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Protein

T-cell surface glycoprotein CD1a

Gene

CD1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.3 Publications

Miscellaneous

During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei171GlycolipidCombined sources1 Publication1
Binding sitei175GlycolipidCombined sources1 Publication1

GO - Molecular functioni

  • endogenous lipid antigen binding Source: GO_Central
  • exogenous lipid antigen binding Source: GO_Central
  • lipopeptide binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD1a
Alternative name(s):
T-cell surface antigen T6/Leu-6
Short name:
hTa1 thymocyte antigen
CD_antigen: CD1a
Gene namesi
Name:CD1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000158477.6
HGNCiHGNC:1634 CD1A
MIMi188370 gene
neXtProtiNX_P06126

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 300ExtracellularSequence analysisAdd BLAST284
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 327CytoplasmicSequence analysis6

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi909
OpenTargetsiENSG00000158477
PharmGKBiPA26193

Chemistry databases

DrugBankiDB00098 Anti-thymocyte Globulin (Rabbit)

Polymorphism and mutation databases

BioMutaiCD1A
DMDMi288558852

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Add BLAST16
ChainiPRO_000001457817 – 327T-cell surface glycoprotein CD1aAdd BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi74N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi119 ↔ 183Combined sources1 Publication
Glycosylationi145N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi223 ↔ 278Combined sources3 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP06126
PaxDbiP06126
PeptideAtlasiP06126
PRIDEiP06126
ProteomicsDBi51868

PTM databases

iPTMnetiP06126
PhosphoSitePlusiP06126
SwissPalmiP06126

Expressioni

Tissue specificityi

Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.2 Publications

Gene expression databases

BgeeiENSG00000158477 Expressed in 60 organ(s), highest expression level in thymus
CleanExiHS_CD1A
GenevisibleiP06126 HS

Organism-specific databases

HPAiCAB000009
HPA010734

Interactioni

Subunit structurei

Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
B2MP617692EBI-1036766,EBI-714718

Protein-protein interaction databases

BioGridi107347, 42 interactors
IntActiP06126, 4 interactors
STRINGi9606.ENSP00000289429

Structurei

Secondary structure

1327
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP06126
SMRiP06126
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06126

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini184 – 291Ig-likeAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni90 – 94Glycolipid bindingCombined sources1 Publication5

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JACG Eukaryota
ENOG41113WA LUCA
GeneTreeiENSGT00480000042665
HOGENOMiHOG000111666
HOVERGENiHBG004453
InParanoidiP06126
KOiK06448
OMAiFEGIRRY
OrthoDBiEOG091G0DB3
PhylomeDBiP06126
TreeFamiTF336723

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF16497 MHC_I_3, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06126-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLFLLLPLLA VLPGDGNADG LKEPLSFHVT WIASFYNHSW KQNLVSGWLS
60 70 80 90 100
DLQTHTWDSN SSTIVFLCPW SRGNFSNEEW KELETLFRIR TIRSFEGIRR
110 120 130 140 150
YAHELQFEYP FEIQVTGGCE LHSGKVSGSF LQLAYQGSDF VSFQNNSWLP
160 170 180 190 200
YPVAGNMAKH FCKVLNQNQH ENDITHNLLS DTCPRFILGL LDAGKAHLQR
210 220 230 240 250
QVKPEAWLSH GPSPGPGHLQ LVCHVSGFYP KPVWVMWMRG EQEQQGTQRG
260 270 280 290 300
DILPSADGTW YLRATLEVAA GEAADLSCRV KHSSLEGQDI VLYWEHHSSV
310 320
GFIILAVIVP LLLLIGLALW FRKRCFC
Length:327
Mass (Da):37,077
Last modified:February 9, 2010 - v4
Checksum:iC575C3C538F0AA29
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70 – 71WS → V in AAA51933 (PubMed:2784820).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06252222K → N. Corresponds to variant dbSNP:rs3087217Ensembl.1
Natural variantiVAR_01020930T → I2 PublicationsCorresponds to variant dbSNP:rs2269714Ensembl.1
Natural variantiVAR_01021068C → W2 PublicationsCorresponds to variant dbSNP:rs2269715Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28825 mRNA Translation: AAA51931.1
M22167
, M22080, M22163, M22164, M22165, M22166 Genomic DNA Translation: AAA51932.1
AK312945 mRNA Translation: BAG35786.1
AL121986 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52843.1
CH471121 Genomic DNA Translation: EAW52844.1
AF142665 Genomic DNA Translation: AAD37578.1
M27735 mRNA Translation: AAA51933.1
X04450 mRNA Translation: CAA28049.1
M14663 Genomic DNA Translation: AAA51934.1
CCDSiCCDS1174.1
PIRiA39957 HLHUCD
RefSeqiNP_001307581.1, NM_001320652.1
NP_001754.2, NM_001763.2
UniGeneiHs.1309

Genome annotation databases

EnsembliENST00000289429; ENSP00000289429; ENSG00000158477
GeneIDi909
KEGGihsa:909
UCSCiuc001frt.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28825 mRNA Translation: AAA51931.1
M22167
, M22080, M22163, M22164, M22165, M22166 Genomic DNA Translation: AAA51932.1
AK312945 mRNA Translation: BAG35786.1
AL121986 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52843.1
CH471121 Genomic DNA Translation: EAW52844.1
AF142665 Genomic DNA Translation: AAD37578.1
M27735 mRNA Translation: AAA51933.1
X04450 mRNA Translation: CAA28049.1
M14663 Genomic DNA Translation: AAA51934.1
CCDSiCCDS1174.1
PIRiA39957 HLHUCD
RefSeqiNP_001307581.1, NM_001320652.1
NP_001754.2, NM_001763.2
UniGeneiHs.1309

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ONQX-ray2.15A/C18-294[»]
1XZ0X-ray2.80A/C18-294[»]
4X6CX-ray2.80A/C21-295[»]
4X6DX-ray2.98A/C21-295[»]
4X6EX-ray2.10A21-295[»]
4X6FX-ray1.91A21-295[»]
5J1AX-ray1.86A1-295[»]
ProteinModelPortaliP06126
SMRiP06126
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107347, 42 interactors
IntActiP06126, 4 interactors
STRINGi9606.ENSP00000289429

Chemistry databases

DrugBankiDB00098 Anti-thymocyte Globulin (Rabbit)

PTM databases

iPTMnetiP06126
PhosphoSitePlusiP06126
SwissPalmiP06126

Polymorphism and mutation databases

BioMutaiCD1A
DMDMi288558852

Proteomic databases

MaxQBiP06126
PaxDbiP06126
PeptideAtlasiP06126
PRIDEiP06126
ProteomicsDBi51868

Protocols and materials databases

DNASUi909
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289429; ENSP00000289429; ENSG00000158477
GeneIDi909
KEGGihsa:909
UCSCiuc001frt.4 human

Organism-specific databases

CTDi909
DisGeNETi909
EuPathDBiHostDB:ENSG00000158477.6
GeneCardsiCD1A
H-InvDBiHIX0001190
HGNCiHGNC:1634 CD1A
HPAiCAB000009
HPA010734
MIMi188370 gene
neXtProtiNX_P06126
OpenTargetsiENSG00000158477
PharmGKBiPA26193
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JACG Eukaryota
ENOG41113WA LUCA
GeneTreeiENSGT00480000042665
HOGENOMiHOG000111666
HOVERGENiHBG004453
InParanoidiP06126
KOiK06448
OMAiFEGIRRY
OrthoDBiEOG091G0DB3
PhylomeDBiP06126
TreeFamiTF336723

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

EvolutionaryTraceiP06126
GeneWikiiCD1A
GenomeRNAii909
PROiPR:P06126
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158477 Expressed in 60 organ(s), highest expression level in thymus
CleanExiHS_CD1A
GenevisibleiP06126 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF16497 MHC_I_3, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCD1A_HUMAN
AccessioniPrimary (citable) accession number: P06126
Secondary accession number(s): D3DVD7
, Q13962, Q5TDJ8, Q9UMM4, Q9Y5M5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 9, 2010
Last modified: November 7, 2018
This is version 175 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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