The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P05543 (THBG_HUMAN)
Protein
Thyroxine-binding globulin
Gene
SERPINA7
Organism
Homo sapiens (Human)
Status
Functioni
Major thyroid hormone transport protein in serum.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 293 | Thyroxine1 Publication | 1 | |
Binding sitei | 398 | Thyroxine1 Publication | 1 |
GO - Molecular functioni
- serine-type endopeptidase inhibitor activity Source: GO_Central
GO - Biological processi
- negative regulation of endopeptidase activity Source: GO_Central
- thyroid hormone transport Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | P05543 |
SignaLinki | P05543 |
Protein family/group databases
MEROPSi | I04.955 |
Names & Taxonomyi
Protein namesi | Recommended name: Thyroxine-binding globulinAlternative name(s): Serpin A7 T4-binding globulin |
Gene namesi | Name:SERPINA7 Synonyms:TBG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11583, SERPINA7 |
MIMi | 314200, gene |
neXtProti | NX_P05543 |
VEuPathDBi | HostDB:ENSG00000123561 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: UniProtKB
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 6906 |
MalaCardsi | SERPINA7 |
MIMi | 300932, phenotype |
OpenTargetsi | ENSG00000123561 |
Orphaneti | 209893, NON RARE IN EUROPE: Congenital isolated thyroxine-binding globulin deficiency |
PharmGKBi | PA36347 |
Miscellaneous databases
Pharosi | P05543, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3843 |
DrugBanki | DB01629, 5-fluorouridine DB11100, Allantoin DB00023, Asparaginase Escherichia coli DB00636, Clofibrate DB00286, Conjugated estrogens DB09130, Copper DB01219, Dantrolene DB01452, Diamorphine DB08899, Enzalutamide DB09381, Esterified estrogens DB00754, Ethotoin DB08984, Etofenamate DB00322, Floxuridine DB00544, Fluorouracil DB01320, Fosphenytoin DB00695, Furosemide DB01109, Heparin DB00451, Levothyroxine DB00279, Liothyronine DB12425, Liothyronine I-131 DB01583, Liotrix DB00939, Meclofenamic acid DB00532, Mephenytoin DB00648, Mitotane DB13396, Neocitrullamon DB00627, Niacin DB05235, NRP409 DB00059, Pegaspargase DB00252, Phenytoin DB09317, Synthetic Conjugated Estrogens, A DB09318, Synthetic Conjugated Estrogens, B DB00675, Tamoxifen DB09256, Tegafur DB09100, Thyroid, porcine |
Genetic variation databases
BioMutai | SERPINA7 |
DMDMi | 1351236 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | 1 PublicationAdd BLAST | 20 | |
ChainiPRO_0000032436 | 21 – 415 | Thyroxine-binding globulinAdd BLAST | 395 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 36 | N-linked (GlcNAc...) (complex) asparagine2 Publications | 1 | |
Glycosylationi | 99 | N-linked (GlcNAc...) asparagine | 1 | |
Glycosylationi | 116 | N-linked (GlcNAc...) asparagine; in variant GaryCurated | 1 | |
Glycosylationi | 165 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 253 | N-linked (GlcNAc...) asparagine | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | P05543 |
jPOSTi | P05543 |
MassIVEi | P05543 |
MaxQBi | P05543 |
PaxDbi | P05543 |
PeptideAtlasi | P05543 |
PRIDEi | P05543 |
ProteomicsDBi | 51845 |
PTM databases
GlyConnecti | 750, 13 N-Linked glycans (3 sites) |
GlyGeni | P05543, 5 sites, 17 N-linked glycans (3 sites), 1 O-linked glycan (1 site) |
iPTMneti | P05543 |
PhosphoSitePlusi | P05543 |
Expressioni
Tissue specificityi
Expressed by the liver and secreted in plasma.
Gene expression databases
Bgeei | ENSG00000123561, Expressed in liver and 56 other tissues |
Genevisiblei | P05543, HS |
Organism-specific databases
HPAi | ENSG00000123561, Tissue enriched (liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 112769, 9 interactors |
IntActi | P05543, 4 interactors |
STRINGi | 9606.ENSP00000329374 |
Miscellaneous databases
RNActi | P05543, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P05543 |
SMRi | P05543 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P05543 |
Family & Domainsi
Sequence similaritiesi
Belongs to the serpin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000161113 |
HOGENOMi | CLU_023330_2_1_1 |
InParanoidi | P05543 |
OMAi | CFKAQWA |
OrthoDBi | 1124079at2759 |
PhylomeDBi | P05543 |
TreeFami | TF343201 |
Family and domain databases
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P05543-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSPFLYLVLL VLGLHATIHC ASPEGKVTAC HSSQPNATLY KMSSINADFA
60 70 80 90 100
FNLYRRFTVE TPDKNIFFSP VSISAALVML SFGACCSTQT EIVETLGFNL
110 120 130 140 150
TDTPMVEIQH GFQHLICSLN FPKKELELQI GNALFIGKHL KPLAKFLNDV
160 170 180 190 200
KTLYETEVFS TDFSNISAAK QEINSHVEMQ TKGKVVGLIQ DLKPNTIMVL
210 220 230 240 250
VNYIHFKAQW ANPFDPSKTE DSSSFLIDKT TTVQVPMMHQ MEQYYHLVDM
260 270 280 290 300
ELNCTVLQMD YSKNALALFV LPKEGQMESV EAAMSSKTLK KWNRLLQKGW
310 320 330 340 350
VDLFVPKFSI SATYDLGATL LKMGIQHAYS ENADFSGLTE DNGLKLSNAA
360 370 380 390 400
HKAVLHIGEK GTEAAAVPEV ELSDQPENTF LHPIIQIDRS FMLLILERST
410
RSILFLGKVV NPTEA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 30 – 31 | CH → DS AA sequence (PubMed:414747).Curated | 2 | |
Sequence conflicti | 38 | T → S AA sequence (PubMed:414747).Curated | 1 | |
Sequence conflicti | 197 | I → T in AAA60616 (PubMed:3094014).Curated | 1 |
Polymorphismi
Genetic variants in SERPINA7 influence the serum levels of thyroxine-binding globulin and define the thyroxine-binding globulin quantitative trait locus (TBGQTL) [MIMi:300932]. Individuals with low or high serum levels of thyroxine-binding globulin show, respectively, reduced or elevated protein-bound iodine but are euthyroid and do not manifest major metabolic alterations (PubMed:1294376, PubMed:1515456, PubMed:1901689, PubMed:1906047, PubMed:2155256, PubMed:2501669). Two qualitative TBG variants occur in particular populations. TBG-A is found in 40% of Australian aborigines, it has reduced affinity for thyroxine and triiodothyroxine and increased susceptibility to inactivation by heat or acid (PubMed:2495303). TBG-S ('s' for slow shift on isoelectic focusing) is found in blacks, Eskimos, Melanesians, Polynesians and Indonesians, but not in Caucasians; TBG-S is slightly more thermolabile (PubMed:2115061).8 Publications
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_007102 | 43 | S → T Associated with F-303 in San Diego; partial thyroxine-binding globulin deficiency. 1 PublicationCorresponds to variant dbSNP:rs72554662Ensembl. | 1 | |
Natural variantiVAR_007103 | 116 | I → N Gary; severe thyroxine-binding globulin deficiency. 1 PublicationCorresponds to variant dbSNP:rs28933689EnsemblClinVar. | 1 | |
Natural variantiVAR_007104 | 133 | A → P Montreal/TBG-M; partial thyroxine-binding globulin deficiency. 1 PublicationCorresponds to variant dbSNP:rs28933688EnsemblClinVar. | 1 | |
Natural variantiVAR_007105 | 191 | D → N TBG-S/Slow. 1 PublicationCorresponds to variant dbSNP:rs1050086EnsemblClinVar. | 1 | |
Natural variantiVAR_007106 | 211 | A → T TBG-A/Aborigine. 1 PublicationCorresponds to variant dbSNP:rs2234036EnsemblClinVar. | 1 | |
Natural variantiVAR_007107 | 247 | L → P CD5; complete thyroxine-binding globulin deficiency. 1 PublicationCorresponds to variant dbSNP:rs28937312EnsemblClinVar. | 1 | |
Natural variantiVAR_007108 | 303 | L → F Associated with T-43 in San Diego. 1 PublicationCorresponds to variant dbSNP:rs1804495EnsemblClinVar. | 1 | |
Natural variantiVAR_007109 | 351 | H → Y Quebec; partial thyroxine-binding globulin deficiency. 1 PublicationCorresponds to variant dbSNP:rs72554659EnsemblClinVar. | 1 | |
Natural variantiVAR_007110 | 383 | P → L Kumamoto; partial thyroxine-binding globulin deficiency. 1 PublicationCorresponds to variant dbSNP:rs72554658EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14091 mRNA Translation: AAA60616.1 X64171 Genomic DNA Translation: CAA45509.1 L13470 Genomic DNA Translation: AAA16067.1 Z83850 Genomic DNA No translation available. CH471120 Genomic DNA Translation: EAX02747.1 CH471120 Genomic DNA Translation: EAX02748.1 BC020747 mRNA Translation: AAH20747.1 |
CCDSi | CCDS14518.1 |
PIRi | A47224 |
RefSeqi | NP_000345.2, NM_000354.5 |
Genome annotation databases
Ensembli | ENST00000327674.8; ENSP00000329374.4; ENSG00000123561.15 ENST00000372563.2; ENSP00000361644.1; ENSG00000123561.15 |
GeneIDi | 6906 |
KEGGi | hsa:6906 |
MANE-Selecti | ENST00000372563.2; ENSP00000361644.1; NM_000354.6; NP_000345.2 |
UCSCi | uc004eme.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14091 mRNA Translation: AAA60616.1 X64171 Genomic DNA Translation: CAA45509.1 L13470 Genomic DNA Translation: AAA16067.1 Z83850 Genomic DNA No translation available. CH471120 Genomic DNA Translation: EAX02747.1 CH471120 Genomic DNA Translation: EAX02748.1 BC020747 mRNA Translation: AAH20747.1 |
CCDSi | CCDS14518.1 |
PIRi | A47224 |
RefSeqi | NP_000345.2, NM_000354.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CEO | X-ray | 2.80 | A/B | 39-415 | [»] | |
2RIV | X-ray | 1.50 | A | 33-386 | [»] | |
B | 376-415 | [»] | ||||
2RIW | X-ray | 2.04 | A | 39-386 | [»] | |
B | 376-415 | [»] | ||||
2XN3 | X-ray | 2.09 | A | 33-386 | [»] | |
B | 377-415 | [»] | ||||
2XN5 | X-ray | 1.70 | A | 32-380 | [»] | |
B | 381-415 | [»] | ||||
2XN6 | X-ray | 1.29 | A | 32-380 | [»] | |
B | 381-415 | [»] | ||||
2XN7 | X-ray | 1.43 | A | 32-380 | [»] | |
B | 381-415 | [»] | ||||
4X30 | X-ray | 1.55 | A | 21-415 | [»] | |
4YIA | X-ray | 1.58 | A | 1-386 | [»] | |
B | 382-415 | [»] | ||||
AlphaFoldDBi | P05543 | |||||
SMRi | P05543 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112769, 9 interactors |
IntActi | P05543, 4 interactors |
STRINGi | 9606.ENSP00000329374 |
Chemistry databases
ChEMBLi | CHEMBL3843 |
DrugBanki | DB01629, 5-fluorouridine DB11100, Allantoin DB00023, Asparaginase Escherichia coli DB00636, Clofibrate DB00286, Conjugated estrogens DB09130, Copper DB01219, Dantrolene DB01452, Diamorphine DB08899, Enzalutamide DB09381, Esterified estrogens DB00754, Ethotoin DB08984, Etofenamate DB00322, Floxuridine DB00544, Fluorouracil DB01320, Fosphenytoin DB00695, Furosemide DB01109, Heparin DB00451, Levothyroxine DB00279, Liothyronine DB12425, Liothyronine I-131 DB01583, Liotrix DB00939, Meclofenamic acid DB00532, Mephenytoin DB00648, Mitotane DB13396, Neocitrullamon DB00627, Niacin DB05235, NRP409 DB00059, Pegaspargase DB00252, Phenytoin DB09317, Synthetic Conjugated Estrogens, A DB09318, Synthetic Conjugated Estrogens, B DB00675, Tamoxifen DB09256, Tegafur DB09100, Thyroid, porcine |
Protein family/group databases
MEROPSi | I04.955 |
PTM databases
GlyConnecti | 750, 13 N-Linked glycans (3 sites) |
GlyGeni | P05543, 5 sites, 17 N-linked glycans (3 sites), 1 O-linked glycan (1 site) |
iPTMneti | P05543 |
PhosphoSitePlusi | P05543 |
Genetic variation databases
BioMutai | SERPINA7 |
DMDMi | 1351236 |
Proteomic databases
EPDi | P05543 |
jPOSTi | P05543 |
MassIVEi | P05543 |
MaxQBi | P05543 |
PaxDbi | P05543 |
PeptideAtlasi | P05543 |
PRIDEi | P05543 |
ProteomicsDBi | 51845 |
Protocols and materials databases
Antibodypediai | 452, 450 antibodies from 33 providers |
DNASUi | 6906 |
Genome annotation databases
Ensembli | ENST00000327674.8; ENSP00000329374.4; ENSG00000123561.15 ENST00000372563.2; ENSP00000361644.1; ENSG00000123561.15 |
GeneIDi | 6906 |
KEGGi | hsa:6906 |
MANE-Selecti | ENST00000372563.2; ENSP00000361644.1; NM_000354.6; NP_000345.2 |
UCSCi | uc004eme.3, human |
Organism-specific databases
CTDi | 6906 |
DisGeNETi | 6906 |
GeneCardsi | SERPINA7 |
HGNCi | HGNC:11583, SERPINA7 |
HPAi | ENSG00000123561, Tissue enriched (liver) |
MalaCardsi | SERPINA7 |
MIMi | 300932, phenotype 314200, gene |
neXtProti | NX_P05543 |
OpenTargetsi | ENSG00000123561 |
Orphaneti | 209893, NON RARE IN EUROPE: Congenital isolated thyroxine-binding globulin deficiency |
PharmGKBi | PA36347 |
VEuPathDBi | HostDB:ENSG00000123561 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2392, Eukaryota |
GeneTreei | ENSGT00940000161113 |
HOGENOMi | CLU_023330_2_1_1 |
InParanoidi | P05543 |
OMAi | CFKAQWA |
OrthoDBi | 1124079at2759 |
PhylomeDBi | P05543 |
TreeFami | TF343201 |
Enzyme and pathway databases
PathwayCommonsi | P05543 |
SignaLinki | P05543 |
Miscellaneous databases
BioGRID-ORCSi | 6906, 11 hits in 688 CRISPR screens |
EvolutionaryTracei | P05543 |
GenomeRNAii | 6906 |
Pharosi | P05543, Tbio |
PROi | PR:P05543 |
RNActi | P05543, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000123561, Expressed in liver and 56 other tissues |
Genevisiblei | P05543, HS |
Family and domain databases
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR023795, Serpin_CS IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
PROSITEi | View protein in PROSITE PS00284, SERPIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | THBG_HUMAN | |
Accessioni | P05543Primary (citable) accession number: P05543 Secondary accession number(s): D3DUX1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | February 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 213 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families