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UniProtKB - P05388 (RLA0_HUMAN)

Entry version 226 (02 Dec 2020)
Sequence version 1 (01 Nov 1988)
Previous versions | rss
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Protein

60S acidic ribosomal protein P0

Gene

RPLP0

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P05388

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902, Peptide chain elongation
R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823, Viral mRNA Translation
R-HSA-2408557, Selenocysteine synthesis
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689, Formation of a pool of free 40S subunits
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764, Eukaryotic Translation Termination
R-HSA-8950505, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60S acidic ribosomal protein P0
Alternative name(s):
60S ribosomal protein L10E
Large ribosomal subunit protein uL101 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPLP0
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000089157.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:10371, RPLP0

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		180510, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P05388

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6175

Open Targets

More...OpenTargetsi		ENSG00000089157

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34772

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P05388, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RPLP0

Domain mapping of disease mutations (DMDM)

More...DMDMi		133041

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001547581 – 31760S acidic ribosomal protein P0Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24PhosphotyrosineBy similarity1
Modified residuei59PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki297Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki297Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei304PhosphoserineCombined sources1
Modified residuei307PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P05388

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P05388

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P05388

MaxQB - The MaxQuant DataBase

More...MaxQBi		P05388

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P05388

PeptideAtlas

More...PeptideAtlasi		P05388

PRoteomics IDEntifications database

More...PRIDEi		P05388

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51833 [P05388-1]
61651

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P05388-1 [P05388-1]

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		P05388

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P05388

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P05388

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P05388

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P05388

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000089157, Expressed in ventricular zone and 114 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P05388, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P05388, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000089157, Tissue enhanced (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

P0 forms a pentameric complex by interaction with dimers of P1 and P2 (PubMed:3323886).

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661).

Interacts with APEX1 (PubMed:19188445).

Interacts with FMR1 isoform 6 (PubMed:24658146).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112094, 274 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5183, 60S cytosolic large ribosomal subunit

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P05388

Protein interaction database and analysis system

More...IntActi		P05388, 95 interactors

Molecular INTeraction database

More...MINTi		P05388

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000449328

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P05388, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the universal ribosomal protein uL10 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0815, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000017839

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P05388

Identification of Orthologs from Complete Genome Data

More...OMAi		VWVPAGN

Database for complete collections of gene phylogenies

More...PhylomeDBi		P05388

TreeFam database of animal gene trees

More...TreeFami		TF300849

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.1730, 1 hit
3.90.105.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR030670, L10E_eukaryotes
IPR043141, Ribosomal_L10-like_sf
IPR001790, Ribosomal_L10P
IPR043164, RL10_insert_sf
IPR040637, RL10P_insert

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00466, Ribosomal_L10, 1 hit
PF17777, RL10P_insert, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF039087, L10E, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF160369, SSF160369, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P05388-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPREDRATWK SNYFLKIIQL LDDYPKCFIV GADNVGSKQM QQIRMSLRGK 
        60         70         80         90        100
AVVLMGKNTM MRKAIRGHLE NNPALEKLLP HIRGNVGFVF TKEDLTEIRD 
       110        120        130        140        150
MLLANKVPAA ARAGAIAPCE VTVPAQNTGL GPEKTSFFQA LGITTKISRG 
       160        170        180        190        200
TIEILSDVQL IKTGDKVGAS EATLLNMLNI SPFSFGLVIQ QVFDNGSIYN 
       210        220        230        240        250
PEVLDITEET LHSRFLEGVR NVASVCLQIG YPTVASVPHS IINGYKRVLA 
       260        270        280        290        300
LSVETDYTFP LAEKVKAFLA DPSAFVAAAP VAAATTAAPA AAAAPAKVEA 
       310 
KEESEESDED MGFGLFD
Length:317
Mass (Da):34,274
Last modified:November 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i255AD25571C51199
GO
Isoform 2 (identifier: P05388-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-217: Missing.

Show »
Length:255
Mass (Da):27,436
Checksum:iB10D4073AAA5990A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VWS0F8VWS0_HUMAN
60S acidic ribosomal protein P0
RPLP0
281Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VW21F8VW21_HUMAN
60S acidic ribosomal protein P0
RPLP0
244Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VU65F8VU65_HUMAN
60S acidic ribosomal protein P0
RPLP0
247Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VPE8F8VPE8_HUMAN
60S acidic ribosomal protein P0
RPLP0
153Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VWV4F8VWV4_HUMAN
60S acidic ribosomal protein P0
RPLP0
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V210G3V210_HUMAN
60S acidic ribosomal protein P0
RPLP0 hCG_2016152
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VS58F8VS58_HUMAN
60S acidic ribosomal protein P0
RPLP0
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VZS0F8VZS0_HUMAN
60S acidic ribosomal protein P0
RPLP0
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQY6F8VQY6_HUMAN
60S acidic ribosomal protein P0
RPLP0
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VRK7F8VRK7_HUMAN
60S acidic ribosomal protein P0
RPLP0
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti246K → E in AAH01127 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055867156 – 217Missing in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M17885 mRNA Translation: AAA36470.1
AC004263 Genomic DNA Translation: AAC05176.1
BC000087 mRNA Translation: AAH00087.1
BC000345 mRNA Translation: AAH00345.1
BC000752 mRNA Translation: AAH00752.1
BC001127 mRNA Translation: AAH01127.1
BC001834 mRNA Translation: AAH01834.1
BC003655 mRNA Translation: AAH03655.1
BC005863 mRNA Translation: AAH05863.1
BC008092 mRNA Translation: AAH08092.1
BC008594 mRNA Translation: AAH08594.1
BC009867 mRNA Translation: AAH09867.1
BC015173 mRNA Translation: AAH15173.1
BC015690 mRNA Translation: AAH15690.1
BC107717 mRNA Translation: AAI07718.1
AB007187 Genomic DNA Translation: BAA25845.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9193.1 [P05388-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A27125, R5HUP0

NCBI Reference Sequences

More...RefSeqi		NP_000993.1, NM_001002.3 [P05388-1]
NP_444505.1, NM_053275.3 [P05388-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000228306; ENSP00000339027; ENSG00000089157 [P05388-1]
ENST00000313104; ENSP00000366471; ENSG00000089157 [P05388-2]
ENST00000392514; ENSP00000376299; ENSG00000089157 [P05388-1]
ENST00000551150; ENSP00000449328; ENSG00000089157 [P05388-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6175

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6175

UCSC genome browser

More...UCSCi		uc001txp.4, human [P05388-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17885 mRNA Translation: AAA36470.1
AC004263 Genomic DNA Translation: AAC05176.1
BC000087 mRNA Translation: AAH00087.1
BC000345 mRNA Translation: AAH00345.1
BC000752 mRNA Translation: AAH00752.1
BC001127 mRNA Translation: AAH01127.1
BC001834 mRNA Translation: AAH01834.1
BC003655 mRNA Translation: AAH03655.1
BC005863 mRNA Translation: AAH05863.1
BC008092 mRNA Translation: AAH08092.1
BC008594 mRNA Translation: AAH08594.1
BC009867 mRNA Translation: AAH09867.1
BC015173 mRNA Translation: AAH15173.1
BC015690 mRNA Translation: AAH15690.1
BC107717 mRNA Translation: AAI07718.1
AB007187 Genomic DNA Translation: BAA25845.1
CCDSiCCDS9193.1 [P05388-1]
PIRiA27125, R5HUP0
RefSeqiNP_000993.1, NM_001002.3 [P05388-1]
NP_444505.1, NM_053275.3 [P05388-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00q5-227[»]
4V6Xelectron microscopy5.00Cq1-317[»]
5AJ0electron microscopy3.50AK1-317[»]
6OLGelectron microscopy3.40AK1-109[»]
6ZM7electron microscopy2.70Ls1-317[»]
6ZMEelectron microscopy3.00Ls1-317[»]
6ZMIelectron microscopy2.60Ls1-317[»]
6ZMOelectron microscopy3.10Ls1-317[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112094, 274 interactors
ComplexPortaliCPX-5183, 60S cytosolic large ribosomal subunit
CORUMiP05388
IntActiP05388, 95 interactors
MINTiP05388
STRINGi9606.ENSP00000449328

PTM databases

iPTMnetiP05388
MetOSiteiP05388
PhosphoSitePlusiP05388
SwissPalmiP05388

Polymorphism and mutation databases

BioMutaiRPLP0
DMDMi133041

2D gel databases

REPRODUCTION-2DPAGEiP05388

Proteomic databases

EPDiP05388
jPOSTiP05388
MassIVEiP05388
MaxQBiP05388
PaxDbiP05388
PeptideAtlasiP05388
PRIDEiP05388
ProteomicsDBi51833 [P05388-1]
61651
TopDownProteomicsiP05388-1 [P05388-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1255, 262 antibodies

The DNASU plasmid repository

More...DNASUi		6175

Genome annotation databases

EnsembliENST00000228306; ENSP00000339027; ENSG00000089157 [P05388-1]
ENST00000313104; ENSP00000366471; ENSG00000089157 [P05388-2]
ENST00000392514; ENSP00000376299; ENSG00000089157 [P05388-1]
ENST00000551150; ENSP00000449328; ENSG00000089157 [P05388-1]
GeneIDi6175
KEGGihsa:6175
UCSCiuc001txp.4, human [P05388-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6175
DisGeNETi6175
EuPathDBiHostDB:ENSG00000089157.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		RPLP0
HGNCiHGNC:10371, RPLP0
HPAiENSG00000089157, Tissue enhanced (pancreas)
MIMi180510, gene
neXtProtiNX_P05388
OpenTargetsiENSG00000089157
PharmGKBiPA34772

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0815, Eukaryota
GeneTreeiENSGT00390000017839
InParanoidiP05388
OMAiVWVPAGN
PhylomeDBiP05388
TreeFamiTF300849

Enzyme and pathway databases

PathwayCommonsiP05388
ReactomeiR-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902, Peptide chain elongation
R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823, Viral mRNA Translation
R-HSA-2408557, Selenocysteine synthesis
R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689, Formation of a pool of free 40S subunits
R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764, Eukaryotic Translation Termination
R-HSA-8950505, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
R-HSA-9010553, Regulation of expression of SLITs and ROBOs
R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency
R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6175, 759 hits in 847 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RPLP0, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RPLP0

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6175
PharosiP05388, Tbio

Protein Ontology

More...PROi		PR:P05388
RNActiP05388, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000089157, Expressed in ventricular zone and 114 other tissues
ExpressionAtlasiP05388, baseline and differential
GenevisibleiP05388, HS

Family and domain databases

Gene3Di3.30.70.1730, 1 hit
3.90.105.20, 1 hit
InterProiView protein in InterPro
IPR030670, L10E_eukaryotes
IPR043141, Ribosomal_L10-like_sf
IPR001790, Ribosomal_L10P
IPR043164, RL10_insert_sf
IPR040637, RL10P_insert
PfamiView protein in Pfam
PF00466, Ribosomal_L10, 1 hit
PF17777, RL10P_insert, 1 hit
PIRSFiPIRSF039087, L10E, 1 hit
SUPFAMiSSF160369, SSF160369, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRLA0_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05388
Secondary accession number(s): Q3B7A4, Q9BVK4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: December 2, 2020
This is version 226 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
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