Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lithostathine-1-alpha

Gene

REG1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.

GO - Molecular functioni

  • growth factor activity Source: MGI
  • oligosaccharide binding Source: GO_Central
  • peptidoglycan binding Source: GO_Central
  • protein homodimerization activity Source: Ensembl
  • protein phosphatase binding Source: Ensembl
  • transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

LigandLectin

Protein family/group databases

MEROPSiI63.002

Names & Taxonomyi

Protein namesi
Recommended name:
Lithostathine-1-alpha
Alternative name(s):
Islet cells regeneration factor
Short name:
ICRF
Islet of Langerhans regenerating protein
Short name:
REG
Pancreatic stone protein
Short name:
PSP
Pancreatic thread protein
Short name:
PTP
Regenerating islet-derived protein 1-alpha
Short name:
REG-1-alpha
Regenerating protein I alpha
Gene namesi
Name:REG1A
Synonyms:PSPS, PSPS1, REG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115386.5
HGNCiHGNC:9951 REG1A
MIMi167770 gene
neXtProtiNX_P05451

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5967
OpenTargetsiENSG00000115386
PharmGKBiPA34318

Chemistry databases

DrugBankiDB03721 N-acetyl-alpha-neuraminic acid
DB04522 Phosphonoserine

Polymorphism and mutation databases

BioMutaiREG1A
DMDMi131433

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 222 PublicationsAdd BLAST22
ChainiPRO_000001742423 – 166Lithostathine-1-alphaAdd BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23Pyrrolidone carboxylic acid1 Publication1
Glycosylationi27O-linked (GlcNAc...) threonine1 Publication1
Disulfide bondi36 ↔ 47PROSITE-ProRule annotation1 Publication
Disulfide bondi64 ↔ 162PROSITE-ProRule annotation1 Publication
Disulfide bondi137 ↔ 154PROSITE-ProRule annotation1 Publication

Post-translational modificationi

The composition of the O-linked carbohydrate on Thr-27 is complex and varied. In the crystallographic structure, the attached sugar appears to be N-acetylglucosamine, typical of an intracellular protein, rather than N-acetylgalactosamine.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP05451
PeptideAtlasiP05451
PRIDEiP05451
ProteomicsDBi51839

PTM databases

iPTMnetiP05451
PhosphoSitePlusiP05451

Expressioni

Tissue specificityi

In pancreatic acinar cells and, in lower levels, in brain. Enhanced expression of PSP-related transcripts and intraneuronal accumulation of PSP-like proteins is found in brain from Alzheimer disease and Down syndrome patients.1 Publication

Developmental stagei

High expression levels in fetal and infant brains; much lower in adult brains.1 Publication

Gene expression databases

BgeeiENSG00000115386 Expressed in 96 organ(s), highest expression level in islet of Langerhans
CleanExiHS_REG1A
GenevisibleiP05451 HS

Organism-specific databases

HPAiCAB025138
HPA045549
HPA045579

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111899, 6 interactors
STRINGi9606.ENSP00000233735

Structurei

Secondary structure

1166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP05451
SMRiP05451
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05451

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 164C-type lectinPROSITE-ProRule annotationAdd BLAST131

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104249
HOGENOMiHOG000010281
HOVERGENiHBG004151
InParanoidiP05451
OMAiYCYYFME
OrthoDBiEOG091G0OLC
PhylomeDBiP05451

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05451-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQTSSYFML ISCLMFLSQS QGQEAQTELP QARISCPEGT NAYRSYCYYF
60 70 80 90 100
NEDRETWVDA DLYCQNMNSG NLVSVLTQAE GAFVASLIKE SGTDDFNVWI
110 120 130 140 150
GLHDPKKNRR WHWSSGSLVS YKSWGIGAPS SVNPGYCVSL TSSTGFQKWK
160
DVPCEDKFSF VCKFKN
Length:166
Mass (Da):18,731
Last modified:October 1, 1989 - v3
Checksum:iEF93C760DC2DBCC3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5 – 7SSY → NSF in AAA60546 (PubMed:2525567).Curated3
Sequence conflicti5 – 7SSY → NSF in AAA60545 (PubMed:2525567).Curated3
Sequence conflicti13C → S in AAA60546 (PubMed:2525567).Curated1
Sequence conflicti13C → S in AAA60545 (PubMed:2525567).Curated1
Sequence conflicti19Q → L in AAA60546 (PubMed:2525567).Curated1
Sequence conflicti101G → A in AAA36559 (PubMed:2332435).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18963 mRNA Translation: AAA36558.1
J05412 Genomic DNA Translation: AAA36559.1
M27190 mRNA Translation: AAA60546.1
M27189 Genomic DNA Translation: AAA60545.1
AF172331 mRNA Translation: AAD51330.1
AC017004 Genomic DNA Translation: AAX88842.1
CH471053 Genomic DNA Translation: EAW99576.1
CH471053 Genomic DNA Translation: EAW99578.1
BC005350 mRNA Translation: AAH05350.1
CCDSiCCDS1964.1
PIRiA35197 RGHU1A
A45751
RefSeqiNP_002900.2, NM_002909.4
UniGeneiHs.4158
Hs.49407
Hs.708865

Genome annotation databases

EnsembliENST00000233735; ENSP00000233735; ENSG00000115386
GeneIDi5967
KEGGihsa:5967
UCSCiuc002snz.3 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Lithostathine A

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18963 mRNA Translation: AAA36558.1
J05412 Genomic DNA Translation: AAA36559.1
M27190 mRNA Translation: AAA60546.1
M27189 Genomic DNA Translation: AAA60545.1
AF172331 mRNA Translation: AAD51330.1
AC017004 Genomic DNA Translation: AAX88842.1
CH471053 Genomic DNA Translation: EAW99576.1
CH471053 Genomic DNA Translation: EAW99578.1
BC005350 mRNA Translation: AAH05350.1
CCDSiCCDS1964.1
PIRiA35197 RGHU1A
A45751
RefSeqiNP_002900.2, NM_002909.4
UniGeneiHs.4158
Hs.49407
Hs.708865

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LITX-ray1.55A23-166[»]
1QDDX-ray1.30A23-166[»]
ProteinModelPortaliP05451
SMRiP05451
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111899, 6 interactors
STRINGi9606.ENSP00000233735

Chemistry databases

DrugBankiDB03721 N-acetyl-alpha-neuraminic acid
DB04522 Phosphonoserine

Protein family/group databases

MEROPSiI63.002

PTM databases

iPTMnetiP05451
PhosphoSitePlusiP05451

Polymorphism and mutation databases

BioMutaiREG1A
DMDMi131433

Proteomic databases

PaxDbiP05451
PeptideAtlasiP05451
PRIDEiP05451
ProteomicsDBi51839

Protocols and materials databases

DNASUi5967
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233735; ENSP00000233735; ENSG00000115386
GeneIDi5967
KEGGihsa:5967
UCSCiuc002snz.3 human

Organism-specific databases

CTDi5967
DisGeNETi5967
EuPathDBiHostDB:ENSG00000115386.5
GeneCardsiREG1A
HGNCiHGNC:9951 REG1A
HPAiCAB025138
HPA045549
HPA045579
MIMi167770 gene
neXtProtiNX_P05451
OpenTargetsiENSG00000115386
PharmGKBiPA34318
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104249
HOGENOMiHOG000010281
HOVERGENiHBG004151
InParanoidiP05451
OMAiYCYYFME
OrthoDBiEOG091G0OLC
PhylomeDBiP05451

Miscellaneous databases

ChiTaRSiREG1A human
EvolutionaryTraceiP05451
GeneWikiiREG1A
GenomeRNAii5967
PROiPR:P05451
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115386 Expressed in 96 organ(s), highest expression level in islet of Langerhans
CleanExiHS_REG1A
GenevisibleiP05451 HS

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiREG1A_HUMAN
AccessioniPrimary (citable) accession number: P05451
Secondary accession number(s): P11379, Q4ZG28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1989
Last modified: November 7, 2018
This is version 192 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again