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Protein

Conophysin-conopressin

Gene
N/A
Organism
Conus geographus (Geography cone) (Nubecula geographus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conopressin G: Targets vasopressin-oxytocin related receptors.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conophysin-conopressinCurated
Cleaved into the following 2 chains:
Conopressin-G1 Publication
Alternative name(s):
Lys-conopressin-G1 Publication
Conophysin-G1 Publication
OrganismiConus geographus (Geography cone) (Nubecula geographus)
Taxonomic identifieri6491 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusGastridium

Organism-specific databases

ConoServeri1266 Lys-conopressin G

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
PeptideiPRO_000004409828 – 36Conopressin-G1 Publication9
PropeptideiPRO_000043503237 – 44Curated8
ChainiPRO_000043503345 – 128Conophysin-GAdd BLAST84

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 331 Publication
Modified residuei36Glycine amide1 Publication1
Disulfide bondi50 ↔ 90By similarity
Disulfide bondi53 ↔ 64By similarity
Disulfide bondi58 ↔ 80By similarity
Disulfide bondi65 ↔ 70By similarity
Disulfide bondi97 ↔ 115By similarity
Disulfide bondi109 ↔ 127By similarity
Disulfide bondi116 ↔ 121By similarity

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiP05486
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.9.10, 1 hit
InterProiView protein in InterPro
IPR000981 Neurhyp_horm
IPR036387 Neurhyp_horm_dom_sf
IPR022423 Neurohypophysial_hormone_CS
PANTHERiPTHR11681 PTHR11681, 1 hit
PfamiView protein in Pfam
PF00184 Hormone_5, 1 hit
PRINTSiPR00831 NEUROPHYSIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001676 Neurhyp_horm, 1 hit
SMARTiView protein in SMART
SM00003 NH, 1 hit
SUPFAMiSSF49606 SSF49606, 1 hit
PROSITEiView protein in PROSITE
PS00264 NEUROHYPOPHYS_HORM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05486-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRSAMQMGR LTLVLCLLLL LLLTTQACFI RNCPKGGKRD VDERYLFKAC
60 70 80 90 100
MSCSFGQCVG PRICCGPRGC EMGTAEANRC IEEDEDPIPC QVVGQHCDLN
110 120
NPGNIHGNCV ANGICCVDDT CTIHTGCL
Length:128
Mass (Da):13,875
Last modified:December 9, 2015 - v2
Checksum:i8E5916B8FCD844D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB910804 mRNA Translation: BAO65572.1
PIRiA28495

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB910804 mRNA Translation: BAO65572.1
PIRiA28495

3D structure databases

SMRiP05486
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri1266 Lys-conopressin G

Family and domain databases

Gene3Di2.60.9.10, 1 hit
InterProiView protein in InterPro
IPR000981 Neurhyp_horm
IPR036387 Neurhyp_horm_dom_sf
IPR022423 Neurohypophysial_hormone_CS
PANTHERiPTHR11681 PTHR11681, 1 hit
PfamiView protein in Pfam
PF00184 Hormone_5, 1 hit
PRINTSiPR00831 NEUROPHYSIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001676 Neurhyp_horm, 1 hit
SMARTiView protein in SMART
SM00003 NH, 1 hit
SUPFAMiSSF49606 SSF49606, 1 hit
PROSITEiView protein in PROSITE
PS00264 NEUROHYPOPHYS_HORM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCESS_CONGE
AccessioniPrimary (citable) accession number: P05486
Secondary accession number(s): X5I9X9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: December 9, 2015
Last modified: September 12, 2018
This is version 66 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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