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Protein

Lupus La protein

Gene

SSB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).3 Publications

Miscellaneous

Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular La protein as if this antigen was foreign.

GO - Molecular functioni

  • mRNA binding Source: ProtInc
  • poly(U) RNA binding Source: CAFA
  • RNA binding Source: CAFA
  • sequence-specific mRNA binding Source: CAFA
  • tRNA binding Source: CAFA

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-73980 RNA Polymerase III Transcription Termination
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
SIGNORiP05455

Names & Taxonomyi

Protein namesi
Recommended name:
Lupus La protein
Alternative name(s):
La autoantigen
La ribonucleoprotein
Sjoegren syndrome type B antigen
Short name:
SS-B
Gene namesi
Name:SSB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000138385.15
HGNCiHGNC:11316 SSB
MIMi109090 gene
neXtProtiNX_P05455

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Systemic lupus erythematosus

Organism-specific databases

DisGeNETi6741
OpenTargetsiENSG00000138385
PharmGKBiPA36140

Chemistry databases

ChEMBLiCHEMBL2040701

Polymorphism and mutation databases

BioMutaiSSB
DMDMi125985

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002075991 – 408Lupus La proteinAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei92PhosphoserineCombined sources1
Modified residuei94PhosphoserineCombined sources1
Modified residuei116N6-acetyllysineCombined sources1
Modified residuei120PhosphothreonineCombined sources1
Modified residuei128N6-acetyllysineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei328N6-acetyllysineCombined sources1
Modified residuei341N6-acetyllysineBy similarity1
Modified residuei360N6-acetyllysineCombined sources1
Modified residuei362PhosphothreonineCombined sources1
Modified residuei366Phosphoserine; by CK2Combined sources1 Publication1

Post-translational modificationi

Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.1 Publication
The N-terminus is blocked.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP05455
MaxQBiP05455
PaxDbiP05455
PeptideAtlasiP05455
PRIDEiP05455
ProteomicsDBi51841

PTM databases

iPTMnetiP05455
PhosphoSitePlusiP05455
SwissPalmiP05455

Miscellaneous databases

PMAP-CutDBiP05455

Expressioni

Gene expression databases

BgeeiENSG00000138385 Expressed in 237 organ(s), highest expression level in tendon
CleanExiHS_SSB
ExpressionAtlasiP05455 baseline and differential
GenevisibleiP05455 HS

Organism-specific databases

HPAiCAB004643
HPA017287

Interactioni

Subunit structurei

Interacts with DDX15. May interact with RUFY1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q99IB82EBI-358037,EBI-6927928From Hepatitis C virus genotype 2a (isolate JFH-1).

Protein-protein interaction databases

BioGridi112619, 125 interactors
CORUMiP05455
DIPiDIP-29750N
IntActiP05455, 47 interactors
MINTiP05455
STRINGi9606.ENSP00000260956

Structurei

Secondary structure

1408
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00229
ProteinModelPortaliP05455
SMRiP05455
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05455

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 99HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST93
Domaini111 – 187RRMPROSITE-ProRule annotationAdd BLAST77

Phylogenomic databases

eggNOGiENOG410IQXQ Eukaryota
COG5193 LUCA
GeneTreeiENSGT00830000128380
HOGENOMiHOG000006947
HOVERGENiHBG001407
InParanoidiP05455
KOiK11090
OMAiPEHNEER
OrthoDBiEOG091G0K95
PhylomeDBiP05455
TreeFamiTF314476

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR006630 La_HTH
IPR014886 La_RRM
IPR002344 Lupus_La
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383 La, 1 hit
PF00076 RRM_1, 1 hit
PF08777 RRM_3, 1 hit
PRINTSiPR00302 LUPUSLA
SMARTiView protein in SMART
SM00715 LA, 1 hit
SM00360 RRM, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50961 HTH_LA, 1 hit
PS50102 RRM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P05455-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAENGDNEKM AALEAKICHQ IEYYFGDFNL PRDKFLKEQI KLDEGWVPLE
60 70 80 90 100
IMIKFNRLNR LTTDFNVIVE ALSKSKAELM EISEDKTKIR RSPSKPLPEV
110 120 130 140 150
TDEYKNDVKN RSVYIKGFPT DATLDDIKEW LEDKGQVLNI QMRRTLHKAF
160 170 180 190 200
KGSIFVVFDS IESAKKFVET PGQKYKETDL LILFKDDYFA KKNEERKQNK
210 220 230 240 250
VEAKLRAKQE QEAKQKLEED AEMKSLEEKI GCLLKFSGDL DDQTCREDLH
260 270 280 290 300
ILFSNHGEIK WIDFVRGAKE GIILFKEKAK EALGKAKDAN NGNLQLRNKE
310 320 330 340 350
VTWEVLEGEV EKEALKKIIE DQQESLNKWK SKGRRFKGKG KGNKAAQPGS
360 370 380 390 400
GKGKVQFQGK KTKFASDDEH DEHDENGATG PVKRAREETD KEEPASKQQK

TENGAGDQ
Length:408
Mass (Da):46,837
Last modified:July 1, 1989 - v2
Checksum:iEC153C15F9187FC4
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ERC4E7ERC4_HUMAN
Lupus La protein
SSB
184Annotation score:
E9PFL9E9PFL9_HUMAN
Lupus La protein
SSB
134Annotation score:
E9PGX9E9PGX9_HUMAN
Lupus La protein
SSB
120Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54K → E in AAA36577 (PubMed:2452201).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13697 mRNA Translation: CAA31985.1
J04205 mRNA Translation: AAA51885.1
BT009862 mRNA Translation: AAP88864.1
AB451228 mRNA Translation: BAG70042.1
AC009967 Genomic DNA Translation: AAY14868.1
CH471058 Genomic DNA Translation: EAX11258.1
CH471058 Genomic DNA Translation: EAX11259.1
BC001289 mRNA Translation: AAH01289.1
BC020818 mRNA Translation: AAH20818.1
M20328 mRNA Translation: AAA36577.1
CCDSiCCDS2237.1
PIRiA31888
RefSeqiNP_001281074.1, NM_001294145.1
NP_003133.1, NM_003142.4
UniGeneiHs.632535

Genome annotation databases

EnsembliENST00000260956; ENSP00000260956; ENSG00000138385
ENST00000409333; ENSP00000386636; ENSG00000138385
GeneIDi6741
KEGGihsa:6741
UCSCiuc002ufk.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13697 mRNA Translation: CAA31985.1
J04205 mRNA Translation: AAA51885.1
BT009862 mRNA Translation: AAP88864.1
AB451228 mRNA Translation: BAG70042.1
AC009967 Genomic DNA Translation: AAY14868.1
CH471058 Genomic DNA Translation: EAX11258.1
CH471058 Genomic DNA Translation: EAX11259.1
BC001289 mRNA Translation: AAH01289.1
BC020818 mRNA Translation: AAH20818.1
M20328 mRNA Translation: AAA36577.1
CCDSiCCDS2237.1
PIRiA31888
RefSeqiNP_001281074.1, NM_001294145.1
NP_003133.1, NM_003142.4
UniGeneiHs.632535

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OWXNMR-A225-334[»]
1S79NMR-A105-202[»]
1S7ANMR-A1-103[»]
1YTYX-ray2.29A/B1-194[»]
1ZH5X-ray1.85A/B1-194[»]
2VODX-ray2.10A/B4-194[»]
2VONX-ray2.10A/B4-194[»]
2VOOX-ray1.80A/B4-194[»]
2VOPX-ray2.80A4-194[»]
DisProtiDP00229
ProteinModelPortaliP05455
SMRiP05455
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112619, 125 interactors
CORUMiP05455
DIPiDIP-29750N
IntActiP05455, 47 interactors
MINTiP05455
STRINGi9606.ENSP00000260956

Chemistry databases

ChEMBLiCHEMBL2040701

PTM databases

iPTMnetiP05455
PhosphoSitePlusiP05455
SwissPalmiP05455

Polymorphism and mutation databases

BioMutaiSSB
DMDMi125985

Proteomic databases

EPDiP05455
MaxQBiP05455
PaxDbiP05455
PeptideAtlasiP05455
PRIDEiP05455
ProteomicsDBi51841

Protocols and materials databases

DNASUi6741
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260956; ENSP00000260956; ENSG00000138385
ENST00000409333; ENSP00000386636; ENSG00000138385
GeneIDi6741
KEGGihsa:6741
UCSCiuc002ufk.4 human

Organism-specific databases

CTDi6741
DisGeNETi6741
EuPathDBiHostDB:ENSG00000138385.15
GeneCardsiSSB
HGNCiHGNC:11316 SSB
HPAiCAB004643
HPA017287
MIMi109090 gene
neXtProtiNX_P05455
OpenTargetsiENSG00000138385
PharmGKBiPA36140
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQXQ Eukaryota
COG5193 LUCA
GeneTreeiENSGT00830000128380
HOGENOMiHOG000006947
HOVERGENiHBG001407
InParanoidiP05455
KOiK11090
OMAiPEHNEER
OrthoDBiEOG091G0K95
PhylomeDBiP05455
TreeFamiTF314476

Enzyme and pathway databases

ReactomeiR-HSA-73980 RNA Polymerase III Transcription Termination
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
SIGNORiP05455

Miscellaneous databases

ChiTaRSiSSB human
EvolutionaryTraceiP05455
GeneWikiiSjogren_syndrome_antigen_B
GenomeRNAii6741
PMAP-CutDBiP05455
PROiPR:P05455
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138385 Expressed in 237 organ(s), highest expression level in tendon
CleanExiHS_SSB
ExpressionAtlasiP05455 baseline and differential
GenevisibleiP05455 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR006630 La_HTH
IPR014886 La_RRM
IPR002344 Lupus_La
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383 La, 1 hit
PF00076 RRM_1, 1 hit
PF08777 RRM_3, 1 hit
PRINTSiPR00302 LUPUSLA
SMARTiView protein in SMART
SM00715 LA, 1 hit
SM00360 RRM, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50961 HTH_LA, 1 hit
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLA_HUMAN
AccessioniPrimary (citable) accession number: P05455
Secondary accession number(s): Q15367, Q53XJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 216 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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