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Protein

Lymphocyte antigen 6A-2/6E-1

Gene

Ly6a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

T-cell activation.

GO - Biological processi

  • response to bacterium Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte antigen 6A-2/6E-1
Short name:
Ly-6A.2/Ly-6E.1
Alternative name(s):
Stem cell antigen 1
Short name:
SCA-1
T-cell-activating protein
Short name:
TAP
Gene namesi
Name:Ly6a
Synonyms:Ly6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:107527 Ly6a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000003613027 – 112Lymphocyte antigen 6A-2/6E-1Add BLAST86
PropeptideiPRO_0000036131113 – 134Removed in mature formSequence analysisAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 53By similarity
Disulfide bondi32 ↔ 41By similarity
Disulfide bondi46 ↔ 74By similarity
Disulfide bondi78 ↔ 98By similarity
Disulfide bondi99 ↔ 104By similarity
Lipidationi112GPI-anchor amidated glycineSequence analysis1

Post-translational modificationi

O-glycosylated. Not N-glycosylated.1 Publication
Not phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiP05533
MaxQBiP05533
PaxDbiP05533
PeptideAtlasiP05533
PRIDEiP05533

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

BgeeiENSMUSG00000075602 Expressed in 271 organ(s), highest expression level in decidua
CleanExiMM_LY6A
ExpressionAtlasiP05533 baseline and differential
GenevisibleiP05533 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Tgfbr1Q647292EBI-11600492,EBI-2899393

Protein-protein interaction databases

DIPiDIP-59628N
IntActiP05533, 2 interactors
STRINGi10090.ENSMUSP00000023248

Structurei

3D structure databases

ProteinModelPortaliP05533
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 119UPAR/Ly6Add BLAST93

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JI0Q Eukaryota
ENOG41117PH LUCA
GeneTreeiENSGT00730000111651
HOGENOMiHOG000035114
HOVERGENiHBG001716
InParanoidiP05533
KOiK06846
OMAiCKEAKET
OrthoDBiEOG091G12TM
PhylomeDBiP05533
TreeFamiTF337757

Family and domain databases

InterProiView protein in InterPro
IPR018363 CD59_antigen_CS
IPR016054 LY6_UPA_recep-like
PfamiView protein in Pfam
PF00021 UPAR_LY6, 1 hit
SMARTiView protein in SMART
SM00134 LU, 1 hit
PROSITEiView protein in PROSITE
PS00983 LY6_UPAR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P05533-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTSHTTKSC LLILLVALLC AERAQGLECY QCYGVPFETS CPSITCPYPD
60 70 80 90 100
GVCVTQEAAV IVDSQTRKVK NNLCLPICPP NIESMEILGT KVNVKTSCCQ
110 120 130
EDLCNVAVPN GGSTWTMAGV LLFSLSSVLL QTLL
Length:134
Mass (Da):14,377
Last modified:November 1, 1988 - v1
Checksum:i883C771EB3430315
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WNT7A0A087WNT7_MOUSE
Lymphocyte antigen 6A-2/6E-1
Ly6a
35Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32C → S in BAC36250 (PubMed:16141072).Curated1
Sequence conflicti56Q → H in BAC36250 (PubMed:16141072).Curated1
Sequence conflicti59A → T in BAC36250 (PubMed:16141072).Curated1
Sequence conflicti101E → Q in BAC36250 (PubMed:16141072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti63D → G in Ly-6E.1. 1
Natural varianti106V → A in Ly-6E.1. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18184 mRNA Translation: AAA39463.1
J03636 mRNA Translation: AAA40163.1
X04653 mRNA Translation: CAA28351.1
M37707 Genomic DNA Translation: AAA39467.1
M74013 Genomic DNA Translation: AAA39464.1
M73552 Genomic DNA Translation: AAA39465.1
M59713 Genomic DNA Translation: AAA40164.1
AK076200 mRNA Translation: BAC36250.1
BC002070 mRNA Translation: AAH02070.1
CCDSiCCDS27540.1
PIRiA25708
A35921 A32506
RefSeqiNP_001258345.1, NM_001271416.1
NP_001258346.1, NM_001271417.1
NP_001258347.1, NM_001271418.1
NP_001258348.1, NM_001271419.1
NP_001258375.1, NM_001271446.1
NP_034868.1, NM_010738.3
UniGeneiMm.425949

Genome annotation databases

EnsembliENSMUST00000023248; ENSMUSP00000023248; ENSMUSG00000075602
ENSMUST00000186526; ENSMUSP00000140998; ENSMUSG00000075602
ENSMUST00000187171; ENSMUSP00000140099; ENSMUSG00000075602
ENSMUST00000187994; ENSMUSP00000140287; ENSMUSG00000075602
ENSMUST00000189068; ENSMUSP00000140638; ENSMUSG00000075602
GeneIDi110454
KEGGimmu:110454
UCSCiuc007wgk.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18184 mRNA Translation: AAA39463.1
J03636 mRNA Translation: AAA40163.1
X04653 mRNA Translation: CAA28351.1
M37707 Genomic DNA Translation: AAA39467.1
M74013 Genomic DNA Translation: AAA39464.1
M73552 Genomic DNA Translation: AAA39465.1
M59713 Genomic DNA Translation: AAA40164.1
AK076200 mRNA Translation: BAC36250.1
BC002070 mRNA Translation: AAH02070.1
CCDSiCCDS27540.1
PIRiA25708
A35921 A32506
RefSeqiNP_001258345.1, NM_001271416.1
NP_001258346.1, NM_001271417.1
NP_001258347.1, NM_001271418.1
NP_001258348.1, NM_001271419.1
NP_001258375.1, NM_001271446.1
NP_034868.1, NM_010738.3
UniGeneiMm.425949

3D structure databases

ProteinModelPortaliP05533
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59628N
IntActiP05533, 2 interactors
STRINGi10090.ENSMUSP00000023248

Proteomic databases

EPDiP05533
MaxQBiP05533
PaxDbiP05533
PeptideAtlasiP05533
PRIDEiP05533

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023248; ENSMUSP00000023248; ENSMUSG00000075602
ENSMUST00000186526; ENSMUSP00000140998; ENSMUSG00000075602
ENSMUST00000187171; ENSMUSP00000140099; ENSMUSG00000075602
ENSMUST00000187994; ENSMUSP00000140287; ENSMUSG00000075602
ENSMUST00000189068; ENSMUSP00000140638; ENSMUSG00000075602
GeneIDi110454
KEGGimmu:110454
UCSCiuc007wgk.2 mouse

Organism-specific databases

CTDi110454
MGIiMGI:107527 Ly6a

Phylogenomic databases

eggNOGiENOG410JI0Q Eukaryota
ENOG41117PH LUCA
GeneTreeiENSGT00730000111651
HOGENOMiHOG000035114
HOVERGENiHBG001716
InParanoidiP05533
KOiK06846
OMAiCKEAKET
OrthoDBiEOG091G12TM
PhylomeDBiP05533
TreeFamiTF337757

Miscellaneous databases

ChiTaRSiLy6a mouse
PROiPR:P05533
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000075602 Expressed in 271 organ(s), highest expression level in decidua
CleanExiMM_LY6A
ExpressionAtlasiP05533 baseline and differential
GenevisibleiP05533 MM

Family and domain databases

InterProiView protein in InterPro
IPR018363 CD59_antigen_CS
IPR016054 LY6_UPA_recep-like
PfamiView protein in Pfam
PF00021 UPAR_LY6, 1 hit
SMARTiView protein in SMART
SM00134 LU, 1 hit
PROSITEiView protein in PROSITE
PS00983 LY6_UPAR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLY6A_MOUSE
AccessioniPrimary (citable) accession number: P05533
Secondary accession number(s): Q8BPD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: September 12, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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