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Protein

Tetranectin

Gene

CLEC3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis.

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • carbohydrate binding Source: UniProtKB-KW
  • heparin binding Source: UniProtKB
  • kringle domain binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandLectin

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Protein family/group databases

UniLectiniP05452

Names & Taxonomyi

Protein namesi
Recommended name:
Tetranectin
Short name:
TN
Alternative name(s):
C-type lectin domain family 3 member B
Plasminogen kringle 4-binding protein
Gene namesi
Name:CLEC3B
Synonyms:TNA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163815.5
HGNCiHGNC:11891 CLEC3B
MIMi187520 gene
neXtProtiNX_P05452

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7123
OpenTargetsiENSG00000163815
PharmGKBiPA36590

Chemistry databases

DrugBankiDB00031 Tenecteplase

Polymorphism and mutation databases

BioMutaiCLEC3B
DMDMi317373499

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000001747122 – 202Tetranectin1 PublicationAdd BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25O-linked (GalNAc...) threonine1
Disulfide bondi71 ↔ 81PROSITE-ProRule annotation1 Publication
Disulfide bondi98 ↔ 197PROSITE-ProRule annotation1 Publication
Disulfide bondi173 ↔ 189PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP05452
PeptideAtlasiP05452
PRIDEiP05452
ProteomicsDBi51840

Expressioni

Tissue specificityi

Found in plasma.

Gene expression databases

BgeeiENSG00000163815 Expressed in 92 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiHS_CLEC3B
ExpressionAtlasiP05452 baseline and differential
GenevisibleiP05452 HS

Organism-specific databases

HPAiCAB002582
HPA034794

Interactioni

Subunit structurei

Homotrimer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112978, 15 interactors
IntActiP05452, 8 interactors
MINTiP05452
STRINGi9606.ENSP00000296130

Structurei

Secondary structure

1202
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP05452
SMRiP05452
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05452

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 198C-type lectinPROSITE-ProRule annotationAdd BLAST122

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IS3U Eukaryota
ENOG4111IV3 LUCA
GeneTreeiENSGT00610000086061
HOGENOMiHOG000060248
HOVERGENiHBG108270
InParanoidiP05452
KOiK17520
OMAiGKAENCA
OrthoDBiEOG091G0NMQ
PhylomeDBiP05452
TreeFamiTF330481

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P05452-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELWGAYLLL CLFSLLTQVT TEPPTQKPKK IVNAKKDVVN TKMFEELKSR
60 70 80 90 100
LDTLAQEVAL LKEQQALQTV CLKGTKVHMK CFLAFTQTKT FHEASEDCIS
110 120 130 140 150
RGGTLGTPQT GSENDALYEY LRQSVGNEAE IWLGLNDMAA EGTWVDMTGA
160 170 180 190 200
RIAYKNWETE ITAQPDGGKT ENCAVLSGAA NGKWFDKRCR DQLPYICQFG

IV
Length:202
Mass (Da):22,537
Last modified:January 11, 2011 - v3
Checksum:i370C174033F21B78
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PHK0E9PHK0_HUMAN
Tetranectin
CLEC3B
160Annotation score:

Mass spectrometryi

Molecular mass is 20535.8±2.4 Da from positions 22 - 202. Determined by ESI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00418955A → S1 Publication1
Natural variantiVAR_00419058V → M1 Publication1
Natural variantiVAR_012318106G → S5 PublicationsCorresponds to variant dbSNP:rs13963Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64559 mRNA Translation: CAA45860.1
X70910, X70911, X70912 Genomic DNA Translation: CAA50265.1
CR541981 mRNA Translation: CAG46778.1
CR542009 mRNA Translation: CAG46806.1
AC104165 Genomic DNA No translation available.
BC011024 mRNA Translation: AAH11024.1
X98121 Genomic DNA Translation: CAA66803.1
CCDSiCCDS2726.1
PIRiS24126 TTHUN
RefSeqiNP_003269.2, NM_003278.2
UniGeneiHs.476092

Genome annotation databases

EnsembliENST00000296130; ENSP00000296130; ENSG00000163815
GeneIDi7123
KEGGihsa:7123
UCSCiuc003cok.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Tetranectin

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64559 mRNA Translation: CAA45860.1
X70910, X70911, X70912 Genomic DNA Translation: CAA50265.1
CR541981 mRNA Translation: CAG46778.1
CR542009 mRNA Translation: CAG46806.1
AC104165 Genomic DNA No translation available.
BC011024 mRNA Translation: AAH11024.1
X98121 Genomic DNA Translation: CAA66803.1
CCDSiCCDS2726.1
PIRiS24126 TTHUN
RefSeqiNP_003269.2, NM_003278.2
UniGeneiHs.476092

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HTNX-ray2.80A22-202[»]
1RJHNMR-A85-202[»]
1TN3X-ray2.00A66-202[»]
3L9JX-ray2.10C67-201[»]
ProteinModelPortaliP05452
SMRiP05452
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112978, 15 interactors
IntActiP05452, 8 interactors
MINTiP05452
STRINGi9606.ENSP00000296130

Chemistry databases

DrugBankiDB00031 Tenecteplase

Protein family/group databases

UniLectiniP05452

Polymorphism and mutation databases

BioMutaiCLEC3B
DMDMi317373499

Proteomic databases

PaxDbiP05452
PeptideAtlasiP05452
PRIDEiP05452
ProteomicsDBi51840

Protocols and materials databases

DNASUi7123
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296130; ENSP00000296130; ENSG00000163815
GeneIDi7123
KEGGihsa:7123
UCSCiuc003cok.5 human

Organism-specific databases

CTDi7123
DisGeNETi7123
EuPathDBiHostDB:ENSG00000163815.5
GeneCardsiCLEC3B
H-InvDBiHIX0163464
HGNCiHGNC:11891 CLEC3B
HPAiCAB002582
HPA034794
MIMi187520 gene
neXtProtiNX_P05452
OpenTargetsiENSG00000163815
PharmGKBiPA36590
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS3U Eukaryota
ENOG4111IV3 LUCA
GeneTreeiENSGT00610000086061
HOGENOMiHOG000060248
HOVERGENiHBG108270
InParanoidiP05452
KOiK17520
OMAiGKAENCA
OrthoDBiEOG091G0NMQ
PhylomeDBiP05452
TreeFamiTF330481

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Miscellaneous databases

ChiTaRSiCLEC3B human
EvolutionaryTraceiP05452
GeneWikiiCLEC3B
GenomeRNAii7123
PROiPR:P05452
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163815 Expressed in 92 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiHS_CLEC3B
ExpressionAtlasiP05452 baseline and differential
GenevisibleiP05452 HS

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTETN_HUMAN
AccessioniPrimary (citable) accession number: P05452
Secondary accession number(s): Q6FGX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 11, 2011
Last modified: October 10, 2018
This is version 182 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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