Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-casein

Gene

CSN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Important role in determination of the surface properties of the casein micelles.

GO - Molecular functioni

  • calcium ion binding Source: ProtInc
  • cysteine-type endopeptidase inhibitor activity Source: CAFA
  • enzyme inhibitor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionMilk protein

Enzyme and pathway databases

ReactomeiR-HSA-1251985 Nuclear signaling by ERBB4

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-casein
Gene namesi
Name:CSN2
Synonyms:CASB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000135222.6
HGNCiHGNC:2447 CSN2
MIMi115460 gene
neXtProtiNX_P05814

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1447
OpenTargetsiENSG00000135222
PharmGKBiPA26950

Protein family/group databases

Allergomei1064 Hom s 8

Polymorphism and mutation databases

BioMutaiCSN2
DMDMi115661

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 151 PublicationAdd BLAST15
ChainiPRO_000000447516 – 226Beta-casein1 PublicationAdd BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18Phosphothreonine; in form 5-P2 Publications1
Modified residuei21Phosphoserine; in form 4-P and form 5-P2 Publications1
Modified residuei23Phosphoserine; in form 3-P, form 4-P and form 5-P2 Publications1
Modified residuei24Phosphoserine; in form 1-P, form 2-P, form 3-P, form 4-P and form 5-P2 Publications1
Modified residuei25Phosphoserine; in form 1-P, form 2-P, form 3-P, form 4-P and form 5-P2 Publications1

Post-translational modificationi

Form 1-P is phosphorylated once; half of the molecules are phosphorylated on Ser-24, half on Ser-25.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP05814
PeptideAtlasiP05814
PRIDEiP05814
ProteomicsDBi51861

PTM databases

iPTMnetiP05814
PhosphoSitePlusiP05814

Miscellaneous databases

PMAP-CutDBiP05814

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

BgeeiENSG00000135222 Expressed in 52 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_CSN2
ExpressionAtlasiP05814 baseline and differential
GenevisibleiP05814 HS

Organism-specific databases

HPAiHPA041036

Interactioni

Protein-protein interaction databases

BioGridi107834, 22 interactors
IntActiP05814, 11 interactors
MINTiP05814
STRINGi9606.ENSP00000341030

Structurei

3D structure databases

ProteinModelPortaliP05814
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYJE Eukaryota
ENOG411197Z LUCA
GeneTreeiENSGT00390000001890
HOGENOMiHOG000074044
HOVERGENiHBG004973
InParanoidiP05814
KOiK17107
OMAiEIMEVPK
OrthoDBiEOG091G0XI8
PhylomeDBiP05814
TreeFamiTF336929

Family and domain databases

InterProiView protein in InterPro
IPR001588 Casein
IPR016345 Casein_beta
IPR031305 Casein_CS
PANTHERiPTHR11500 PTHR11500, 1 hit
PfamiView protein in Pfam
PF00363 Casein, 1 hit
PIRSFiPIRSF002372 Beta-casein, 1 hit
PROSITEiView protein in PROSITE
PS00306 CASEIN_ALPHA_BETA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05814-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVLILACLV ALALARETIE SLSSSEESIT EYKQKVEKVK HEDQQQGEDE
60 70 80 90 100
HQDKIYPSFQ PQPLIYPFVE PIPYGFLPQN ILPLAQPAVV LPVPQPEIME
110 120 130 140 150
VPKAKDTVYT KGRVMPVLKS PTIPFFDPQI PKLTDLENLH LPLPLLQPLM
160 170 180 190 200
QQVPQPIPQT LALPPQPLWS VPQPKVLPIP QQVVPYPQRA VPVQALLLNQ
210 220
ELLLNPTHQI YPVTQPLAPV HNPISV
Length:226
Mass (Da):25,382
Last modified:August 1, 1992 - v4
Checksum:i2619C524EA1358E8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30T → P AA sequence (PubMed:6715339).Curated1
Sequence conflicti34Missing in CAA39270 (PubMed:2387396).Curated1
Sequence conflicti48 – 50EDE → TDQ AA sequence (PubMed:6715339).Curated3
Sequence conflicti120S → Q AA sequence (PubMed:6715339).Curated1
Sequence conflicti133L → V in CAA34916 (Ref. 3) Curated1
Sequence conflicti140H → Q in CAA34916 (Ref. 3) Curated1
Sequence conflicti149L → S AA sequence (PubMed:6715339).Curated1
Sequence conflicti173Q → E AA sequence (PubMed:6715339).Curated1
Sequence conflicti182 – 184QVV → EVL AA sequence (PubMed:6715339).Curated3
Sequence conflicti188Q → V AA sequence (PubMed:6715339).Curated1
Sequence conflicti207T → P AA sequence (PubMed:6715339).Curated1
Sequence conflicti214 – 222TQPLAPVHN → PEPSTTZABH AA sequence (PubMed:6715339).Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55739 mRNA Translation: CAA39270.1
AF027807 Genomic DNA Translation: AAC82978.1
X17070 mRNA Translation: CAA34916.1
BC069554 mRNA Translation: AAH69554.1
BC096194 mRNA Translation: AAH96194.1
BC096195 mRNA Translation: AAH96195.1
BC096196 mRNA Translation: AAH96196.1
BC096197 mRNA Translation: AAH96197.1
X13766 mRNA Translation: CAA32017.1
CCDSiCCDS3532.1
PIRiI53730 KBHU
RefSeqiNP_001289699.1, NM_001302770.1
NP_001882.1, NM_001891.3
XP_016863249.1, XM_017007760.1
UniGeneiHs.2242

Genome annotation databases

EnsembliENST00000353151; ENSP00000341030; ENSG00000135222
ENST00000635174; ENSP00000489488; ENSG00000283030
GeneIDi1447
KEGGihsa:1447

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

Of buttons, digestion and glue - Issue 16 of November 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55739 mRNA Translation: CAA39270.1
AF027807 Genomic DNA Translation: AAC82978.1
X17070 mRNA Translation: CAA34916.1
BC069554 mRNA Translation: AAH69554.1
BC096194 mRNA Translation: AAH96194.1
BC096195 mRNA Translation: AAH96195.1
BC096196 mRNA Translation: AAH96196.1
BC096197 mRNA Translation: AAH96197.1
X13766 mRNA Translation: CAA32017.1
CCDSiCCDS3532.1
PIRiI53730 KBHU
RefSeqiNP_001289699.1, NM_001302770.1
NP_001882.1, NM_001891.3
XP_016863249.1, XM_017007760.1
UniGeneiHs.2242

3D structure databases

ProteinModelPortaliP05814
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107834, 22 interactors
IntActiP05814, 11 interactors
MINTiP05814
STRINGi9606.ENSP00000341030

Protein family/group databases

Allergomei1064 Hom s 8

PTM databases

iPTMnetiP05814
PhosphoSitePlusiP05814

Polymorphism and mutation databases

BioMutaiCSN2
DMDMi115661

Proteomic databases

PaxDbiP05814
PeptideAtlasiP05814
PRIDEiP05814
ProteomicsDBi51861

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000353151; ENSP00000341030; ENSG00000135222
ENST00000635174; ENSP00000489488; ENSG00000283030
GeneIDi1447
KEGGihsa:1447

Organism-specific databases

CTDi1447
DisGeNETi1447
EuPathDBiHostDB:ENSG00000135222.6
GeneCardsiCSN2
HGNCiHGNC:2447 CSN2
HPAiHPA041036
MIMi115460 gene
neXtProtiNX_P05814
OpenTargetsiENSG00000135222
PharmGKBiPA26950
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYJE Eukaryota
ENOG411197Z LUCA
GeneTreeiENSGT00390000001890
HOGENOMiHOG000074044
HOVERGENiHBG004973
InParanoidiP05814
KOiK17107
OMAiEIMEVPK
OrthoDBiEOG091G0XI8
PhylomeDBiP05814
TreeFamiTF336929

Enzyme and pathway databases

ReactomeiR-HSA-1251985 Nuclear signaling by ERBB4

Miscellaneous databases

GeneWikiiCSN2
GenomeRNAii1447
PMAP-CutDBiP05814
PROiPR:P05814
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135222 Expressed in 52 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_CSN2
ExpressionAtlasiP05814 baseline and differential
GenevisibleiP05814 HS

Family and domain databases

InterProiView protein in InterPro
IPR001588 Casein
IPR016345 Casein_beta
IPR031305 Casein_CS
PANTHERiPTHR11500 PTHR11500, 1 hit
PfamiView protein in Pfam
PF00363 Casein, 1 hit
PIRSFiPIRSF002372 Beta-casein, 1 hit
PROSITEiView protein in PROSITE
PS00306 CASEIN_ALPHA_BETA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCASB_HUMAN
AccessioniPrimary (citable) accession number: P05814
Secondary accession number(s): Q4VAZ9, Q9UCM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: August 1, 1992
Last modified: September 12, 2018
This is version 161 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again