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Protein

Fibroblast growth factor 3

Gene

Fgf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Mitogen
Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 3
Short name:
FGF-3
Alternative name(s):
Heparin-binding growth factor 3
Short name:
HBGF-3
Proto-oncogene Int-2
Gene namesi
Name:Fgf3
Synonyms:Fgf-3, Int-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95517 Fgf3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi65N → Q: Not glycosylated. 1 Publication1

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000023878418 – 245Fibroblast growth factor 3Add BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...) asparagine1

Post-translational modificationi

Glycosylated.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP05524
PRIDEiP05524

PTM databases

iPTMnetiP05524
PhosphoSitePlusiP05524

Expressioni

Inductioni

By integration of mouse mammary tumor virus.

Gene expression databases

CleanExiMM_FGF3

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101518

Structurei

3D structure databases

ProteinModelPortaliP05524
SMRiP05524
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiP05524
PhylomeDBiP05524

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028232 FGF3
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF26 PTHR11486:SF26, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: P05524-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLIWLLLLS LLEPSWPTTG PGTRLRRDAG GRGGVYEHLG GAPRRRKLYC
60 70 80 90 100
ATKYHLQLHP SGRVNGSLEN SAYSILEITA VEVGVVAIKG LFSGRYLAMN
110 120 130 140 150
KRGRLYASDH YNAECEFVER IHELGYNTYA SRLYRTGSSG PGAQRQPGAQ
160 170 180 190 200
RPWYVSVNGK GRPRRGFKTR RTQKSSLFLP RVLGHKDHEM VRLLQSSQPR
210 220 230 240
APGEGSQPRQ RRQKKQSPGD HGKMETLSTR ATPSTQLHTG GLAVA
Length:245
Mass (Da):27,214
Last modified:May 30, 2006 - v3
Checksum:i70D94FD6A7837C79
GO
Isoform 1 (identifier: P05524-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MARGRVLPAPRLRETRAGAAAAAGGRDAG

Note: Starts at an alternative CUG codon.
Show »
Length:273
Mass (Da):29,941
Checksum:i263A041EF2853421
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q0VG15Q0VG15_MOUSE
Fibroblast growth factor
Fgf3 mCG_21250
245Annotation score:
D3YWD4D3YWD4_MOUSE
Fibroblast growth factor
Fgf3
156Annotation score:

Sequence cautioni

The sequence CAA68767 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0187271M → MARGRVLPAPRLRETRAGAA AAAGGRDAG in isoform 1. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52014 mRNA Translation: CAA36261.1
Y00848 Genomic DNA Translation: CAA68767.1 Different initiation.
CCDSiCCDS22051.1 [P05524-1]
PIRiA23930 TVMST2
UniGeneiMm.4947

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52014 mRNA Translation: CAA36261.1
Y00848 Genomic DNA Translation: CAA68767.1 Different initiation.
CCDSiCCDS22051.1 [P05524-1]
PIRiA23930 TVMST2
UniGeneiMm.4947

3D structure databases

ProteinModelPortaliP05524
SMRiP05524
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101518

PTM databases

iPTMnetiP05524
PhosphoSitePlusiP05524

Proteomic databases

PaxDbiP05524
PRIDEiP05524

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95517 Fgf3

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiP05524
PhylomeDBiP05524

Miscellaneous databases

PROiPR:P05524
SOURCEiSearch...

Gene expression databases

CleanExiMM_FGF3

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028232 FGF3
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF26 PTHR11486:SF26, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGF3_MOUSE
AccessioniPrimary (citable) accession number: P05524
Secondary accession number(s): Q61736
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: May 30, 2006
Last modified: October 25, 2017
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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