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Protein

Protein S100-A4

Gene

S100a4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinityPROSITE-ProRule annotationAdd BLAST14
Calcium bindingi63 – 742; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A4
Alternative name(s):
Metastasin
Nerve growth factor-induced protein 42A
P9K
Placental calcium-binding protein
S100 calcium-binding protein A4
Gene namesi
Name:S100a4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi3245 S100a4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001439792 – 101Protein S100-A4Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei35N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP05942
PRIDEiP05942

PTM databases

iPTMnetiP05942
PhosphoSitePlusiP05942

Expressioni

Inductioni

By nerve growth factor.

Gene expression databases

BgeeiENSRNOG00000011821 Expressed in 9 organ(s), highest expression level in lung
GenevisibleiP05942 RN

Interactioni

Subunit structurei

Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015958

Structurei

3D structure databases

ProteinModelPortaliP05942
SMRiP05942
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYVZ Eukaryota
ENOG4111DV3 LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP05942
OMAiFFEGCPD
OrthoDBiEOG091G10JX
PhylomeDBiP05942
TreeFamiTF332727

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR034325 S-100_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05942-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARPLEEALD VIVSTFHKYS GNEGDKFKLN KTELKELLTR ELPSFLGRRT
60 70 80 90 100
DEAAFQKLMN NLDSNRDNEV DFQEYCVFLS CIAMMCNEFF EGCPDKEPRK

K
Length:101
Mass (Da):11,776
Last modified:November 1, 1988 - v1
Checksum:iEA0619CEE4F487C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06916 Genomic DNA Translation: CAA30014.1
J03628 mRNA Translation: AAA42098.1
X64022 mRNA No translation available.
X64023 mRNA No translation available.
PIRiS01759
RefSeqiNP_036750.1, NM_012618.2
XP_006232654.1, XM_006232592.3
UniGeneiRn.504

Genome annotation databases

EnsembliENSRNOT00000015958; ENSRNOP00000015958; ENSRNOG00000011821
GeneIDi24615
KEGGirno:24615
UCSCiRGD:3245 rat

Similar proteinsi

Entry informationi

Entry nameiS10A4_RAT
AccessioniPrimary (citable) accession number: P05942
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: September 12, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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