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Protein

Methyl-accepting chemotaxis protein III

Gene

trg

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates taxis to the sugars ribose and galactose via an interaction with the periplasmic ribose- or galactose-binding proteins.
Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Attractants increase the level of methylation while repellents decrease the level of methylation, the methyl groups are added by the methyltransferase CheR and removed by the methylesterase CheB.

GO - Molecular functioni

  • protein homodimerization activity Source: CAFA
  • transmembrane signaling receptor activity Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionTransducer
Biological processChemotaxis

Enzyme and pathway databases

BioCyciEcoCyc:TRG-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-accepting chemotaxis protein III
Short name:
MCP-III
Alternative name(s):
Ribose and galactose chemoreceptor protein
Gene namesi
Name:trg
Ordered Locus Names:b1421, JW1417
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11018 trg

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Topological domaini45 – 201PeriplasmicSequence analysisAdd BLAST157
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 546CytoplasmicSequence analysisAdd BLAST324

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001105401 – 546Methyl-accepting chemotaxis protein IIIAdd BLAST546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei305Glutamate methyl ester (Glu)2 Publications1
Modified residuei312Glutamate methyl ester (Gln)2 Publications1
Modified residuei319Glutamate methyl ester (Gln)2 Publications1
Modified residuei501Glutamate methyl ester (Glu)2 Publications1
Modified residuei510Glutamate methyl ester (Glu)1 Publication1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiP05704
PRIDEiP05704

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
frlDP455435EBI-557436,EBI-562037

GO - Molecular functioni

Protein-protein interaction databases

BioGridi4261384, 396 interactors
DIPiDIP-11027N
IntActiP05704, 5 interactors
STRINGi316385.ECDH10B_1549

Structurei

3D structure databases

ProteinModelPortaliP05704
SMRiP05704
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini224 – 276HAMPPROSITE-ProRule annotationAdd BLAST53
Domaini281 – 510Methyl-accepting transducerPROSITE-ProRule annotationAdd BLAST230

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C8Q Bacteria
COG0840 LUCA
HOGENOMiHOG000148074
InParanoidiP05704
KOiK05876
PhylomeDBiP05704

Family and domain databases

CDDicd06225 HAMP, 1 hit
cd00181 Tar_Tsr_LBD, 1 hit
InterProiView protein in InterPro
IPR035440 4HB_MCP_dom_sf
IPR004090 Chemotax_Me-accpt_rcpt
IPR004091 Chemotax_Me-accpt_rcpt_Me-site
IPR003660 HAMP_dom
IPR004089 MCPsignal_dom
IPR003122 Tar_rcpt_lig-bd
PfamiView protein in Pfam
PF00672 HAMP, 1 hit
PF00015 MCPsignal, 1 hit
PF02203 TarH, 1 hit
PRINTSiPR00260 CHEMTRNSDUCR
SMARTiView protein in SMART
SM00304 HAMP, 1 hit
SM00283 MA, 1 hit
SM00319 TarH, 1 hit
SUPFAMiSSF47170 SSF47170, 1 hit
PROSITEiView protein in PROSITE
PS00538 CHEMOTAXIS_TRANSDUC_1, 1 hit
PS50111 CHEMOTAXIS_TRANSDUC_2, 1 hit
PS50885 HAMP, 1 hit

Sequencei

Sequence statusi: Complete.

P05704-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTTPSQRLG FLHHIRLVPL FACILGGILV LFALSSALAG YFLWQADRDQ
60 70 80 90 100
RDVTAEIEIR TGLANSSDFL RSARINMIQA GAASRIAEME AMKRNIAQAE
110 120 130 140 150
SEIKQSQQGY RAYQNRPVKT PADEALDTEL NQRFQAYITG MQPMLKYAKN
160 170 180 190 200
GMFEAIINHE SEQIRPLDNA YTDILNKAVK IRSTRANQLA ELAHQRTRLG
210 220 230 240 250
GMFMIGAFVL ALVMTLITFM VLRRIVIRPL QHAAQRIEKI ASGDLTMNDE
260 270 280 290 300
PAGRNEIGRL SRHLQQMQHS LGMTVGTVRQ GAEEIYRGTS EISAGNADLS
310 320 330 340 350
SRTEEQAAAI EQTAASMEQL TATVKQNADN AHHASKLAQE ASIKASDGGQ
360 370 380 390 400
TVSGVVKTMG AISTSSKKIS EITAVINSIA FQTNILALNA AVEAARAGEQ
410 420 430 440 450
GRGFAVVASE VRTLASRSAQ AAKEIEGLIS ESVRLIDLGS DEVATAGKTM
460 470 480 490 500
STIVDAVASV THIMQEIAAA SDEQSRGITQ VSQAISEMDK VTQQNASLVE
510 520 530 540
EASAAAVSLE EQAARLTEAV DVFRLHKHSV SAEPRGAGEP VSFATV
Length:546
Mass (Da):58,899
Last modified:November 1, 1997 - v3
Checksum:iFDB40374C0E83E7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02073 Genomic DNA Translation: AAA81329.2
U00096 Genomic DNA Translation: AAC74503.1
AP009048 Genomic DNA Translation: BAA15044.1
PIRiH64893 QREC3M
RefSeqiNP_415938.1, NC_000913.3
WP_001098559.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74503; AAC74503; b1421
BAA15044; BAA15044; BAA15044
GeneIDi945995
KEGGiecj:JW1417
eco:b1421
PATRICifig|1411691.4.peg.849

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02073 Genomic DNA Translation: AAA81329.2
U00096 Genomic DNA Translation: AAC74503.1
AP009048 Genomic DNA Translation: BAA15044.1
PIRiH64893 QREC3M
RefSeqiNP_415938.1, NC_000913.3
WP_001098559.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP05704
SMRiP05704
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261384, 396 interactors
DIPiDIP-11027N
IntActiP05704, 5 interactors
STRINGi316385.ECDH10B_1549

Proteomic databases

PaxDbiP05704
PRIDEiP05704

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74503; AAC74503; b1421
BAA15044; BAA15044; BAA15044
GeneIDi945995
KEGGiecj:JW1417
eco:b1421
PATRICifig|1411691.4.peg.849

Organism-specific databases

EchoBASEiEB1011
EcoGeneiEG11018 trg

Phylogenomic databases

eggNOGiENOG4105C8Q Bacteria
COG0840 LUCA
HOGENOMiHOG000148074
InParanoidiP05704
KOiK05876
PhylomeDBiP05704

Enzyme and pathway databases

BioCyciEcoCyc:TRG-MONOMER

Miscellaneous databases

PROiPR:P05704

Family and domain databases

CDDicd06225 HAMP, 1 hit
cd00181 Tar_Tsr_LBD, 1 hit
InterProiView protein in InterPro
IPR035440 4HB_MCP_dom_sf
IPR004090 Chemotax_Me-accpt_rcpt
IPR004091 Chemotax_Me-accpt_rcpt_Me-site
IPR003660 HAMP_dom
IPR004089 MCPsignal_dom
IPR003122 Tar_rcpt_lig-bd
PfamiView protein in Pfam
PF00672 HAMP, 1 hit
PF00015 MCPsignal, 1 hit
PF02203 TarH, 1 hit
PRINTSiPR00260 CHEMTRNSDUCR
SMARTiView protein in SMART
SM00304 HAMP, 1 hit
SM00283 MA, 1 hit
SM00319 TarH, 1 hit
SUPFAMiSSF47170 SSF47170, 1 hit
PROSITEiView protein in PROSITE
PS00538 CHEMOTAXIS_TRANSDUC_1, 1 hit
PS50111 CHEMOTAXIS_TRANSDUC_2, 1 hit
PS50885 HAMP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMCP3_ECOLI
AccessioniPrimary (citable) accession number: P05704
Secondary accession number(s): P77448
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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