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UniProtKB - P05981 (HEPS_HUMAN)

Entry version 201 (25 May 2022)
Sequence version 1 (01 Nov 1988)
Previous versions | rss
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Protein

Serine protease hepsin

Gene

HPN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837).

Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933).

Plays a role in the proteolytic processing of ACE2 (PubMed:24227843).

Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890).

5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei203Charge relay system2 Publications1
Active sitei257Charge relay system2 Publications1
Active sitei353Charge relay system2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.4.21.106, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P05981

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6806942, MET Receptor Activation
R-HSA-8852405, Signaling by MST1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P05981

SIGNOR Signaling Network Open Resource

More...SIGNORi		P05981

Protein family/group databases

MEROPS protease database

More...MEROPSi		S01.224

Transport Classification Database

More...TCDBi		8.A.131.1.12, the transmembrane protease serine 3 (tmprss3) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine protease hepsin (EC:3.4.21.1061 Publication2 Publications)
Alternative name(s):
Transmembrane protease serine 1
Cleaved into the following 2 chains:
Serine protease hepsin non-catalytic chain
Serine protease hepsin catalytic chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HPN
Synonyms:TMPRSS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5155, HPN

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		142440, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P05981

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000105707

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei24 – 44Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini45 – 417ExtracellularSequence analysisAdd BLAST373

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3249

Open Targets

More...OpenTargetsi		ENSG00000105707

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29425

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P05981, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2079849

Drug and drug target database

More...DrugBanki		DB03865, 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine
DB00522, Bentiromide
DB03297, Benzylsulfonic acid
DB03643, CRA_1144

DrugCentral

More...DrugCentrali		P05981

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HPN

Domain mapping of disease mutations (DMDM)

More...DMDMi		123057

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000278411 – 162Serine protease hepsin non-catalytic chainSequence analysisAdd BLAST162
ChainiPRO_0000027842163 – 417Serine protease hepsin catalytic chainSequence analysisAdd BLAST255

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi77 ↔ 140PROSITE-ProRule annotationCombined sources2 Publications
Disulfide bondi90 ↔ 150PROSITE-ProRule annotationCombined sources2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi112N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi119 ↔ 138PROSITE-ProRule annotationCombined sources2 Publications
Disulfide bondi153 ↔ 277Interchain (between non-catalytic and catalytic chains)PROSITE-ProRule annotationCombined sources2 Publications
Disulfide bondi188 ↔ 204PROSITE-ProRule annotationCombined sources2 Publications
Disulfide bondi291 ↔ 359PROSITE-ProRule annotationCombined sources2 Publications
Disulfide bondi322 ↔ 338PROSITE-ProRule annotationCombined sources2 Publications
Disulfide bondi349 ↔ 381PROSITE-ProRule annotationCombined sources2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P05981

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P05981

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P05981

MaxQB - The MaxQuant DataBase

More...MaxQBi		P05981

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P05981

PeptideAtlas

More...PeptideAtlasi		P05981

PRoteomics IDEntifications database

More...PRIDEi		P05981

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51865

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P05981, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P05981

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P05981

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in liver and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105707, Expressed in right lobe of liver and 142 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P05981, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P05981, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000105707, Tissue enhanced (kidney, liver, pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109486, 116 interactors

Protein interaction database and analysis system

More...IntActi		P05981, 3 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000262626

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P05981

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P05981, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1417
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P05981

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P05981

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P05981

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 151SRCRAdd BLAST98
Domaini163 – 405Peptidase S1PROSITE-ProRule annotationAdd BLAST243

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3627, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159697

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006842_19_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P05981

Identification of Orthologs from Complete Genome Data

More...OMAi		GQTVPCC

Database of Orthologous Groups

More...OrthoDBi		1314811at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P05981

TreeFam database of animal gene trees

More...TreeFami		TF351678

Family and domain databases

Conserved Domains Database

More...CDDi		cd00190, Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.10.10, 1 hit
3.10.250.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038957, Hepsin
IPR015352, Hepsin-SRCR_dom
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR017448, SRCR-like_dom
IPR036772, SRCR-like_dom_sf
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
IPR033116, TRYPSIN_SER

The PANTHER Classification System

More...PANTHERi		PTHR24253:SF38, PTHR24253:SF38, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09272, Hepsin-SRCR, 1 hit
PF00089, Trypsin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00722, CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00202, SR, 1 hit
SM00020, Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50494, SSF50494, 1 hit
SSF56487, SSF56487, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50240, TRYPSIN_DOM, 1 hit
PS00134, TRYPSIN_HIS, 1 hit
PS00135, TRYPSIN_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P05981-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQKEGGRTV PCCSRPKVAA LTAGTLLLLT AIGAASWAIV AVLLRSDQEP 
        60         70         80         90        100
LYPVQVSSAD ARLMVFDKTE GTWRLLCSSR SNARVAGLSC EEMGFLRALT 
       110        120        130        140        150
HSELDVRTAG ANGTSGFFCV DEGRLPHTQR LLEVISVCDC PRGRFLAAIC 
       160        170        180        190        200
QDCGRRKLPV DRIVGGRDTS LGRWPWQVSL RYDGAHLCGG SLLSGDWVLT 
       210        220        230        240        250
AAHCFPERNR VLSRWRVFAG AVAQASPHGL QLGVQAVVYH GGYLPFRDPN 
       260        270        280        290        300
SEENSNDIAL VHLSSPLPLT EYIQPVCLPA AGQALVDGKI CTVTGWGNTQ 
       310        320        330        340        350
YYGQQAGVLQ EARVPIISND VCNGADFYGN QIKPKMFCAG YPEGGIDACQ 
       360        370        380        390        400
GDSGGPFVCE DSISRTPRWR LCGIVSWGTG CALAQKPGVY TKVSDFREWI 
       410 
FQAIKTHSEA SGMVTQL
Length:417
Mass (Da):45,011
Last modified:November 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2086FF661E551D7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R244M0R244_HUMAN
Serine protease hepsin
HPN
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZ63M0QZ63_HUMAN
Serine protease hepsin
HPN
259Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M18930 mRNA Translation: AAA36013.1
X07732 mRNA Translation: CAA30558.1
X07002 mRNA Translation: CAA30058.1
AK315655 mRNA Translation: BAG38021.1
BC025716 mRNA Translation: AAH25716.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32993.1

Protein sequence database of the Protein Information Resource

More...PIRi		S00845

NCBI Reference Sequences

More...RefSeqi		NP_002142.1, NM_002151.2
NP_892028.1, NM_182983.2
XP_005258895.2, XM_005258838.4
XP_006723244.2, XM_006723181.3
XP_016882220.1, XM_017026731.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262626.6; ENSP00000262626.2; ENSG00000105707.15
ENST00000392226.5; ENSP00000376060.1; ENSG00000105707.15
ENST00000672452.2; ENSP00000500664.1; ENSG00000105707.15
ENST00000673426.1; ENSP00000500909.1; ENSG00000105707.15

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3249

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3249

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000672452.2; ENSP00000500664.1; NM_001384133.1; NP_001371062.1

UCSC genome browser

More...UCSCi		uc002nxq.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18930 mRNA Translation: AAA36013.1
X07732 mRNA Translation: CAA30558.1
X07002 mRNA Translation: CAA30058.1
AK315655 mRNA Translation: BAG38021.1
BC025716 mRNA Translation: AAH25716.1
CCDSiCCDS32993.1
PIRiS00845
RefSeqiNP_002142.1, NM_002151.2
NP_892028.1, NM_182983.2
XP_005258895.2, XM_005258838.4
XP_006723244.2, XM_006723181.3
XP_016882220.1, XM_017026731.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O5EX-ray1.75H163-417[»]
L46-159[»]
1O5FX-ray1.78H163-417[»]
L46-159[»]
1P57X-ray1.75A46-159[»]
B163-417[»]
1Z8GX-ray1.55A46-417[»]
3T2NX-ray2.55A/B46-417[»]
5CE1X-ray2.50A46-417[»]
AlphaFoldDBiP05981
SMRiP05981
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109486, 116 interactors
IntActiP05981, 3 interactors
STRINGi9606.ENSP00000262626

Chemistry databases

BindingDBiP05981
ChEMBLiCHEMBL2079849
DrugBankiDB03865, 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine
DB00522, Bentiromide
DB03297, Benzylsulfonic acid
DB03643, CRA_1144
DrugCentraliP05981

Protein family/group databases

MEROPSiS01.224
TCDBi8.A.131.1.12, the transmembrane protease serine 3 (tmprss3) family

PTM databases

GlyGeniP05981, 1 site
iPTMnetiP05981
PhosphoSitePlusiP05981

Genetic variation databases

BioMutaiHPN
DMDMi123057

Proteomic databases

EPDiP05981
jPOSTiP05981
MassIVEiP05981
MaxQBiP05981
PaxDbiP05981
PeptideAtlasiP05981
PRIDEiP05981
ProteomicsDBi51865

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P05981, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1718, 201 antibodies from 33 providers

The DNASU plasmid repository

More...DNASUi		3249

Genome annotation databases

EnsembliENST00000262626.6; ENSP00000262626.2; ENSG00000105707.15
ENST00000392226.5; ENSP00000376060.1; ENSG00000105707.15
ENST00000672452.2; ENSP00000500664.1; ENSG00000105707.15
ENST00000673426.1; ENSP00000500909.1; ENSG00000105707.15
GeneIDi3249
KEGGihsa:3249
MANE-SelectiENST00000672452.2; ENSP00000500664.1; NM_001384133.1; NP_001371062.1
UCSCiuc002nxq.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3249
DisGeNETi3249

GeneCards: human genes, protein and diseases

More...GeneCardsi		HPN
HGNCiHGNC:5155, HPN
HPAiENSG00000105707, Tissue enhanced (kidney, liver, pancreas)
MIMi142440, gene
neXtProtiNX_P05981
OpenTargetsiENSG00000105707
PharmGKBiPA29425
VEuPathDBiHostDB:ENSG00000105707

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3627, Eukaryota
GeneTreeiENSGT00940000159697
HOGENOMiCLU_006842_19_2_1
InParanoidiP05981
OMAiGQTVPCC
OrthoDBi1314811at2759
PhylomeDBiP05981
TreeFamiTF351678

Enzyme and pathway databases

BRENDAi3.4.21.106, 2681
PathwayCommonsiP05981
ReactomeiR-HSA-6806942, MET Receptor Activation
R-HSA-8852405, Signaling by MST1
SignaLinkiP05981
SIGNORiP05981

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3249, 18 hits in 1079 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HPN, human
EvolutionaryTraceiP05981

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HPN_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3249
PharosiP05981, Tchem

Protein Ontology

More...PROi		PR:P05981
RNActiP05981, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000105707, Expressed in right lobe of liver and 142 other tissues
ExpressionAtlasiP05981, baseline and differential
GenevisibleiP05981, HS

Family and domain databases

CDDicd00190, Tryp_SPc, 1 hit
Gene3Di2.40.10.10, 1 hit
3.10.250.10, 1 hit
InterProiView protein in InterPro
IPR038957, Hepsin
IPR015352, Hepsin-SRCR_dom
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR017448, SRCR-like_dom
IPR036772, SRCR-like_dom_sf
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
IPR033116, TRYPSIN_SER
PANTHERiPTHR24253:SF38, PTHR24253:SF38, 1 hit
PfamiView protein in Pfam
PF09272, Hepsin-SRCR, 1 hit
PF00089, Trypsin, 1 hit
PRINTSiPR00722, CHYMOTRYPSIN
SMARTiView protein in SMART
SM00202, SR, 1 hit
SM00020, Tryp_SPc, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF56487, SSF56487, 1 hit
PROSITEiView protein in PROSITE
PS50240, TRYPSIN_DOM, 1 hit
PS00134, TRYPSIN_HIS, 1 hit
PS00135, TRYPSIN_SER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHEPS_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05981
Secondary accession number(s): B2RDS4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: May 25, 2022
This is version 201 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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