UniProtKB - P05413 (FABPH_HUMAN)
Protein
Fatty acid-binding protein, heart
Gene
FABP3
Organism
Homo sapiens (Human)
Status
Functioni
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 127 | Fatty acid | 1 | |
Binding sitei | 129 | Fatty acid | 1 |
GO - Molecular functioni
- cytoskeletal protein binding Source: UniProtKB
- icosatetraenoic acid binding Source: Ensembl
- long-chain fatty acid binding Source: BHF-UCL
- long-chain fatty acid transporter activity Source: Ensembl
- oleic acid binding Source: BHF-UCL
GO - Biological processi
- brown fat cell differentiation Source: Ensembl
- cholesterol homeostasis Source: BHF-UCL
- fatty acid metabolic process Source: Ensembl
- intracellular lipid transport Source: BHF-UCL
- long-chain fatty acid transport Source: ARUK-UCL
- negative regulation of cell population proliferation Source: ProtInc
- phospholipid homeostasis Source: BHF-UCL
- positive regulation of long-chain fatty acid import into cell Source: ARUK-UCL
- positive regulation of phospholipid biosynthetic process Source: BHF-UCL
- regulation of fatty acid oxidation Source: BHF-UCL
- regulation of phosphatidylcholine biosynthetic process Source: Ensembl
- response to drug Source: Ensembl
- response to fatty acid Source: Ensembl
- response to insulin Source: Ensembl
- triglyceride catabolic process Source: Reactome
Keywordsi
Biological process | Transport |
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | P05413 |
Reactomei | R-HSA-163560, Triglyceride catabolism |
Chemistry databases
SwissLipidsi | SLP:000001521 |
Names & Taxonomyi
Protein namesi | Recommended name: Fatty acid-binding protein, heartAlternative name(s): Fatty acid-binding protein 3 Heart-type fatty acid-binding protein Short name: H-FABP Mammary-derived growth inhibitor Short name: MDGI Muscle fatty acid-binding protein Short name: M-FABP |
Gene namesi | Name:FABP3 Synonyms:FABP11, MDGI |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3557, FABP3 |
MIMi | 134651, gene |
neXtProti | NX_P05413 |
VEuPathDBi | HostDB:ENSG00000121769.7 |
Subcellular locationi
Other locations
Cytosol
- cytosol Source: BHF-UCL
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular space Source: BHF-UCL
Other locations
- sarcoplasm Source: Ensembl
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 2170 |
OpenTargetsi | ENSG00000121769 |
PharmGKBi | PA27958 |
Miscellaneous databases
Pharosi | P05413, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3344 |
DrugBanki | DB04224, Oleic Acid DB03796, Palmitic Acid DB03193, Stearic acid |
DrugCentrali | P05413 |
GuidetoPHARMACOLOGYi | 2533 |
Genetic variation databases
BioMutai | FABP3 |
DMDMi | 119802 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources2 Publications | |||
ChainiPRO_0000067321 | 2 – 133 | Fatty acid-binding protein, heartAdd BLAST | 132 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylvalineCombined sources | 1 | |
Modified residuei | 8 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 20 | Phosphotyrosine; by Tyr-kinasesBy similarity | 1 | |
Modified residuei | 23 | PhosphoserineBy similarity | 1 | |
Modified residuei | 30 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 83 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P05413 |
jPOSTi | P05413 |
MassIVEi | P05413 |
MaxQBi | P05413 |
PaxDbi | P05413 |
PeptideAtlasi | P05413 |
PRIDEi | P05413 |
ProteomicsDBi | 12633 51837 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00219684 |
UCD-2DPAGEi | P05413 |
PTM databases
CarbonylDBi | P05413 |
iPTMneti | P05413 |
PhosphoSitePlusi | P05413 |
SwissPalmi | P05413 |
Expressioni
Gene expression databases
Bgeei | ENSG00000121769, Expressed in heart left ventricle and 205 other tissues |
ExpressionAtlasi | P05413, baseline and differential |
Genevisiblei | P05413, HS |
Organism-specific databases
HPAi | ENSG00000121769, Group enriched (heart muscle, skeletal muscle) |
Interactioni
Binary interactionsi
Hide detailsP05413
With | #Exp. | IntAct |
---|---|---|
ITGB1 [P05556] | 2 | EBI-704216,EBI-703066 |
NUP62 [P37198] | 7 | EBI-704216,EBI-347978 |
SHTN1 [A0MZ66] | 3 | EBI-704216,EBI-308778 |
SHTN1 - isoform 4 [A0MZ66-4] | 3 | EBI-704216,EBI-12097232 |
GO - Molecular functioni
- cytoskeletal protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 108468, 28 interactors |
IntActi | P05413, 13 interactors |
MINTi | P05413 |
STRINGi | 9606.ENSP00000362817 |
Chemistry databases
BindingDBi | P05413 |
Miscellaneous databases
RNActi | P05413, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P05413 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P05413 |
Family & Domainsi
Domaini
Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4015, Eukaryota |
GeneTreei | ENSGT00940000155104 |
InParanoidi | P05413 |
OMAi | THGSVVC |
OrthoDBi | 1417203at2759 |
PhylomeDBi | P05413 |
TreeFami | TF316894 |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR000463, Fatty_acid-bd IPR031259, ILBP IPR000566, Lipocln_cytosolic_FA-bd_dom |
PANTHERi | PTHR11955, PTHR11955, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PRINTSi | PR00178, FATTYACIDBP |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00214, FABP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P05413-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVDAFLGTWK LVDSKNFDDY MKSLGVGFAT RQVASMTKPT TIIEKNGDIL
60 70 80 90 100
TLKTHSTFKN TEISFKLGVE FDETTADDRK VKSIVTLDGG KLVHLQKWDG
110 120 130
QETTLVRELI DGKLILTLTH GTAVCTRTYE KEA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketS4R371 | S4R371_HUMAN | Fatty acid-binding protein, heart | FABP3 | 132 | Annotation score: | ||
S4R3A2 | S4R3A2_HUMAN | Fatty acid-binding protein, heart | FABP3 | 89 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 | V → A in CAA71305 (Ref. 2) Curated | 1 | |
Sequence conflicti | 105 | L → K AA sequence (PubMed:3421901).Curated | 1 | |
Sequence conflicti | 125 | C → S AA sequence (PubMed:3421901).Curated | 1 | |
Sequence conflicti | 130 | E → Q AA sequence (PubMed:2266954).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061165 | 53 | K → R. Corresponds to variant dbSNP:rs2228194Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56549 mRNA Translation: CAA39889.1 Y10255 mRNA Translation: CAA71305.1 U57623 Genomic DNA Translation: AAB02555.1 AK314122 mRNA Translation: BAG36813.1 U17081 Genomic DNA Translation: AAC99800.1 S67314 mRNA Translation: AAB29294.1 BT006727 mRNA Translation: AAP35373.1 AL451070 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07619.1 BC007021 mRNA Translation: AAH07021.1 |
CCDSi | CCDS342.1 |
PIRi | S15432, FZHUC |
RefSeqi | NP_004093.1, NM_004102.4 |
Genome annotation databases
Ensembli | ENST00000373713; ENSP00000362817; ENSG00000121769 |
GeneIDi | 2170 |
KEGGi | hsa:2170 |
UCSCi | uc001bss.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56549 mRNA Translation: CAA39889.1 Y10255 mRNA Translation: CAA71305.1 U57623 Genomic DNA Translation: AAB02555.1 AK314122 mRNA Translation: BAG36813.1 U17081 Genomic DNA Translation: AAC99800.1 S67314 mRNA Translation: AAB29294.1 BT006727 mRNA Translation: AAP35373.1 AL451070 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07619.1 BC007021 mRNA Translation: AAH07021.1 |
CCDSi | CCDS342.1 |
PIRi | S15432, FZHUC |
RefSeqi | NP_004093.1, NM_004102.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1G5W | NMR | - | A | 2-133 | [»] | |
1HMR | X-ray | 1.40 | A | 2-133 | [»] | |
1HMS | X-ray | 1.40 | A | 2-133 | [»] | |
1HMT | X-ray | 1.40 | A | 2-133 | [»] | |
2HMB | X-ray | 2.10 | A | 2-133 | [»] | |
3RSW | X-ray | 2.60 | A/B | 1-133 | [»] | |
3WBG | X-ray | 2.15 | A/B/C/D | 1-133 | [»] | |
3WVM | X-ray | 0.88 | A | 1-133 | [»] | |
3WXQ | X-ray | 1.60 | A | 1-133 | [»] | |
4TJZ | X-ray | 0.87 | A | 1-133 | [»] | |
4TKB | X-ray | 0.86 | A | 1-133 | [»] | |
4TKH | X-ray | 0.93 | A | 1-133 | [»] | |
4TKJ | X-ray | 0.87 | A | 1-133 | [»] | |
4WBK | X-ray | 1.37 | A | 1-133 | [»] | |
5B27 | X-ray | 1.02 | A | 1-133 | [»] | |
5B28 | X-ray | 0.90 | A | 1-133 | [»] | |
5B29 | X-ray | 1.28 | A | 2-133 | [»] | |
5CE4 | Other | 0.98 | A | 1-132 | [»] | |
5HZ9 | X-ray | 2.30 | A/B/C/D/E/F/G/H | 1-133 | [»] | |
6AQ1 | X-ray | 1.40 | A/B | 1-133 | [»] | |
SMRi | P05413 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108468, 28 interactors |
IntActi | P05413, 13 interactors |
MINTi | P05413 |
STRINGi | 9606.ENSP00000362817 |
Chemistry databases
BindingDBi | P05413 |
ChEMBLi | CHEMBL3344 |
DrugBanki | DB04224, Oleic Acid DB03796, Palmitic Acid DB03193, Stearic acid |
DrugCentrali | P05413 |
GuidetoPHARMACOLOGYi | 2533 |
SwissLipidsi | SLP:000001521 |
PTM databases
CarbonylDBi | P05413 |
iPTMneti | P05413 |
PhosphoSitePlusi | P05413 |
SwissPalmi | P05413 |
Genetic variation databases
BioMutai | FABP3 |
DMDMi | 119802 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00219684 |
UCD-2DPAGEi | P05413 |
Proteomic databases
EPDi | P05413 |
jPOSTi | P05413 |
MassIVEi | P05413 |
MaxQBi | P05413 |
PaxDbi | P05413 |
PeptideAtlasi | P05413 |
PRIDEi | P05413 |
ProteomicsDBi | 12633 51837 |
Protocols and materials databases
Antibodypediai | 4505, 1109 antibodies |
DNASUi | 2170 |
Genome annotation databases
Ensembli | ENST00000373713; ENSP00000362817; ENSG00000121769 |
GeneIDi | 2170 |
KEGGi | hsa:2170 |
UCSCi | uc001bss.2, human |
Organism-specific databases
CTDi | 2170 |
DisGeNETi | 2170 |
GeneCardsi | FABP3 |
HGNCi | HGNC:3557, FABP3 |
HPAi | ENSG00000121769, Group enriched (heart muscle, skeletal muscle) |
MIMi | 134651, gene |
neXtProti | NX_P05413 |
OpenTargetsi | ENSG00000121769 |
PharmGKBi | PA27958 |
VEuPathDBi | HostDB:ENSG00000121769.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4015, Eukaryota |
GeneTreei | ENSGT00940000155104 |
InParanoidi | P05413 |
OMAi | THGSVVC |
OrthoDBi | 1417203at2759 |
PhylomeDBi | P05413 |
TreeFami | TF316894 |
Enzyme and pathway databases
PathwayCommonsi | P05413 |
Reactomei | R-HSA-163560, Triglyceride catabolism |
Miscellaneous databases
BioGRID-ORCSi | 2170, 6 hits in 872 CRISPR screens |
ChiTaRSi | FABP3, human |
EvolutionaryTracei | P05413 |
GeneWikii | Heart-type_fatty_acid_binding_protein |
GenomeRNAii | 2170 |
Pharosi | P05413, Tchem |
PROi | PR:P05413 |
RNActi | P05413, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000121769, Expressed in heart left ventricle and 205 other tissues |
ExpressionAtlasi | P05413, baseline and differential |
Genevisiblei | P05413, HS |
Family and domain databases
Gene3Di | 2.40.128.20, 1 hit |
InterProi | View protein in InterPro IPR012674, Calycin IPR000463, Fatty_acid-bd IPR031259, ILBP IPR000566, Lipocln_cytosolic_FA-bd_dom |
PANTHERi | PTHR11955, PTHR11955, 1 hit |
Pfami | View protein in Pfam PF00061, Lipocalin, 1 hit |
PRINTSi | PR00178, FATTYACIDBP |
SUPFAMi | SSF50814, SSF50814, 1 hit |
PROSITEi | View protein in PROSITE PS00214, FABP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FABPH_HUMAN | |
Accessioni | P05413Primary (citable) accession number: P05413 Secondary accession number(s): B2RAB6, Q5VV93, Q99957 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 10, 2021 | |
This is version 199 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families