UniProtKB - P05937 (CALB1_HUMAN)
Protein
Calbindin
Gene
CALB1
Organism
Homo sapiens (Human)
Status
Functioni
Buffers cytosolic calcium. May stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 24 – 35 | 1Combined sources1 PublicationAdd BLAST | 12 | |
Calcium bindingi | 111 – 122 | 2Combined sources1 PublicationAdd BLAST | 12 | |
Calcium bindingi | 155 – 166 | 3Combined sources1 PublicationAdd BLAST | 12 | |
Calcium bindingi | 199 – 210 | 4Combined sources1 PublicationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- vitamin D binding Source: UniProtKB-KW
- zinc ion binding Source: UniProtKB
GO - Biological processi
- cellular protein metabolic process Source: Reactome
- cellular response to organic substance Source: Ensembl
- cochlea development Source: Ensembl
- locomotory behavior Source: Ensembl
- long-term memory Source: UniProtKB
- metanephric collecting duct development Source: Ensembl
- metanephric connecting tubule development Source: Ensembl
- metanephric distal convoluted tubule development Source: Ensembl
- metanephric part of ureteric bud development Source: Ensembl
- regulation of cytosolic calcium ion concentration Source: GO_Central
- regulation of long-term synaptic potentiation Source: GO_Central
- regulation of presynaptic cytosolic calcium ion concentration Source: GO_Central
- retina layer formation Source: Ensembl
- short-term memory Source: UniProtKB
Keywordsi
Ligand | Calcium, Metal-binding, Vitamin D |
Enzyme and pathway databases
PathwayCommonsi | P05937 |
Reactomei | R-HSA-977225, Amyloid fiber formation |
Names & Taxonomyi
Protein namesi | Recommended name: CalbindinAlternative name(s): Calbindin D28 D-28K Vitamin D-dependent calcium-binding protein, avian-type |
Gene namesi | Name:CALB1 Synonyms:CAB27 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000104327.7 |
HGNCi | HGNC:1434, CALB1 |
MIMi | 114050, gene |
neXtProti | NX_P05937 |
Subcellular locationi
Cytoskeleton
- cuticular plate Source: Ensembl
Cytosol
- cytosol Source: GO_Central
- presynaptic cytosol Source: Ensembl
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- axon Source: UniProtKB
- dendrite Source: UniProtKB
- dendritic spine Source: GO_Central
- neuron projection Source: GO_Central
- neuronal cell body Source: UniProtKB
- stereocilium Source: Ensembl
- synapse Source: GO_Central
- terminal bouton Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 793 |
OpenTargetsi | ENSG00000104327 |
PharmGKBi | PA26026 |
Miscellaneous databases
Pharosi | P05937, Tbio |
Chemistry databases
DrugBanki | DB11093, Calcium citrate DB11348, Calcium Phosphate DB14481, Calcium phosphate dihydrate |
Polymorphism and mutation databases
BioMutai | CALB1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000073472 | 2 – 261 | CalbindinAdd BLAST | 260 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | P05937 |
jPOSTi | P05937 |
MassIVEi | P05937 |
MaxQBi | P05937 |
PaxDbi | P05937 |
PeptideAtlasi | P05937 |
PRIDEi | P05937 |
ProteomicsDBi | 51862 [P05937-1] 7034 |
PTM databases
GlyConnecti | 1056, 3 N-Linked glycans (1 site) |
GlyGeni | P05937, 1 site |
iPTMneti | P05937 |
PhosphoSitePlusi | P05937 |
Expressioni
Gene expression databases
Bgeei | ENSG00000104327, Expressed in caudate nucleus and 155 other tissues |
ExpressionAtlasi | P05937, baseline and differential |
Genevisiblei | P05937, HS |
Organism-specific databases
HPAi | ENSG00000104327, Group enriched (brain, kidney) |
Interactioni
Subunit structurei
Interacts with RANBP9.
1 PublicationBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 107244, 5 interactors |
IntActi | P05937, 5 interactors |
MINTi | P05937 |
STRINGi | 9606.ENSP00000265431 |
Miscellaneous databases
RNActi | P05937, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SASBDBi | P05937 |
SMRi | P05937 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 46 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 53 – 88 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 98 – 133 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 142 – 177 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 186 – 221 | EF-hand 5PROSITE-ProRule annotationAdd BLAST | 36 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 7 | Interaction with RANBP91 Publication | 6 |
Domaini
This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.1 Publication
Sequence similaritiesi
Belongs to the calbindin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0027, Eukaryota |
GeneTreei | ENSGT00950000183108 |
HOGENOMi | CLU_054826_1_1_1 |
InParanoidi | P05937 |
OMAi | WLHFDSD |
OrthoDBi | 979297at2759 |
PhylomeDBi | P05937 |
TreeFami | TF325083 |
Family and domain databases
InterProi | View protein in InterPro IPR029634, Calbindin IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
PANTHERi | PTHR19972:SF14, PTHR19972:SF14, 1 hit |
Pfami | View protein in Pfam PF00036, EF-hand_1, 1 hit PF13499, EF-hand_7, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 4 hits PS50222, EF_HAND_2, 5 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P05937-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELQQARKKA
60 70 80 90 100
GLELSPEMKT FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC
110 120 130 140 150
EEFMKTWRKY DTDHSGFIET EELKNFLKDL LEKANKTVDD TKLAEYTDLM
160 170 180 190 200
LKLFDSNNDG KLELTEMARL LPVQENFLLK FQGIKMCGKE FNKAFELYDQ
210 220 230 240 250
DGNGYIDENE LDALLKDLCE KNKQDLDINN ITTYKKNIMA LSDGGKLYRT
260
DLALILCAGD N
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RG14 | E5RG14_HUMAN | Calbindin | CALB1 | 102 | Annotation score: | ||
E5RIZ8 | E5RIZ8_HUMAN | Calbindin | CALB1 | 119 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055508 | 1 – 57 | Missing in isoform 2. 1 PublicationAdd BLAST | 57 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X06661 mRNA Translation: CAA29860.1 AF068862 Genomic DNA Translation: AAC62230.1 AC004612 Genomic DNA Translation: AAC14672.1 AK054881 mRNA Translation: BAG51438.1 AK312491 mRNA Translation: BAG35393.1 AK315959 mRNA Translation: BAH14330.1 AF049895 Genomic DNA No translation available. AC123779 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW91665.1 CH471060 Genomic DNA Translation: EAW91666.1 BC006478 mRNA Translation: AAH06478.1 BC020864 mRNA Translation: AAH20864.1 M19878 Genomic DNA Translation: AAA98991.1 M19879 Genomic DNA Translation: AAA98992.1 |
CCDSi | CCDS6251.1 [P05937-1] |
PIRi | S00234 |
RefSeqi | NP_004920.1, NM_004929.3 [P05937-1] |
Genome annotation databases
Ensembli | ENST00000265431; ENSP00000265431; ENSG00000104327 [P05937-1] ENST00000518457; ENSP00000429602; ENSG00000104327 [P05937-2] |
GeneIDi | 793 |
KEGGi | hsa:793 |
UCSCi | uc003yel.2, human [P05937-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Calbindin entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X06661 mRNA Translation: CAA29860.1 AF068862 Genomic DNA Translation: AAC62230.1 AC004612 Genomic DNA Translation: AAC14672.1 AK054881 mRNA Translation: BAG51438.1 AK312491 mRNA Translation: BAG35393.1 AK315959 mRNA Translation: BAH14330.1 AF049895 Genomic DNA No translation available. AC123779 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW91665.1 CH471060 Genomic DNA Translation: EAW91666.1 BC006478 mRNA Translation: AAH06478.1 BC020864 mRNA Translation: AAH20864.1 M19878 Genomic DNA Translation: AAA98991.1 M19879 Genomic DNA Translation: AAA98992.1 |
CCDSi | CCDS6251.1 [P05937-1] |
PIRi | S00234 |
RefSeqi | NP_004920.1, NM_004929.3 [P05937-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6FIE | X-ray | 1.51 | B | 1-261 | [»] | |
SASBDBi | P05937 | |||||
SMRi | P05937 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107244, 5 interactors |
IntActi | P05937, 5 interactors |
MINTi | P05937 |
STRINGi | 9606.ENSP00000265431 |
Chemistry databases
DrugBanki | DB11093, Calcium citrate DB11348, Calcium Phosphate DB14481, Calcium phosphate dihydrate |
PTM databases
GlyConnecti | 1056, 3 N-Linked glycans (1 site) |
GlyGeni | P05937, 1 site |
iPTMneti | P05937 |
PhosphoSitePlusi | P05937 |
Polymorphism and mutation databases
BioMutai | CALB1 |
Proteomic databases
EPDi | P05937 |
jPOSTi | P05937 |
MassIVEi | P05937 |
MaxQBi | P05937 |
PaxDbi | P05937 |
PeptideAtlasi | P05937 |
PRIDEi | P05937 |
ProteomicsDBi | 51862 [P05937-1] 7034 |
Protocols and materials databases
ABCDi | P05937, 2 sequenced antibodies |
Antibodypediai | 3678, 443 antibodies |
Genome annotation databases
Ensembli | ENST00000265431; ENSP00000265431; ENSG00000104327 [P05937-1] ENST00000518457; ENSP00000429602; ENSG00000104327 [P05937-2] |
GeneIDi | 793 |
KEGGi | hsa:793 |
UCSCi | uc003yel.2, human [P05937-1] |
Organism-specific databases
CTDi | 793 |
DisGeNETi | 793 |
EuPathDBi | HostDB:ENSG00000104327.7 |
GeneCardsi | CALB1 |
HGNCi | HGNC:1434, CALB1 |
HPAi | ENSG00000104327, Group enriched (brain, kidney) |
MIMi | 114050, gene |
neXtProti | NX_P05937 |
OpenTargetsi | ENSG00000104327 |
PharmGKBi | PA26026 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0027, Eukaryota |
GeneTreei | ENSGT00950000183108 |
HOGENOMi | CLU_054826_1_1_1 |
InParanoidi | P05937 |
OMAi | WLHFDSD |
OrthoDBi | 979297at2759 |
PhylomeDBi | P05937 |
TreeFami | TF325083 |
Enzyme and pathway databases
PathwayCommonsi | P05937 |
Reactomei | R-HSA-977225, Amyloid fiber formation |
Miscellaneous databases
BioGRID-ORCSi | 793, 3 hits in 849 CRISPR screens |
ChiTaRSi | CALB1, human |
GenomeRNAii | 793 |
Pharosi | P05937, Tbio |
PROi | PR:P05937 |
RNActi | P05937, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104327, Expressed in caudate nucleus and 155 other tissues |
ExpressionAtlasi | P05937, baseline and differential |
Genevisiblei | P05937, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029634, Calbindin IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
PANTHERi | PTHR19972:SF14, PTHR19972:SF14, 1 hit |
Pfami | View protein in Pfam PF00036, EF-hand_1, 1 hit PF13499, EF-hand_7, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 2 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 4 hits PS50222, EF_HAND_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CALB1_HUMAN | |
Accessioni | P05937Primary (citable) accession number: P05937 Secondary accession number(s): B2R696, B7Z9J4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 192 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM