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UniProtKB - P05798 (RNSA_KITAU)
Protein
Guanyl-specific ribonuclease Sa
Gene
rnaSA
Organism
Kitasatospora aureofaciens (Streptomyces aureofaciens)
Status
Functioni
Catalytic activityi
- (RNA) containing guanosine + H(2)O = an (RNA fragment)-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA fragment). EC:4.6.1.24
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 54 | Proton acceptor | 1 | |
Active sitei | 85 | Proton donor | 1 |
GO - Molecular functioni
- endoribonuclease activity Source: InterPro
- lyase activity Source: UniProtKB-KW
- ribonuclease T1 activity Source: UniProtKB-EC
- RNA binding Source: InterPro
Keywordsi
Molecular function | Endonuclease, Hydrolase, Lyase, Nuclease |
Enzyme and pathway databases
BRENDAi | 4.6.1.24, 5978 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:rnaSA |
Organismi | Kitasatospora aureofaciens (Streptomyces aureofaciens) |
Taxonomic identifieri | 1894 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Kitasatospora |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 39 | N → A, D or S: Decreases protein stability. | 1 |
Chemistry databases
DrugBanki | DB03178, Guanosine-2',3'-cyclophosphorothioate DB01937, Guanosine-2'-monophosphate |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000137367 | 1 – 96 | Guanyl-specific ribonuclease SaAdd BLAST | 96 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 7 ↔ 96 |
Keywords - PTMi
Disulfide bondInteractioni
Protein-protein interaction databases
IntActi | P05798, 1 interactor |
STRINGi | 1894.JOER01000031_gene352 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P05798 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P05798 |
Family & Domainsi
Sequence similaritiesi
Belongs to the ribonuclease N1/T1 family.Curated
Phylogenomic databases
eggNOGi | COG4290, Bacteria |
OMAi | YGYYHEY |
Family and domain databases
InterProi | View protein in InterPro IPR000026, Gua-sp_ribonuclease_N1/T1/U2 IPR016191, Ribonuclease/ribotoxin |
Pfami | View protein in Pfam PF00545, Ribonuclease, 1 hit |
SUPFAMi | SSF53933, SSF53933, 1 hit |
i Sequence
Sequence statusi: Complete.
P05798-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
DVSGTVCLSA LPPEATDTLN LIASDGPFPY SQDGVVFQNR ESVLPTQSYG
60 70 80 90
YYHEYTVITP GARTRGTRRI ITGEATQEDY YTGDHYATFS LIDQTC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 72 | T → C AA sequence (PubMed:3098582).Curated | 1 | |
Sequence conflicti | 72 | T → C AA sequence (PubMed:3118883).Curated | 1 |
Sequence databases
PIRi | A25655, NRSM |
Similar proteinsi
Cross-referencesi
Sequence databases
PIRi | A25655, NRSM |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AY7 | X-ray | 1.70 | A | 1-96 | [»] | |
1BOX | X-ray | 1.60 | A | 1-96 | [»] | |
1C54 | NMR | - | A | 1-96 | [»] | |
1GMP | X-ray | 1.70 | A/B | 1-96 | [»] | |
1GMQ | X-ray | 1.80 | A/B | 1-96 | [»] | |
1GMR | X-ray | 1.77 | A/B | 1-96 | [»] | |
1I70 | X-ray | 1.70 | A/B | 1-96 | [»] | |
1I8V | X-ray | 1.25 | A/B | 1-96 | [»] | |
1LNI | X-ray | 1.00 | A/B | 1-96 | [»] | |
1RGE | X-ray | 1.15 | A/B | 1-96 | [»] | |
1RGF | X-ray | 1.20 | A/B | 1-96 | [»] | |
1RGG | X-ray | 1.20 | A/B | 1-96 | [»] | |
1RGH | X-ray | 1.20 | A/B | 1-96 | [»] | |
1RSN | X-ray | 2.00 | A/B | 1-96 | [»] | |
1SAR | X-ray | 1.80 | A/B | 1-96 | [»] | |
1T2H | X-ray | 1.00 | A/B | 1-96 | [»] | |
1T2I | X-ray | 1.10 | A | 1-96 | [»] | |
1UCI | X-ray | 1.80 | A/B | 1-96 | [»] | |
1UCJ | X-ray | 1.81 | A/B | 1-96 | [»] | |
1UCK | X-ray | 1.80 | A/B | 1-96 | [»] | |
1UCL | X-ray | 1.82 | A/B | 1-96 | [»] | |
1YNV | X-ray | 1.20 | X | 1-96 | [»] | |
1ZGX | X-ray | 1.13 | A | 1-63 | [»] | |
B | 64-96 | [»] | ||||
2SAR | X-ray | 1.80 | A/B | 1-96 | [»] | |
3A5E | X-ray | 1.60 | A | 1-96 | [»] | |
4GHO | X-ray | 1.10 | A/B | 1-96 | [»] | |
4J5G | X-ray | 1.31 | A/B | 1-94 | [»] | |
4J5K | X-ray | 1.23 | A/B | 1-96 | [»] | |
SMRi | P05798 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P05798, 1 interactor |
STRINGi | 1894.JOER01000031_gene352 |
Chemistry databases
DrugBanki | DB03178, Guanosine-2',3'-cyclophosphorothioate DB01937, Guanosine-2'-monophosphate |
Phylogenomic databases
eggNOGi | COG4290, Bacteria |
OMAi | YGYYHEY |
Enzyme and pathway databases
BRENDAi | 4.6.1.24, 5978 |
Miscellaneous databases
EvolutionaryTracei | P05798 |
Family and domain databases
InterProi | View protein in InterPro IPR000026, Gua-sp_ribonuclease_N1/T1/U2 IPR016191, Ribonuclease/ribotoxin |
Pfami | View protein in Pfam PF00545, Ribonuclease, 1 hit |
SUPFAMi | SSF53933, SSF53933, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RNSA_KITAU | |
Accessioni | P05798Primary (citable) accession number: P05798 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | April 27, 2001 | |
Last modified: | September 29, 2021 | |
This is version 123 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families