Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein S100-A10

Gene

S100a10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.By similarity

Miscellaneous

Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.

GO - Molecular functioni

GO - Biological processi

  • positive regulation of binding Source: Ensembl
  • regulation of cell differentiation Source: RGD
  • regulation of cell growth Source: RGD
  • response to drug Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-75205 Dissolution of Fibrin Clot

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A10
Alternative name(s):
Calpactin I light chain
Calpactin-1 light chain
Cellular ligand of annexin II
Nerve growth factor-induced protein 42C
S100 calcium-binding protein A10
p10 protein
p11
Gene namesi
Name:S100a10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi628655 S100a10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440061 – 95Protein S100-A10Add BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23N6-acetyllysineBy similarity1
Modified residuei28N6-acetyllysineBy similarity1
Modified residuei54N6-acetyllysineBy similarity1
Modified residuei57N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP05943
PRIDEiP05943

PTM databases

iPTMnetiP05943
PhosphoSitePlusiP05943

Expressioni

Inductioni

By nerve growth factor.

Gene expression databases

BgeeiENSRNOG00000023226 Expressed in 10 organ(s), highest expression level in colon
ExpressionAtlasiP05943 baseline and differential
GenevisibleiP05943 RN

Interactioni

Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Scn10aQ629684EBI-1800351,EBI-1800320

Protein-protein interaction databases

IntActiP05943, 6 interactors
STRINGi10116.ENSRNOP00000037097

Structurei

3D structure databases

ProteinModelPortaliP05943
SMRiP05943
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni60 – 71Ancestral calcium siteAdd BLAST12

Sequence similaritiesi

Belongs to the S-100 family.Curated

Phylogenomic databases

eggNOGiENOG410YSSI LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP05943
KOiK17274
OMAiAMETLMF
OrthoDBiEOG091G10QT
PhylomeDBiP05943
TreeFamiTF332727

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR028476 S100-A10
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PANTHERiPTHR11639:SF74 PTHR11639:SF74, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

P05943-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSQMEHAME TMMLTFHRFA GEKNYLTKED LRVLMEREFP GFLENQKDPL
60 70 80 90
AVDKIMKDLD QCRDGKVGFQ SFLSLVAGLI IACNDYFVVH MKQKK
Length:95
Mass (Da):11,075
Last modified:January 23, 2007 - v2
Checksum:iEC12960C177F1BBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03627 mRNA Translation: AAA42097.1
AF465254 Genomic DNA Translation: AAO33353.1
BC091565 mRNA Translation: AAH91565.1
PIRiA31373
RefSeqiNP_112376.1, NM_031114.1
UniGeneiRn.4083

Genome annotation databases

EnsembliENSRNOT00000035240; ENSRNOP00000037097; ENSRNOG00000023226
GeneIDi81778
KEGGirno:81778
UCSCiRGD:628655 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03627 mRNA Translation: AAA42097.1
AF465254 Genomic DNA Translation: AAO33353.1
BC091565 mRNA Translation: AAH91565.1
PIRiA31373
RefSeqiNP_112376.1, NM_031114.1
UniGeneiRn.4083

3D structure databases

ProteinModelPortaliP05943
SMRiP05943
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP05943, 6 interactors
STRINGi10116.ENSRNOP00000037097

PTM databases

iPTMnetiP05943
PhosphoSitePlusiP05943

Proteomic databases

PaxDbiP05943
PRIDEiP05943

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000035240; ENSRNOP00000037097; ENSRNOG00000023226
GeneIDi81778
KEGGirno:81778
UCSCiRGD:628655 rat

Organism-specific databases

CTDi6281
RGDi628655 S100a10

Phylogenomic databases

eggNOGiENOG410YSSI LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP05943
KOiK17274
OMAiAMETLMF
OrthoDBiEOG091G10QT
PhylomeDBiP05943
TreeFamiTF332727

Enzyme and pathway databases

ReactomeiR-RNO-75205 Dissolution of Fibrin Clot

Miscellaneous databases

PROiPR:P05943

Gene expression databases

BgeeiENSRNOG00000023226 Expressed in 10 organ(s), highest expression level in colon
ExpressionAtlasiP05943 baseline and differential
GenevisibleiP05943 RN

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR028476 S100-A10
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PANTHERiPTHR11639:SF74 PTHR11639:SF74, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS10AA_RAT
AccessioniPrimary (citable) accession number: P05943
Secondary accession number(s): Q5BJ98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again