UniProtKB - P05496 (AT5G1_HUMAN)
ATP synthase F(0) complex subunit C1, mitochondrial
ATP5MC1
Functioni
Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
Miscellaneous
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 119 | Reversibly protonated during proton transportBy similarity | 1 |
GO - Molecular functioni
- lipid binding Source: UniProtKB-KW
- proton transmembrane transporter activity Source: InterPro
GO - Biological processi
- ATP synthesis coupled proton transport Source: GO_Central
Keywordsi
Biological process | Hydrogen ion transport, Ion transport, Transport |
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | P05496 |
Reactomei | R-HSA-1268020, Mitochondrial protein import R-HSA-163210, Formation of ATP by chemiosmotic coupling R-HSA-8949613, Cristae formation |
SignaLinki | P05496 |
SIGNORi | P05496 |
Protein family/group databases
TCDBi | 3.A.2.1.15, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: ATP synthase F(0) complex subunit C1, mitochondrialCuratedAlternative name(s): ATP synthase lipid-binding protein ATP synthase membrane subunit c locus 1Imported ATP synthase proteolipid P1 ATP synthase proton-transporting mitochondrial F(0) complex subunit C1 ATPase protein 9 ATPase subunit c |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:841, ATP5MC1 |
MIMi | 603192, gene |
neXtProti | NX_P05496 |
VEuPathDBi | HostDB:ENSG00000159199 |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrial proton-transporting ATP synthase complex Source: UniProtKB
- mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Source: GO_Central
- mitochondrion Source: LIFEdb
Other locations
- integral component of membrane Source: UniProtKB-KW
- proton-transporting ATP synthase complex, coupling factor F(o) Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 77 – 97 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 112 – 132 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
CF(0), Membrane, MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 516 |
OpenTargetsi | ENSG00000159199 |
PharmGKBi | PA25131 |
Miscellaneous databases
Pharosi | P05496, Tbio |
Genetic variation databases
BioMutai | ATP5G1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 61 | MitochondrionAdd BLAST | 61 | |
ChainiPRO_0000002557 | 62 – 136 | ATP synthase F(0) complex subunit C1, mitochondrialAdd BLAST | 75 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 104 | N6,N6,N6-trimethyllysine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
MethylationProteomic databases
EPDi | P05496 |
jPOSTi | P05496 |
MassIVEi | P05496 |
PaxDbi | P05496 |
PeptideAtlasi | P05496 |
PRIDEi | P05496 |
ProteomicsDBi | 51842 |
TopDownProteomicsi | P05496 |
PTM databases
iPTMneti | P05496 |
PhosphoSitePlusi | P05496 |
Expressioni
Gene expression databases
Bgeei | ENSG00000159199, Expressed in heart and 235 other tissues |
ExpressionAtlasi | P05496, baseline and differential |
Genevisiblei | P05496, HS |
Organism-specific databases
HPAi | ENSG00000159199, Tissue enhanced (skeletal muscle, tongue) |
Interactioni
Subunit structurei
Homooligomer (PubMed:31652072). F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.
Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).
Interacts with TMEM70 (homooligomer form); this interaction facilitates the oligomer formation of subunit c/ATP5MC1 (c-ring) and the c-ring membrane insertion and also protects ATP5MC1 against intramitochondrial proteolysis (PubMed:31652072).
By similarity1 PublicationBinary interactionsi
P05496
With | #Exp. | IntAct |
---|---|---|
ACTN2 [P35609] | 3 | EBI-10194585,EBI-77797 |
TRIM69 [Q86WT6] | 4 | EBI-10194585,EBI-749955 |
TRIM69 - isoform 2 [Q86WT6-2] | 3 | EBI-10194585,EBI-11525489 |
Protein-protein interaction databases
BioGRIDi | 107001, 32 interactors |
ComplexPortali | CPX-6151, Mitochondrial proton-transporting ATP synthase complex |
CORUMi | P05496 |
IntActi | P05496, 9 interactors |
STRINGi | 9606.ENSP00000377033 |
Miscellaneous databases
RNActi | P05496, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptide, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3025, Eukaryota |
GeneTreei | ENSGT00940000154298 |
InParanoidi | P05496 |
OMAi | MDPQAAK |
OrthoDBi | 1564365at2759 |
PhylomeDBi | P05496 |
TreeFami | TF300140 |
Family and domain databases
Gene3Di | 1.20.20.10, 1 hit |
HAMAPi | MF_01396, ATP_synth_c_bact, 1 hit |
InterProi | View protein in InterPro IPR000454, ATP_synth_F0_csu IPR020537, ATP_synth_F0_csu_DDCD_BS IPR038662, ATP_synth_F0_csu_sf IPR002379, ATPase_proteolipid_c-like_dom IPR035921, F/V-ATP_Csub_sf |
PANTHERi | PTHR10031, PTHR10031, 1 hit |
Pfami | View protein in Pfam PF00137, ATP-synt_C, 1 hit |
PRINTSi | PR00124, ATPASEC |
SUPFAMi | SSF81333, SSF81333, 1 hit |
PROSITEi | View protein in PROSITE PS00605, ATPASE_C, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MQTAGALFIS PALIRCCTRG LIRPVSASFL NSPVNSSKQP SYSNFPLQVA
60 70 80 90 100
RREFQTSVVS RDIDTAAKFI GAGAATVGVA GSGAGIGTVF GSLIIGYARN
110 120 130
PSLKQQLFSY AILGFALSEA MGLFCLMVAF LILFAM
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EQ97 | E7EQ97_HUMAN | ATP synthase lipid-binding protein | ATP5MC1 | 110 | Annotation score: | ||
E7EPU7 | E7EPU7_HUMAN | ATP synthase lipid-binding protein | ATP5MC1 | 127 | Annotation score: | ||
D6R9H7 | D6R9H7_HUMAN | ATP synthase F(0) complex subunit C... | ATP5MC1 | 99 | Annotation score: | ||
I3L0Y5 | I3L0Y5_HUMAN | ATP synthase F(0) complex subunit C... | ATP5MC1 | 98 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 53 | E → G in AAA51806 (PubMed:2883974).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69907 Genomic DNA Translation: CAA49532.1 D13118 mRNA Translation: BAA02420.1 AL080089 mRNA Translation: CAB45704.1 BT007230 mRNA Translation: AAP35894.1 BC004963 mRNA Translation: AAH04963.1 M16453 mRNA Translation: AAA51806.1 |
CCDSi | CCDS11539.1 |
PIRi | S34066 |
RefSeqi | NP_001002027.1, NM_001002027.1 NP_005166.1, NM_005175.2 |
Genome annotation databases
Ensembli | ENST00000355938; ENSP00000348205; ENSG00000159199 ENST00000393366; ENSP00000377033; ENSG00000159199 |
GeneIDi | 516 |
KEGGi | hsa:516 |
MANE-Selecti | ENST00000393366.7; ENSP00000377033.2; NM_005175.3; NP_005166.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X69907 Genomic DNA Translation: CAA49532.1 D13118 mRNA Translation: BAA02420.1 AL080089 mRNA Translation: CAB45704.1 BT007230 mRNA Translation: AAP35894.1 BC004963 mRNA Translation: AAH04963.1 M16453 mRNA Translation: AAA51806.1 |
CCDSi | CCDS11539.1 |
PIRi | S34066 |
RefSeqi | NP_001002027.1, NM_001002027.1 NP_005166.1, NM_005175.2 |
3D structure databases
SMRi | P05496 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107001, 32 interactors |
ComplexPortali | CPX-6151, Mitochondrial proton-transporting ATP synthase complex |
CORUMi | P05496 |
IntActi | P05496, 9 interactors |
STRINGi | 9606.ENSP00000377033 |
Protein family/group databases
TCDBi | 3.A.2.1.15, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily |
PTM databases
iPTMneti | P05496 |
PhosphoSitePlusi | P05496 |
Genetic variation databases
BioMutai | ATP5G1 |
Proteomic databases
EPDi | P05496 |
jPOSTi | P05496 |
MassIVEi | P05496 |
PaxDbi | P05496 |
PeptideAtlasi | P05496 |
PRIDEi | P05496 |
ProteomicsDBi | 51842 |
TopDownProteomicsi | P05496 |
Protocols and materials databases
Antibodypediai | 30318, 128 antibodies from 29 providers |
DNASUi | 516 |
Genome annotation databases
Ensembli | ENST00000355938; ENSP00000348205; ENSG00000159199 ENST00000393366; ENSP00000377033; ENSG00000159199 |
GeneIDi | 516 |
KEGGi | hsa:516 |
MANE-Selecti | ENST00000393366.7; ENSP00000377033.2; NM_005175.3; NP_005166.1 |
Organism-specific databases
CTDi | 516 |
DisGeNETi | 516 |
GeneCardsi | ATP5MC1 |
HGNCi | HGNC:841, ATP5MC1 |
HPAi | ENSG00000159199, Tissue enhanced (skeletal muscle, tongue) |
MIMi | 603192, gene |
neXtProti | NX_P05496 |
OpenTargetsi | ENSG00000159199 |
PharmGKBi | PA25131 |
VEuPathDBi | HostDB:ENSG00000159199 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3025, Eukaryota |
GeneTreei | ENSGT00940000154298 |
InParanoidi | P05496 |
OMAi | MDPQAAK |
OrthoDBi | 1564365at2759 |
PhylomeDBi | P05496 |
TreeFami | TF300140 |
Enzyme and pathway databases
PathwayCommonsi | P05496 |
Reactomei | R-HSA-1268020, Mitochondrial protein import R-HSA-163210, Formation of ATP by chemiosmotic coupling R-HSA-8949613, Cristae formation |
SignaLinki | P05496 |
SIGNORi | P05496 |
Miscellaneous databases
BioGRID-ORCSi | 516, 63 hits in 1039 CRISPR screens |
ChiTaRSi | ATP5G1, human |
GeneWikii | ATP5G1 |
GenomeRNAii | 516 |
Pharosi | P05496, Tbio |
PROi | PR:P05496 |
RNActi | P05496, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000159199, Expressed in heart and 235 other tissues |
ExpressionAtlasi | P05496, baseline and differential |
Genevisiblei | P05496, HS |
Family and domain databases
Gene3Di | 1.20.20.10, 1 hit |
HAMAPi | MF_01396, ATP_synth_c_bact, 1 hit |
InterProi | View protein in InterPro IPR000454, ATP_synth_F0_csu IPR020537, ATP_synth_F0_csu_DDCD_BS IPR038662, ATP_synth_F0_csu_sf IPR002379, ATPase_proteolipid_c-like_dom IPR035921, F/V-ATP_Csub_sf |
PANTHERi | PTHR10031, PTHR10031, 1 hit |
Pfami | View protein in Pfam PF00137, ATP-synt_C, 1 hit |
PRINTSi | PR00124, ATPASEC |
SUPFAMi | SSF81333, SSF81333, 1 hit |
PROSITEi | View protein in PROSITE PS00605, ATPASE_C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AT5G1_HUMAN | |
Accessioni | P05496Primary (citable) accession number: P05496 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | February 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 201 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families