TFAP2A

Functionⁱ

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.2 Publications

GO - Molecular functionⁱ

chromatin binding Source: UniProtKB
protein dimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12072434
protein homodimerization activity
Source: UniProtKB
Traceable author statementⁱ
- 7559606
proximal promoter sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 7559606
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
RNA polymerase II transcription factor activity, sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 7555706
sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12586840
- 8321221
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11278550
- 20808827
transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
transcription coactivator activity
Source: UniProtKB
Inferred from direct assayⁱ
transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 21084835
transcription regulatory region DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12586840
transcription regulatory region sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18718911

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

bone morphogenesis Source: UniProtKB
cellular response to iron ion
Source: UniProtKB
Inferred from direct assayⁱ
- 20808827
embryonic cranial skeleton morphogenesis Source: UniProtKB
embryonic forelimb morphogenesis Source: UniProtKB
eyelid development in camera-type eye Source: UniProtKB
inner ear morphogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21204207
kidney development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21204207
negative regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 20066163
negative regulation of cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 20607706
negative regulation of reactive oxygen species metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 20066163
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 20607706
negative regulation of transcription by competitive promoter binding
Source: UniProtKB
Inferred from direct assayⁱ
- 8321221
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
oculomotor nerve formation Source: UniProtKB
optic cup structural organization Source: UniProtKB
optic vesicle morphogenesis Source: UniProtKB
positive regulation of bone mineralization
Source: UniProtKB
Inferred from direct assayⁱ
- 19578371
positive regulation of gene expression Source: UniProtKB
positive regulation of neuron apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 20607706
positive regulation of tooth mineralization
Source: UniProtKB
Inferred from direct assayⁱ
- 19578371
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 12586840
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
regulation of cell differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 20607706
regulation of transcription by RNA polymerase II Source: Reactome
retina layer formation
Source: UniProtKB
Inferred from expression patternⁱ
- 20607706
roof of mouth development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21204207
sensory perception of sound
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21204207
trigeminal nerve development Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3232118 SUMOylation of transcription factors R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866906 TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
SIGNORⁱ	P05549

Reactomeⁱ

R-HSA-3232118 SUMOylation of transcription factors
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-HSA-8866906 TFAP2 (AP-2) family regulates transcription of other transcription factors
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation

SIGNORⁱ

P05549

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor AP-2-alpha Short name: AP2-alpha Alternative name(s): AP-2 transcription factor Activating enhancer-binding protein 2-alpha Activator protein 2 Short name: AP-2
Gene namesⁱ	Name:TFAP2A Synonyms:AP2TF, TFAP2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000137203.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11742 TFAP2A
MIMⁱ	107580 gene
neXtProtⁱ	NX_P05549

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Branchiooculofacial syndrome (BOFS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA syndrome characterized by growth retardation, bilateral branchial sinus defects with hemangiomatous, scarred skin, cleft lip with or without cleft palate, pseudocleft of the upper lip, nasolacrimal duct obstruction, low set ears with posterior rotation, a malformed, asymmetrical nose with a broad bridge and flattened tip, conductive or sensorineural deafness, ocular and renal anomalies.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	239	S → A: No phosphorylation. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7020
GeneReviewsⁱ	TFAP2A
MalaCards human disease database More...MalaCardsⁱ	TFAP2A
MIMⁱ	113620 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000137203
Orphanetⁱ	1297 Branchio-oculo-facial syndrome
PharmGKBⁱ	PA36459

Polymorphism and mutation databases

BioMutaⁱ	TFAP2A
DMDMⁱ	135302

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000184796	1 – 437	Transcription factor AP-2-alphaAdd BLAST		437

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	10	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate1 Publication
Cross-linkⁱ	10	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	177	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	184	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	239	Phosphoserine; by PKA1 Publication	1

Post-translational modificationⁱ

Sumoylated on Lys-10; which inhibits transcriptional activity.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P05549
PaxDbⁱ	P05549
PeptideAtlas More...PeptideAtlasⁱ	P05549
PRIDEⁱ	P05549
ProteomicsDBⁱ	51847 51848 [P05549-2] 51849 [P05549-5]

PTM databases

iPTMnetⁱ	P05549
PhosphoSitePlusⁱ	P05549

Miscellaneous databases

PMAP-CutDBⁱ	P05549

PMAP-CutDBⁱ

P05549

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000137203 Expressed in 162 organ(s), highest expression level in placenta
CleanExⁱ	HS_TFAP2A
ExpressionAtlasⁱ	P05549 baseline and differential
Genevisibleⁱ	P05549 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB000326 HPA028850 HPA056871

HPAⁱ

CAB000326
HPA028850
HPA056871

Interactionⁱ

Subunit structureⁱ

Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with RALBP1 in a complex also containing EPN1 and NUMB during interphase and mitosis. Interacts with KCTD1; this interaction represses transcription activation. Interacts (via C-terminus) with CITED2 (via C-terminus); the interaction stimulates TFAP2A-transcriptional activation. Interacts (via N-terminus) with EP300 (via N-terminus); the interaction requires CITED2. Interacts with KCTD15; this interaction inhibits TFAP2A transcriptional activation.9 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
EP300	Q09472	7	EBI-347351,EBI-447295
GSTO2	Q9H4Y5	5	EBI-12194905,EBI-10194609
MAX	P61244	2	EBI-347351,EBI-751711
MKRN3	Q13064	3	EBI-347351,EBI-2340269
NPM1	P06748	6	EBI-347351,EBI-78579
UBE2I	P63279	4	EBI-347351,EBI-80168

GO - Molecular functionⁱ

protein dimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12072434
protein homodimerization activity
Source: UniProtKB
Traceable author statementⁱ
- 7559606

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112878, 63 interactors
CORUMⁱ	P05549
IntActⁱ	P05549, 91 interactors
Molecular INTeraction database More...MINTⁱ	P05549
STRINGⁱ	9606.ENSP00000368924

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P05549
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	280 – 410	H-S-H (helix-span-helix), dimerizationAdd BLAST		131

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	57 – 62	PPxY motif		6

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	29 – 117	Gln/Pro-rich (transactivation domain)Add BLAST		89

Domainⁱ

The PPxY motif mediates interaction with WWOX.By similarity

Sequence similaritiesⁱ

Belongs to the AP-2 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3811 Eukaryota ENOG410XR9E LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074577
HOGENOMⁱ	HOG000231737
HOVERGENⁱ	HBG002455
InParanoidⁱ	P05549
KEGG Orthology (KO) More...KOⁱ	K09176
PhylomeDBⁱ	P05549
TreeFamⁱ	TF313718

Family and domain databases

InterProⁱ	View protein in InterPro IPR004979 TF_AP2 IPR008121 TF_AP2_alpha_N IPR013854 TF_AP2_C
PANTHERⁱ	PTHR10812 PTHR10812, 1 hit PTHR10812:SF8 PTHR10812:SF8, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03299 TF_AP-2, 1 hit
PRINTSⁱ	PR01749 AP2ATNSCPFCT PR01748 AP2TNSCPFCT

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Experimental confirmation may be lacking for some isoforms.

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P05549-1) [UniParc]FASTA Add to basket

Also known as: AP-2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLWKLTDNIK YEDCEDRHDG TSNGTARLPQ LGTVGQSPYT SAPPLSHTPN 
        60         70         80         90        100
ADFQPPYFPP PYQPIYPQSQ DPYSHVNDPY SLNPLHAQPQ PQHPGWPGQR 
       110        120        130        140        150
QSQESGLLHT HRGLPHQLSG LDPRRDYRRH EDLLHGPHAL SSGLGDLSIH 
       160        170        180        190        200
SLPHAIEEVP HVEDPGINIP DQTVIKKGPV SLSKSNSNAV SAIPINKDNL 
       210        220        230        240        250
FGGVVNPNEV FCSVPGRLSL LSSTSKYKVT VAEVQRRLSP PECLNASLLG 
       260        270        280        290        300
GVLRRAKSKN GGRSLREKLD KIGLNLPAGR RKAANVTLLT SLVEGEAVHL 
       310        320        330        340        350
ARDFGYVCET EFPAKAVAEF LNRQHSDPNE QVTRKNMLLA TKQICKEFTD 
       360        370        380        390        400
LLAQDRSPLG NSRPNPILEP GIQSCLTHFN LISHGFGSPA VCAAVTALQN 
       410        420        430 
YLTEALKAMD KMYLSNNPNS HTDNNAKSSD KEEKHRK

Length:437

Mass (Da):48,062

Last modified:July 1, 1989 - v1

Checksum:ⁱFB8FA33C3AEED71F

GO

Isoform 2 (identifier: P05549-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-15: MLWKLTDNIKYEDCE → MLVHSFSAM

« Hide

        10         20         30         40         50
MLVHSFSAMD RHDGTSNGTA RLPQLGTVGQ SPYTSAPPLS HTPNADFQPP 
        60         70         80         90        100
YFPPPYQPIY PQSQDPYSHV NDPYSLNPLH AQPQPQHPGW PGQRQSQESG 
       110        120        130        140        150
LLHTHRGLPH QLSGLDPRRD YRRHEDLLHG PHALSSGLGD LSIHSLPHAI 
       160        170        180        190        200
EEVPHVEDPG INIPDQTVIK KGPVSLSKSN SNAVSAIPIN KDNLFGGVVN 
       210        220        230        240        250
PNEVFCSVPG RLSLLSSTSK YKVTVAEVQR RLSPPECLNA SLLGGVLRRA 
       260        270        280        290        300
KSKNGGRSLR EKLDKIGLNL PAGRRKAANV TLLTSLVEGE AVHLARDFGY 
       310        320        330        340        350
VCETEFPAKA VAEFLNRQHS DPNEQVTRKN MLLATKQICK EFTDLLAQDR 
       360        370        380        390        400
SPLGNSRPNP ILEPGIQSCL THFNLISHGF GSPAVCAAVT ALQNYLTEAL 
       410        420        430 
KAMDKMYLSN NPNSHTDNNA KSSDKEEKHR K

Note: No experimental confirmation available.

Show »

Length:431

Mass (Da):47,183

Checksum:ⁱ17337CD2D317620F

GO

Isoform 4 (identifier: P05549-2) [UniParc]FASTA Add to basket

Also known as: AP-2B

The sequence of this isoform differs from the canonical sequence as follows:
296-437: EAVHLARDFG...SSDKEEKHRK → KRIHLLTRRN...SILLPSFPLP

« Hide

        10         20         30         40         50
MLWKLTDNIK YEDCEDRHDG TSNGTARLPQ LGTVGQSPYT SAPPLSHTPN 
        60         70         80         90        100
ADFQPPYFPP PYQPIYPQSQ DPYSHVNDPY SLNPLHAQPQ PQHPGWPGQR 
       110        120        130        140        150
QSQESGLLHT HRGLPHQLSG LDPRRDYRRH EDLLHGPHAL SSGLGDLSIH 
       160        170        180        190        200
SLPHAIEEVP HVEDPGINIP DQTVIKKGPV SLSKSNSNAV SAIPINKDNL 
       210        220        230        240        250
FGGVVNPNEV FCSVPGRLSL LSSTSKYKVT VAEVQRRLSP PECLNASLLG 
       260        270        280        290        300
GVLRRAKSKN GGRSLREKLD KIGLNLPAGR RKAANVTLLT SLVEGKRIHL 
       310        320        330        340        350
LTRRNFLLGK WIIFSGQMFG RILCQLGSFI FAENIARCEW NYFMAKRNIC 
       360 
MYSYTSILLP SFPLP

Note: May be an aberrantly processed form with no significant distribution in vivo.

Show »

Length:365

Mass (Da):40,557

Checksum:ⁱC0D74B07799B98A5

GO

Isoform 5 (identifier: P05549-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-15: MLWKLTDNIKYEDCE → MSILAKMGDWQ

« Hide

        10         20         30         40         50
MSILAKMGDW QDRHDGTSNG TARLPQLGTV GQSPYTSAPP LSHTPNADFQ 
        60         70         80         90        100
PPYFPPPYQP IYPQSQDPYS HVNDPYSLNP LHAQPQPQHP GWPGQRQSQE 
       110        120        130        140        150
SGLLHTHRGL PHQLSGLDPR RDYRRHEDLL HGPHALSSGL GDLSIHSLPH 
       160        170        180        190        200
AIEEVPHVED PGINIPDQTV IKKGPVSLSK SNSNAVSAIP INKDNLFGGV 
       210        220        230        240        250
VNPNEVFCSV PGRLSLLSST SKYKVTVAEV QRRLSPPECL NASLLGGVLR 
       260        270        280        290        300
RAKSKNGGRS LREKLDKIGL NLPAGRRKAA NVTLLTSLVE GEAVHLARDF 
       310        320        330        340        350
GYVCETEFPA KAVAEFLNRQ HSDPNEQVTR KNMLLATKQI CKEFTDLLAQ 
       360        370        380        390        400
DRSPLGNSRP NPILEPGIQS CLTHFNLISH GFGSPAVCAA VTALQNYLTE 
       410        420        430 
ALKAMDKMYL SNNPNSHTDN NAKSSDKEEK HRK

Note: Gene prediction based on EST data.

Show »

Length:433

Mass (Da):47,440

Checksum:ⁱ2521AB97F25AD8B1

GO

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q96SH1	Q96SH1_HUMAN	Transcription factor AP-2 alpha (Ac... Transcription factor AP-2 alpha (Activating enhancer binding protein 2 alpha), isoform CRA_c (Transcription factor AP-2-alpha)	TFAP2A hCG_37170	439	Annotation score:
C1K3N0	C1K3N0_HUMAN	Transcription factor AP-2-alpha Transcription factor AP-2-alpha	TFAP2A	328	Annotation score:
H7C5E5	H7C5E5_HUMAN	Transcription factor AP-2-alpha Transcription factor AP-2-alpha	TFAP2A	218	Annotation score:
C9J6N8	C9J6N8_HUMAN	Transcription factor AP-2-alpha Transcription factor AP-2-alpha	TFAP2A	173	Annotation score:
C9JXZ2	C9JXZ2_HUMAN	Transcription factor AP-2-alpha Transcription factor AP-2-alpha	TFAP2A	136	Annotation score:
H7C4N4	H7C4N4_HUMAN	Transcription factor AP-2-alpha Transcription factor AP-2-alpha	TFAP2A	81	Annotation score:
F8WEX2	F8WEX2_HUMAN	Transcription factor AP-2-alpha Transcription factor AP-2-alpha	TFAP2A	121	Annotation score:
F8WDC8	F8WDC8_HUMAN	Transcription factor AP-2-alpha Transcription factor AP-2-alpha	TFAP2A	113	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_045838	249	L → P in BOFS. 1 Publication	1
Natural variantⁱVAR_045839	254	R → G in BOFS. 1 PublicationCorresponds to variant dbSNP:rs151344528EnsemblClinVar.	1
Natural variantⁱVAR_045840	255	R → G in BOFS. 1 PublicationCorresponds to variant dbSNP:rs121909574Ensembl.	1
Natural variantⁱVAR_045841	262	G → E in BOFS. 1 PublicationCorresponds to variant dbSNP:rs121909575Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_043268	1 – 15	MLWKL…YEDCE → MLVHSFSAM in isoform 2. 1 PublicationAdd BLAST	15
Alternative sequenceⁱVSP_047050	1 – 15	MLWKL…YEDCE → MSILAKMGDWQ in isoform 5. CuratedAdd BLAST	15
Alternative sequenceⁱVSP_006401	296 – 437	EAVHL…EKHRK → KRIHLLTRRNFLLGKWIIFS GQMFGRILCQLGSFIFAENI ARCEWNYFMAKRNICMYSYT SILLPSFPLP in isoform 4. 1 PublicationAdd BLAST	142

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M36711 mRNA Translation: AAA35539.1 M61156 mRNA Translation: AAA02487.1 X52611 mRNA Translation: CAA36842.1 X77343 Genomic DNA Translation: CAB59735.1 AL138885 Genomic DNA No translation available. CH471087 Genomic DNA Translation: EAW55249.1 BC017754 mRNA Translation: AAH17754.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34337.1 [P05549-5] CCDS43422.1 [P05549-6] CCDS4510.1 [P05549-1]
PIRⁱ	A31752
NCBI Reference Sequences More...RefSeqⁱ	NP_001027451.1, NM_001032280.2 [P05549-5] NP_001035890.1, NM_001042425.1 [P05549-6] NP_003211.1, NM_003220.2 [P05549-1]
UniGeneⁱ	Hs.519880

Genome annotation databases

Ensemblⁱ	ENST00000319516; ENSP00000316516; ENSG00000137203 [P05549-6] ENST00000379608; ENSP00000368928; ENSG00000137203 [P05549-5] ENST00000482890; ENSP00000418541; ENSG00000137203 [P05549-1]
GeneIDⁱ	7020
KEGGⁱ	hsa:7020
UCSC genome browser More...UCSCⁱ	uc003myq.4 human [P05549-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
P05549	Transcription factor AP-2 alpha (Activating enhancer binding protein 2 alpha), isoform CRA_c		HUMAN		439	UniRef100_P05549
TFAP2A isoform 7		PANTR		439
TFAP2A isoform 2		PONAB		439
Transcription factor AP-2 alpha		SAIBB		439
Uncharacterized protein		MACMU		439
+13
P05549-5	Transcription factor AP-2 alpha		CALJA		431	UniRef100_F7FSR4
TFAP2A isoform 13		PANTR		431
Transcription factor AP-2 alpha		SAIBB		431
Uncharacterized protein		MACMU		431
Uncharacterized protein		COLAP		431
+9
P05549-6	TFAP2A isoform 2		PANTR		433	UniRef100_H2Q848
Transcription factor AP-2 alpha		SAIBB		433
Uncharacterized protein		CALJA		433
Uncharacterized protein		MACMU		433
Uncharacterized protein		Cebus capucinus imitator		433
+9

Protein	Similar proteins		Species	Score	Length	Source
P05549	Transcription factor AP-2-alpha		MOUSE		437	UniRef90_P34056
Transcription factor AP-2-alpha		RAT		437
Transcription factor AP-2-alpha		BOVIN		437
Transcription factor AP-2 alpha		OTOGA		444
Uncharacterized protein		PROCO		439
+188

Protein	Similar proteins		Species	Score	Length	Source
P05549	Transcription factor AP-2-alpha		MOUSE		437	UniRef50_P34056
Transcription factor AP-2-alpha		BOVIN		437
Transcription factor AP-2-alpha		RAT		437
Transcription factor AP-2 alpha		OTOGA		444
Uncharacterized protein		PROCO		439
+253
P05549-2	transcription factor AP-2-alpha isoform X8		PHYCD		376	UniRef50_P05549-2
Uncharacterized protein		MACMU		308
Transcription factor AP-2 alpha		GORGO		307
Uncharacterized protein		COLAP		307
Uncharacterized protein		RHIRO		307
+8

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Activating protein 2 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M36711 mRNA Translation: AAA35539.1 M61156 mRNA Translation: AAA02487.1 X52611 mRNA Translation: CAA36842.1 X77343 Genomic DNA Translation: CAB59735.1 AL138885 Genomic DNA No translation available. CH471087 Genomic DNA Translation: EAW55249.1 BC017754 mRNA Translation: AAH17754.1
CCDSⁱ	CCDS34337.1 [P05549-5] CCDS43422.1 [P05549-6] CCDS4510.1 [P05549-1]
PIRⁱ	A31752
RefSeqⁱ	NP_001027451.1, NM_001032280.2 [P05549-5] NP_001035890.1, NM_001042425.1 [P05549-6] NP_003211.1, NM_003220.2 [P05549-1]
UniGeneⁱ	Hs.519880

3D structure databases

ProteinModelPortalⁱ	P05549
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112878, 63 interactors
CORUMⁱ	P05549
IntActⁱ	P05549, 91 interactors
MINTⁱ	P05549
STRINGⁱ	9606.ENSP00000368924

PTM databases

iPTMnetⁱ	P05549
PhosphoSitePlusⁱ	P05549

Polymorphism and mutation databases

BioMutaⁱ	TFAP2A
DMDMⁱ	135302

Proteomic databases

EPDⁱ	P05549
PaxDbⁱ	P05549
PeptideAtlasⁱ	P05549
PRIDEⁱ	P05549
ProteomicsDBⁱ	51847 51848 [P05549-2] 51849 [P05549-5]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7020
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000319516; ENSP00000316516; ENSG00000137203 [P05549-6] ENST00000379608; ENSP00000368928; ENSG00000137203 [P05549-5] ENST00000482890; ENSP00000418541; ENSG00000137203 [P05549-1]
GeneIDⁱ	7020
KEGGⁱ	hsa:7020
UCSCⁱ	uc003myq.4 human [P05549-1]

Organism-specific databases

CTDⁱ	7020
DisGeNETⁱ	7020
EuPathDBⁱ	HostDB:ENSG00000137203.10
GeneCardsⁱ	TFAP2A
GeneReviewsⁱ	TFAP2A
HGNCⁱ	HGNC:11742 TFAP2A
HPAⁱ	CAB000326 HPA028850 HPA056871
MalaCardsⁱ	TFAP2A
MIMⁱ	107580 gene 113620 phenotype
neXtProtⁱ	NX_P05549
OpenTargetsⁱ	ENSG00000137203
Orphanetⁱ	1297 Branchio-oculo-facial syndrome
PharmGKBⁱ	PA36459
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3811 Eukaryota ENOG410XR9E LUCA
GeneTreeⁱ	ENSGT00550000074577
HOGENOMⁱ	HOG000231737
HOVERGENⁱ	HBG002455
InParanoidⁱ	P05549
KOⁱ	K09176
PhylomeDBⁱ	P05549
TreeFamⁱ	TF313718

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3232118 SUMOylation of transcription factors R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866906 TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
SIGNORⁱ	P05549

Reactomeⁱ

R-HSA-3232118 SUMOylation of transcription factors
R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-HSA-8866906 TFAP2 (AP-2) family regulates transcription of other transcription factors
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors
R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation

SIGNORⁱ

P05549

Miscellaneous databases

ChiTaRSⁱ	TFAP2A human
GeneWikiⁱ	TFAP2A
GenomeRNAiⁱ	7020
PMAP-CutDBⁱ	P05549
Protein Ontology More...PROⁱ	PR:P05549
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000137203 Expressed in 162 organ(s), highest expression level in placenta
CleanExⁱ	HS_TFAP2A
ExpressionAtlasⁱ	P05549 baseline and differential
Genevisibleⁱ	P05549 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR004979 TF_AP2 IPR008121 TF_AP2_alpha_N IPR013854 TF_AP2_C
PANTHERⁱ	PTHR10812 PTHR10812, 1 hit PTHR10812:SF8 PTHR10812:SF8, 1 hit
Pfamⁱ	View protein in Pfam PF03299 TF_AP-2, 1 hit
PRINTSⁱ	PR01749 AP2ATNSCPFCT PR01748 AP2TNSCPFCT
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AP2A_HUMAN
Accessionⁱ	P05549Primary (citable) accession number: P05549 Secondary accession number(s): Q13777, Q5TAV5, Q8N1C6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1989
	Last sequence update:	July 1, 1989
	Last modified:	September 12, 2018
	This is version 186 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P05549 (AP2A_HUMAN)

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Transcription factor AP-2-alpha

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Enzyme and pathway databases

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Gene expression databases

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3D structure databases

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Sequence databases

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Proteomic databases

Protocols and materials databases

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Miscellaneous databases

Gene expression databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ