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Protein

HLA class I histocompatibility antigen, A-24 alpha chain

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB
  • peptide antigen binding Source: UniProtKB
  • TAP binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, A-24 alpha chain
Alternative name(s):
Aw-24
HLA class I histocompatibility antigen, A-9 alpha chain
MHC class I antigen A*24
Gene namesi
Name:HLA-A
Synonyms:HLAA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4931 HLA-A
MIMi142800 gene
neXtProtiNX_P05534

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 365CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3105
MalaCardsiHLA-A

Polymorphism and mutation databases

DMDMi32363482

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001881825 – 365HLA class I histocompatibility antigen, A-24 alpha chainAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation1 Publication
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation1 Publication
Modified residuei343PhosphoserineBy similarity1
Modified residuei344PhosphotyrosineBy similarity1
Modified residuei345PhosphoserineBy similarity1
Modified residuei349PhosphoserineBy similarity1
Modified residuei350PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP05534
MaxQBiP05534
PeptideAtlasiP05534
PRIDEiP05534

PTM databases

GlyConnecti1316
iPTMnetiP05534
SwissPalmiP05534

Expressioni

Gene expression databases

CleanExiHS_HLA-A

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP05534, 5 interactors

Structurei

Secondary structure

1365
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP05534
SMRiP05534
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05534

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709
PhylomeDBiP05534

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 47 potential isoforms that are computationally mapped.Show allAlign All

P05534-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDEETGK VKAHSQTDRE
110 120 130 140 150
NLRIALRYYN QSEAGSHTLQ MMFGCDVGSD GRFLRGYHQY AYDGKDYIAL
160 170 180 190 200
KEDLRSWTAA DMAAQITKRK WEAAHVAEQQ RAYLEGTCVD GLRRYLENGK
210 220 230 240 250
ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQPTVPIVG IIAGLVLLGA VITGAVVAAV MWRRNSSDRK GGSYSQAASS
360
DSAQGSDVSL TACKV
Length:365
Mass (Da):40,689
Last modified:June 27, 2003 - v2
Checksum:iD33684D126F98EC3
GO

Computationally mapped potential isoform sequencesi

There are 47 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P018921A02_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:
P304431A01_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:
P018911A68_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:
P044391A03_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:
P137461A11_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:
P161881A30_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:
P304501A26_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:
P103141A32_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:
P304531A34_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:
P304591A74_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:
There are more potential isoformsShow all

Polymorphismi

The following alleles of A-24 are known: A*24:01, A*24:02, A*24:03, A*24:06, A*24:08 (A9HH), A*24:10 (A*24JV), A*24:13 (A*24YM), A*24:14 (A*24SA) and A*24:29. Allele A*24:02 is represented in all major racial groups. Allele A*24:06 and allele A*24:13 are found in the Australian Aboriginal population. Allele A*24:14 is found in individuals of South American descent. The sequence shown is that of A*24:02.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0043545A → G in allele A*24:01. 1 Publication1
Natural variantiVAR_00435527H → Q in allele A*24:08. 1 PublicationCorresponds to variant dbSNP:rs41541319Ensembl.1
Natural variantiVAR_00435686E → G in allele A*24:08. 1 Publication1
Natural variantiVAR_00435789G → R in allele A*24:08 and allele A*24:29. 2 Publications1
Natural variantiVAR_015765119L → V in allele A*24:14. 1 Publication1
Natural variantiVAR_015766121M → R in allele A*24:14. 1 Publication1
Natural variantiVAR_015767123F → Y in allele A*24:14. 1 Publication1
Natural variantiVAR_015768131G → W in allele A*24:14. 1 Publication1
Natural variantiVAR_015769180Q → L in allele A*24:13. 1 Publication1
Natural variantiVAR_004358180Q → W in allele A*24:06; requires 2 nucleotide substitutions. Combined sources1 Publication1
Natural variantiVAR_015770187T → R in allele A*24:10. 1 Publication1
Natural variantiVAR_004359190 – 191DG → EW in allele A*24:03 and allele A*24:10. 2 Publications2
Natural variantiVAR_056263205R → H. Corresponds to variant dbSNP:rs17185861Ensembl.1
Natural variantiVAR_004360206T → A in allele A*24:01. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15497 Genomic DNA Translation: AAA59611.1
M64740 mRNA Translation: AAA59600.1
M64741 Genomic DNA Translation: AAA59601.1
Z72422 Genomic DNA Translation: CAA96532.1
D83516 mRNA Translation: BAA11936.1
U37111, U37110 Genomic DNA Translation: AAA83264.1
U37113, U37112 Genomic DNA Translation: AAA83265.1
AH004915 Genomic DNA Translation: AAB40048.1
AH005378 Genomic DNA Translation: AAB60651.1
PIRiI54416
UniGeneiHs.181244
Hs.713441

Genome annotation databases

EnsembliENST00000431930; ENSP00000406366; ENSG00000229215
ENST00000443552; ENSP00000404678; ENSG00000224320

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15497 Genomic DNA Translation: AAA59611.1
M64740 mRNA Translation: AAA59600.1
M64741 Genomic DNA Translation: AAA59601.1
Z72422 Genomic DNA Translation: CAA96532.1
D83516 mRNA Translation: BAA11936.1
U37111, U37110 Genomic DNA Translation: AAA83264.1
U37113, U37112 Genomic DNA Translation: AAA83265.1
AH004915 Genomic DNA Translation: AAB40048.1
AH005378 Genomic DNA Translation: AAB60651.1
PIRiI54416
UniGeneiHs.181244
Hs.713441

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BCKX-ray2.80A/D25-300[»]
3I6LX-ray2.40D25-298[»]
3NFNX-ray2.39A25-298[»]
3QZWX-ray2.80A/D25-298[»]
3VXMX-ray2.50A25-298[»]
3VXNX-ray1.95A25-298[»]
3VXOX-ray2.61A/D25-298[»]
3VXPX-ray2.50A/D25-298[»]
3VXRX-ray2.40A25-298[»]
3VXSX-ray1.80A25-298[»]
3VXUX-ray2.70A/F25-298[»]
3W0WX-ray2.60A25-298[»]
3WL9X-ray1.66A25-298[»]
3WLBX-ray2.00A25-298[»]
4F7MX-ray2.40A/D25-298[»]
4F7PX-ray1.90A25-298[»]
4F7TX-ray1.70A/D25-298[»]
4WU5X-ray2.40A/D25-298[»]
4WU7X-ray2.30A/D25-298[»]
5HGAX-ray2.20A/D25-298[»]
5HGBX-ray2.40A/D/G/J25-298[»]
5HGDX-ray2.07A/D25-298[»]
5HGHX-ray2.39A25-298[»]
5WWIX-ray3.19A25-298[»]
5WWJX-ray2.29A/C25-298[»]
5WWUX-ray2.79A25-298[»]
5WXCX-ray2.29A/C25-298[»]
5WXDX-ray3.29A25-298[»]
5XOVX-ray2.68A/D25-298[»]
ProteinModelPortaliP05534
SMRiP05534
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP05534, 5 interactors

PTM databases

GlyConnecti1316
iPTMnetiP05534
SwissPalmiP05534

Polymorphism and mutation databases

DMDMi32363482

Proteomic databases

EPDiP05534
MaxQBiP05534
PeptideAtlasiP05534
PRIDEiP05534

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000431930; ENSP00000406366; ENSG00000229215
ENST00000443552; ENSP00000404678; ENSG00000224320

Organism-specific databases

DisGeNETi3105
GeneCardsiHLA-A
H-InvDBiHIX0165910
HIX0165954
HIX0166079
HIX0166152
HIX0166432
HIX0166685
HIX0166954
HGNCiHGNC:4931 HLA-A
MalaCardsiHLA-A
MIMi142800 gene
neXtProtiNX_P05534
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG016709
PhylomeDBiP05534

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

ChiTaRSiHLA-A human
EvolutionaryTraceiP05534
SOURCEiSearch...

Gene expression databases

CleanExiHS_HLA-A

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei1A24_HUMAN
AccessioniPrimary (citable) accession number: P05534
Secondary accession number(s): P30448
, P30449, Q29908, Q29909, Q29910, Q95355
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: June 27, 2003
Last modified: October 10, 2018
This is version 179 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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