CALB1

Functionⁱ

Buffers cytosolic calcium. May stimulate a membrane Ca²⁺-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

Regions

Feature key	Position(s)	DescriptionActions	Length
Calcium bindingⁱ	24 – 35	1Add BLAST	12
Calcium bindingⁱ	111 – 122	2Add BLAST	12
Calcium bindingⁱ	155 – 166	3Add BLAST	12
Calcium bindingⁱ	199 – 210	4Add BLAST	12

GO - Molecular functionⁱ

calcium ion binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18359862
calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration Source: Ensembl
calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration Source: Ensembl
vitamin D binding Source: UniProtKB-KW
zinc ion binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18359862

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein metabolic process Source: Reactome
cellular response to organic substance Source: Ensembl
locomotory behavior Source: Ensembl
long-term memory
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22796338
metanephric collecting duct development Source: Ensembl
metanephric connecting tubule development Source: Ensembl
metanephric distal convoluted tubule development Source: Ensembl
metanephric part of ureteric bud development Source: Ensembl
regulation of cytosolic calcium ion concentration
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of long-term synaptic potentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of presynaptic cytosolic calcium ion concentration
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
retina layer formation Source: Ensembl
short-term memory
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22796338

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Calcium, Metal-binding, Vitamin D

Ligand

Calcium, Metal-binding, Vitamin D

Enzyme and pathway databases

Reactomeⁱ	R-HSA-977225 Amyloid fiber formation

Reactomeⁱ

R-HSA-977225 Amyloid fiber formation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Calbindin Alternative name(s): Calbindin D28 D-28K Vitamin D-dependent calcium-binding protein, avian-type
Gene namesⁱ	Name:CALB1 Synonyms:CAB27
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000104327.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1434 CALB1
MIMⁱ	114050 gene
neXtProtⁱ	NX_P05937

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	793
Open Targets More...OpenTargetsⁱ	ENSG00000104327
PharmGKBⁱ	PA26026

Polymorphism and mutation databases

BioMutaⁱ	CALB1

BioMutaⁱ

CALB1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedBy similarity
ChainⁱPRO_0000073472	2 – 261	CalbindinAdd BLAST		260

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineBy similarity		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	P05937
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P05937
PaxDbⁱ	P05937
PeptideAtlas More...PeptideAtlasⁱ	P05937
PRIDEⁱ	P05937
ProteomicsDBⁱ	51862

PTM databases

GlyConnectⁱ	1056
iPTMnetⁱ	P05937
PhosphoSitePlusⁱ	P05937

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000104327 Expressed in 140 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_CALB1
ExpressionAtlasⁱ	P05937 baseline and differential
Genevisibleⁱ	P05937 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002138 HPA023099 HPA056734

HPAⁱ

CAB002138
HPA023099
HPA056734

Interactionⁱ

Subunit structureⁱ

Interacts with RANBP9.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
IKBKG	Q9Y6K9	3	EBI-4286943,EBI-81279
TRPV5	Q9NQA5	4	EBI-4286943,EBI-751281

Protein-protein interaction databases

BioGridⁱ	107244, 5 interactors
IntActⁱ	P05937, 5 interactors
Molecular INTeraction database More...MINTⁱ	P05937
STRINGⁱ	9606.ENSP00000265431

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P05937
SMRⁱ	P05937
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	11 – 46	EF-hand 1PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	53 – 88	EF-hand 2PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	98 – 133	EF-hand 3PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	142 – 177	EF-hand 4PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	186 – 221	EF-hand 5PROSITE-ProRule annotationAdd BLAST	36

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	2 – 7	Interaction with RANBP91 Publication		6

Domainⁱ

This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.

Sequence similaritiesⁱ

Belongs to the calbindin family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0027 Eukaryota COG5126 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013118
HOGENOMⁱ	HOG000231866
HOVERGENⁱ	HBG000855
InParanoidⁱ	P05937
KEGG Orthology (KO) More...KOⁱ	K14757
OMAⁱ	MQTWRKY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GNH
PhylomeDBⁱ	P05937
TreeFamⁱ	TF325083

Family and domain databases

InterProⁱ	View protein in InterPro IPR029634 Calbindin IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom
PANTHERⁱ	PTHR19972:SF3 PTHR19972:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13405 EF-hand_6, 1 hit PF13499 EF-hand_7, 1 hit
SMARTⁱ	View protein in SMART SM00054 EFh, 4 hits
SUPFAMⁱ	SSF47473 SSF47473, 2 hits
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 4 hits PS50222 EF_HAND_2, 5 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P05937-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELQQARKKA 
        60         70         80         90        100
GLELSPEMKT FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC 
       110        120        130        140        150
EEFMKTWRKY DTDHSGFIET EELKNFLKDL LEKANKTVDD TKLAEYTDLM 
       160        170        180        190        200
LKLFDSNNDG KLELTEMARL LPVQENFLLK FQGIKMCGKE FNKAFELYDQ 
       210        220        230        240        250
DGNGYIDENE LDALLKDLCE KNKQDLDINN ITTYKKNIMA LSDGGKLYRT 
       260 
DLALILCAGD N

Length:261

Mass (Da):30,025

Last modified:January 23, 2007 - v2

Checksum:ⁱ8ED7A09BCC5FE5E4

GO

Isoform 2 (identifier: P05937-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-57: Missing.

« Hide

        10         20         30         40         50
MKTFVDQYGQ RDDGKIGIVE LAHVLPTEEN FLLLFRCQQL KSCEEFMKTW 
        60         70         80         90        100
RKYDTDHSGF IETEELKNFL KDLLEKANKT VDDTKLAEYT DLMLKLFDSN 
       110        120        130        140        150
NDGKLELTEM ARLLPVQENF LLKFQGIKMC GKEFNKAFEL YDQDGNGYID 
       160        170        180        190        200
ENELDALLKD LCEKNKQDLD INNITTYKKN IMALSDGGKL YRTDLALILC 

AGDN

Note: No experimental confirmation available.

Show »

Length:204

Mass (Da):23,609

Checksum:ⁱ50B8050A3B9210E3

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E5RIZ8	E5RIZ8_HUMAN	Calbindin Calbindin	CALB1	119	Annotation score:
E5RG14	E5RG14_HUMAN	Calbindin Calbindin	CALB1	102	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055508	1 – 57	Missing in isoform 2. 1 PublicationAdd BLAST		57

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X06661 mRNA Translation: CAA29860.1 AF068862 Genomic DNA Translation: AAC62230.1 AC004612 Genomic DNA Translation: AAC14672.1 AK054881 mRNA Translation: BAG51438.1 AK312491 mRNA Translation: BAG35393.1 AK315959 mRNA Translation: BAH14330.1 AF049895 Genomic DNA No translation available. AC123779 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW91665.1 CH471060 Genomic DNA Translation: EAW91666.1 BC006478 mRNA Translation: AAH06478.1 BC020864 mRNA Translation: AAH20864.1 M19878 Genomic DNA Translation: AAA98991.1 M19879 Genomic DNA Translation: AAA98992.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6251.1 [P05937-1]
PIRⁱ	S00234
NCBI Reference Sequences More...RefSeqⁱ	NP_004920.1, NM_004929.3 [P05937-1]
UniGeneⁱ	Hs.65425

Genome annotation databases

Ensemblⁱ	ENST00000265431; ENSP00000265431; ENSG00000104327 [P05937-1] ENST00000518457; ENSP00000429602; ENSG00000104327 [P05937-2]
GeneIDⁱ	793
KEGGⁱ	hsa:793
UCSC genome browser More...UCSCⁱ	uc003yel.2 human [P05937-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
P05937	CALB1 isoform 3		PANTR		261	UniRef100_P05937
CALB1 isoform 2		PONAB		261
Uncharacterized protein		PANPA		261
Uncharacterized protein		NOMLE		261
Calbindin 1		GORGO		261
+3

Protein	Similar proteins		Species	Score	Length	Source
P05937	Calbindin		MOUSE		261	UniRef90_P12658
Calbindin		BOVIN		261
Calbindin		PONAB		261
Calbindin	)	RAT		261
Uncharacterized protein		FELCA		271
+99

Protein	Similar proteins		Species	Score	Length	Source
P05937	Calbindin		MOUSE		261	UniRef50_P12658
Calbindin		PONAB		261
Calbindin		BOVIN		261
Calbindin	)	RAT		261
Calretinin		CHICK		269
+264

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Calbindin entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X06661 mRNA Translation: CAA29860.1 AF068862 Genomic DNA Translation: AAC62230.1 AC004612 Genomic DNA Translation: AAC14672.1 AK054881 mRNA Translation: BAG51438.1 AK312491 mRNA Translation: BAG35393.1 AK315959 mRNA Translation: BAH14330.1 AF049895 Genomic DNA No translation available. AC123779 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW91665.1 CH471060 Genomic DNA Translation: EAW91666.1 BC006478 mRNA Translation: AAH06478.1 BC020864 mRNA Translation: AAH20864.1 M19878 Genomic DNA Translation: AAA98991.1 M19879 Genomic DNA Translation: AAA98992.1
CCDSⁱ	CCDS6251.1 [P05937-1]
PIRⁱ	S00234
RefSeqⁱ	NP_004920.1, NM_004929.3 [P05937-1]
UniGeneⁱ	Hs.65425

3D structure databases

ProteinModelPortalⁱ	P05937
SMRⁱ	P05937
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107244, 5 interactors
IntActⁱ	P05937, 5 interactors
MINTⁱ	P05937
STRINGⁱ	9606.ENSP00000265431

PTM databases

GlyConnectⁱ	1056
iPTMnetⁱ	P05937
PhosphoSitePlusⁱ	P05937

Polymorphism and mutation databases

BioMutaⁱ	CALB1

BioMutaⁱ

CALB1

Proteomic databases

EPDⁱ	P05937
MaxQBⁱ	P05937
PaxDbⁱ	P05937
PeptideAtlasⁱ	P05937
PRIDEⁱ	P05937
ProteomicsDBⁱ	51862

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000265431; ENSP00000265431; ENSG00000104327 [P05937-1] ENST00000518457; ENSP00000429602; ENSG00000104327 [P05937-2]
GeneIDⁱ	793
KEGGⁱ	hsa:793
UCSCⁱ	uc003yel.2 human [P05937-1]

Organism-specific databases

CTDⁱ	793
DisGeNETⁱ	793
EuPathDBⁱ	HostDB:ENSG00000104327.7
GeneCardsⁱ	CALB1
HGNCⁱ	HGNC:1434 CALB1
HPAⁱ	CAB002138 HPA023099 HPA056734
MIMⁱ	114050 gene
neXtProtⁱ	NX_P05937
OpenTargetsⁱ	ENSG00000104327
PharmGKBⁱ	PA26026
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0027 Eukaryota COG5126 LUCA
GeneTreeⁱ	ENSGT00390000013118
HOGENOMⁱ	HOG000231866
HOVERGENⁱ	HBG000855
InParanoidⁱ	P05937
KOⁱ	K14757
OMAⁱ	MQTWRKY
OrthoDBⁱ	EOG091G0GNH
PhylomeDBⁱ	P05937
TreeFamⁱ	TF325083

Enzyme and pathway databases

Reactomeⁱ	R-HSA-977225 Amyloid fiber formation

Reactomeⁱ

R-HSA-977225 Amyloid fiber formation

Miscellaneous databases

GenomeRNAiⁱ	793
Protein Ontology More...PROⁱ	PR:P05937
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000104327 Expressed in 140 organ(s), highest expression level in caudate nucleus
CleanExⁱ	HS_CALB1
ExpressionAtlasⁱ	P05937 baseline and differential
Genevisibleⁱ	P05937 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR029634 Calbindin IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR002048 EF_hand_dom
PANTHERⁱ	PTHR19972:SF3 PTHR19972:SF3, 1 hit
Pfamⁱ	View protein in Pfam PF13405 EF-hand_6, 1 hit PF13499 EF-hand_7, 1 hit
SMARTⁱ	View protein in SMART SM00054 EFh, 4 hits
SUPFAMⁱ	SSF47473 SSF47473, 2 hits
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 4 hits PS50222 EF_HAND_2, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CALB1_HUMAN
Accessionⁱ	P05937Primary (citable) accession number: P05937 Secondary accession number(s): B2R696, B7Z9J4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P05937 (CALB1_HUMAN)

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Calbindin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Extracellular region or secreted

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ