Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S acidic ribosomal protein P2

Gene

RpLP2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the elongation step of protein synthesis.

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: FlyBase
  • translational elongation Source: InterPro

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S acidic ribosomal protein P2
Alternative name(s):
Acidic ribosomal protein RPA1
Gene namesi
Name:RpLP2
Synonyms:rpA1, RpP1
ORF Names:CG4918
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0003274 RpLP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001576521 – 11360S acidic ribosomal protein P2Add BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei100Phosphoserine1 Publication1
Modified residuei102Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP05389
PRIDEiP05389

PTM databases

iPTMnetiP05389

Expressioni

Gene expression databases

BgeeiFBgn0003274
ExpressionAtlasiP05389 baseline and differential
GenevisibleiP05389 DM

Interactioni

Subunit structurei

P1 and P2 exist as dimers at the large ribosomal subunit.

Protein-protein interaction databases

BioGridi62568, 22 interactors
DIPiDIP-19859N
IntActiP05389, 22 interactors
STRINGi7227.FBpp0089424

Structurei

3D structure databases

ProteinModelPortaliP05389
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3449 Eukaryota
COG2058 LUCA
GeneTreeiENSGT00550000074828
InParanoidiP05389
KOiK02943
OMAiAFFNFTM
OrthoDBiEOG091G14BD
PhylomeDBiP05389

Family and domain databases

Gene3Di1.10.10.1410, 1 hit
HAMAPiMF_01478 Ribosomal_L12_arch, 1 hit
InterProiView protein in InterPro
IPR038716 P1/P2_N_sf
IPR027534 Ribosomal_L12

Sequencei

Sequence statusi: Complete.

P05389-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYVAAYLLA VLGGKDSPAN SDLEKILSSV GVEVDAERLT KVIKELAGKS
60 70 80 90 100
IDDLIKEGRE KLSSMPVGGG GAVAAADAAP AAAAGGDKKE AKKEEKKEES
110
ESEDDDMGFA LFE
Length:113
Mass (Da):11,757
Last modified:November 1, 1988 - v1
Checksum:iDDA5F5A4219BD65A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21S → G in CAA29026 (PubMed:3103101).Curated1
Sequence conflicti21S → G in AAM51113 (PubMed:12537569).Curated1
Sequence conflicti76A → V in AAM51113 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05016 Genomic DNA Translation: CAA28672.1
X05466 mRNA Translation: CAA29026.1
AE013599 Genomic DNA Translation: AAF57979.1
AY119253 mRNA Translation: AAM51113.1
PIRiA26401 R6FFP2
RefSeqiNP_523764.1, NM_079040.4

Genome annotation databases

EnsemblMetazoaiFBtr0087105; FBpp0086252; FBgn0003274
GeneIDi36855
KEGGidme:Dmel_CG4918

Similar proteinsi

Entry informationi

Entry nameiRLA2_DROME
AccessioniPrimary (citable) accession number: P05389
Secondary accession number(s): A4UZK7, Q8MRV1, Q9V7R6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: July 18, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health