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Protein

Glycophorin-B

Gene

GYPB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is a minor sialoglycoprotein in erythrocyte membranes.

GO - Biological processi

Keywordsi

Molecular functionBlood group antigen
LigandSialic acid

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Glycophorin-B
Alternative name(s):
PAS-3
SS-active sialoglycoprotein
Sialoglycoprotein delta
CD_antigen: CD235b
Gene namesi
Name:GYPB
Synonyms:GPB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000250361.6
HGNCiHGNC:4703 GYPB
MIMi617923 gene
neXtProtiNX_P06028

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 59ExtracellularSequence analysisAdd BLAST40
Transmembranei60 – 81HelicalSequence analysisAdd BLAST22
Topological domaini82 – 91CytoplasmicSequence analysis10

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2994
MalaCardsiGYPB
MIMi111740 phenotype
OpenTargetsiENSG00000250361
PharmGKBiPA29081

Polymorphism and mutation databases

BioMutaiGYPB
DMDMi380865467

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 193 PublicationsAdd BLAST19
ChainiPRO_000001213620 – 91Glycophorin-BAdd BLAST72

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36O-linked (GalNAc...) threonine1 Publication1
Glycosylationi38O-linked (GalNAc...) serine1 Publication1

Post-translational modificationi

The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei33Not glycosylated1
Sitei34Not glycosylated1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP06028
PRIDEiP06028
ProteomicsDBi51867

PTM databases

GlyConnecti188
189
iPTMnetiP06028
PhosphoSitePlusiP06028
UniCarbKBiP06028

Expressioni

Gene expression databases

BgeeiENSG00000250361 Expressed in 93 organ(s), highest expression level in trabecular bone tissue
CleanExiHS_GYPB
ExpressionAtlasiP06028 baseline and differential
GenevisibleiP06028 HS

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi109249, 53 interactors
IntActiP06028, 2 interactors
STRINGi9606.ENSP00000427690

Structurei

3D structure databases

ProteinModelPortaliP06028
SMRiP06028
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycophorin-A family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KCDX Eukaryota
ENOG4110P2G LUCA
GeneTreeiENSGT00550000075214
HOGENOMiHOG000089933
HOVERGENiHBG005850
InParanoidiP06028
KOiK20925
OMAiIFEMTAV
PhylomeDBiP06028
TreeFamiTF338555

Family and domain databases

InterProiView protein in InterPro
IPR001195 Glycophorin
IPR018938 Glycophorin_CS
PANTHERiPTHR13813 PTHR13813, 1 hit
PROSITEiView protein in PROSITE
PS00312 GLYCOPHORIN_A, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P06028-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYGKIIFVLL LSEIVSISAL STTEVAMHTS TSSSVTKSYI SSQTNGETGQ
60 70 80 90
LVHRFTVPAP VVIILIILCV MAGIIGTILL ISYSIRRLIK A
Length:91
Mass (Da):9,782
Last modified:March 21, 2012 - v3
Checksum:iEF15A64BAA929B7B
GO
Isoform 2 (identifier: P06028-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-45: Missing.

Show »
Length:58
Mass (Da):6,352
Checksum:i1DE98AE83FBB43A2
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PQZ9A0A1W2PQZ9_HUMAN
Glycophorin
GYPB
121Annotation score:
E7ERJ5E7ERJ5_HUMAN
Glycophorin-B
GYPB
62Annotation score:
D6RBP2D6RBP2_HUMAN
Glycophorin-B
GYPB
65Annotation score:
D6RA87D6RA87_HUMAN
Glycophorin-B
GYPB
45Annotation score:
D6RAD9D6RAD9_HUMAN
Glycophorin-B
GYPB
42Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69C → S AA sequence (PubMed:3595615).Curated1
Sequence conflicti69C → S AA sequence (PubMed:3571235).Curated1

Polymorphismi

Along with GYPA, GYPB is responsible for the MNS blood group system. The molecular basis of the S/s blood group antigen is a single variation in position 48; Thr-48 corresponds to s=MSN4 and Met-48 to S=MNS3.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04794822T → S in M(v) antigen. 1 PublicationCorresponds to variant dbSNP:rs199937833Ensembl.1
Natural variantiVAR_00319248T → M in S antigen and Mit antigen. 1 PublicationCorresponds to variant dbSNP:rs7683365Ensembl.1
Natural variantiVAR_04794954R → H in Mit antigen. 1 PublicationCorresponds to variant dbSNP:rs370332485Ensembl.1
Natural variantiVAR_04795058P → R in s(D) antigen. 1 PublicationCorresponds to variant dbSNP:rs374811215Ensembl.1
Natural variantiVAR_03078584S → T3 PublicationsCorresponds to variant dbSNP:rs1132783Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04782413 – 45Missing in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02982 mRNA Translation: AAA52573.1
X08055 mRNA Translation: CAB42645.1
M24137
, M24130, M24131, M24135 Genomic DNA Translation: AAA58626.1
AY950609 mRNA Translation: AAX53130.1
AY950610 mRNA Translation: AAX53131.1
AY950611 mRNA Translation: AAX53132.1
EU338223 mRNA Translation: ACA96781.1
EU338235 mRNA Translation: ACA96793.1
AC093890 Genomic DNA No translation available.
AC107223 Genomic DNA No translation available.
AC110762 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05058.1
BC069310 mRNA Translation: AAH69310.1
BC121077 mRNA Translation: AAI21078.1
BC121078 mRNA Translation: AAI21079.1
M60708 Genomic DNA Translation: AAC63048.1
CCDSiCCDS54809.1 [P06028-1]
PIRiB33931
RefSeqiNP_001291311.1, NM_001304382.1
NP_002091.3, NM_002100.5
UniGeneiHs.654368

Genome annotation databases

EnsembliENST00000502664; ENSP00000427690; ENSG00000250361 [P06028-1]
ENST00000513128; ENSP00000425244; ENSG00000250361 [P06028-2]
GeneIDi2994
KEGGihsa:2994
UCSCiuc003ijm.2 human [P06028-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

dbRBC/BGMUT

Blood group antigen gene mutation database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02982 mRNA Translation: AAA52573.1
X08055 mRNA Translation: CAB42645.1
M24137
, M24130, M24131, M24135 Genomic DNA Translation: AAA58626.1
AY950609 mRNA Translation: AAX53130.1
AY950610 mRNA Translation: AAX53131.1
AY950611 mRNA Translation: AAX53132.1
EU338223 mRNA Translation: ACA96781.1
EU338235 mRNA Translation: ACA96793.1
AC093890 Genomic DNA No translation available.
AC107223 Genomic DNA No translation available.
AC110762 Genomic DNA No translation available.
CH471056 Genomic DNA Translation: EAX05058.1
BC069310 mRNA Translation: AAH69310.1
BC121077 mRNA Translation: AAI21078.1
BC121078 mRNA Translation: AAI21079.1
M60708 Genomic DNA Translation: AAC63048.1
CCDSiCCDS54809.1 [P06028-1]
PIRiB33931
RefSeqiNP_001291311.1, NM_001304382.1
NP_002091.3, NM_002100.5
UniGeneiHs.654368

3D structure databases

ProteinModelPortaliP06028
SMRiP06028
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109249, 53 interactors
IntActiP06028, 2 interactors
STRINGi9606.ENSP00000427690

PTM databases

GlyConnecti188
189
iPTMnetiP06028
PhosphoSitePlusiP06028
UniCarbKBiP06028

Polymorphism and mutation databases

BioMutaiGYPB
DMDMi380865467

Proteomic databases

PaxDbiP06028
PRIDEiP06028
ProteomicsDBi51867

Protocols and materials databases

DNASUi2994
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000502664; ENSP00000427690; ENSG00000250361 [P06028-1]
ENST00000513128; ENSP00000425244; ENSG00000250361 [P06028-2]
GeneIDi2994
KEGGihsa:2994
UCSCiuc003ijm.2 human [P06028-1]

Organism-specific databases

CTDi2994
DisGeNETi2994
EuPathDBiHostDB:ENSG00000250361.6
GeneCardsiGYPB
HGNCiHGNC:4703 GYPB
MalaCardsiGYPB
MIMi111740 phenotype
617923 gene
neXtProtiNX_P06028
OpenTargetsiENSG00000250361
PharmGKBiPA29081
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCDX Eukaryota
ENOG4110P2G LUCA
GeneTreeiENSGT00550000075214
HOGENOMiHOG000089933
HOVERGENiHBG005850
InParanoidiP06028
KOiK20925
OMAiIFEMTAV
PhylomeDBiP06028
TreeFamiTF338555

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

GeneWikiiGYPB
GenomeRNAii2994
PROiPR:P06028
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000250361 Expressed in 93 organ(s), highest expression level in trabecular bone tissue
CleanExiHS_GYPB
ExpressionAtlasiP06028 baseline and differential
GenevisibleiP06028 HS

Family and domain databases

InterProiView protein in InterPro
IPR001195 Glycophorin
IPR018938 Glycophorin_CS
PANTHERiPTHR13813 PTHR13813, 1 hit
PROSITEiView protein in PROSITE
PS00312 GLYCOPHORIN_A, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLPB_HUMAN
AccessioniPrimary (citable) accession number: P06028
Secondary accession number(s): B8Q174
, E2QBW7, Q0VAF4, Q58HE9, Q58HF0, Q58HF1, Q9UCH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: March 21, 2012
Last modified: September 12, 2018
This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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