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Entry version 207 (13 Feb 2019)
Sequence version 3 (03 Apr 2007)
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Protein

Collagen alpha-2(V) chain

Gene

COL5A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1314CalciumBy similarity1
Metal bindingi1316CalciumBy similarity1
Metal bindingi1317Calcium; via carbonyl oxygenBy similarity1
Metal bindingi1322CalciumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1442490 Collagen degradation
R-HSA-1474244 Extracellular matrix organization
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-186797 Signaling by PDGF
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000170 Syndecan interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-419037 NCAM1 interactions
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-2(V) chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL5A2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000204262.11

Human Gene Nomenclature Database

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HGNCi
HGNC:2210 COL5A2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
120190 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P05997

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ehlers-Danlos syndrome, classic type, 2 (EDSCL2)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Ehlers-Danlos syndrome, a group of connective tissue disorders characterized by skin hyperextensibility, articular hypermobility, and tissue fragility. The main features of classic Ehlers-Danlos syndrome are joint hypermobility and dislocation, and fragile, bruisable skin. EDSCL2 inheritance is autosomal dominant.
See also OMIM:130010
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_078424228G → R in EDSCL2. 1 Publication1
Natural variantiVAR_013588963G → R in EDSCL2. 1 PublicationCorresponds to variant dbSNP:rs1186550791Ensembl.1

Keywords - Diseasei

Disease mutation, Ehlers-Danlos syndrome

Organism-specific databases

DisGeNET

More...
DisGeNETi
1290

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
COL5A2

MalaCards human disease database

More...
MalaCardsi
COL5A2
MIMi130010 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000204262

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
90309 Ehlers-Danlos syndrome type 1
90318 Ehlers-Danlos syndrome type 2

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26725

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2364188

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
COL5A2

Domain mapping of disease mutations (DMDM)

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DMDMi
143811378

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Add BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000583027 – 1229Collagen alpha-2(V) chainAdd BLAST1203
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000058311230 – 1499C-terminal propeptideAdd BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei290Hydroxyproline1 Publication1
Modified residuei293Hydroxyproline1 Publication1
Modified residuei296Hydroxyproline1 Publication1
Modified residuei611Hydroxyproline1 Publication1
Modified residuei617Hydroxyproline1 Publication1
Modified residuei9193-hydroxyproline; partial1 Publication1
Modified residuei11563-hydroxyproline; partial1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi1262N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1296 ↔ 1328PROSITE-ProRule annotation
Disulfide bondi1336 ↔ 1497PROSITE-ProRule annotation
Glycosylationi1400N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1405 ↔ 1450PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Probably 3-hydroxylated on Pro-919 and Pro-1156 by LEPREL1.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P05997

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P05997

MaxQB - The MaxQuant DataBase

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MaxQBi
P05997

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P05997

PeptideAtlas

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PeptideAtlasi
P05997

PRoteomics IDEntifications database

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PRIDEi
P05997

ProteomicsDB human proteome resource

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ProteomicsDBi
51866

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1136

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P05997

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P05997

Miscellaneous databases

CutDB - Proteolytic event database

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PMAP-CutDBi
P05997

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000204262 Expressed in 221 organ(s), highest expression level in tibia

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P05997 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P05997 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107687, 4 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1727 Collagen type V trimer variant 1
CPX-1728 Collagen type V trimer variant 2
CPX-1751 Collagen type XI trimer variant 2
CPX-1752 Collagen type XI trimer variant 3

Protein interaction database and analysis system

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IntActi
P05997, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000364000

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A9Amodel-B561-581[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P05997

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P05997

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 97VWFCPROSITE-ProRule annotationAdd BLAST59
Domaini1266 – 1499Fibrillar collagen NC1PROSITE-ProRule annotationAdd BLAST234

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi506 – 508Cell attachment siteSequence analysis3
Motifi944 – 946Cell attachment siteSequence analysis3
Motifi1067 – 1069Cell attachment siteSequence analysis3
Motifi1070 – 1072Cell attachment siteSequence analysis3
Motifi1100 – 1102Cell attachment siteSequence analysis3
Motifi1127 – 1129Cell attachment siteSequence analysis3
Motifi1136 – 1138Cell attachment siteSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3544 Eukaryota
ENOG4110XTV LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155675

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004933

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P05997

KEGG Orthology (KO)

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KOi
K19721

Identification of Orthologs from Complete Genome Data

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OMAi
PNAAITQ

Database of Orthologous Groups

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OrthoDBi
1406711at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P05997

TreeFam database of animal gene trees

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TreeFami
TF344135

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR008160 Collagen
IPR000885 Fib_collagen_C
IPR001007 VWF_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 5 hits
PF00093 VWC, 1 hit

ProDom; a protein domain database

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ProDomi
View protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00038 COLFI, 1 hit
SM00214 VWC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461 NC1_FIB, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P05997-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMANWAEARP LLILIVLLGQ FVSIKAQEED EDEGYGEEIA CTQNGQMYLN
60 70 80 90 100
RDIWKPAPCQ ICVCDNGAIL CDKIECQDVL DCADPVTPPG ECCPVCSQTP
110 120 130 140 150
GGGNTNFGRG RKGQKGEPGL VPVVTGIRGR PGPAGPPGSQ GPRGERGPKG
160 170 180 190 200
RPGPRGPQGI DGEPGVPGQP GAPGPPGHPS HPGPDGLSRP FSAQMAGLDE
210 220 230 240 250
KSGLGSQVGL MPGSVGPVGP RGPQGLQGQQ GGAGPTGPPG EPGDPGPMGP
260 270 280 290 300
IGSRGPEGPP GKPGEDGEPG RNGNPGEVGF AGSPGARGFP GAPGLPGLKG
310 320 330 340 350
HRGHKGLEGP KGEVGAPGSK GEAGPTGPMG AMGPLGPRGM PGERGRLGPQ
360 370 380 390 400
GAPGQRGAHG MPGKPGPMGP LGIPGSSGFP GNPGMKGEAG PTGARGPEGP
410 420 430 440 450
QGQRGETGPP GPVGSPGLPG AIGTDGTPGA KGPTGSPGTS GPPGSAGPPG
460 470 480 490 500
SPGPQGSTGP QGIRGQPGDP GVPGFKGEAG PKGEPGPHGI QGPIGPPGEE
510 520 530 540 550
GKRGPRGDPG TVGPPGPVGE RGAPGNRGFP GSDGLPGPKG AQGERGPVGS
560 570 580 590 600
SGPKGSQGDP GRPGEPGLPG ARGLTGNPGV QGPEGKLGPL GAPGEDGRPG
610 620 630 640 650
PPGSIGIRGQ PGSMGLPGPK GSSGDPGKPG EAGNAGVPGQ RGAPGKDGEV
660 670 680 690 700
GPSGPVGPPG LAGERGEQGP PGPTGFQGLP GPPGPPGEGG KPGDQGVPGD
710 720 730 740 750
PGAVGPLGPR GERGNPGERG EPGITGLPGE KGMAGGHGPD GPKGSPGPSG
760 770 780 790 800
TPGDTGPPGL QGMPGERGIA GTPGPKGDRG GIGEKGAEGT AGNDGARGLP
810 820 830 840 850
GPLGPPGPAG PTGEKGEPGP RGLVGPPGSR GNPGSRGENG PTGAVGFAGP
860 870 880 890 900
QGPDGQPGVK GEPGEPGQKG DAGSPGPQGL AGSPGPHGPN GVPGLKGGRG
910 920 930 940 950
TQGPPGATGF PGSAGRVGPP GPAGAPGPAG PLGEPGKEGP PGLRGDPGSH
960 970 980 990 1000
GRVGDRGPAG PPGGPGDKGD PGEDGQPGPD GPPGPAGTTG QRGIVGMPGQ
1010 1020 1030 1040 1050
RGERGMPGLP GPAGTPGKVG PTGATGDKGP PGPVGPPGSN GPVGEPGPEG
1060 1070 1080 1090 1100
PAGNDGTPGR DGAVGERGDR GDPGPAGLPG SQGAPGTPGP VGAPGDAGQR
1110 1120 1130 1140 1150
GDPGSRGPIG PPGRAGKRGL PGPQGPRGDK GDHGDRGDRG QKGHRGFTGL
1160 1170 1180 1190 1200
QGLPGPPGPN GEQGSAGIPG PFGPRGPPGP VGPSGKEGNP GPLGPIGPPG
1210 1220 1230 1240 1250
VRGSVGEAGP EGPPGEPGPP GPPGPPGHLT AALGDIMGHY DESMPDPLPE
1260 1270 1280 1290 1300
FTEDQAAPDD KNKTDPGVHA TLKSLSSQIE TMRSPDGSKK HPARTCDDLK
1310 1320 1330 1340 1350
LCHSAKQSGE YWIDPNQGSV EDAIKVYCNM ETGETCISAN PSSVPRKTWW
1360 1370 1380 1390 1400
ASKSPDNKPV WYGLDMNRGS QFAYGDHQSP NTAITQMTFL RLLSKEASQN
1410 1420 1430 1440 1450
ITYICKNSVG YMDDQAKNLK KAVVLKGAND LDIKAEGNIR FRYIVLQDTC
1460 1470 1480 1490
SKRNGNVGKT VFEYRTQNVA RLPIIDLAPV DVGGTDQEFG VEIGPVCFV
Length:1,499
Mass (Da):144,910
Last modified:April 3, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE8C92BF5E749EC97
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WYX9A0A087WYX9_HUMAN
Collagen alpha-2(V) chain
COL5A2
1,112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRH9A0A3B3IRH9_HUMAN
Collagen alpha-2(V) chain
COL5A2
216Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH43613 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAY24185 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAD92282 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti292A → P AA sequence (PubMed:8181482).Curated1
Sequence conflicti361M → L in AAL13166 (PubMed:11566270).Curated1
Sequence conflicti430A → P in CAA75002 (Ref. 1) Curated1
Sequence conflicti430A → P in AAA51859 (PubMed:2914927).Curated1
Sequence conflicti430A → P in CAA28454 (PubMed:3029669).Curated1
Sequence conflicti463 – 466IRGQ → NSGL in CAA75002 (Ref. 1) Curated4
Sequence conflicti463 – 466IRGQ → NSGL in CAA28454 (PubMed:3029669).Curated4
Sequence conflicti463I → N in AAA51859 (PubMed:2914927).Curated1
Sequence conflicti472 – 474Missing in CAA75002 (Ref. 1) Curated3
Sequence conflicti472 – 474Missing in CAA28454 (PubMed:3029669).Curated3
Sequence conflicti512V → L in CAA75002 (Ref. 1) Curated1
Sequence conflicti512V → L in CAA28454 (PubMed:3029669).Curated1
Sequence conflicti608R → K in CAA75002 (Ref. 1) Curated1
Sequence conflicti608R → K in CAA28454 (PubMed:3029669).Curated1
Sequence conflicti613S → T in CAA75002 (Ref. 1) Curated1
Sequence conflicti613S → T in CAA28454 (PubMed:3029669).Curated1
Sequence conflicti623S → N in CAA75002 (Ref. 1) Curated1
Sequence conflicti623S → N in CAA28454 (PubMed:3029669).Curated1
Sequence conflicti635A → P in CAA75002 (Ref. 1) Curated1
Sequence conflicti635A → P in CAA28454 (PubMed:3029669).Curated1
Sequence conflicti649E → K in CAA75002 (Ref. 1) Curated1
Sequence conflicti649E → K in CAA28454 (PubMed:3029669).Curated1
Sequence conflicti653S → Y in CAA75002 (Ref. 1) Curated1
Sequence conflicti653S → Y in CAA28454 (PubMed:3029669).Curated1
Sequence conflicti656V → P in CAA75002 (Ref. 1) Curated1
Sequence conflicti656V → P in CAA28454 (PubMed:3029669).Curated1
Sequence conflicti662A → R in CAA75002 (Ref. 1) Curated1
Sequence conflicti662A → R in CAA28454 (PubMed:3029669).Curated1
Sequence conflicti679L → H in CAA75002 (Ref. 1) Curated1
Sequence conflicti679L → H in CAA28454 (PubMed:3029669).Curated1
Sequence conflicti700D → G in CAA75002 (Ref. 1) Curated1
Sequence conflicti700D → G in CAA28454 (PubMed:3029669).Curated1
Sequence conflicti797R → G in CAA75002 (Ref. 1) Curated1
Sequence conflicti797R → G in CAA28454 (PubMed:3029669).Curated1
Sequence conflicti811 – 812PT → LL in CAA75002 (Ref. 1) Curated2
Sequence conflicti811 – 812PT → LL in CAA28454 (PubMed:3029669).Curated2
Sequence conflicti853P → S in CAA75002 (Ref. 1) Curated1
Sequence conflicti853P → S in CAA28454 (PubMed:3029669).Curated1
Sequence conflicti943L → P in CAA75002 (Ref. 1) Curated1
Sequence conflicti943L → P in CAA28454 (PubMed:3029669).Curated1
Sequence conflicti955D → V in CAA75002 (Ref. 1) Curated1
Sequence conflicti955D → V in CAA28454 (PubMed:3029669).Curated1
Sequence conflicti1111 – 1112PP → HL in CAA75002 (Ref. 1) Curated2
Sequence conflicti1111 – 1112PP → HL in CAA28454 (PubMed:3029669).Curated2
Sequence conflicti1111 – 1112PP → HL in AAA52007 (PubMed:2985598).Curated2
Sequence conflicti1196I → L in CAA75002 (Ref. 1) Curated1
Sequence conflicti1196I → L in CAA28454 (PubMed:3029669).Curated1
Sequence conflicti1196I → L in AAA52007 (PubMed:2985598).Curated1
Sequence conflicti1421K → T in AAA52058 (PubMed:2411731).Curated1
Sequence conflicti1441F → S in AAA52058 (PubMed:2411731).Curated1
Sequence conflicti1467Q → E in AAA51858 (PubMed:3224983).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078424228G → R in EDSCL2. 1 Publication1
Natural variantiVAR_048799460P → S. Corresponds to variant dbSNP:rs35830636EnsemblClinVar.1
Natural variantiVAR_057910512V → A1 PublicationCorresponds to variant dbSNP:rs35852101EnsemblClinVar.1
Natural variantiVAR_057911833P → L1 PublicationCorresponds to variant dbSNP:rs116298748EnsemblClinVar.1
Natural variantiVAR_048800956R → P. Corresponds to variant dbSNP:rs6434313EnsemblClinVar.1
Natural variantiVAR_013588963G → R in EDSCL2. 1 PublicationCorresponds to variant dbSNP:rs1186550791Ensembl.1
Natural variantiVAR_0579121230T → S1 PublicationCorresponds to variant dbSNP:rs767234623Ensembl.1
Natural variantiVAR_0579131432D → V1 PublicationCorresponds to variant dbSNP:rs141777954EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y14690 mRNA Translation: CAA75002.1
AB209045 mRNA Translation: BAD92282.1 Different initiation.
AC064833 Genomic DNA No translation available.
AC133106 Genomic DNA Translation: AAY24185.1 Sequence problems.
J04478 mRNA Translation: AAA51859.1
AY016288, AY016287 Genomic DNA Translation: AAL13165.1
AY016295
, AY016289, AY016290, AY016291, AY016292, AY016293, AY016294 Genomic DNA Translation: AAL13166.1
M58529 Genomic DNA Translation: AAC41699.1
X04758 mRNA Translation: CAA28454.1
BC043613 mRNA Translation: AAH43613.1 Different initiation.
M10956 mRNA Translation: AAA52007.1
M11135 mRNA Translation: AAA51857.1
M11718 mRNA Translation: AAA52058.1
J03051 Genomic DNA Translation: AAA51858.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33350.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A31427 CGHU2V

NCBI Reference Sequences

More...
RefSeqi
NP_000384.2, NM_000393.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.445827

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000374866; ENSP00000364000; ENSG00000204262
ENST00000649066; ENSP00000497741; ENSG00000204262

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1290

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1290

UCSC genome browser

More...
UCSCi
uc002uqk.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14690 mRNA Translation: CAA75002.1
AB209045 mRNA Translation: BAD92282.1 Different initiation.
AC064833 Genomic DNA No translation available.
AC133106 Genomic DNA Translation: AAY24185.1 Sequence problems.
J04478 mRNA Translation: AAA51859.1
AY016288, AY016287 Genomic DNA Translation: AAL13165.1
AY016295
, AY016289, AY016290, AY016291, AY016292, AY016293, AY016294 Genomic DNA Translation: AAL13166.1
M58529 Genomic DNA Translation: AAC41699.1
X04758 mRNA Translation: CAA28454.1
BC043613 mRNA Translation: AAH43613.1 Different initiation.
M10956 mRNA Translation: AAA52007.1
M11135 mRNA Translation: AAA51857.1
M11718 mRNA Translation: AAA52058.1
J03051 Genomic DNA Translation: AAA51858.1
CCDSiCCDS33350.1
PIRiA31427 CGHU2V
RefSeqiNP_000384.2, NM_000393.4
UniGeneiHs.445827

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A9Amodel-B561-581[»]
ProteinModelPortaliP05997
SMRiP05997
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107687, 4 interactors
ComplexPortaliCPX-1727 Collagen type V trimer variant 1
CPX-1728 Collagen type V trimer variant 2
CPX-1751 Collagen type XI trimer variant 2
CPX-1752 Collagen type XI trimer variant 3
IntActiP05997, 3 interactors
STRINGi9606.ENSP00000364000

Chemistry databases

ChEMBLiCHEMBL2364188

PTM databases

GlyConnecti1136
iPTMnetiP05997
PhosphoSitePlusiP05997

Polymorphism and mutation databases

BioMutaiCOL5A2
DMDMi143811378

Proteomic databases

EPDiP05997
jPOSTiP05997
MaxQBiP05997
PaxDbiP05997
PeptideAtlasiP05997
PRIDEiP05997
ProteomicsDBi51866

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374866; ENSP00000364000; ENSG00000204262
ENST00000649066; ENSP00000497741; ENSG00000204262
GeneIDi1290
KEGGihsa:1290
UCSCiuc002uqk.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1290
DisGeNETi1290
EuPathDBiHostDB:ENSG00000204262.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
COL5A2
GeneReviewsiCOL5A2
HGNCiHGNC:2210 COL5A2
MalaCardsiCOL5A2
MIMi120190 gene
130010 phenotype
neXtProtiNX_P05997
OpenTargetsiENSG00000204262
Orphaneti90309 Ehlers-Danlos syndrome type 1
90318 Ehlers-Danlos syndrome type 2
PharmGKBiPA26725

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG4110XTV LUCA
GeneTreeiENSGT00940000155675
HOVERGENiHBG004933
InParanoidiP05997
KOiK19721
OMAiPNAAITQ
OrthoDBi1406711at2759
PhylomeDBiP05997
TreeFamiTF344135

Enzyme and pathway databases

ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1474244 Extracellular matrix organization
R-HSA-1650814 Collagen biosynthesis and modifying enzymes
R-HSA-186797 Signaling by PDGF
R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000170 Syndecan interactions
R-HSA-3000171 Non-integrin membrane-ECM interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-419037 NCAM1 interactions
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8948216 Collagen chain trimerization

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
COL5A2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
COL5A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1290
PMAP-CutDBiP05997

Protein Ontology

More...
PROi
PR:P05997

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204262 Expressed in 221 organ(s), highest expression level in tibia
ExpressionAtlasiP05997 baseline and differential
GenevisibleiP05997 HS

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR000885 Fib_collagen_C
IPR001007 VWF_dom
PfamiView protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 5 hits
PF00093 VWC, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00214 VWC, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO5A2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05997
Secondary accession number(s): P78440
, Q13908, Q53WR4, Q59GR4, Q6LDJ5, Q7KZ55, Q86XF6, Q96QB0, Q96QB3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: April 3, 2007
Last modified: February 13, 2019
This is version 207 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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