMAN)
Protein
T-cell surface glycoprotein CD5
Gene
CD5
Organism
Homo sapiens (Human)
Status
Functioni
May act as a receptor in regulating T-cell proliferation.
GO - Molecular functioni
- scavenger receptor activity Source: InterPro
- signaling receptor activity Source: UniProtKB
GO - Biological processi
- apoptotic signaling pathway Source: Ensembl
- cell recognition Source: UniProtKB
- T cell costimulation Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | P06127 |
SIGNORi | P06127 |
Names & Taxonomyi
Protein namesi | Recommended name: T-cell surface glycoprotein CD5Alternative name(s): Lymphocyte antigen T1/Leu-1 CD_antigen: CD5 |
Gene namesi | Name:CD5 Synonyms:LEU1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1685, CD5 |
MIMi | 153340, gene |
neXtProti | NX_P06127 |
VEuPathDBi | HostDB:ENSG00000110448.10 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- external side of plasma membrane Source: Ensembl
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 372 | ExtracellularSequence analysisAdd BLAST | 348 | |
Transmembranei | 373 – 402 | HelicalSequence analysisAdd BLAST | 30 | |
Topological domaini | 403 – 495 | CytoplasmicSequence analysisAdd BLAST | 93 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 921 |
OpenTargetsi | ENSG00000110448 |
PharmGKBi | PA26224 |
Miscellaneous databases
Pharosi | P06127, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3712888 |
Genetic variation databases
BioMutai | CD5 |
DMDMi | 313104090 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Add BLAST | 24 | |
ChainiPRO_0000033222 | 25 – 495 | T-cell surface glycoprotein CD5Add BLAST | 471 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 44 ↔ 86 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 60 ↔ 125 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 81 ↔ 132 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 107 ↔ 117 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 116 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 201 ↔ 267 | PROSITE-ProRule annotation | ||
Glycosylationi | 241 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 244 ↔ 250 | PROSITE-ProRule annotation | ||
Disulfide bondi | 285 ↔ 321 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 301 ↔ 360 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 316 ↔ 367 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 342 ↔ 350 | PROSITE-ProRule annotation1 Publication | ||
Modified residuei | 439 | PhosphoserineCombined sources | 1 | |
Modified residuei | 453 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 460 | PhosphoserineCombined sources | 1 | |
Modified residuei | 483 | PhosphoserineCombined sources | 1 | |
Modified residuei | 485 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | P06127 |
MassIVEi | P06127 |
MaxQBi | P06127 |
PaxDbi | P06127 |
PeptideAtlasi | P06127 |
PRIDEi | P06127 |
ProteomicsDBi | 51869 |
PTM databases
GlyConnecti | 589, 5 N-Linked glycans |
GlyGeni | P06127, 2 sites |
iPTMneti | P06127 |
PhosphoSitePlusi | P06127 |
SwissPalmi | P06127 |
Expressioni
Gene expression databases
Bgeei | ENSG00000110448, Expressed in leukocyte and 137 other tissues |
ExpressionAtlasi | P06127, baseline and differential |
Genevisiblei | P06127, HS |
Organism-specific databases
HPAi | ENSG00000110448, Group enriched (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts with CD72/LYB-2.
Interacts with PTPN6/SHP-1 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 107359, 14 interactors |
DIPi | DIP-21N |
IntActi | P06127, 4 interactors |
MINTi | P06127 |
STRINGi | 9606.ENSP00000342681 |
Miscellaneous databases
RNActi | P06127, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P06127 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06127 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 133 | SRCR 1PROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 159 – 268 | SRCR 2PROSITE-ProRule annotationAdd BLAST | 110 | |
Domaini | 276 – 368 | SRCR 3PROSITE-ProRule annotationAdd BLAST | 93 |
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RYTM, Eukaryota |
GeneTreei | ENSGT00390000017536 |
HOGENOMi | CLU_047656_0_0_1 |
InParanoidi | P06127 |
OMAi | FHRNHTA |
OrthoDBi | 1017770at2759 |
PhylomeDBi | P06127 |
TreeFami | TF329295 |
Family and domain databases
Gene3Di | 3.10.250.10, 2 hits |
InterProi | View protein in InterPro IPR001190, SRCR IPR017448, SRCR-like_dom IPR036772, SRCR-like_dom_sf IPR003566, Tcell_CD5 |
PANTHERi | PTHR47309, PTHR47309, 1 hit |
Pfami | View protein in Pfam PF00530, SRCR, 1 hit |
PRINTSi | PR00258, SPERACTRCPTR PR01409, TCELLCD5 |
SMARTi | View protein in SMART SM00202, SR, 2 hits |
SUPFAMi | SSF56487, SSF56487, 2 hits |
PROSITEi | View protein in PROSITE PS50287, SRCR_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P06127-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPMGSLQPLA TLYLLGMLVA SCLGRLSWYD PDFQARLTRS NSKCQGQLEV
60 70 80 90 100
YLKDGWHMVC SQSWGRSSKQ WEDPSQASKV CQRLNCGVPL SLGPFLVTYT
110 120 130 140 150
PQSSIICYGQ LGSFSNCSHS RNDMCHSLGL TCLEPQKTTP PTTRPPPTTT
160 170 180 190 200
PEPTAPPRLQ LVAQSGGQHC AGVVEFYSGS LGGTISYEAQ DKTQDLENFL
210 220 230 240 250
CNNLQCGSFL KHLPETEAGR AQDPGEPREH QPLPIQWKIQ NSSCTSLEHC
260 270 280 290 300
FRKIKPQKSG RVLALLCSGF QPKVQSRLVG GSSICEGTVE VRQGAQWAAL
310 320 330 340 350
CDSSSARSSL RWEEVCREQQ CGSVNSYRVL DAGDPTSRGL FCPHQKLSQC
360 370 380 390 400
HELWERNSYC KKVFVTCQDP NPAGLAAGTV ASIILALVLL VVLLVVCGPL
410 420 430 440 450
AYKKLVKKFR QKKQRQWIGP TGMNQNMSFH RNHTATVRSH AENPTASHVD
460 470 480 490
NEYSQPPRNS HLSAYPALEG ALHRSSMQPD NSSDSDYDLH GAQRL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF5GYK3 | F5GYK3_HUMAN | T-cell surface glycoprotein CD5 | CD5 | 165 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 289 | V → E in BAF85387 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020411 | 224 | P → L1 PublicationCorresponds to variant dbSNP:rs2241002Ensembl. | 1 | |
Natural variantiVAR_024649 | 461 | H → RCombined sources5 PublicationsCorresponds to variant dbSNP:rs637186Ensembl. | 1 | |
Natural variantiVAR_058203 | 471 | A → V4 PublicationsCorresponds to variant dbSNP:rs2229177Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04391 mRNA Translation: CAA27979.1 X89405 , AJ237927, AJ237928, AJ237929, AJ237930, AJ237931, AJ237932 Genomic DNA Translation: CAA61584.2 EF064752 Genomic DNA Translation: ABK41935.1 AK292698 mRNA Translation: BAF85387.1 AP000437 Genomic DNA No translation available. BC027901 mRNA Translation: AAH27901.1 |
CCDSi | CCDS8000.1 |
PIRi | A26396 |
RefSeqi | NP_001333385.1, NM_001346456.1 NP_055022.2, NM_014207.3 |
Genome annotation databases
Ensembli | ENST00000347785; ENSP00000342681; ENSG00000110448 |
GeneIDi | 921 |
KEGGi | hsa:921 |
UCSCi | uc009ynk.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04391 mRNA Translation: CAA27979.1 X89405 , AJ237927, AJ237928, AJ237929, AJ237930, AJ237931, AJ237932 Genomic DNA Translation: CAA61584.2 EF064752 Genomic DNA Translation: ABK41935.1 AK292698 mRNA Translation: BAF85387.1 AP000437 Genomic DNA No translation available. BC027901 mRNA Translation: AAH27901.1 |
CCDSi | CCDS8000.1 |
PIRi | A26396 |
RefSeqi | NP_001333385.1, NM_001346456.1 NP_055022.2, NM_014207.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2JA4 | X-ray | 2.21 | A | 270-369 | [»] | |
2JOP | NMR | - | A | 25-134 | [»] | |
2JP0 | NMR | - | A | 25-134 | [»] | |
2OTT | X-ray | 2.50 | X/Y | 276-368 | [»] | |
SMRi | P06127 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107359, 14 interactors |
DIPi | DIP-21N |
IntActi | P06127, 4 interactors |
MINTi | P06127 |
STRINGi | 9606.ENSP00000342681 |
Chemistry databases
ChEMBLi | CHEMBL3712888 |
PTM databases
GlyConnecti | 589, 5 N-Linked glycans |
GlyGeni | P06127, 2 sites |
iPTMneti | P06127 |
PhosphoSitePlusi | P06127 |
SwissPalmi | P06127 |
Genetic variation databases
BioMutai | CD5 |
DMDMi | 313104090 |
Proteomic databases
jPOSTi | P06127 |
MassIVEi | P06127 |
MaxQBi | P06127 |
PaxDbi | P06127 |
PeptideAtlasi | P06127 |
PRIDEi | P06127 |
ProteomicsDBi | 51869 |
Protocols and materials databases
ABCDi | P06127, 79 sequenced antibodies |
Antibodypediai | 4206, 3660 antibodies |
DNASUi | 921 |
Genome annotation databases
Ensembli | ENST00000347785; ENSP00000342681; ENSG00000110448 |
GeneIDi | 921 |
KEGGi | hsa:921 |
UCSCi | uc009ynk.4, human |
Organism-specific databases
CTDi | 921 |
DisGeNETi | 921 |
GeneCardsi | CD5 |
HGNCi | HGNC:1685, CD5 |
HPAi | ENSG00000110448, Group enriched (blood, lymphoid tissue) |
MIMi | 153340, gene |
neXtProti | NX_P06127 |
OpenTargetsi | ENSG00000110448 |
PharmGKBi | PA26224 |
VEuPathDBi | HostDB:ENSG00000110448.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RYTM, Eukaryota |
GeneTreei | ENSGT00390000017536 |
HOGENOMi | CLU_047656_0_0_1 |
InParanoidi | P06127 |
OMAi | FHRNHTA |
OrthoDBi | 1017770at2759 |
PhylomeDBi | P06127 |
TreeFami | TF329295 |
Enzyme and pathway databases
PathwayCommonsi | P06127 |
SIGNORi | P06127 |
Miscellaneous databases
BioGRID-ORCSi | 921, 18 hits in 872 CRISPR screens |
EvolutionaryTracei | P06127 |
GeneWikii | CD5_(protein) |
GenomeRNAii | 921 |
Pharosi | P06127, Tbio |
PROi | PR:P06127 |
RNActi | P06127, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000110448, Expressed in leukocyte and 137 other tissues |
ExpressionAtlasi | P06127, baseline and differential |
Genevisiblei | P06127, HS |
Family and domain databases
Gene3Di | 3.10.250.10, 2 hits |
InterProi | View protein in InterPro IPR001190, SRCR IPR017448, SRCR-like_dom IPR036772, SRCR-like_dom_sf IPR003566, Tcell_CD5 |
PANTHERi | PTHR47309, PTHR47309, 1 hit |
Pfami | View protein in Pfam PF00530, SRCR, 1 hit |
PRINTSi | PR00258, SPERACTRCPTR PR01409, TCELLCD5 |
SMARTi | View protein in SMART SM00202, SR, 2 hits |
SUPFAMi | SSF56487, SSF56487, 2 hits |
PROSITEi | View protein in PROSITE PS50287, SRCR_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CD5_HUMAN | |
Accessioni | P06127Primary (citable) accession number: P06127 Secondary accession number(s): A0N0P4, A8K9I3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | November 30, 2010 | |
Last modified: | February 10, 2021 | |
This is version 195 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries