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Protein

60S ribosomal protein L36-A

Gene

RPL36A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 31600 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for eL36 in yeast.Curated

GO - Molecular functioni

  • RNA binding Source: SGD
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-32881-MONOMER
ReactomeiR-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L36-A1 Publication
Alternative name(s):
L39
Large ribosomal subunit protein eL36-A1 Publication
YL39
Gene namesi
Name:RPL36A1 Publication
Synonyms:RPL39A
Ordered Locus Names:YMR194W
ORF Names:YM9646.06
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR194W
SGDiS000004807 RPL36A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001950202 – 10060S ribosomal protein L36-AAdd BLAST99

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonine1 Publication1

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP05745
PaxDbiP05745
PRIDEiP05745
TopDownProteomicsiP05745

PTM databases

iPTMnetiP05745

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi35372, 224 interactors
IntActiP05745, 14 interactors
MINTiP05745
STRINGi4932.YMR194W

Structurei

Secondary structure

1100
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 10Combined sources5
Helixi26 – 29Combined sources4
Helixi35 – 48Combined sources14
Helixi52 – 64Combined sources13
Helixi66 – 76Combined sources11
Beta strandi77 – 79Combined sources3
Helixi80 – 96Combined sources17
Turni97 – 99Combined sources3

3D structure databases

ProteinModelPortaliP05745
SMRiP05745
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000011943
HOGENOMiHOG000155312
InParanoidiP05745
KOiK02920
OMAiNICAKRR
OrthoDBiEOG092C5H47

Family and domain databases

Gene3Di1.10.10.1760, 1 hit
InterProiView protein in InterPro
IPR038097 L36e_sf
IPR000509 Ribosomal_L36e
PANTHERiPTHR10114 PTHR10114, 1 hit
PfamiView protein in Pfam
PF01158 Ribosomal_L36e, 1 hit
PROSITEiView protein in PROSITE
PS01190 RIBOSOMAL_L36E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVKTGIAIG LNKGKKVTSM TPAPKISYKK GAASNRTKFV RSLVREIAGL
60 70 80 90 100
SPYERRLIDL IRNSGEKRAR KVAKKRLGSF TRAKAKVEEM NNIIAASRRH
Length:100
Mass (Da):11,124
Last modified:January 23, 2007 - v3
Checksum:i9CAA7BFFF33D0C25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47815 Genomic DNA Translation: CAA87815.1
BK006946 Genomic DNA Translation: DAA10092.1
PIRiS11263 S50922
RefSeqiNP_013920.1, NM_001182701.1

Genome annotation databases

EnsemblFungiiYMR194W; YMR194W; YMR194W
GeneIDi855232
KEGGisce:YMR194W

Similar proteinsi

Entry informationi

Entry nameiRL36A_YEAST
AccessioniPrimary (citable) accession number: P05745
Secondary accession number(s): D6W018
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

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