UniProtKB - P05835 (TRAY3_ECOLX)
Protein
Relaxosome protein TraY
Gene
traY
Organism
Escherichia coli
Status
Functioni
Conjugative DNA transfer (CDT) is the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Part of the relaxosome, which facilitates a site- and strand-specific cut in the origin of transfer by TraI, at the nic site. Relaxosome formation requires binding of IHF and TraY to the oriT region, which then facilitates binding of TraI. Also positively regulates tra gene expression (By similarity).By similarity
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
GO - Biological processi
- conjugation Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Conjugation, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Relaxosome protein TraY |
Gene namesi | Name:traY |
Encoded oni | Plasmid IncFII R100-11 Publication Plasmid IncFII R100 (NR1)1 Publication |
Organismi | Escherichia coli |
Taxonomic identifieri | 562 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia |
Subcellular locationi
- Cytoplasm By similarity
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068482 | 1 – 75 | Relaxosome protein TraYAdd BLAST | 75 |
Interactioni
Subunit structurei
Part of the relaxosome, a complex composed of plasmid encoded TraI, TraM, TraY and host-encoded IHF bound to the F plasmid origin of transfer (oriT).
Interacts with TraM, probably through its C-terminus (By similarity).
By similarityFamily & Domainsi
Sequence similaritiesi
Belongs to the TraY family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR008876, TraY |
Pfami | View protein in Pfam PF05509, TraY, 1 hit |
i Sequence
Sequence statusi: Complete.
P05835-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRNIIRPAP GNKVLLVLDD ATNHKLLGAR ERSGRTKTNE VLVRLRDHLN
60 70
RFPDFYNLDA IKEGAEETDS IIKDL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M15136 Genomic DNA Translation: AAA26076.1 M20941 Genomic DNA Translation: AAA26073.1 |
PIRi | C25033, BVECRY |
RefSeqi | NP_957599.1, NC_005327.1 WP_000089263.1, NZ_WVVN01000094.1 YP_001096467.1, NC_009133.1 YP_003108229.1, NC_013121.1 YP_006952237.1, NC_019057.1 YP_006953321.1, NC_019071.1 YP_006953420.1, NC_019072.1 YP_006953947.1, NC_019090.1 YP_006954268.1, NC_019095.1 YP_006990759.1, NC_019424.1 YP_007447545.1, NC_020278.2 YP_009070966.1, NC_025177.1 YP_788061.1, NC_008460.1 |
Genome annotation databases
GeneIDi | 40043865 58462407 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M15136 Genomic DNA Translation: AAA26076.1 M20941 Genomic DNA Translation: AAA26073.1 |
PIRi | C25033, BVECRY |
RefSeqi | NP_957599.1, NC_005327.1 WP_000089263.1, NZ_WVVN01000094.1 YP_001096467.1, NC_009133.1 YP_003108229.1, NC_013121.1 YP_006952237.1, NC_019057.1 YP_006953321.1, NC_019071.1 YP_006953420.1, NC_019072.1 YP_006953947.1, NC_019090.1 YP_006954268.1, NC_019095.1 YP_006990759.1, NC_019424.1 YP_007447545.1, NC_020278.2 YP_009070966.1, NC_025177.1 YP_788061.1, NC_008460.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 40043865 58462407 |
Family and domain databases
InterProi | View protein in InterPro IPR008876, TraY |
Pfami | View protein in Pfam PF05509, TraY, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRAY3_ECOLX | |
Accessioni | P05835Primary (citable) accession number: P05835 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | November 1, 1988 | |
Last modified: | February 10, 2021 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
PlasmidDocuments
- SIMILARITY comments
Index of protein domains and families