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UniProtKB - P05543 (THBG_HUMAN)

Entry version 213 (25 May 2022)
Sequence version 2 (01 Feb 1996)
Previous versions | rss
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Protein

Thyroxine-binding globulin

Gene

SERPINA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major thyroid hormone transport protein in serum.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei293Thyroxine1 Publication1
Binding sitei398Thyroxine1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P05543

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P05543

Protein family/group databases

MEROPS protease database

More...MEROPSi		I04.955

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thyroxine-binding globulin
Alternative name(s):
Serpin A7
T4-binding globulin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SERPINA7
Synonyms:TBG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11583, SERPINA7

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		314200, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P05543

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000123561

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6906

MalaCards human disease database

More...MalaCardsi		SERPINA7
MIMi300932, phenotype

Open Targets

More...OpenTargetsi		ENSG00000123561

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		209893, NON RARE IN EUROPE: Congenital isolated thyroxine-binding globulin deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36347

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P05543, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3843

Drug and drug target database

More...DrugBanki		DB01629, 5-fluorouridine
DB11100, Allantoin
DB00023, Asparaginase Escherichia coli
DB00636, Clofibrate
DB00286, Conjugated estrogens
DB09130, Copper
DB01219, Dantrolene
DB01452, Diamorphine
DB08899, Enzalutamide
DB09381, Esterified estrogens
DB00754, Ethotoin
DB08984, Etofenamate
DB00322, Floxuridine
DB00544, Fluorouracil
DB01320, Fosphenytoin
DB00695, Furosemide
DB01109, Heparin
DB00451, Levothyroxine
DB00279, Liothyronine
DB12425, Liothyronine I-131
DB01583, Liotrix
DB00939, Meclofenamic acid
DB00532, Mephenytoin
DB00648, Mitotane
DB13396, Neocitrullamon
DB00627, Niacin
DB05235, NRP409
DB00059, Pegaspargase
DB00252, Phenytoin
DB09317, Synthetic Conjugated Estrogens, A
DB09318, Synthetic Conjugated Estrogens, B
DB00675, Tamoxifen
DB09256, Tegafur
DB09100, Thyroid, porcine

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SERPINA7

Domain mapping of disease mutations (DMDM)

More...DMDMi		1351236

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 201 PublicationAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003243621 – 415Thyroxine-binding globulinAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi36N-linked (GlcNAc...) (complex) asparagine2 Publications1
Glycosylationi99N-linked (GlcNAc...) asparagine1
Glycosylationi116N-linked (GlcNAc...) asparagine; in variant GaryCurated1
Glycosylationi165N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi253N-linked (GlcNAc...) asparagine1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P05543

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P05543

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P05543

MaxQB - The MaxQuant DataBase

More...MaxQBi		P05543

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P05543

PeptideAtlas

More...PeptideAtlasi		P05543

PRoteomics IDEntifications database

More...PRIDEi		P05543

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51845

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		750, 13 N-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P05543, 5 sites, 17 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P05543

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P05543

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000123561, Expressed in liver and 56 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P05543, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000123561, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112769, 9 interactors

Protein interaction database and analysis system

More...IntActi		P05543, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000329374

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P05543, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1415
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P05543

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P05543

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P05543

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2392, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161113

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_023330_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P05543

Identification of Orthologs from Complete Genome Data

More...OMAi		CFKAQWA

Database of Orthologous Groups

More...OrthoDBi		1124079at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P05543

TreeFam database of animal gene trees

More...TreeFami		TF343201

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.39.10, 1 hit
3.30.497.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR023795, Serpin_CS
IPR023796, Serpin_dom
IPR000215, Serpin_fam
IPR036186, Serpin_sf
IPR042178, Serpin_sf_1
IPR042185, Serpin_sf_2

The PANTHER Classification System

More...PANTHERi		PTHR11461, PTHR11461, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00079, Serpin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00093, SERPIN, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56574, SSF56574, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00284, SERPIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P05543-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPFLYLVLL VLGLHATIHC ASPEGKVTAC HSSQPNATLY KMSSINADFA 
        60         70         80         90        100
FNLYRRFTVE TPDKNIFFSP VSISAALVML SFGACCSTQT EIVETLGFNL 
       110        120        130        140        150
TDTPMVEIQH GFQHLICSLN FPKKELELQI GNALFIGKHL KPLAKFLNDV 
       160        170        180        190        200
KTLYETEVFS TDFSNISAAK QEINSHVEMQ TKGKVVGLIQ DLKPNTIMVL 
       210        220        230        240        250
VNYIHFKAQW ANPFDPSKTE DSSSFLIDKT TTVQVPMMHQ MEQYYHLVDM 
       260        270        280        290        300
ELNCTVLQMD YSKNALALFV LPKEGQMESV EAAMSSKTLK KWNRLLQKGW 
       310        320        330        340        350
VDLFVPKFSI SATYDLGATL LKMGIQHAYS ENADFSGLTE DNGLKLSNAA 
       360        370        380        390        400
HKAVLHIGEK GTEAAAVPEV ELSDQPENTF LHPIIQIDRS FMLLILERST 
       410 
RSILFLGKVV NPTEA
Length:415
Mass (Da):46,325
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B24EF8C7CEF8F0A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30 – 31CH → DS AA sequence (PubMed:414747).Curated2
Sequence conflicti38T → S AA sequence (PubMed:414747).Curated1
Sequence conflicti197I → T in AAA60616 (PubMed:3094014).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variants in SERPINA7 influence the serum levels of thyroxine-binding globulin and define the thyroxine-binding globulin quantitative trait locus (TBGQTL) [MIMi:300932]. Individuals with low or high serum levels of thyroxine-binding globulin show, respectively, reduced or elevated protein-bound iodine but are euthyroid and do not manifest major metabolic alterations (PubMed:1294376, PubMed:1515456, PubMed:1901689, PubMed:1906047, PubMed:2155256, PubMed:2501669). Two qualitative TBG variants occur in particular populations. TBG-A is found in 40% of Australian aborigines, it has reduced affinity for thyroxine and triiodothyroxine and increased susceptibility to inactivation by heat or acid (PubMed:2495303). TBG-S ('s' for slow shift on isoelectic focusing) is found in blacks, Eskimos, Melanesians, Polynesians and Indonesians, but not in Caucasians; TBG-S is slightly more thermolabile (PubMed:2115061).8 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00710243S → T Associated with F-303 in San Diego; partial thyroxine-binding globulin deficiency. 1 PublicationCorresponds to variant dbSNP:rs72554662Ensembl.1
Natural variantiVAR_007103116I → N Gary; severe thyroxine-binding globulin deficiency. 1 PublicationCorresponds to variant dbSNP:rs28933689EnsemblClinVar.1
Natural variantiVAR_007104133A → P Montreal/TBG-M; partial thyroxine-binding globulin deficiency. 1 PublicationCorresponds to variant dbSNP:rs28933688EnsemblClinVar.1
Natural variantiVAR_007105191D → N TBG-S/Slow. 1 PublicationCorresponds to variant dbSNP:rs1050086EnsemblClinVar.1
Natural variantiVAR_007106211A → T TBG-A/Aborigine. 1 PublicationCorresponds to variant dbSNP:rs2234036EnsemblClinVar.1
Natural variantiVAR_007107247L → P CD5; complete thyroxine-binding globulin deficiency. 1 PublicationCorresponds to variant dbSNP:rs28937312EnsemblClinVar.1
Natural variantiVAR_007108303L → F Associated with T-43 in San Diego. 1 PublicationCorresponds to variant dbSNP:rs1804495EnsemblClinVar.1
Natural variantiVAR_007109351H → Y Quebec; partial thyroxine-binding globulin deficiency. 1 PublicationCorresponds to variant dbSNP:rs72554659EnsemblClinVar.1
Natural variantiVAR_007110383P → L Kumamoto; partial thyroxine-binding globulin deficiency. 1 PublicationCorresponds to variant dbSNP:rs72554658EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M14091 mRNA Translation: AAA60616.1
X64171 Genomic DNA Translation: CAA45509.1
L13470 Genomic DNA Translation: AAA16067.1
Z83850 Genomic DNA No translation available.
CH471120 Genomic DNA Translation: EAX02747.1
CH471120 Genomic DNA Translation: EAX02748.1
BC020747 mRNA Translation: AAH20747.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14518.1

Protein sequence database of the Protein Information Resource

More...PIRi		A47224

NCBI Reference Sequences

More...RefSeqi		NP_000345.2, NM_000354.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000327674.8; ENSP00000329374.4; ENSG00000123561.15
ENST00000372563.2; ENSP00000361644.1; ENSG00000123561.15

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6906

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6906

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000372563.2; ENSP00000361644.1; NM_000354.6; NP_000345.2

UCSC genome browser

More...UCSCi		uc004eme.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14091 mRNA Translation: AAA60616.1
X64171 Genomic DNA Translation: CAA45509.1
L13470 Genomic DNA Translation: AAA16067.1
Z83850 Genomic DNA No translation available.
CH471120 Genomic DNA Translation: EAX02747.1
CH471120 Genomic DNA Translation: EAX02748.1
BC020747 mRNA Translation: AAH20747.1
CCDSiCCDS14518.1
PIRiA47224
RefSeqiNP_000345.2, NM_000354.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CEOX-ray2.80A/B39-415[»]
2RIVX-ray1.50A33-386[»]
B376-415[»]
2RIWX-ray2.04A39-386[»]
B376-415[»]
2XN3X-ray2.09A33-386[»]
B377-415[»]
2XN5X-ray1.70A32-380[»]
B381-415[»]
2XN6X-ray1.29A32-380[»]
B381-415[»]
2XN7X-ray1.43A32-380[»]
B381-415[»]
4X30X-ray1.55A21-415[»]
4YIAX-ray1.58A1-386[»]
B382-415[»]
AlphaFoldDBiP05543
SMRiP05543
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112769, 9 interactors
IntActiP05543, 4 interactors
STRINGi9606.ENSP00000329374

Chemistry databases

ChEMBLiCHEMBL3843
DrugBankiDB01629, 5-fluorouridine
DB11100, Allantoin
DB00023, Asparaginase Escherichia coli
DB00636, Clofibrate
DB00286, Conjugated estrogens
DB09130, Copper
DB01219, Dantrolene
DB01452, Diamorphine
DB08899, Enzalutamide
DB09381, Esterified estrogens
DB00754, Ethotoin
DB08984, Etofenamate
DB00322, Floxuridine
DB00544, Fluorouracil
DB01320, Fosphenytoin
DB00695, Furosemide
DB01109, Heparin
DB00451, Levothyroxine
DB00279, Liothyronine
DB12425, Liothyronine I-131
DB01583, Liotrix
DB00939, Meclofenamic acid
DB00532, Mephenytoin
DB00648, Mitotane
DB13396, Neocitrullamon
DB00627, Niacin
DB05235, NRP409
DB00059, Pegaspargase
DB00252, Phenytoin
DB09317, Synthetic Conjugated Estrogens, A
DB09318, Synthetic Conjugated Estrogens, B
DB00675, Tamoxifen
DB09256, Tegafur
DB09100, Thyroid, porcine

Protein family/group databases

MEROPSiI04.955

PTM databases

GlyConnecti750, 13 N-Linked glycans (3 sites)
GlyGeniP05543, 5 sites, 17 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
iPTMnetiP05543
PhosphoSitePlusiP05543

Genetic variation databases

BioMutaiSERPINA7
DMDMi1351236

Proteomic databases

EPDiP05543
jPOSTiP05543
MassIVEiP05543
MaxQBiP05543
PaxDbiP05543
PeptideAtlasiP05543
PRIDEiP05543
ProteomicsDBi51845

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		452, 450 antibodies from 33 providers

The DNASU plasmid repository

More...DNASUi		6906

Genome annotation databases

EnsembliENST00000327674.8; ENSP00000329374.4; ENSG00000123561.15
ENST00000372563.2; ENSP00000361644.1; ENSG00000123561.15
GeneIDi6906
KEGGihsa:6906
MANE-SelectiENST00000372563.2; ENSP00000361644.1; NM_000354.6; NP_000345.2
UCSCiuc004eme.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6906
DisGeNETi6906

GeneCards: human genes, protein and diseases

More...GeneCardsi		SERPINA7
HGNCiHGNC:11583, SERPINA7
HPAiENSG00000123561, Tissue enriched (liver)
MalaCardsiSERPINA7
MIMi300932, phenotype
314200, gene
neXtProtiNX_P05543
OpenTargetsiENSG00000123561
Orphaneti209893, NON RARE IN EUROPE: Congenital isolated thyroxine-binding globulin deficiency
PharmGKBiPA36347
VEuPathDBiHostDB:ENSG00000123561

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2392, Eukaryota
GeneTreeiENSGT00940000161113
HOGENOMiCLU_023330_2_1_1
InParanoidiP05543
OMAiCFKAQWA
OrthoDBi1124079at2759
PhylomeDBiP05543
TreeFamiTF343201

Enzyme and pathway databases

PathwayCommonsiP05543
SignaLinkiP05543

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6906, 11 hits in 688 CRISPR screens
EvolutionaryTraceiP05543

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6906
PharosiP05543, Tbio

Protein Ontology

More...PROi		PR:P05543
RNActiP05543, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000123561, Expressed in liver and 56 other tissues
GenevisibleiP05543, HS

Family and domain databases

Gene3Di2.30.39.10, 1 hit
3.30.497.10, 1 hit
InterProiView protein in InterPro
IPR023795, Serpin_CS
IPR023796, Serpin_dom
IPR000215, Serpin_fam
IPR036186, Serpin_sf
IPR042178, Serpin_sf_1
IPR042185, Serpin_sf_2
PANTHERiPTHR11461, PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079, Serpin, 1 hit
SMARTiView protein in SMART
SM00093, SERPIN, 1 hit
SUPFAMiSSF56574, SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284, SERPIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHBG_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05543
Secondary accession number(s): D3DUX1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: February 1, 1996
Last modified: May 25, 2022
This is version 213 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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