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Entry version 231 (18 Sep 2019)
Sequence version 7 (23 Jan 2007)
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Protein

Keratin, type II cytoskeletal 8

Gene

KRT8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.1 Publication

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei342Stutter1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P05787

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P05787

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type II cytoskeletal 8
Alternative name(s):
Cytokeratin-8
Short name:
CK-8
Keratin-8
Short name:
K8
Type-II keratin Kb8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT8
Synonyms:CYK8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6446 KRT8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
148060 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P05787

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Intermediate filament, Keratin, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cirrhosis (CIRRH)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02305853G → V in CIRRH. 1 PublicationCorresponds to variant dbSNP:rs61710484EnsemblClinVar.1
Natural variantiVAR_02305954Y → C in CIRRH. 1 Publication1
Natural variantiVAR_02306062G → C in CIRRH. 2 PublicationsCorresponds to variant dbSNP:rs11554495EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi72L → P: Increases phosphorylation. 1 Publication1
Mutagenesisi74S → A: Generates normal-appearing filaments, that remain stable after okadaic acid treatment. 1 Publication1
Mutagenesisi74S → D: Generates normal-appearing filaments, that are destabilized by okadaic acid. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
3856

MalaCards human disease database

More...
MalaCardsi
KRT8
MIMi215600 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000170421

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30234

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB09130 Copper
DB06245 Lanoteplase
DB00031 Tenecteplase

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRT8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
90110027

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000637401 – 483Keratin, type II cytoskeletal 8Add BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9Phosphoserine; by PKC/PRKCE1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei13PhosphoserineCombined sources1
Modified residuei15PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei23Omega-N-methylarginineCombined sources1
Modified residuei24Phosphoserine; by PKC/PRKCECombined sources2 Publications1
Modified residuei26PhosphothreonineBy similarity1
Modified residuei27PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei32Omega-N-methylarginineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei37PhosphoserineBy similarity1
Modified residuei39PhosphoserineCombined sources1
Modified residuei40Omega-N-methylarginineCombined sources1
Modified residuei43PhosphoserineCombined sources1
Modified residuei44PhosphoserineBy similarity1
Modified residuei47Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei47Omega-N-methylarginine; alternateCombined sources1
Modified residuei74Phosphoserine; by MAPK2 Publications1
Modified residuei101N6-malonyllysine1 Publication1
Cross-linki122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki197Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki197Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei207N6-acetyllysineCombined sources1
Modified residuei228PhosphotyrosineCombined sources1
Modified residuei253PhosphoserineCombined sources1
Modified residuei258PhosphoserineCombined sources1
Cross-linki264Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei274PhosphoserineCombined sources1
Cross-linki285Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei291PhosphoserineCombined sources1
Modified residuei295N6-acetyllysine; alternateCombined sources1
Cross-linki295Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki304Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei325N6-acetyllysine; alternateCombined sources1
Cross-linki325Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei330PhosphoserineCombined sources1
Cross-linki393Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei400PhosphoserineCombined sources1
Modified residuei404PhosphoserineCombined sources1
Modified residuei410PhosphoserineCombined sources1
Modified residuei417PhosphoserineBy similarity1
Modified residuei424PhosphoserineBy similarity1
Modified residuei432Phosphoserine; by CaMK2 and MAPKCombined sources1 Publication1
Cross-linki472Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki472Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei475PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1
Modified residuei478PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.4 Publications
O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation.
O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.

Keywords - PTMi

Acetylation, Glycoprotein, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P05787

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P05787

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P05787

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P05787

PeptideAtlas

More...
PeptideAtlasi
P05787

PRoteomics IDEntifications database

More...
PRIDEi
P05787

ProteomicsDB human proteome resource

More...
ProteomicsDBi
29093
51858 [P05787-1]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P05787-1 [P05787-1]
P05787-2 [P05787-2]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P05787

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
313

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P05787

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P05787

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P05787

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P05787

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P05787

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170421 Expressed in 114 organ(s), highest expression level in mucosa of transverse colon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P05787 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P05787 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000131
CAB001696
HPA049866

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two type I and two type II keratins. KRT8 associates with KRT18. Associates with KRT20.

Interacts with PNN. When associated with KRT19, interacts with DMD.

Interacts with TCHP.

Interacts with APEX1.

Interacts with GPER1.

Interacts with EPPK1 (By similarity).

By similarity8 Publications

(Microbial infection)

Interacts with hepatitis C virus/HCV core protein.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110054, 80 interactors

Database of interacting proteins

More...
DIPi
DIP-424N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P05787

Protein interaction database and analysis system

More...
IntActi
P05787, 92 interactors

Molecular INTeraction database

More...
MINTi
P05787

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000449404

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P05787

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini91 – 402IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 90HeadAdd BLAST90
Regioni91 – 126Coil 1AAdd BLAST36
Regioni127 – 143Linker 1Add BLAST17
Regioni144 – 235Coil 1BAdd BLAST92
Regioni236 – 259Linker 12Add BLAST24
Regioni260 – 398Coil 2Add BLAST139
Regioni261 – 382Necessary for interaction with PNN1 PublicationAdd BLAST122
Regioni399 – 483TailAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 49Ser-richAdd BLAST41

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG4R Eukaryota
ENOG410YY6B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153339

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P05787

KEGG Orthology (KO)

More...
KOi
K07605

Identification of Orthologs from Complete Genome Data

More...
OMAi
IKGQRAN

Database of Orthologous Groups

More...
OrthoDBi
692811at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P05787

TreeFam database of animal gene trees

More...
TreeFami
TF317854

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR032444 Keratin_2_head
IPR003054 Keratin_II

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01276 TYPE2KERATIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01391 Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P05787-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSIRVTQKSY KVSTSGPRAF SSRSYTSGPG SRISSSSFSR VGSSNFRGGL
60 70 80 90 100
GGGYGGASGM GGITAVTVNQ SLLSPLVLEV DPNIQAVRTQ EKEQIKTLNN
110 120 130 140 150
KFASFIDKVR FLEQQNKMLE TKWSLLQQQK TARSNMDNMF ESYINNLRRQ
160 170 180 190 200
LETLGQEKLK LEAELGNMQG LVEDFKNKYE DEINKRTEME NEFVLIKKDV
210 220 230 240 250
DEAYMNKVEL ESRLEGLTDE INFLRQLYEE EIRELQSQIS DTSVVLSMDN
260 270 280 290 300
SRSLDMDSII AEVKAQYEDI ANRSRAEAES MYQIKYEELQ SLAGKHGDDL
310 320 330 340 350
RRTKTEISEM NRNISRLQAE IEGLKGQRAS LEAAIADAEQ RGELAIKDAN
360 370 380 390 400
AKLSELEAAL QRAKQDMARQ LREYQELMNV KLALDIEIAT YRKLLEGEES
410 420 430 440 450
RLESGMQNMS IHTKTTSGYA GGLSSAYGGL TSPGLSYSLG SSFGSGAGSS
460 470 480
SFSRTSSSRA VVVKKIETRD GKLVSESSDV LPK
Length:483
Mass (Da):53,704
Last modified:January 23, 2007 - v7
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB0BC730B65929D37
GO
Isoform 2 (identifier: P05787-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNGVSWSQDLQEGISAWFGPPASTPASTM

Note: No experimental confirmation available.
Show »
Length:511
Mass (Da):56,608
Checksum:iDB55C0367CD6C37C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VUG2F8VUG2_HUMAN
Keratin, type II cytoskeletal 8
KRT8
273Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1U3F8W1U3_HUMAN
Keratin, type II cytoskeletal 8
KRT8
289Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VP67F8VP67_HUMAN
Keratin, type II cytoskeletal 8
KRT8
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIB2H0YIB2_HUMAN
Keratin, type II cytoskeletal 8
KRT8
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQY3F8VQY3_HUMAN
Keratin, type II cytoskeletal 8
KRT8
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQU6A0A0U1RQU6_HUMAN
Keratin, type II cytoskeletal 8
KRT8
32Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti56G → V in BAF83627 (PubMed:14702039).Curated1
Sequence conflicti77V → S in AAA35748 (PubMed:1692965).Curated1
Sequence conflicti201D → DVD in CAA52882 (PubMed:1705144).Curated1
Sequence conflicti232I → L in CAA67203 (PubMed:2434381).Curated1
Sequence conflicti257D → E in AAA35748 (PubMed:1692965).Curated1
Sequence conflicti310M → I in CAA31376 (PubMed:2434381).Curated1
Sequence conflicti324L → F in BAD96661 (Ref. 6) Curated1
Sequence conflicti384L → M in CAA67203 (PubMed:2434381).Curated1
Sequence conflicti387E → D in AAA35748 (PubMed:1692965).Curated1
Sequence conflicti401R → P in AAA35748 (PubMed:1692965).Curated1
Sequence conflicti430 – 433LTSP → SQA in AAA35763 (PubMed:1691124).Curated4
Sequence conflicti431T → A in CAA67203 (PubMed:2434381).Curated1
Sequence conflicti432S → D in AAA35748 (PubMed:1692965).Curated1
Sequence conflicti432S → D in CAA67203 (PubMed:2434381).Curated1
Sequence conflicti432S → D in CAA31376 (PubMed:2434381).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02305853G → V in CIRRH. 1 PublicationCorresponds to variant dbSNP:rs61710484EnsemblClinVar.1
Natural variantiVAR_02305954Y → C in CIRRH. 1 Publication1
Natural variantiVAR_02306062G → C in CIRRH. 2 PublicationsCorresponds to variant dbSNP:rs11554495EnsemblClinVar.1
Natural variantiVAR_02306163I → V1 PublicationCorresponds to variant dbSNP:rs59536457EnsemblClinVar.1
Natural variantiVAR_049805401R → W. Corresponds to variant dbSNP:rs2277330Ensembl.1
Natural variantiVAR_069106417S → G2 Publications1
Natural variantiVAR_069107429G → D1 PublicationCorresponds to variant dbSNP:rs1065648Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0460001M → MNGVSWSQDLQEGISAWFGP PASTPASTM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M34482 Genomic DNA Translation: AAA35763.1
M34225 mRNA Translation: AAA35748.1
X74929 mRNA Translation: CAA52882.1
X74981 Genomic DNA Translation: CAA52916.1
U76549 mRNA Translation: AAB18966.1
AK290938 mRNA Translation: BAF83627.1
AK310257 mRNA No translation available.
AK315826 mRNA Translation: BAF98717.1
AK222941 mRNA Translation: BAD96661.1
AC107016 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96653.1
BC000654 mRNA Translation: AAH00654.3
BC063513 mRNA Translation: AAH63513.2
BC073760 mRNA Translation: AAH73760.1
BC075839 mRNA Translation: AAH75839.1
M26512 mRNA Translation: AAA51542.1
X12882 mRNA Translation: CAA31376.1
X98614 mRNA Translation: CAA67203.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS58234.1 [P05787-2]
CCDS8841.1 [P05787-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A34720

NCBI Reference Sequences

More...
RefSeqi
NP_001243222.1, NM_001256293.1 [P05787-1]
NP_002264.1, NM_002273.3 [P05787-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000293308; ENSP00000293308; ENSG00000170421 [P05787-1]
ENST00000546897; ENSP00000447402; ENSG00000170421 [P05787-1]
ENST00000552150; ENSP00000449404; ENSG00000170421 [P05787-2]
ENST00000552551; ENSP00000447566; ENSG00000170421 [P05787-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3856

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3856

UCSC genome browser

More...
UCSCi
uc001sbd.3 human [P05787-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Human Intermediate Filament Mutation Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34482 Genomic DNA Translation: AAA35763.1
M34225 mRNA Translation: AAA35748.1
X74929 mRNA Translation: CAA52882.1
X74981 Genomic DNA Translation: CAA52916.1
U76549 mRNA Translation: AAB18966.1
AK290938 mRNA Translation: BAF83627.1
AK310257 mRNA No translation available.
AK315826 mRNA Translation: BAF98717.1
AK222941 mRNA Translation: BAD96661.1
AC107016 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96653.1
BC000654 mRNA Translation: AAH00654.3
BC063513 mRNA Translation: AAH63513.2
BC073760 mRNA Translation: AAH73760.1
BC075839 mRNA Translation: AAH75839.1
M26512 mRNA Translation: AAA51542.1
X12882 mRNA Translation: CAA31376.1
X98614 mRNA Translation: CAA67203.1
CCDSiCCDS58234.1 [P05787-2]
CCDS8841.1 [P05787-1]
PIRiA34720
RefSeqiNP_001243222.1, NM_001256293.1 [P05787-1]
NP_002264.1, NM_002273.3 [P05787-1]

3D structure databases

SMRiP05787
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110054, 80 interactors
DIPiDIP-424N
ELMiP05787
IntActiP05787, 92 interactors
MINTiP05787
STRINGi9606.ENSP00000449404

Chemistry databases

DrugBankiDB09130 Copper
DB06245 Lanoteplase
DB00031 Tenecteplase

PTM databases

GlyConnecti313
iPTMnetiP05787
PhosphoSitePlusiP05787
SwissPalmiP05787
UniCarbKBiP05787

Polymorphism and mutation databases

BioMutaiKRT8
DMDMi90110027

2D gel databases

SWISS-2DPAGEiP05787

Proteomic databases

EPDiP05787
jPOSTiP05787
MassIVEiP05787
PaxDbiP05787
PeptideAtlasiP05787
PRIDEiP05787
ProteomicsDBi29093
51858 [P05787-1]
TopDownProteomicsiP05787-1 [P05787-1]
P05787-2 [P05787-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P05787

The DNASU plasmid repository

More...
DNASUi
3856
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293308; ENSP00000293308; ENSG00000170421 [P05787-1]
ENST00000546897; ENSP00000447402; ENSG00000170421 [P05787-1]
ENST00000552150; ENSP00000449404; ENSG00000170421 [P05787-2]
ENST00000552551; ENSP00000447566; ENSG00000170421 [P05787-1]
GeneIDi3856
KEGGihsa:3856
UCSCiuc001sbd.3 human [P05787-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3856
DisGeNETi3856

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KRT8
HGNCiHGNC:6446 KRT8
HPAiCAB000131
CAB001696
HPA049866
MalaCardsiKRT8
MIMi148060 gene
215600 phenotype
neXtProtiNX_P05787
OpenTargetsiENSG00000170421
PharmGKBiPA30234

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IG4R Eukaryota
ENOG410YY6B LUCA
GeneTreeiENSGT00940000153339
InParanoidiP05787
KOiK07605
OMAiIKGQRAN
OrthoDBi692811at2759
PhylomeDBiP05787
TreeFamiTF317854

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
SignaLinkiP05787
SIGNORiP05787

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KRT8 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Keratin_8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3856

Pharos

More...
Pharosi
P05787
PMAP-CutDBiP05787

Protein Ontology

More...
PROi
PR:P05787

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170421 Expressed in 114 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiP05787 baseline and differential
GenevisibleiP05787 HS

Family and domain databases

Gene3Di1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR042180 IF_rod_dom_coil1B
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK2C8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05787
Secondary accession number(s): A8K4H3
, B0AZN5, F8VXB4, Q14099, Q14716, Q14717, Q53GJ0, Q6DHW5, Q6GMY0, Q6P4C7, Q96J60
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: September 18, 2019
This is version 231 of the entry and version 7 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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