UniProtKB - P05412 (JUN_HUMAN)
Transcription factor AP-1
JUN
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 272 | Necessary for synergistic transcriptional activity with SMAD3 | 1 |
GO - Molecular functioni
- cAMP response element binding Source: BHF-UCL
- chromatin binding Source: Ensembl
- DNA binding Source: ProtInc
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: BHF-UCL
- DNA-binding transcription factor activity Source: BHF-UCL
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: ARUK-UCL
- enzyme binding Source: UniProtKB
- GTPase activator activity Source: UniProtKB
- HMG box domain binding Source: Ensembl
- identical protein binding Source: IntAct
- protein-containing complex binding Source: Ensembl
- RNA binding Source: UniProtKB
- RNA polymerase II activating transcription factor binding Source: CAFA
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: BHF-UCL
- R-SMAD binding Source: BHF-UCL
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription factor binding Source: BHF-UCL
- transcription regulatory region sequence-specific DNA binding Source: UniProtKB
- ubiquitin-like protein ligase binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
GO - Biological processi
- aging Source: Ensembl
- angiogenesis Source: Ensembl
- axon regeneration Source: Ensembl
- cellular response to cadmium ion Source: CAFA
- cellular response to calcium ion Source: Ensembl
- cellular response to potassium ion starvation Source: Ensembl
- cellular response to reactive oxygen species Source: CAFA
- circadian rhythm Source: Ensembl
- eyelid development in camera-type eye Source: Ensembl
- Fc-epsilon receptor signaling pathway Source: Reactome
- leading edge cell differentiation Source: Ensembl
- learning Source: Ensembl
- liver development Source: Ensembl
- membrane depolarization Source: Ensembl
- microglial cell activation Source: Ensembl
- monocyte differentiation Source: Ensembl
- negative regulation by host of viral transcription Source: UniProtKB
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of DNA binding Source: UniProtKB
- negative regulation of neuron apoptotic process Source: Ensembl
- negative regulation of protein autophosphorylation Source: Ensembl
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
- negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
- outflow tract morphogenesis Source: Ensembl
- positive regulation by host of viral transcription Source: UniProtKB
- positive regulation of apoptotic process Source: CAFA
- positive regulation of DNA replication Source: Ensembl
- positive regulation of DNA-templated transcription, initiation Source: CACAO
- positive regulation of endothelial cell proliferation Source: Ensembl
- positive regulation of epithelial cell migration Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
- positive regulation of fibroblast proliferation Source: Ensembl
- positive regulation of monocyte differentiation Source: Ensembl
- positive regulation of neuron apoptotic process Source: Ensembl
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
- Ras protein signal transduction Source: UniProtKB
- regulation of cell cycle Source: GO_Central
- regulation of cell population proliferation Source: GO_Central
- regulation of DNA-binding transcription factor activity Source: Reactome
- regulation of transcription by RNA polymerase II Source: GO_Central
- release of cytochrome c from mitochondria Source: Ensembl
- response to cAMP Source: Ensembl
- response to cytokine Source: Ensembl
- response to drug Source: Ensembl
- response to hydrogen peroxide Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- response to muscle stretch Source: Ensembl
- response to radiation Source: Ensembl
- SMAD protein signal transduction Source: BHF-UCL
- transcription by RNA polymerase II Source: Ensembl
- transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P05412 |
Reactomei | R-HSA-1912408, Pre-NOTCH Transcription and Translation R-HSA-2559580, Oxidative Stress Induced Senescence R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-2871796, FCERI mediated MAPK activation R-HSA-450341, Activation of the AP-1 family of transcription factors R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes R-HSA-8862803, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9673324, WNT5:FZD7-mediated leishmania damping |
SignaLinki | P05412 |
SIGNORi | P05412 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor AP-1Alternative name(s): Activator protein 1 Short name: AP1 Proto-oncogene c-Jun V-jun avian sarcoma virus 17 oncogene homolog p39 |
Gene namesi | Name:JUN |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6204, JUN |
MIMi | 165160, gene |
neXtProti | NX_P05412 |
VEuPathDBi | HostDB:ENSG00000177606.6 |
Subcellular locationi
Nucleus
Cytosol
- cytosol Source: Ensembl
Nucleus
- nuclear chromatin Source: NTNU_SB
- nuclear chromosome Source: ProtInc
- nuclear euchromatin Source: BHF-UCL
- nucleoplasm Source: HPA
- nucleus Source: ParkinsonsUK-UCL
Other locations
- transcription factor AP-1 complex Source: CAFA
- transcription regulator complex Source: GO_Central
- transcription repressor complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2 | T → A: Complete loss of PAK2-mediated phosphorylation; when associated with A-8; A-89; A-93; and A-286. 1 Publication | 1 | |
Mutagenesisi | 8 | T → A: Complete loss of PAK2-mediated phosphorylation; when associated with A-2; A-89; A-93; and A-286. 1 Publication | 1 | |
Mutagenesisi | 63 | S → A: Greatly reduced ATF7-mediated transcriptional activity; when associated with A-73. Abolishes interaction with FBXW7; when associated with A-73; A-91 and A-93. 2 Publications | 1 | |
Mutagenesisi | 73 | S → A: Greatly reduced ATF7-mediated transcriptional activity; when associated with A-63. Abolishes interaction with FBXW7; when associated with A-63; A-91 and A-93. 2 Publications | 1 | |
Mutagenesisi | 89 | T → A: Complete loss of PAK2-mediated phosphorylation; when associated with A-2; A-8; A-93; and A-286. 1 Publication | 1 | |
Mutagenesisi | 91 | T → A: Abolishes interaction with FBXW7; when associated with A-63; A-73 and A-93. 1 Publication | 1 | |
Mutagenesisi | 93 | T → A: Abolishes interaction with FBXW7; when associated with A-63; A-73 and A-91. 1 Publication | 1 | |
Mutagenesisi | 93 | T → A: Complete loss of PAK2-mediated phosphorylation; when associated with A-2; A-8; A-89; and A-286. 1 Publication | 1 | |
Mutagenesisi | 243 | S → A: Abolishes phosphorylation by DYRK2. Abolishes phosphorylation by GSK3B at Thr-239. 1 Publication | 1 | |
Mutagenesisi | 272 | R → V: Abolishes the synergistic activity with SMAD3 to activate TGF-beta-mediated transcription. 1 Publication | 1 | |
Mutagenesisi | 286 | T → A: Complete loss of PAK2-mediated phosphorylation; when associated with A-2; A-8; A-89; and A-93. 1 Publication | 1 |
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 3725 |
OpenTargetsi | ENSG00000177606 |
PharmGKBi | PA30006 |
Miscellaneous databases
Pharosi | P05412, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4977 |
DrugBanki | DB00210, Adapalene DB01169, Arsenic trioxide DB01029, Irbesartan DB05785, LGD-1550 DB00852, Pseudoephedrine DB00570, Vinblastine |
Genetic variation databases
BioMutai | JUN |
DMDMi | 135298 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076429 | 1 – 331 | Transcription factor AP-1Add BLAST | 331 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | Phosphothreonine; by PAK21 Publication | 1 | |
Modified residuei | 8 | Phosphothreonine; by PAK21 Publication | 1 | |
Cross-linki | 35 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 50 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 56 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 56 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 58 | PhosphoserineCombined sources | 1 | |
Modified residuei | 63 | Phosphoserine; by MAPK8 and PLK3Combined sources3 Publications | 1 | |
Cross-linki | 70 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 73 | Phosphoserine; by MAPK8 and PLK33 Publications | 1 | |
Modified residuei | 89 | Phosphothreonine; by PAK21 Publication | 1 | |
Modified residuei | 91 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 93 | Phosphothreonine; by PAK22 Publications | 1 | |
Cross-linki | 226 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 239 | Phosphothreonine; by GSK3-betaCombined sources1 Publication | 1 | |
Modified residuei | 243 | Phosphoserine; by DYRK2 and GSK3-betaCombined sources2 Publications | 1 | |
Modified residuei | 249 | Phosphoserine; by GSK3-beta2 Publications | 1 | |
Modified residuei | 271 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 286 | Phosphothreonine; by PAK21 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1222 CPTAC-1324 CPTAC-3232 CPTAC-3233 CPTAC-807 CPTAC-927 |
EPDi | P05412 |
jPOSTi | P05412 |
MassIVEi | P05412 |
MaxQBi | P05412 |
PaxDbi | P05412 |
PeptideAtlasi | P05412 |
PRIDEi | P05412 |
ProteomicsDBi | 51836 |
PTM databases
GlyGeni | P05412, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P05412 |
PhosphoSitePlusi | P05412 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000177606, Expressed in amniotic fluid and 250 other tissues |
Genevisiblei | P05412, HS |
Organism-specific databases
HPAi | ENSG00000177606, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer with either FOS or BATF3 or ATF7 (PubMed:10376527, PubMed:12087103, PubMed:15467742). The ATF7/JUN heterodimer is essential for ATF7 transactivation activity (PubMed:10376527).
Interacts with DSIPI; the interaction inhibits the binding of active AP1 to its target DNA (By similarity).
Interacts with HIVEP3 and MYBBP1A (By similarity).
Interacts with SP1, SPIB and TCF20 (PubMed:10196196, PubMed:16478997, PubMed:8663478).
Interacts with COPS5; the interaction leads indirectly to its phosphorylation (PubMed:8837781).
Component of the SMAD3/SMAD4/JUN/FOS/complex which forms at the AP1 promoter site (PubMed:10995748). The SMAD3/SMAD4 heterodimer acts synergistically with the JUN/FOS heterodimer to activate transcription in response to TGF-beta (PubMed:9732876).
Interacts (via its basic DNA binding and leucine zipper domains) with SMAD3 (via an N-terminal domain); the interaction is required for TGF-beta-mediated transactivation of the SMAD3/SMAD4/JUN/FOS/complex (PubMed:10995748).
Interacts with methylated RNF187 (PubMed:20852630, PubMed:23624934). Binds to HIPK3.
Interacts (when phosphorylated) with FBXW7 (PubMed:14739463).
Found in a complex with PRR7 and FBXW7 (PubMed:27458189).
Interacts with PRR7 and FBXW7; the interaction inhibits ubiquitination-mediated JUN degradation promoting its phosphorylation and transcriptional activity (PubMed:27458189).
Interacts with RBM39 (By similarity).
Interacts with PAGE4 (PubMed:24263171, PubMed:24559171, PubMed:26242913).
By similarity16 PublicationsBinary interactionsi
P05412
GO - Molecular functioni
- enzyme binding Source: UniProtKB
- HMG box domain binding Source: Ensembl
- identical protein binding Source: IntAct
- RNA polymerase II activating transcription factor binding Source: CAFA
- R-SMAD binding Source: BHF-UCL
- transcription factor binding Source: BHF-UCL
- ubiquitin-like protein ligase binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109928, 268 interactors |
ComplexPortali | CPX-480, AP-1 transcription factor complex FOS-JUN-NFATC2 CPX-486, AP-1 transcription factor complex FOS-JUN CPX-490, AP-1 transcription factor complex JUN dimer |
CORUMi | P05412 |
DIPi | DIP-5961N |
ELMi | P05412 |
IntActi | P05412, 1402 interactors |
MINTi | P05412 |
STRINGi | 9606.ENSP00000360266 |
Chemistry databases
BindingDBi | P05412 |
Miscellaneous databases
RNActi | P05412, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P05412 |
SMRi | P05412 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P05412 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 252 – 315 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 150 – 223 | Interaction with PAGE41 PublicationAdd BLAST | 74 | |
Regioni | 252 – 279 | Basic motifPROSITE-ProRule annotationAdd BLAST | 28 | |
Regioni | 280 – 308 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 29 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0837, Eukaryota |
GeneTreei | ENSGT00940000162061 |
HOGENOMi | CLU_057007_0_0_1 |
InParanoidi | P05412 |
OMAi | ELHHQHM |
OrthoDBi | 1090460at2759 |
PhylomeDBi | P05412 |
TreeFami | TF323952 |
Family and domain databases
IDEALi | IID00437 |
InterProi | View protein in InterPro IPR004827, bZIP IPR015558, C_Jun/v-Jun IPR005643, JNK IPR002112, Leuzip_Jun IPR008917, TF_DNA-bd_sf |
PANTHERi | PTHR11462:SF8, PTHR11462:SF8, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit PF03957, Jun, 1 hit |
PRINTSi | PR00043, LEUZIPPRJUN |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MTAKMETTFY DDALNASFLP SESGPYGYSN PKILKQSMTL NLADPVGSLK
60 70 80 90 100
PHLRAKNSDL LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP
110 120 130 140 150
KNVTDEQEGF AEGFVRALAE LHSQNTLPSV TSAAQPVNGA GMVAPAVASV
160 170 180 190 200
AGGSGSGGFS ASLHSEPPVY ANLSNFNPGA LSSGGGAPSY GAAGLAFPAQ
210 220 230 240 250
PQQQQQPPHH LPQQMPVQHP RLQALKEEPQ TVPEMPGETP PLSPIDMESQ
260 270 280 290 300
ERIKAERKRM RNRIAASKCR KRKLERIARL EEKVKTLKAQ NSELASTANM
310 320 330
LREQVAQLKQ KVMNHVNSGC QLMLTQQLQT F
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 11 | D → G AA sequence (PubMed:2825349).Curated | 1 | |
Sequence conflicti | 14 | L → F AA sequence (PubMed:2825349).Curated | 1 | |
Sequence conflicti | 80 | I → V AA sequence (PubMed:2825349).Curated | 1 | |
Sequence conflicti | 151 | A → S in CAG46525 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012070 | 297 | T → M. Corresponds to variant dbSNP:rs9989Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04111 Genomic DNA Translation: AAA59197.1 CR541724 mRNA Translation: CAG46525.1 BT019759 mRNA Translation: AAV38564.1 AY217548 Genomic DNA Translation: AAO22993.1 AL136985 Genomic DNA No translation available. BC002646 mRNA No translation available. BC006175 mRNA Translation: AAH06175.1 BC009874 mRNA Translation: AAH09874.2 BC068522 mRNA Translation: AAH68522.1 |
CCDSi | CCDS610.1 |
PIRi | A31264, TVHUJN |
RefSeqi | NP_002219.1, NM_002228.3 |
Genome annotation databases
Ensembli | ENST00000371222; ENSP00000360266; ENSG00000177606 |
GeneIDi | 3725 |
KEGGi | hsa:3725 |
UCSCi | uc001cze.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04111 Genomic DNA Translation: AAA59197.1 CR541724 mRNA Translation: CAG46525.1 BT019759 mRNA Translation: AAV38564.1 AY217548 Genomic DNA Translation: AAO22993.1 AL136985 Genomic DNA No translation available. BC002646 mRNA No translation available. BC006175 mRNA Translation: AAH06175.1 BC009874 mRNA Translation: AAH09874.2 BC068522 mRNA Translation: AAH68522.1 |
CCDSi | CCDS610.1 |
PIRi | A31264, TVHUJN |
RefSeqi | NP_002219.1, NM_002228.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1A02 | X-ray | 2.70 | J | 253-308 | [»] | |
1FOS | X-ray | 3.05 | F/H | 254-315 | [»] | |
1JNM | X-ray | 2.20 | A/B | 254-315 | [»] | |
1JUN | NMR | - | A/B | 276-314 | [»] | |
1S9K | X-ray | 3.10 | E | 257-308 | [»] | |
1T2K | X-ray | 3.00 | C | 254-314 | [»] | |
5FV8 | X-ray | 1.99 | D/E | 277-308 | [»] | |
5T01 | X-ray | 1.89 | A/B | 254-315 | [»] | |
BMRBi | P05412 | |||||
SMRi | P05412 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109928, 268 interactors |
ComplexPortali | CPX-480, AP-1 transcription factor complex FOS-JUN-NFATC2 CPX-486, AP-1 transcription factor complex FOS-JUN CPX-490, AP-1 transcription factor complex JUN dimer |
CORUMi | P05412 |
DIPi | DIP-5961N |
ELMi | P05412 |
IntActi | P05412, 1402 interactors |
MINTi | P05412 |
STRINGi | 9606.ENSP00000360266 |
Chemistry databases
BindingDBi | P05412 |
ChEMBLi | CHEMBL4977 |
DrugBanki | DB00210, Adapalene DB01169, Arsenic trioxide DB01029, Irbesartan DB05785, LGD-1550 DB00852, Pseudoephedrine DB00570, Vinblastine |
PTM databases
GlyGeni | P05412, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P05412 |
PhosphoSitePlusi | P05412 |
Genetic variation databases
BioMutai | JUN |
DMDMi | 135298 |
Proteomic databases
CPTACi | CPTAC-1222 CPTAC-1324 CPTAC-3232 CPTAC-3233 CPTAC-807 CPTAC-927 |
EPDi | P05412 |
jPOSTi | P05412 |
MassIVEi | P05412 |
MaxQBi | P05412 |
PaxDbi | P05412 |
PeptideAtlasi | P05412 |
PRIDEi | P05412 |
ProteomicsDBi | 51836 |
Protocols and materials databases
Antibodypediai | 3535, 3690 antibodies |
CPTCi | P05412, 6 antibodies |
DNASUi | 3725 |
Genome annotation databases
Ensembli | ENST00000371222; ENSP00000360266; ENSG00000177606 |
GeneIDi | 3725 |
KEGGi | hsa:3725 |
UCSCi | uc001cze.4, human |
Organism-specific databases
CTDi | 3725 |
DisGeNETi | 3725 |
GeneCardsi | JUN |
HGNCi | HGNC:6204, JUN |
HPAi | ENSG00000177606, Low tissue specificity |
MIMi | 165160, gene |
neXtProti | NX_P05412 |
OpenTargetsi | ENSG00000177606 |
PharmGKBi | PA30006 |
VEuPathDBi | HostDB:ENSG00000177606.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0837, Eukaryota |
GeneTreei | ENSGT00940000162061 |
HOGENOMi | CLU_057007_0_0_1 |
InParanoidi | P05412 |
OMAi | ELHHQHM |
OrthoDBi | 1090460at2759 |
PhylomeDBi | P05412 |
TreeFami | TF323952 |
Enzyme and pathway databases
PathwayCommonsi | P05412 |
Reactomei | R-HSA-1912408, Pre-NOTCH Transcription and Translation R-HSA-2559580, Oxidative Stress Induced Senescence R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-2871796, FCERI mediated MAPK activation R-HSA-450341, Activation of the AP-1 family of transcription factors R-HSA-5617472, Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-6796648, TP53 Regulates Transcription of DNA Repair Genes R-HSA-8862803, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9673324, WNT5:FZD7-mediated leishmania damping |
SignaLinki | P05412 |
SIGNORi | P05412 |
Miscellaneous databases
BioGRID-ORCSi | 3725, 99 hits in 901 CRISPR screens |
ChiTaRSi | JUN, human |
EvolutionaryTracei | P05412 |
GeneWikii | C-jun |
GenomeRNAii | 3725 |
Pharosi | P05412, Tchem |
PROi | PR:P05412 |
RNActi | P05412, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177606, Expressed in amniotic fluid and 250 other tissues |
Genevisiblei | P05412, HS |
Family and domain databases
IDEALi | IID00437 |
InterProi | View protein in InterPro IPR004827, bZIP IPR015558, C_Jun/v-Jun IPR005643, JNK IPR002112, Leuzip_Jun IPR008917, TF_DNA-bd_sf |
PANTHERi | PTHR11462:SF8, PTHR11462:SF8, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit PF03957, Jun, 1 hit |
PRINTSi | PR00043, LEUZIPPRJUN |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF47454, SSF47454, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | JUN_HUMAN | |
Accessioni | P05412Primary (citable) accession number: P05412 Secondary accession number(s): Q6FHM7, Q96G93 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | October 1, 1989 | |
Last modified: | February 10, 2021 | |
This is version 254 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families