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Protein

Keratin, type II cytoskeletal 8

Gene

KRT8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.1 Publication

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei342Stutter1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
SignaLinkiP05787
SIGNORiP05787

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 8
Alternative name(s):
Cytokeratin-8
Short name:
CK-8
Keratin-8
Short name:
K8
Type-II keratin Kb8
Gene namesi
Name:KRT8
Synonyms:CYK8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000170421.12
HGNCiHGNC:6446 KRT8
MIMi148060 gene
neXtProtiNX_P05787

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Intermediate filament, Keratin, Nucleus

Pathology & Biotechi

Involvement in diseasei

Cirrhosis (CIRRH)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension.
See also OMIM:215600
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02305853G → V in CIRRH. 1 PublicationCorresponds to variant dbSNP:rs61710484EnsemblClinVar.1
Natural variantiVAR_02305954Y → C in CIRRH. 1 Publication1
Natural variantiVAR_02306062G → C in CIRRH. 2 PublicationsCorresponds to variant dbSNP:rs11554495EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi72L → P: Increases phosphorylation. 1 Publication1
Mutagenesisi74S → A: Generates normal-appearing filaments, that remain stable after okadaic acid treatment. 1 Publication1
Mutagenesisi74S → D: Generates normal-appearing filaments, that are destabilized by okadaic acid. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi3856
MalaCardsiKRT8
MIMi215600 phenotype
OpenTargetsiENSG00000170421
PharmGKBiPA30234

Chemistry databases

DrugBankiDB00031 Tenecteplase

Polymorphism and mutation databases

BioMutaiKRT8
DMDMi90110027

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637401 – 483Keratin, type II cytoskeletal 8Add BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9Phosphoserine; by PKC/PRKCE1 Publication1
Cross-linki11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei13PhosphoserineCombined sources1
Modified residuei15PhosphoserineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei23Omega-N-methylarginineCombined sources1
Modified residuei24Phosphoserine; by PKC/PRKCECombined sources2 Publications1
Modified residuei26PhosphothreonineBy similarity1
Modified residuei27PhosphoserineCombined sources1
Modified residuei31PhosphoserineCombined sources1
Modified residuei32Omega-N-methylarginineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei37PhosphoserineBy similarity1
Modified residuei39PhosphoserineCombined sources1
Modified residuei40Omega-N-methylarginineCombined sources1
Modified residuei43PhosphoserineCombined sources1
Modified residuei44PhosphoserineBy similarity1
Modified residuei47Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei47Omega-N-methylarginine; alternateCombined sources1
Modified residuei74Phosphoserine; by MAPK2 Publications1
Modified residuei101N6-malonyllysine1 Publication1
Cross-linki122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki197Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki197Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei207N6-acetyllysineCombined sources1
Modified residuei228PhosphotyrosineCombined sources1
Modified residuei253PhosphoserineCombined sources1
Modified residuei258PhosphoserineCombined sources1
Cross-linki264Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei274PhosphoserineCombined sources1
Cross-linki285Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei291PhosphoserineCombined sources1
Modified residuei295N6-acetyllysine; alternateCombined sources1
Cross-linki295Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linki304Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei325N6-acetyllysine; alternateCombined sources1
Cross-linki325Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei330PhosphoserineCombined sources1
Cross-linki393Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei400PhosphoserineCombined sources1
Modified residuei404PhosphoserineCombined sources1
Modified residuei410PhosphoserineCombined sources1
Modified residuei417PhosphoserineBy similarity1
Modified residuei424PhosphoserineBy similarity1
Modified residuei432Phosphoserine; by CaMK2 and MAPKCombined sources1 Publication1
Cross-linki472Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki472Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei475PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1
Modified residuei478PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.4 Publications
O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation.
O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.

Keywords - PTMi

Acetylation, Glycoprotein, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP05787
PaxDbiP05787
PeptideAtlasiP05787
PRIDEiP05787
ProteomicsDBi51858
TopDownProteomicsiP05787-1 [P05787-1]
P05787-2 [P05787-2]

2D gel databases

SWISS-2DPAGEiP05787

PTM databases

GlyConnecti313
iPTMnetiP05787
PhosphoSitePlusiP05787
SwissPalmiP05787
UniCarbKBiP05787

Miscellaneous databases

PMAP-CutDBiP05787

Expressioni

Tissue specificityi

Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.2 Publications

Gene expression databases

BgeeiENSG00000170421 Expressed in 114 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiP05787 baseline and differential
GenevisibleiP05787 HS

Organism-specific databases

HPAiCAB000131
CAB001696
HPA049866

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. KRT8 associates with KRT18. Associates with KRT20. Interacts with PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP. Interacts with APEX1. Interacts with GPER1. Interacts with EPPK1 (By similarity).By similarity8 Publications
(Microbial infection) Interacts with hepatitis C virus/HCV core protein.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110054, 59 interactors
DIPiDIP-424N
ELMiP05787
IntActiP05787, 49 interactors
MINTiP05787
STRINGi9606.ENSP00000293308

Structurei

3D structure databases

ProteinModelPortaliP05787
SMRiP05787
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 402IF rodPROSITE-ProRule annotationAdd BLAST312

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 90HeadAdd BLAST90
Regioni91 – 126Coil 1AAdd BLAST36
Regioni127 – 143Linker 1Add BLAST17
Regioni144 – 235Coil 1BAdd BLAST92
Regioni236 – 259Linker 12Add BLAST24
Regioni260 – 398Coil 2Add BLAST139
Regioni261 – 382Necessary for interaction with PNN1 PublicationAdd BLAST122
Regioni399 – 483TailAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 49Ser-richAdd BLAST41

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R Eukaryota
ENOG410YY6B LUCA
GeneTreeiENSGT00760000118796
HOVERGENiHBG013015
InParanoidiP05787
KOiK07605
OMAiIQKRTDM
OrthoDBiEOG091G09KR
PhylomeDBiP05787
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P05787-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSIRVTQKSY KVSTSGPRAF SSRSYTSGPG SRISSSSFSR VGSSNFRGGL
60 70 80 90 100
GGGYGGASGM GGITAVTVNQ SLLSPLVLEV DPNIQAVRTQ EKEQIKTLNN
110 120 130 140 150
KFASFIDKVR FLEQQNKMLE TKWSLLQQQK TARSNMDNMF ESYINNLRRQ
160 170 180 190 200
LETLGQEKLK LEAELGNMQG LVEDFKNKYE DEINKRTEME NEFVLIKKDV
210 220 230 240 250
DEAYMNKVEL ESRLEGLTDE INFLRQLYEE EIRELQSQIS DTSVVLSMDN
260 270 280 290 300
SRSLDMDSII AEVKAQYEDI ANRSRAEAES MYQIKYEELQ SLAGKHGDDL
310 320 330 340 350
RRTKTEISEM NRNISRLQAE IEGLKGQRAS LEAAIADAEQ RGELAIKDAN
360 370 380 390 400
AKLSELEAAL QRAKQDMARQ LREYQELMNV KLALDIEIAT YRKLLEGEES
410 420 430 440 450
RLESGMQNMS IHTKTTSGYA GGLSSAYGGL TSPGLSYSLG SSFGSGAGSS
460 470 480
SFSRTSSSRA VVVKKIETRD GKLVSESSDV LPK
Length:483
Mass (Da):53,704
Last modified:January 23, 2007 - v7
Checksum:iB0BC730B65929D37
GO
Isoform 2 (identifier: P05787-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNGVSWSQDLQEGISAWFGPPASTPASTM

Note: No experimental confirmation available.
Show »
Length:511
Mass (Da):56,608
Checksum:iDB55C0367CD6C37C
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W1U3F8W1U3_HUMAN
Keratin, type II cytoskeletal 8
KRT8
289Annotation score:
F8VUG2F8VUG2_HUMAN
Keratin, type II cytoskeletal 8
KRT8
273Annotation score:
F8VP67F8VP67_HUMAN
Keratin, type II cytoskeletal 8
KRT8
113Annotation score:
H0YIB2H0YIB2_HUMAN
Keratin, type II cytoskeletal 8
KRT8
35Annotation score:
F8VQY3F8VQY3_HUMAN
Keratin, type II cytoskeletal 8
KRT8
180Annotation score:
A0A0U1RQU6A0A0U1RQU6_HUMAN
Keratin, type II cytoskeletal 8
KRT8
32Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56G → V in BAF83627 (PubMed:14702039).Curated1
Sequence conflicti77V → S in AAA35748 (PubMed:1692965).Curated1
Sequence conflicti201D → DVD in CAA52882 (PubMed:1705144).Curated1
Sequence conflicti232I → L in CAA67203 (PubMed:2434381).Curated1
Sequence conflicti257D → E in AAA35748 (PubMed:1692965).Curated1
Sequence conflicti310M → I in CAA31376 (PubMed:2434381).Curated1
Sequence conflicti324L → F in BAD96661 (Ref. 6) Curated1
Sequence conflicti384L → M in CAA67203 (PubMed:2434381).Curated1
Sequence conflicti387E → D in AAA35748 (PubMed:1692965).Curated1
Sequence conflicti401R → P in AAA35748 (PubMed:1692965).Curated1
Sequence conflicti430 – 433LTSP → SQA in AAA35763 (PubMed:1691124).Curated4
Sequence conflicti431T → A in CAA67203 (PubMed:2434381).Curated1
Sequence conflicti432S → D in AAA35748 (PubMed:1692965).Curated1
Sequence conflicti432S → D in CAA67203 (PubMed:2434381).Curated1
Sequence conflicti432S → D in CAA31376 (PubMed:2434381).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02305853G → V in CIRRH. 1 PublicationCorresponds to variant dbSNP:rs61710484EnsemblClinVar.1
Natural variantiVAR_02305954Y → C in CIRRH. 1 Publication1
Natural variantiVAR_02306062G → C in CIRRH. 2 PublicationsCorresponds to variant dbSNP:rs11554495EnsemblClinVar.1
Natural variantiVAR_02306163I → V1 PublicationCorresponds to variant dbSNP:rs59536457EnsemblClinVar.1
Natural variantiVAR_049805401R → W. Corresponds to variant dbSNP:rs2277330Ensembl.1
Natural variantiVAR_069106417S → G2 Publications1
Natural variantiVAR_069107429G → D1 PublicationCorresponds to variant dbSNP:rs1065648Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0460001M → MNGVSWSQDLQEGISAWFGP PASTPASTM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34482 Genomic DNA Translation: AAA35763.1
M34225 mRNA Translation: AAA35748.1
X74929 mRNA Translation: CAA52882.1
X74981 Genomic DNA Translation: CAA52916.1
U76549 mRNA Translation: AAB18966.1
AK290938 mRNA Translation: BAF83627.1
AK310257 mRNA No translation available.
AK315826 mRNA Translation: BAF98717.1
AK222941 mRNA Translation: BAD96661.1
AC107016 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96653.1
BC000654 mRNA Translation: AAH00654.3
BC063513 mRNA Translation: AAH63513.2
BC073760 mRNA Translation: AAH73760.1
BC075839 mRNA Translation: AAH75839.1
M26512 mRNA Translation: AAA51542.1
X12882 mRNA Translation: CAA31376.1
X98614 mRNA Translation: CAA67203.1
CCDSiCCDS58234.1 [P05787-2]
CCDS8841.1 [P05787-1]
PIRiA34720
RefSeqiNP_001243222.1, NM_001256293.1 [P05787-1]
NP_002264.1, NM_002273.3 [P05787-1]
UniGeneiHs.533782
Hs.708445

Genome annotation databases

EnsembliENST00000293308; ENSP00000293308; ENSG00000170421 [P05787-1]
ENST00000546897; ENSP00000447402; ENSG00000170421 [P05787-1]
ENST00000552150; ENSP00000449404; ENSG00000170421 [P05787-2]
ENST00000552551; ENSP00000447566; ENSG00000170421 [P05787-1]
GeneIDi3856
KEGGihsa:3856
UCSCiuc001sbd.3 human [P05787-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Human Intermediate Filament Mutation Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34482 Genomic DNA Translation: AAA35763.1
M34225 mRNA Translation: AAA35748.1
X74929 mRNA Translation: CAA52882.1
X74981 Genomic DNA Translation: CAA52916.1
U76549 mRNA Translation: AAB18966.1
AK290938 mRNA Translation: BAF83627.1
AK310257 mRNA No translation available.
AK315826 mRNA Translation: BAF98717.1
AK222941 mRNA Translation: BAD96661.1
AC107016 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96653.1
BC000654 mRNA Translation: AAH00654.3
BC063513 mRNA Translation: AAH63513.2
BC073760 mRNA Translation: AAH73760.1
BC075839 mRNA Translation: AAH75839.1
M26512 mRNA Translation: AAA51542.1
X12882 mRNA Translation: CAA31376.1
X98614 mRNA Translation: CAA67203.1
CCDSiCCDS58234.1 [P05787-2]
CCDS8841.1 [P05787-1]
PIRiA34720
RefSeqiNP_001243222.1, NM_001256293.1 [P05787-1]
NP_002264.1, NM_002273.3 [P05787-1]
UniGeneiHs.533782
Hs.708445

3D structure databases

ProteinModelPortaliP05787
SMRiP05787
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110054, 59 interactors
DIPiDIP-424N
ELMiP05787
IntActiP05787, 49 interactors
MINTiP05787
STRINGi9606.ENSP00000293308

Chemistry databases

DrugBankiDB00031 Tenecteplase

PTM databases

GlyConnecti313
iPTMnetiP05787
PhosphoSitePlusiP05787
SwissPalmiP05787
UniCarbKBiP05787

Polymorphism and mutation databases

BioMutaiKRT8
DMDMi90110027

2D gel databases

SWISS-2DPAGEiP05787

Proteomic databases

EPDiP05787
PaxDbiP05787
PeptideAtlasiP05787
PRIDEiP05787
ProteomicsDBi51858
TopDownProteomicsiP05787-1 [P05787-1]
P05787-2 [P05787-2]

Protocols and materials databases

DNASUi3856
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293308; ENSP00000293308; ENSG00000170421 [P05787-1]
ENST00000546897; ENSP00000447402; ENSG00000170421 [P05787-1]
ENST00000552150; ENSP00000449404; ENSG00000170421 [P05787-2]
ENST00000552551; ENSP00000447566; ENSG00000170421 [P05787-1]
GeneIDi3856
KEGGihsa:3856
UCSCiuc001sbd.3 human [P05787-1]

Organism-specific databases

CTDi3856
DisGeNETi3856
EuPathDBiHostDB:ENSG00000170421.12
GeneCardsiKRT8
H-InvDBiHIX0026255
HIX0034365
HIX0168895
HGNCiHGNC:6446 KRT8
HPAiCAB000131
CAB001696
HPA049866
MalaCardsiKRT8
MIMi148060 gene
215600 phenotype
neXtProtiNX_P05787
OpenTargetsiENSG00000170421
PharmGKBiPA30234
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG4R Eukaryota
ENOG410YY6B LUCA
GeneTreeiENSGT00760000118796
HOVERGENiHBG013015
InParanoidiP05787
KOiK07605
OMAiIQKRTDM
OrthoDBiEOG091G09KR
PhylomeDBiP05787
TreeFamiTF317854

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope
SignaLinkiP05787
SIGNORiP05787

Miscellaneous databases

ChiTaRSiKRT8 human
GeneWikiiKeratin_8
GenomeRNAii3856
PMAP-CutDBiP05787
PROiPR:P05787
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170421 Expressed in 114 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiP05787 baseline and differential
GenevisibleiP05787 HS

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiK2C8_HUMAN
AccessioniPrimary (citable) accession number: P05787
Secondary accession number(s): A8K4H3
, B0AZN5, F8VXB4, Q14099, Q14716, Q14717, Q53GJ0, Q6DHW5, Q6GMY0, Q6P4C7, Q96J60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 221 of the entry and version 7 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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