UniProtKB - P05707 (SRLD_ECOLI)
Protein
Sorbitol-6-phosphate 2-dehydrogenase
Gene
srlD
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalytic activityi
- EC:1.1.1.140
: D-sorbitol degradation Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes D-fructose 6-phosphate from D-sorbitol 6-phosphate.Proteins known to be involved in this subpathway in this organism are:
- Sorbitol-6-phosphate 2-dehydrogenase (srlD)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-fructose 6-phosphate from D-sorbitol 6-phosphate, the pathway D-sorbitol degradation and in Carbohydrate metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 141 | SubstrateBy similarity | 1 | |
Active sitei | 154 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 4 – 33 | NADBy similarityAdd BLAST | 30 |
GO - Molecular functioni
- identical protein binding Source: EcoCyc
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: GO_Central
- sorbitol-6-phosphate 2-dehydrogenase activity Source: EcoCyc
GO - Biological processi
- sorbitol catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
BioCyci | EcoCyc:SORB6PDEHYDROG-MONOMER MetaCyc:SORB6PDEHYDROG-MONOMER |
UniPathwayi | UPA00812;UER00783 |
Names & Taxonomyi
Protein namesi | Recommended name: Sorbitol-6-phosphate 2-dehydrogenase (EC:1.1.1.140)Alternative name(s): Glucitol-6-phosphate dehydrogenase Ketosephosphate reductase |
Gene namesi | Name:srlD Synonyms:gutD Ordered Locus Names:b2705, JW2674 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054779 | 1 – 259 | Sorbitol-6-phosphate 2-dehydrogenaseAdd BLAST | 259 |
Proteomic databases
jPOSTi | P05707 |
PaxDbi | P05707 |
PRIDEi | P05707 |
Interactioni
Subunit structurei
Homotetramer.
GO - Molecular functioni
- identical protein binding Source: EcoCyc
Protein-protein interaction databases
BioGRIDi | 4260703, 18 interactors 853206, 2 interactors |
DIPi | DIP-10917N |
IntActi | P05707, 3 interactors |
STRINGi | 511145.b2705 |
Family & Domainsi
Sequence similaritiesi
Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated
Phylogenomic databases
eggNOGi | COG1028, Bacteria |
HOGENOMi | CLU_010194_1_0_6 |
InParanoidi | P05707 |
PhylomeDBi | P05707 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
i Sequence
Sequence statusi: Complete.
P05707-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNQVAVVIGG GQTLGAFLCH GLAAEGYRVA VVDIQSDKAA NVAQEINAEY
60 70 80 90 100
GESMAYGFGA DATSEQSVLA LSRGVDEIFG RVDLLVYSAG IAKAAFISDF
110 120 130 140 150
QLGDFDRSLQ VNLVGYFLCA REFSRLMIRD GIQGRIIQIN SKSGKVGSKH
160 170 180 190 200
NSGYSAAKFG GVGLTQSLAL DLAEYGITVH SLMLGNLLKS PMFQSLLPQY
210 220 230 240 250
ATKLGIKPDQ VEQYYIDKVP LKRGCDYQDV LNMLLFYASP KASYCTGQSI
NVTGGQVMF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 68 | V → C in AAC13413 (PubMed:3553176).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02708 Genomic DNA Translation: AAC13413.1 U29579 Genomic DNA Translation: AAA69214.1 U00096 Genomic DNA Translation: AAC75747.1 AP009048 Genomic DNA Translation: BAA16566.1 |
PIRi | E65050, DEECSP |
RefSeqi | NP_417185.1, NC_000913.3 WP_001077358.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75747; AAC75747; b2705 BAA16566; BAA16566; BAA16566 |
GeneIDi | 948937 |
KEGGi | ecj:JW2674 eco:b2705 |
PATRICi | fig|1411691.4.peg.4037 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J02708 Genomic DNA Translation: AAC13413.1 U29579 Genomic DNA Translation: AAA69214.1 U00096 Genomic DNA Translation: AAC75747.1 AP009048 Genomic DNA Translation: BAA16566.1 |
PIRi | E65050, DEECSP |
RefSeqi | NP_417185.1, NC_000913.3 WP_001077358.1, NZ_LN832404.1 |
3D structure databases
SMRi | P05707 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4260703, 18 interactors 853206, 2 interactors |
DIPi | DIP-10917N |
IntActi | P05707, 3 interactors |
STRINGi | 511145.b2705 |
Proteomic databases
jPOSTi | P05707 |
PaxDbi | P05707 |
PRIDEi | P05707 |
Genome annotation databases
EnsemblBacteriai | AAC75747; AAC75747; b2705 BAA16566; BAA16566; BAA16566 |
GeneIDi | 948937 |
KEGGi | ecj:JW2674 eco:b2705 |
PATRICi | fig|1411691.4.peg.4037 |
Organism-specific databases
EchoBASEi | EB0964 |
Phylogenomic databases
eggNOGi | COG1028, Bacteria |
HOGENOMi | CLU_010194_1_0_6 |
InParanoidi | P05707 |
PhylomeDBi | P05707 |
Enzyme and pathway databases
UniPathwayi | UPA00812;UER00783 |
BioCyci | EcoCyc:SORB6PDEHYDROG-MONOMER MetaCyc:SORB6PDEHYDROG-MONOMER |
Miscellaneous databases
PROi | PR:P05707 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SRLD_ECOLI | |
Accessioni | P05707Primary (citable) accession number: P05707 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | October 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families