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UniProtKB - P05496 (AT5G1_HUMAN)

Entry version 202 (25 May 2022)
Sequence version 2 (01 Feb 1994)
Previous versions | rss
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Protein

ATP synthase F(0) complex subunit C1, mitochondrial

Gene

ATP5MC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Miscellaneous

There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei119Reversibly protonated during proton transportBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport
LigandLipid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P05496

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1268020, Mitochondrial protein import
R-HSA-163210, Formation of ATP by chemiosmotic coupling
R-HSA-8949613, Cristae formation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P05496

SIGNOR Signaling Network Open Resource

More...SIGNORi		P05496

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.2.1.15, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP synthase F(0) complex subunit C1, mitochondrialCurated
Alternative name(s):
ATP synthase lipid-binding protein
ATP synthase membrane subunit c locus 1Imported
ATP synthase proteolipid P1
ATP synthase proton-transporting mitochondrial F(0) complex subunit C1
ATPase protein 9
ATPase subunit c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP5MC1Imported
Synonyms:ATP5G1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:841, ATP5MC1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603192, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P05496

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000159199

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		516

Open Targets

More...OpenTargetsi		ENSG00000159199

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25131

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P05496, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ATP5G1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 61MitochondrionAdd BLAST61
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000255762 – 136ATP synthase F(0) complex subunit C1, mitochondrialAdd BLAST75

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei104N6,N6,N6-trimethyllysine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Trimethylated by ATPSCKMT at Lys-104. Methylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration.1 Publication

Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P05496

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P05496

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P05496

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P05496

PeptideAtlas

More...PeptideAtlasi		P05496

PRoteomics IDEntifications database

More...PRIDEi		P05496

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51842

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P05496

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P05496

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P05496

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000159199, Expressed in heart and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P05496, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P05496, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000159199, Tissue enhanced (skeletal muscle, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer (PubMed:31652072). F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).

Interacts with TMEM70 (homooligomer form); this interaction facilitates the oligomer formation of subunit c/ATP5MC1 (c-ring) and the c-ring membrane insertion and also protects ATP5MC1 against intramitochondrial proteolysis (PubMed:31652072).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107001, 37 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6151, Mitochondrial proton-transporting ATP synthase complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P05496

Protein interaction database and analysis system

More...IntActi		P05496, 10 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000377033

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P05496, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P05496

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P05496

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATPase C chain family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3025, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154298

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P05496

Identification of Orthologs from Complete Genome Data

More...OMAi		CMGFCIL

Database of Orthologous Groups

More...OrthoDBi		1564365at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P05496

TreeFam database of animal gene trees

More...TreeFami		TF300140

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.20.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_01396, ATP_synth_c_bact, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000454, ATP_synth_F0_csu
IPR020537, ATP_synth_F0_csu_DDCD_BS
IPR038662, ATP_synth_F0_csu_sf
IPR002379, ATPase_proteolipid_c-like_dom
IPR035921, F/V-ATP_Csub_sf

The PANTHER Classification System

More...PANTHERi		PTHR10031, PTHR10031, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00137, ATP-synt_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00124, ATPASEC

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF81333, SSF81333, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00605, ATPASE_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P05496-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQTAGALFIS PALIRCCTRG LIRPVSASFL NSPVNSSKQP SYSNFPLQVA 
        60         70         80         90        100
RREFQTSVVS RDIDTAAKFI GAGAATVGVA GSGAGIGTVF GSLIIGYARN 
       110        120        130 
PSLKQQLFSY AILGFALSEA MGLFCLMVAF LILFAM
Length:136
Mass (Da):14,277
Last modified:February 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1AFF1F16BB532647
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EQ97E7EQ97_HUMAN
ATP synthase lipid-binding protein
ATP5MC1
110Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPU7E7EPU7_HUMAN
ATP synthase lipid-binding protein
ATP5MC1
127Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9H7D6R9H7_HUMAN
ATP synthase F(0) complex subunit C...
ATP5MC1
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L0Y5I3L0Y5_HUMAN
ATP synthase F(0) complex subunit C...
ATP5MC1
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53E → G in AAA51806 (PubMed:2883974).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X69907 Genomic DNA Translation: CAA49532.1
D13118 mRNA Translation: BAA02420.1
AL080089 mRNA Translation: CAB45704.1
BT007230 mRNA Translation: AAP35894.1
BC004963 mRNA Translation: AAH04963.1
M16453 mRNA Translation: AAA51806.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11539.1

Protein sequence database of the Protein Information Resource

More...PIRi		S34066

NCBI Reference Sequences

More...RefSeqi		NP_001002027.1, NM_001002027.1
NP_005166.1, NM_005175.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355938.9; ENSP00000348205.5; ENSG00000159199.14
ENST00000393366.7; ENSP00000377033.2; ENSG00000159199.14

Database of genes from NCBI RefSeq genomes

More...GeneIDi		516

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:516

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000393366.7; ENSP00000377033.2; NM_005175.3; NP_005166.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69907 Genomic DNA Translation: CAA49532.1
D13118 mRNA Translation: BAA02420.1
AL080089 mRNA Translation: CAB45704.1
BT007230 mRNA Translation: AAP35894.1
BC004963 mRNA Translation: AAH04963.1
M16453 mRNA Translation: AAA51806.1
CCDSiCCDS11539.1
PIRiS34066
RefSeqiNP_001002027.1, NM_001002027.1
NP_005166.1, NM_005175.2

3D structure databases

AlphaFoldDBiP05496
SMRiP05496
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi107001, 37 interactors
ComplexPortaliCPX-6151, Mitochondrial proton-transporting ATP synthase complex
CORUMiP05496
IntActiP05496, 10 interactors
STRINGi9606.ENSP00000377033

Protein family/group databases

TCDBi3.A.2.1.15, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

PTM databases

iPTMnetiP05496
PhosphoSitePlusiP05496

Genetic variation databases

BioMutaiATP5G1

Proteomic databases

EPDiP05496
jPOSTiP05496
MassIVEiP05496
PaxDbiP05496
PeptideAtlasiP05496
PRIDEiP05496
ProteomicsDBi51842
TopDownProteomicsiP05496

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30318, 128 antibodies from 29 providers

The DNASU plasmid repository

More...DNASUi		516

Genome annotation databases

EnsembliENST00000355938.9; ENSP00000348205.5; ENSG00000159199.14
ENST00000393366.7; ENSP00000377033.2; ENSG00000159199.14
GeneIDi516
KEGGihsa:516
MANE-SelectiENST00000393366.7; ENSP00000377033.2; NM_005175.3; NP_005166.1

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		516
DisGeNETi516

GeneCards: human genes, protein and diseases

More...GeneCardsi		ATP5MC1
HGNCiHGNC:841, ATP5MC1
HPAiENSG00000159199, Tissue enhanced (skeletal muscle, tongue)
MIMi603192, gene
neXtProtiNX_P05496
OpenTargetsiENSG00000159199
PharmGKBiPA25131
VEuPathDBiHostDB:ENSG00000159199

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3025, Eukaryota
GeneTreeiENSGT00940000154298
InParanoidiP05496
OMAiCMGFCIL
OrthoDBi1564365at2759
PhylomeDBiP05496
TreeFamiTF300140

Enzyme and pathway databases

PathwayCommonsiP05496
ReactomeiR-HSA-1268020, Mitochondrial protein import
R-HSA-163210, Formation of ATP by chemiosmotic coupling
R-HSA-8949613, Cristae formation
SignaLinkiP05496
SIGNORiP05496

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		516, 67 hits in 1071 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ATP5G1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ATP5G1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		516
PharosiP05496, Tbio

Protein Ontology

More...PROi		PR:P05496
RNActiP05496, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000159199, Expressed in heart and 235 other tissues
ExpressionAtlasiP05496, baseline and differential
GenevisibleiP05496, HS

Family and domain databases

Gene3Di1.20.20.10, 1 hit
HAMAPiMF_01396, ATP_synth_c_bact, 1 hit
InterProiView protein in InterPro
IPR000454, ATP_synth_F0_csu
IPR020537, ATP_synth_F0_csu_DDCD_BS
IPR038662, ATP_synth_F0_csu_sf
IPR002379, ATPase_proteolipid_c-like_dom
IPR035921, F/V-ATP_Csub_sf
PANTHERiPTHR10031, PTHR10031, 1 hit
PfamiView protein in Pfam
PF00137, ATP-synt_C, 1 hit
PRINTSiPR00124, ATPASEC
SUPFAMiSSF81333, SSF81333, 1 hit
PROSITEiView protein in PROSITE
PS00605, ATPASE_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAT5G1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05496
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: February 1, 1994
Last modified: May 25, 2022
This is version 202 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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