UniProtKB - P05486 (CESS_CONGE)
Conopressin-conophysin
Functioni
Targets vasopressin-oxytocin related receptors (PubMed:32155768).
Is more active on fish receptors than on their human counterparts, supporting an evolved role of this conopressin in the envenomation process (PubMed:32155768).
Acts as an agonist on zebrafish vasopressin receptors V1a1R (EC(50)=10.6 nM), V1a2R (EC(50)=44.06 nM, partial agonist), V2R (EC(50)=299.2 nM) and oxytocin receptor (EC(50)=353.73 nM, partial agonist) (PubMed:32155768).
Shows a weaker activity on human receptors AVPR1B (EC(50)=51.92 nM), AVPR1A (EC(50)=123.78 nM), AVPR2 (EC(50)=299.2 nM) and oxytocin (OXTR) receptor (EC(50)=455.66 nM, partial agonist). In vivo, exhibits grooming and scratching behavior in mice, following intracerebral injection (PubMed:3680228).
2 PublicationsGO - Molecular functioni
- neurohypophyseal hormone activity Source: InterPro
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | G-protein coupled receptor impairing toxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Conopressin-conophysinCuratedCleaved into the following 2 chains: Alternative name(s): Conopressin-KBy similarity Lys-conopressin-G1 Publication Conophysin-G1 Publication |
Organismi | Conus geographus (Geography cone) (Nubecula geographus) |
Taxonomic identifieri | 6491 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Spiralia › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Neogastropoda › Conoidea › Conidae › Conus › Gastridium |
Organism-specific databases
ConoServeri | 1266, conopressin-G 8951, conopressin-G 8953, conopressin-G 8954, conopressin-G |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
PeptideiPRO_0000044098 | 28 – 36 | Conopressin-G1 Publication | 9 | |
PropeptideiPRO_0000435032 | 37 – 44 | Curated | 8 | |
ChainiPRO_0000435033 | 45 – 128 | Conophysin-GAdd BLAST | 84 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 28 ↔ 33 | 1 Publication | ||
Modified residuei | 36 | Glycine amide1 Publication | 1 | |
Disulfide bondi | 50 ↔ 90 | By similarity | ||
Disulfide bondi | 53 ↔ 64 | By similarity | ||
Disulfide bondi | 58 ↔ 80 | By similarity | ||
Disulfide bondi | 65 ↔ 70 | By similarity | ||
Disulfide bondi | 97 ↔ 115 | By similarity | ||
Disulfide bondi | 109 ↔ 127 | By similarity | ||
Disulfide bondi | 116 ↔ 121 | By similarity |
Keywords - PTMi
Amidation, Disulfide bondExpressioni
Tissue specificityi
Family & Domainsi
Domaini
Sequence similaritiesi
Keywords - Domaini
SignalFamily and domain databases
Gene3Di | 2.60.9.10, 1 hit |
InterProi | View protein in InterPro IPR000981, Neurhyp_horm IPR036387, Neurhyp_horm_dom_sf IPR022423, Neurohypophysial_hormone_CS |
PANTHERi | PTHR11681, PTHR11681, 1 hit |
Pfami | View protein in Pfam PF00184, Hormone_5, 1 hit |
PRINTSi | PR00831, NEUROPHYSIN |
SMARTi | View protein in SMART SM00003, NH, 1 hit |
SUPFAMi | SSF49606, SSF49606, 1 hit |
PROSITEi | View protein in PROSITE PS00264, NEUROHYPOPHYS_HORM, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MTRSAMQMGR LTLVLCLLLL LLLTTQACFI RNCPKGGKRD VDERYLFKAC
60 70 80 90 100
MSCSFGQCVG PRICCGPRGC EMGTAEANRC IEEDEDPIPC QVVGQHCDLN
110 120
NPGNIHGNCV ANGICCVDDT CTIHTGCL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB910804 mRNA Translation: BAO65572.1 |
PIRi | A28495 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB910804 mRNA Translation: BAO65572.1 |
PIRi | A28495 |
3D structure databases
SMRi | P05486 |
ModBasei | Search... |
Organism-specific databases
ConoServeri | 1266, conopressin-G 8951, conopressin-G 8953, conopressin-G 8954, conopressin-G |
Family and domain databases
Gene3Di | 2.60.9.10, 1 hit |
InterProi | View protein in InterPro IPR000981, Neurhyp_horm IPR036387, Neurhyp_horm_dom_sf IPR022423, Neurohypophysial_hormone_CS |
PANTHERi | PTHR11681, PTHR11681, 1 hit |
Pfami | View protein in Pfam PF00184, Hormone_5, 1 hit |
PRINTSi | PR00831, NEUROPHYSIN |
SMARTi | View protein in SMART SM00003, NH, 1 hit |
SUPFAMi | SSF49606, SSF49606, 1 hit |
PROSITEi | View protein in PROSITE PS00264, NEUROHYPOPHYS_HORM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CESS_CONGE | |
Accessioni | P05486Primary (citable) accession number: P05486 Secondary accession number(s): X5I9X9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | December 9, 2015 | |
Last modified: | February 23, 2022 | |
This is version 75 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families