HPN

Functionⁱ

Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837). Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890).5 Publications

Catalytic activityⁱ

Cleavage after basic amino-acid residues, with Arg strongly preferred to Lys.
1 Publication
Manual assertion inferred by curator fromⁱ
- Ref.10
  "The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin."
  Brunati M., Perucca S., Han L., Cattaneo A., Consolato F., Andolfo A., Schaeffer C., Olinger E., Peng J., Santambrogio S., Perrier R., Li S., Bokhove M., Bachi A., Hummler E., Devuyst O., Wu Q., Jovine L., Rampoldi L.
  Elife 4:0-0(2015) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
2 Publications
Manual assertion based on experiment inⁱ
- Ref.7
  "Proteolytic activation of pro-macrophage-stimulating protein by hepsin."
  Ganesan R., Kolumam G.A., Lin S.J., Xie M.H., Santell L., Wu T.D., Lazarus R.A., Chaudhuri A., Kirchhofer D.
  Mol. Cancer Res. 9:1175-1186(2011) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
- Ref.12
  "Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers."
  Herter S., Piper D.E., Aaron W., Gabriele T., Cutler G., Cao P., Bhatt A.S., Choe Y., Craik C.S., Walker N., Meininger D., Hoey T., Austin R.J.
  Biochem. J. 390:125-136(2005) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 46-417, DISULFIDE BONDS, FUNCTION, CATALYTIC ACTIVITY, ACTIVE SITE.
EC:3.4.21.106

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	203	Charge relay system2 Publications	1
Active siteⁱ	257	Charge relay system2 Publications	1
Active siteⁱ	353	Charge relay system2 Publications	1

GO - Molecular functionⁱ

calcium-activated potassium channel activity Source: UniProtKB
peptidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16908524
- 19843851
serine-type endopeptidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 16908524
serine-type exopeptidase activity Source: InterPro
serine-type peptidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19911255

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

basement membrane disassembly
Source: UniProtKB
Inferred from direct assayⁱ
- 16908524
cochlea morphogenesis Source: UniProtKB
detection of mechanical stimulus involved in sensory perception of sound Source: UniProtKB
hepatocyte growth factor receptor signaling pathway Source: Reactome
negative regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 15614436
negative regulation of epithelial cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 19843851
negative regulation of epithelial to mesenchymal transition
Source: UniProtKB
Inferred from direct assayⁱ
- 19843851
pilomotor reflex Source: UniProtKB
positive regulation by host of viral transcription
Source: UniProtKB
Inferred from direct assayⁱ
- 15614436
positive regulation of cell growth
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8346233
positive regulation of gene expression Source: UniProtKB
positive regulation of hepatocyte proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 15614436
positive regulation of plasminogen activation
Source: UniProtKB
Inferred from direct assayⁱ
- 16908524
positive regulation of thyroid hormone generation Source: UniProtKB
potassium ion transmembrane transport Source: UniProtKB
proteolysis
Source: UniProtKB
Inferred from direct assayⁱ
regulation of cell shape
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8346233
response to thyroid hormone Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Serine protease

Molecular function

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAⁱ	3.4.21.106 2681
Reactomeⁱ	R-HSA-6806942 MET Receptor Activation R-HSA-8852405 Signaling by MST1

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	S01.224

MEROPSⁱ

S01.224

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine protease hepsin (EC:3.4.21.1061 Publication2 Publications) Alternative name(s): Transmembrane protease serine 1 Cleaved into the following 2 chains: Serine protease hepsin non-catalytic chain Serine protease hepsin catalytic chain
Gene namesⁱ	Name:HPN Synonyms:TMPRSS1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000105707.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5155 HPN
MIMⁱ	142440 gene
neXtProtⁱ	NX_P05981

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 23	CytoplasmicSequence analysisAdd BLAST	23
Transmembraneⁱ	24 – 44	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	45 – 417	ExtracellularSequence analysisAdd BLAST	373

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3249
Open Targets More...OpenTargetsⁱ	ENSG00000105707
PharmGKBⁱ	PA29425

Chemistry databases

ChEMBLⁱ	CHEMBL2079849
Drug and drug target database More...DrugBankⁱ	DB03865 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine DB00522 Bentiromide DB03297 Benzylsulfinic Acid DB00036 Coagulation factor VIIa Recombinant Human DB03643 CRA_1144

Polymorphism and mutation databases

BioMutaⁱ	HPN
DMDMⁱ	123057

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000027841	1 – 162	Serine protease hepsin non-catalytic chainSequence analysisAdd BLAST		162
ChainⁱPRO_0000027842	163 – 417	Serine protease hepsin catalytic chainSequence analysisAdd BLAST		255

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	77 ↔ 140	PROSITE-ProRule annotationCombined sources2 Publications
Disulfide bondⁱ	90 ↔ 150	PROSITE-ProRule annotationCombined sources2 Publications
Glycosylationⁱ	112	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	119 ↔ 138	PROSITE-ProRule annotationCombined sources2 Publications
Disulfide bondⁱ	153 ↔ 277	Interchain (between non-catalytic and catalytic chains)PROSITE-ProRule annotationCombined sources2 Publications
Disulfide bondⁱ	188 ↔ 204	PROSITE-ProRule annotationCombined sources2 Publications
Disulfide bondⁱ	291 ↔ 359	PROSITE-ProRule annotationCombined sources2 Publications
Disulfide bondⁱ	322 ↔ 338	PROSITE-ProRule annotationCombined sources2 Publications
Disulfide bondⁱ	349 ↔ 381	PROSITE-ProRule annotationCombined sources2 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P05981
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P05981
PaxDbⁱ	P05981
PeptideAtlas More...PeptideAtlasⁱ	P05981
PRIDEⁱ	P05981
ProteomicsDBⁱ	51865

PTM databases

iPTMnetⁱ	P05981
PhosphoSitePlusⁱ	P05981

Miscellaneous databases

PMAP-CutDBⁱ	P05981

PMAP-CutDBⁱ

P05981

Expressionⁱ

Tissue specificityⁱ

Detected in liver and kidney.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000105707 Expressed in 127 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_HPN
ExpressionAtlasⁱ	P05981 baseline and differential
Genevisibleⁱ	P05981 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA006804

HPAⁱ

HPA006804

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	109486, 3 interactors
IntActⁱ	P05981, 3 interactors
STRINGⁱ	9606.ENSP00000262626

Chemistry databases

BindingDBⁱ

P05981

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	53 – 56	Combined sources	4
Turnⁱ	58 – 60	Combined sources	3
Beta strandⁱ	62 – 67	Combined sources	6
Turnⁱ	68 – 71	Combined sources	4
Beta strandⁱ	72 – 77	Combined sources	6
Helixⁱ	82 – 93	Combined sources	12
Beta strandⁱ	98 – 105	Combined sources	8
Helixⁱ	106 – 109	Combined sources	4
Beta strandⁱ	116 – 120	Combined sources	5
Turnⁱ	122 – 124	Combined sources	3
Helixⁱ	125 – 127	Combined sources	3
Helixⁱ	131 – 134	Combined sources	4
Beta strandⁱ	135 – 138	Combined sources	4
Beta strandⁱ	144 – 150	Combined sources	7
Beta strandⁱ	177 – 182	Combined sources	6
Beta strandⁱ	185 – 200	Combined sources	16
Helixⁱ	202 – 204	Combined sources	3
Helixⁱ	207 – 209	Combined sources	3
Helixⁱ	212 – 214	Combined sources	3
Beta strandⁱ	215 – 220	Combined sources	6
Beta strandⁱ	229 – 232	Combined sources	4
Beta strandⁱ	234 – 240	Combined sources	7
Helixⁱ	244 – 246	Combined sources	3
Beta strandⁱ	259 – 265	Combined sources	7
Beta strandⁱ	290 – 300	Combined sources	11
Beta strandⁱ	310 – 317	Combined sources	8
Helixⁱ	319 – 322	Combined sources	4
Turnⁱ	325 – 330	Combined sources	6
Beta strandⁱ	336 – 340	Combined sources	5
Beta strandⁱ	345 – 347	Combined sources	3
Turnⁱ	350 – 354	Combined sources	5
Beta strandⁱ	356 – 361	Combined sources	6
Beta strandⁱ	368 – 382	Combined sources	15
Beta strandⁱ	388 – 392	Combined sources	5
Helixⁱ	393 – 396	Combined sources	4
Helixⁱ	397 – 406	Combined sources	10
Turnⁱ	407 – 409	Combined sources	3
Beta strandⁱ	412 – 416	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P05981
SMRⁱ	P05981
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P05981

EvolutionaryTraceⁱ

P05981

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	54 – 151	SRCRAdd BLAST		98
Domainⁱ	163 – 405	Peptidase S1PROSITE-ProRule annotationAdd BLAST		243

Sequence similaritiesⁱ

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3627 Eukaryota COG5640 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000159697
HOGENOMⁱ	HOG000251822
HOVERGENⁱ	HBG013304
InParanoidⁱ	P05981
KEGG Orthology (KO) More...KOⁱ	K08665
OMAⁱ	RWRQVCS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AH5
PhylomeDBⁱ	P05981
TreeFamⁱ	TF351678

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00190 Tryp_SPc, 1 hit
Gene3Dⁱ	3.10.250.10, 1 hit
InterProⁱ	View protein in InterPro IPR038957 Hepsin IPR015352 Hepsin-SRCR_dom IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR017448 SRCR-like_dom IPR036772 SRCR-like_dom_sf IPR001254 Trypsin_dom IPR018114 TRYPSIN_HIS IPR033116 TRYPSIN_SER
PANTHERⁱ	PTHR45072 PTHR45072, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09272 Hepsin-SRCR, 1 hit PF00089 Trypsin, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD021735 Hepsin-SRCR, 1 hit
SMARTⁱ	View protein in SMART SM00202 SR, 1 hit SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 1 hit SSF56487 SSF56487, 1 hit
PROSITEⁱ	View protein in PROSITE PS50240 TRYPSIN_DOM, 1 hit PS00134 TRYPSIN_HIS, 1 hit PS00135 TRYPSIN_SER, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P05981-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAQKEGGRTV PCCSRPKVAA LTAGTLLLLT AIGAASWAIV AVLLRSDQEP 
        60         70         80         90        100
LYPVQVSSAD ARLMVFDKTE GTWRLLCSSR SNARVAGLSC EEMGFLRALT 
       110        120        130        140        150
HSELDVRTAG ANGTSGFFCV DEGRLPHTQR LLEVISVCDC PRGRFLAAIC 
       160        170        180        190        200
QDCGRRKLPV DRIVGGRDTS LGRWPWQVSL RYDGAHLCGG SLLSGDWVLT 
       210        220        230        240        250
AAHCFPERNR VLSRWRVFAG AVAQASPHGL QLGVQAVVYH GGYLPFRDPN 
       260        270        280        290        300
SEENSNDIAL VHLSSPLPLT EYIQPVCLPA AGQALVDGKI CTVTGWGNTQ 
       310        320        330        340        350
YYGQQAGVLQ EARVPIISND VCNGADFYGN QIKPKMFCAG YPEGGIDACQ 
       360        370        380        390        400
GDSGGPFVCE DSISRTPRWR LCGIVSWGTG CALAQKPGVY TKVSDFREWI 
       410 
FQAIKTHSEA SGMVTQL

Length:417

Mass (Da):45,011

Last modified:November 1, 1988 - v1

Checksum:ⁱB2086FF661E551D7

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

M0QZ63	M0QZ63_HUMAN	Serine protease hepsin Serine protease hepsin	HPN	259	Annotation score:
M0R244	M0R244_HUMAN	Serine protease hepsin Serine protease hepsin	HPN	80	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M18930 mRNA Translation: AAA36013.1 X07732 mRNA Translation: CAA30558.1 X07002 mRNA Translation: CAA30058.1 AK315655 mRNA Translation: BAG38021.1 BC025716 mRNA Translation: AAH25716.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32993.1
PIRⁱ	S00845
NCBI Reference Sequences More...RefSeqⁱ	NP_002142.1, NM_002151.2 NP_892028.1, NM_182983.2 XP_005258895.2, XM_005258838.4 XP_006723244.2, XM_006723181.3 XP_016882220.1, XM_017026731.1
UniGeneⁱ	Hs.182385

Genome annotation databases

Ensemblⁱ	ENST00000262626; ENSP00000262626; ENSG00000105707 ENST00000392226; ENSP00000376060; ENSG00000105707
GeneIDⁱ	3249
KEGGⁱ	hsa:3249
UCSC genome browser More...UCSCⁱ	uc002nxq.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P05981	Testicular tissue protein Li 85		HUMAN		417	UniRef100_P05981
HPN isoform 1		PANTR		417
Hepsin		PANPA		417
UPI0002438B3E		HUMAN		372

Protein	Similar proteins		Species	Score	Length	Source
P05981	Serine protease hepsin		PONAB		417	UniRef90_P05981
Testicular tissue protein Li 85		HUMAN		417
HPN isoform 1		PANTR		417
Hepsin		PANPA		417
Hepsin		NOMLE		431
+83

Protein	Similar proteins		Species	Score	Length	Source
P05981	Serine protease hepsin		PONAB		417	UniRef50_P05981
Serine protease hepsin		MOUSE		436
Serine protease hepsin		RAT		416
Testicular tissue protein Li 85		HUMAN		417
HPN isoform 1		PANTR		417
+169

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M18930 mRNA Translation: AAA36013.1 X07732 mRNA Translation: CAA30558.1 X07002 mRNA Translation: CAA30058.1 AK315655 mRNA Translation: BAG38021.1 BC025716 mRNA Translation: AAH25716.1
CCDSⁱ	CCDS32993.1
PIRⁱ	S00845
RefSeqⁱ	NP_002142.1, NM_002151.2 NP_892028.1, NM_182983.2 XP_005258895.2, XM_005258838.4 XP_006723244.2, XM_006723181.3 XP_016882220.1, XM_017026731.1
UniGeneⁱ	Hs.182385

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1O5E	X-ray	1.75	H	163-417	[»]
				L	46-159	[»]
	1O5F	X-ray	1.78	H	163-417	[»]
				L	46-159	[»]
	1P57	X-ray	1.75	A	46-159	[»]
				B	163-417	[»]
	1Z8G	X-ray	1.55	A	46-417	[»]
	3T2N	X-ray	2.55	A/B	46-417	[»]
	5CE1	X-ray	2.50	A	46-417	[»]
ProteinModelPortalⁱ	P05981
SMRⁱ	P05981
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109486, 3 interactors
IntActⁱ	P05981, 3 interactors
STRINGⁱ	9606.ENSP00000262626

Chemistry databases

BindingDBⁱ	P05981
ChEMBLⁱ	CHEMBL2079849
DrugBankⁱ	DB03865 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine DB00522 Bentiromide DB03297 Benzylsulfinic Acid DB00036 Coagulation factor VIIa Recombinant Human DB03643 CRA_1144

Protein family/group databases

MEROPSⁱ	S01.224

MEROPSⁱ

S01.224

PTM databases

iPTMnetⁱ	P05981
PhosphoSitePlusⁱ	P05981

Polymorphism and mutation databases

BioMutaⁱ	HPN
DMDMⁱ	123057

Proteomic databases

EPDⁱ	P05981
MaxQBⁱ	P05981
PaxDbⁱ	P05981
PeptideAtlasⁱ	P05981
PRIDEⁱ	P05981
ProteomicsDBⁱ	51865

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3249
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262626; ENSP00000262626; ENSG00000105707 ENST00000392226; ENSP00000376060; ENSG00000105707
GeneIDⁱ	3249
KEGGⁱ	hsa:3249
UCSCⁱ	uc002nxq.3 human

Organism-specific databases

CTDⁱ	3249
DisGeNETⁱ	3249
EuPathDBⁱ	HostDB:ENSG00000105707.13
GeneCardsⁱ	HPN
H-InvDBⁱ	HIX0137465
HGNCⁱ	HGNC:5155 HPN
HPAⁱ	HPA006804
MIMⁱ	142440 gene
neXtProtⁱ	NX_P05981
OpenTargetsⁱ	ENSG00000105707
PharmGKBⁱ	PA29425
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3627 Eukaryota COG5640 LUCA
GeneTreeⁱ	ENSGT00940000159697
HOGENOMⁱ	HOG000251822
HOVERGENⁱ	HBG013304
InParanoidⁱ	P05981
KOⁱ	K08665
OMAⁱ	RWRQVCS
OrthoDBⁱ	EOG091G0AH5
PhylomeDBⁱ	P05981
TreeFamⁱ	TF351678

Enzyme and pathway databases

BRENDAⁱ	3.4.21.106 2681
Reactomeⁱ	R-HSA-6806942 MET Receptor Activation R-HSA-8852405 Signaling by MST1

Miscellaneous databases

ChiTaRSⁱ	HPN human
EvolutionaryTraceⁱ	P05981
GeneWikiⁱ	HPN_(gene)
GenomeRNAiⁱ	3249
PMAP-CutDBⁱ	P05981
Protein Ontology More...PROⁱ	PR:P05981
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000105707 Expressed in 127 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_HPN
ExpressionAtlasⁱ	P05981 baseline and differential
Genevisibleⁱ	P05981 HS

Family and domain databases

CDDⁱ	cd00190 Tryp_SPc, 1 hit
Gene3Dⁱ	3.10.250.10, 1 hit
InterProⁱ	View protein in InterPro IPR038957 Hepsin IPR015352 Hepsin-SRCR_dom IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR017448 SRCR-like_dom IPR036772 SRCR-like_dom_sf IPR001254 Trypsin_dom IPR018114 TRYPSIN_HIS IPR033116 TRYPSIN_SER
PANTHERⁱ	PTHR45072 PTHR45072, 1 hit
Pfamⁱ	View protein in Pfam PF09272 Hepsin-SRCR, 1 hit PF00089 Trypsin, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD021735 Hepsin-SRCR, 1 hit
SMARTⁱ	View protein in SMART SM00202 SR, 1 hit SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 1 hit SSF56487 SSF56487, 1 hit
PROSITEⁱ	View protein in PROSITE PS50240 TRYPSIN_DOM, 1 hit PS00134 TRYPSIN_HIS, 1 hit PS00135 TRYPSIN_SER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HEPS_HUMAN
Accessionⁱ	P05981Primary (citable) accession number: P05981 Secondary accession number(s): B2RDS4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
	Last sequence update:	November 1, 1988
	Last modified:	December 5, 2018
	This is version 181 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
Peptidase families
Classification of peptidase families and list of entries
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P05981 (HEPS_HUMAN)

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Serine protease hepsin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endoplasmic reticulum

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ