UniProtKB - P05543 (THBG_HUMAN)

BLAST

>sp|P05543|THBG_HUMAN Thyroxine-binding globulin OS=Homo sapiens OX=9606 GN=SERPINA7 PE=1 SV=2
MSPFLYLVLLVLGLHATIHCASPEGKVTACHSSQPNATLYKMSSINADFAFNLYRRFTVE
TPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVEIQHGFQHLICSLN
FPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQEINSHVEMQ
TKGKVVGLIQDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQ
MEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQMESVEAAMSSKTLKKWNRLLQKGW
VDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNAAHKAVLHIGEK
GTEAAAVPEVELSDQPENTFLHPIIQIDRSFMLLILERSTRSILFLGKVVNPTEA

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History
Entry version 194 (07 Nov 2018)
Sequence version 2 (01 Feb 1996)
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Protein

Thyroxine-binding globulin

Gene

SERPINA7

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Major thyroid hormone transport protein in serum.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	293	Thyroxine1 Publication		1
Binding siteⁱ	398	Thyroxine1 Publication		1

GO - Molecular functionⁱ

serine-type endopeptidase inhibitor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of endopeptidase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
thyroid hormone transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19415532

View the complete GO annotation on QuickGO ...

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I04.955

MEROPSⁱ

I04.955

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Thyroxine-binding globulin Alternative name(s): Serpin A7 T4-binding globulin
Gene namesⁱ	Name:SERPINA7 Synonyms:TBG
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000123561.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11583 SERPINA7
MIMⁱ	314200 gene
neXtProtⁱ	NX_P05543

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6906
MalaCards human disease database More...MalaCardsⁱ	SERPINA7
MIMⁱ	300932 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000123561
Orphanetⁱ	209893 NON RARE IN EUROPE: Congenital isolated thyroxine-binding globulin deficiency
PharmGKBⁱ	PA36347

Chemistry databases

ChEMBLⁱ	CHEMBL3843
Drug and drug target database More...DrugBankⁱ	DB00451 Levothyroxine DB00279 Liothyronine DB01583 Liotrix DB05235 NRP409

Polymorphism and mutation databases

BioMutaⁱ	SERPINA7
DMDMⁱ	1351236

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	1 PublicationAdd BLAST		20
ChainⁱPRO_0000032436	21 – 415	Thyroxine-binding globulinAdd BLAST		395

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	36	N-linked (GlcNAc...) (complex) asparagine2 Publications	1
Glycosylationⁱ	99	N-linked (GlcNAc...) asparagine	1
Glycosylationⁱ	116	N-linked (GlcNAc...) asparagine; in variant GaryCurated	1
Glycosylationⁱ	165	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	253	N-linked (GlcNAc...) asparagine	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	P05543
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P05543
PaxDbⁱ	P05543
PeptideAtlas More...PeptideAtlasⁱ	P05543
PRIDEⁱ	P05543
ProteomicsDBⁱ	51845

PTM databases

GlyConnectⁱ	750
iPTMnetⁱ	P05543
PhosphoSitePlusⁱ	P05543

Expressionⁱ

Tissue specificityⁱ

Expressed by the liver and secreted in plasma.

Gene expression databases

Bgeeⁱ	ENSG00000123561 Expressed in 35 organ(s), highest expression level in liver
CleanExⁱ	HS_SERPINA7
Genevisibleⁱ	P05543 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA002803

HPAⁱ

HPA002803

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	112769, 5 interactors
IntActⁱ	P05543, 1 interactor
STRINGⁱ	9606.ENSP00000329374

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	40 – 60	Combined sources	21
Beta strandⁱ	66 – 68	Combined sources	3
Helixⁱ	70 – 82	Combined sources	13
Helixⁱ	86 – 95	Combined sources	10
Turnⁱ	100 – 102	Combined sources	3
Helixⁱ	105 – 120	Combined sources	16
Beta strandⁱ	126 – 137	Combined sources	12
Helixⁱ	144 – 153	Combined sources	10
Beta strandⁱ	156 – 161	Combined sources	6
Helixⁱ	166 – 180	Combined sources	15
Turnⁱ	181 – 183	Combined sources	3
Beta strandⁱ	198 – 212	Combined sources	15
Helixⁱ	216 – 218	Combined sources	3
Beta strandⁱ	220 – 228	Combined sources	9
Beta strandⁱ	231 – 249	Combined sources	19
Turnⁱ	250 – 253	Combined sources	4
Beta strandⁱ	254 – 272	Combined sources	19
Helixⁱ	277 – 283	Combined sources	7
Helixⁱ	286 – 295	Combined sources	10
Beta strandⁱ	297 – 306	Combined sources	10
Beta strandⁱ	308 – 315	Combined sources	8
Helixⁱ	317 – 323	Combined sources	7
Helixⁱ	327 – 329	Combined sources	3
Turnⁱ	336 – 338	Combined sources	3
Beta strandⁱ	339 – 342	Combined sources	4
Beta strandⁱ	344 – 357	Combined sources	14
Beta strandⁱ	359 – 374	Combined sources	16
Beta strandⁱ	384 – 386	Combined sources	3
Beta strandⁱ	391 – 397	Combined sources	7
Turnⁱ	398 – 401	Combined sources	4
Beta strandⁱ	402 – 410	Combined sources	9

Show more details

3D structure databases

ProteinModelPortalⁱ	P05543
SMRⁱ	P05543
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P05543

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the serpin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG2392 Eukaryota COG4826 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118839
HOGENOMⁱ	HOG000238521
HOVERGENⁱ	HBG005957
InParanoidⁱ	P05543
KEGG Orthology (KO) More...KOⁱ	K20734
OMAⁱ	ELQMGNA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ION
PhylomeDBⁱ	P05543
TreeFamⁱ	TF343201

Family and domain databases

InterProⁱ	View protein in InterPro IPR023795 Serpin_CS IPR023796 Serpin_dom IPR000215 Serpin_fam IPR036186 Serpin_sf
PANTHERⁱ	PTHR11461 PTHR11461, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00079 Serpin, 1 hit
SMARTⁱ	View protein in SMART SM00093 SERPIN, 1 hit
SUPFAMⁱ	SSF56574 SSF56574, 1 hit
PROSITEⁱ	View protein in PROSITE PS00284 SERPIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P05543-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MSPFLYLVLL VLGLHATIHC ASPEGKVTAC HSSQPNATLY KMSSINADFA 
        60         70         80         90        100
FNLYRRFTVE TPDKNIFFSP VSISAALVML SFGACCSTQT EIVETLGFNL 
       110        120        130        140        150
TDTPMVEIQH GFQHLICSLN FPKKELELQI GNALFIGKHL KPLAKFLNDV 
       160        170        180        190        200
KTLYETEVFS TDFSNISAAK QEINSHVEMQ TKGKVVGLIQ DLKPNTIMVL 
       210        220        230        240        250
VNYIHFKAQW ANPFDPSKTE DSSSFLIDKT TTVQVPMMHQ MEQYYHLVDM 
       260        270        280        290        300
ELNCTVLQMD YSKNALALFV LPKEGQMESV EAAMSSKTLK KWNRLLQKGW 
       310        320        330        340        350
VDLFVPKFSI SATYDLGATL LKMGIQHAYS ENADFSGLTE DNGLKLSNAA 
       360        370        380        390        400
HKAVLHIGEK GTEAAAVPEV ELSDQPENTF LHPIIQIDRS FMLLILERST 
       410 
RSILFLGKVV NPTEA

Length:415

Mass (Da):46,325

Last modified:February 1, 1996 - v2

Checksum:ⁱ8B24EF8C7CEF8F0A

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	30 – 31	CH → DS AA sequence (PubMed:414747).Curated	2
Sequence conflictⁱ	38	T → S AA sequence (PubMed:414747).Curated	1
Sequence conflictⁱ	197	I → T in AAA60616 (PubMed:3094014).Curated	1

Polymorphismⁱ

Genetic variants in SERPINA7 influence the serum levels of thyroxine-binding globulin and define the thyroxine-binding globulin quantitaive trait locus (TBGQTL) [MIMⁱ:300932]. Individuals with low or high serum levels of thyroxine-binding globulin show, respectively, reduced or elevated protein-bound iodine but are euthyroid and do not manifest major metabolic alterations (PubMed:1294376, PubMed:1515456, PubMed:1901689, PubMed:1906047, PubMed:2155256, PubMed:2501669). Two qualitative TBG variants occur in particular populations. TBG-A is found in 40% of Australian aborigines, it has reduced affinity for thyroxine and triiodothyroxine and increased susceptibility to inactivation by heat or acid (PubMed:2495303). TBG-S ('s' for slow shift on isoelectic focusing) is found in blacks, Eskimos, Melanesians, Polynesians and Indonesians, but not in Caucasians; TBG-S is slightly more thermolabile (PubMed:2115061).8 Publications

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_007102	43	S → T Polymorphism; associated with F-303 in San Diego; partial thyroxine-binding globulin deficiency. 1 PublicationCorresponds to variant dbSNP:rs72554662Ensembl.	1
Natural variantⁱVAR_007103	116	I → N Polymorphism; Gary; severe thyroxine-binding globulin deficiency. 1 PublicationCorresponds to variant dbSNP:rs28933689EnsemblClinVar.	1
Natural variantⁱVAR_007104	133	A → P Polymorphism; Montreal/TBG-M; partial thyroxine-binding globulin deficiency. 1 PublicationCorresponds to variant dbSNP:rs28933688EnsemblClinVar.	1
Natural variantⁱVAR_007105	191	D → N Polymorphism; TBG-S/Slow. 1 PublicationCorresponds to variant dbSNP:rs1050086EnsemblClinVar.	1
Natural variantⁱVAR_007106	211	A → T Polymorphism; TBG-A/Aborigine. 1 PublicationCorresponds to variant dbSNP:rs2234036EnsemblClinVar.	1
Natural variantⁱVAR_007107	247	L → P Polymorphism; CD5; complete thyroxine-binding globulin deficiency. 1 PublicationCorresponds to variant dbSNP:rs28937312EnsemblClinVar.	1
Natural variantⁱVAR_007108	303	L → F Common polymorphism; associated with T-43 in San Diego. 1 PublicationCorresponds to variant dbSNP:rs1804495EnsemblClinVar.	1
Natural variantⁱVAR_007109	351	H → Y Polymorphism; Quebec; partial thyroxine-binding globulin deficiency. 1 PublicationCorresponds to variant dbSNP:rs72554659EnsemblClinVar.	1
Natural variantⁱVAR_007110	383	P → L Polymorphism; Kumamoto; partial thyroxine-binding globulin deficiency. 1 PublicationCorresponds to variant dbSNP:rs72554658EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14091 mRNA Translation: AAA60616.1 X64171 Genomic DNA Translation: CAA45509.1 L13470 Genomic DNA Translation: AAA16067.1 Z83850 Genomic DNA No translation available. CH471120 Genomic DNA Translation: EAX02747.1 CH471120 Genomic DNA Translation: EAX02748.1 BC020747 mRNA Translation: AAH20747.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14518.1
PIRⁱ	A47224
NCBI Reference Sequences More...RefSeqⁱ	NP_000345.2, NM_000354.5
UniGeneⁱ	Hs.76838

Genome annotation databases

Ensemblⁱ	ENST00000327674; ENSP00000329374; ENSG00000123561 ENST00000372563; ENSP00000361644; ENSG00000123561
GeneIDⁱ	6906
KEGGⁱ	hsa:6906
UCSC genome browser More...UCSCⁱ	uc004eme.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P05543	Uncharacterized protein		PANPA		415	UniRef100_P05543
UPI000719A08B		HUMAN		395

Protein	Similar proteins		Species	Score	Length	Source
P05543	Thyroxine-binding globulin		PANTR		415	UniRef90_P05543
Uncharacterized protein		PANPA		415
SERPINA7 isoform 1		PONAB		415
Uncharacterized protein		MACMU		415
Uncharacterized protein		COLAP		415
+35

Protein	Similar proteins		Species	Score	Length	Source
P05543	Thyroxine-binding globulin		PANTR		415	UniRef50_P05543
Thyroxine-binding globulin		BOVIN		411
Thyroxine-binding globulin		SHEEP		412
Thyroxine-binding globulin		PIG		412
Thyroxine-binding globulin		RAT		418
+182

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14091 mRNA Translation: AAA60616.1 X64171 Genomic DNA Translation: CAA45509.1 L13470 Genomic DNA Translation: AAA16067.1 Z83850 Genomic DNA No translation available. CH471120 Genomic DNA Translation: EAX02747.1 CH471120 Genomic DNA Translation: EAX02748.1 BC020747 mRNA Translation: AAH20747.1
CCDSⁱ	CCDS14518.1
PIRⁱ	A47224
RefSeqⁱ	NP_000345.2, NM_000354.5
UniGeneⁱ	Hs.76838

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CEO	X-ray	2.80	A/B	39-415	[»]
	2RIV	X-ray	1.50	A	33-386	[»]
				B	376-415	[»]
	2RIW	X-ray	2.04	A	39-386	[»]
				B	376-415	[»]
	2XN3	X-ray	2.09	A	33-386	[»]
				B	377-415	[»]
	2XN5	X-ray	1.70	A	32-380	[»]
				B	381-415	[»]
	2XN6	X-ray	1.29	A	32-380	[»]
				B	381-415	[»]
	2XN7	X-ray	1.43	A	32-380	[»]
				B	381-415	[»]
	4X30	X-ray	1.55	A	21-415	[»]
	4YIA	X-ray	1.58	A	1-386	[»]
				B	382-415	[»]
ProteinModelPortalⁱ	P05543
SMRⁱ	P05543
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112769, 5 interactors
IntActⁱ	P05543, 1 interactor
STRINGⁱ	9606.ENSP00000329374

Chemistry databases

ChEMBLⁱ	CHEMBL3843
DrugBankⁱ	DB00451 Levothyroxine DB00279 Liothyronine DB01583 Liotrix DB05235 NRP409

Protein family/group databases

MEROPSⁱ	I04.955

MEROPSⁱ

I04.955

PTM databases

GlyConnectⁱ	750
iPTMnetⁱ	P05543
PhosphoSitePlusⁱ	P05543

Polymorphism and mutation databases

BioMutaⁱ	SERPINA7
DMDMⁱ	1351236

Proteomic databases

EPDⁱ	P05543
MaxQBⁱ	P05543
PaxDbⁱ	P05543
PeptideAtlasⁱ	P05543
PRIDEⁱ	P05543
ProteomicsDBⁱ	51845

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6906
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000327674; ENSP00000329374; ENSG00000123561 ENST00000372563; ENSP00000361644; ENSG00000123561
GeneIDⁱ	6906
KEGGⁱ	hsa:6906
UCSCⁱ	uc004eme.3 human

Organism-specific databases

CTDⁱ	6906
DisGeNETⁱ	6906
EuPathDBⁱ	HostDB:ENSG00000123561.14
GeneCardsⁱ	SERPINA7
HGNCⁱ	HGNC:11583 SERPINA7
HPAⁱ	HPA002803
MalaCardsⁱ	SERPINA7
MIMⁱ	300932 phenotype 314200 gene
neXtProtⁱ	NX_P05543
OpenTargetsⁱ	ENSG00000123561
Orphanetⁱ	209893 NON RARE IN EUROPE: Congenital isolated thyroxine-binding globulin deficiency
PharmGKBⁱ	PA36347
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2392 Eukaryota COG4826 LUCA
GeneTreeⁱ	ENSGT00760000118839
HOGENOMⁱ	HOG000238521
HOVERGENⁱ	HBG005957
InParanoidⁱ	P05543
KOⁱ	K20734
OMAⁱ	ELQMGNA
OrthoDBⁱ	EOG091G0ION
PhylomeDBⁱ	P05543
TreeFamⁱ	TF343201

Miscellaneous databases

EvolutionaryTraceⁱ	P05543
GenomeRNAiⁱ	6906
Protein Ontology More...PROⁱ	PR:P05543
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000123561 Expressed in 35 organ(s), highest expression level in liver
CleanExⁱ	HS_SERPINA7
Genevisibleⁱ	P05543 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR023795 Serpin_CS IPR023796 Serpin_dom IPR000215 Serpin_fam IPR036186 Serpin_sf
PANTHERⁱ	PTHR11461 PTHR11461, 1 hit
Pfamⁱ	View protein in Pfam PF00079 Serpin, 1 hit
SMARTⁱ	View protein in SMART SM00093 SERPIN, 1 hit
SUPFAMⁱ	SSF56574 SSF56574, 1 hit
PROSITEⁱ	View protein in PROSITE PS00284 SERPIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	THBG_HUMAN
Accessionⁱ	P05543Primary (citable) accession number: P05543 Secondary accession number(s): D3DUX1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
	Last sequence update:	February 1, 1996
	Last modified:	November 7, 2018
	This is version 194 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P05543 (THBG_HUMAN)

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Thyroxine-binding globulin

SERPINA7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ