UniProtKB - P05388 (RLA0_HUMAN)
Protein
60S acidic ribosomal protein P0
Gene
RPLP0
Organism
Homo sapiens (Human)
Status
Functioni
Ribosomal protein P0 is the functional equivalent of E.coli protein L10.
GO - Molecular functioni
- large ribosomal subunit rRNA binding Source: GO_Central
- RNA binding Source: UniProtKB
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- cytoplasmic translation Source: GO_Central
- interleukin-12-mediated signaling pathway Source: Reactome
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
- ribosomal large subunit assembly Source: GO_Central
- SRP-dependent cotranslational protein targeting to membrane Source: Reactome
- translation Source: UniProtKB
- translational initiation Source: Reactome
- viral transcription Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
Reactomei | R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902 Peptide chain elongation R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-192823 Viral mRNA Translation R-HSA-2408557 Selenocysteine synthesis R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764 Eukaryotic Translation Termination R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: 60S acidic ribosomal protein P0Alternative name(s): 60S ribosomal protein L10E Large ribosomal subunit protein uL101 Publication |
Gene namesi | Name:RPLP0 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10371 RPLP0 |
MIMi | 180510 gene |
neXtProti | NX_P05388 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
- cytosolic large ribosomal subunit Source: GO_Central
Endoplasmic reticulum
- endoplasmic reticulum Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- cytoplasmic ribonucleoprotein granule Source: ParkinsonsUK-UCL
- focal adhesion Source: UniProtKB
- membrane Source: UniProtKB
- postsynapse Source: SynGO
- postsynaptic density Source: SynGO
- ribonucleoprotein complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6175 |
OpenTargetsi | ENSG00000089157 |
PharmGKBi | PA34772 |
Miscellaneous databases
Pharosi | P05388 |
Polymorphism and mutation databases
BioMutai | RPLP0 |
DMDMi | 133041 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000154758 | 1 – 317 | 60S acidic ribosomal protein P0Add BLAST | 317 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 24 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 59 | PhosphothreonineCombined sources | 1 | |
Cross-linki | 297 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 297 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 304 | PhosphoserineCombined sources | 1 | |
Modified residuei | 307 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P05388 |
jPOSTi | P05388 |
MassIVEi | P05388 |
MaxQBi | P05388 |
PaxDbi | P05388 |
PeptideAtlasi | P05388 |
PRIDEi | P05388 |
ProteomicsDBi | 51833 [P05388-1] 61651 |
TopDownProteomicsi | P05388-1 [P05388-1] |
2D gel databases
REPRODUCTION-2DPAGEi | P05388 |
PTM databases
iPTMneti | P05388 |
PhosphoSitePlusi | P05388 |
SwissPalmi | P05388 |
Expressioni
Gene expression databases
Bgeei | ENSG00000089157 Expressed in 88 organ(s), highest expression level in left adrenal gland |
ExpressionAtlasi | P05388 baseline and differential |
Genevisiblei | P05388 HS |
Organism-specific databases
HPAi | HPA003512 |
Interactioni
Subunit structurei
Binary interactionsi
Protein-protein interaction databases
BioGridi | 112094, 252 interactors |
CORUMi | P05388 |
IntActi | P05388, 80 interactors |
MINTi | P05388 |
STRINGi | 9606.ENSP00000449328 |
Family & Domainsi
Sequence similaritiesi
Belongs to the universal ribosomal protein uL10 family.Curated
Phylogenomic databases
eggNOGi | KOG0815 Eukaryota COG0244 LUCA |
GeneTreei | ENSGT00390000017839 |
HOGENOMi | HOG000210987 |
InParanoidi | P05388 |
KOi | K02941 |
OMAi | VWVPAGN |
OrthoDBi | 1102823at2759 |
PhylomeDBi | P05388 |
TreeFami | TF300849 |
Family and domain databases
InterProi | View protein in InterPro IPR030670 L10E_eukaryotes IPR001790 Ribosomal_L10P IPR040637 RL10P_insert |
Pfami | View protein in Pfam PF00466 Ribosomal_L10, 1 hit PF17777 RL10P_insert, 1 hit |
PIRSFi | PIRSF039087 L10E, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P05388-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPREDRATWK SNYFLKIIQL LDDYPKCFIV GADNVGSKQM QQIRMSLRGK
60 70 80 90 100
AVVLMGKNTM MRKAIRGHLE NNPALEKLLP HIRGNVGFVF TKEDLTEIRD
110 120 130 140 150
MLLANKVPAA ARAGAIAPCE VTVPAQNTGL GPEKTSFFQA LGITTKISRG
160 170 180 190 200
TIEILSDVQL IKTGDKVGAS EATLLNMLNI SPFSFGLVIQ QVFDNGSIYN
210 220 230 240 250
PEVLDITEET LHSRFLEGVR NVASVCLQIG YPTVASVPHS IINGYKRVLA
260 270 280 290 300
LSVETDYTFP LAEKVKAFLA DPSAFVAAAP VAAATTAAPA AAAAPAKVEA
310
KEESEESDED MGFGLFD
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VWS0 | F8VWS0_HUMAN | 60S acidic ribosomal protein P0 | RPLP0 | 281 | Annotation score: | ||
F8VPE8 | F8VPE8_HUMAN | 60S acidic ribosomal protein P0 | RPLP0 | 153 | Annotation score: | ||
F8VU65 | F8VU65_HUMAN | 60S acidic ribosomal protein P0 | RPLP0 | 247 | Annotation score: | ||
F8VW21 | F8VW21_HUMAN | 60S acidic ribosomal protein P0 | RPLP0 | 244 | Annotation score: | ||
F8VWV4 | F8VWV4_HUMAN | 60S acidic ribosomal protein P0 | RPLP0 | 111 | Annotation score: | ||
F8W1K8 | F8W1K8_HUMAN | 60S acidic ribosomal protein P0 | RPLP0 | 107 | Annotation score: | ||
G3V210 | G3V210_HUMAN | 60S acidic ribosomal protein P0 | RPLP0 hCG_2016152 | 166 | Annotation score: | ||
F8VQY6 | F8VQY6_HUMAN | 60S acidic ribosomal protein P0 | RPLP0 | 142 | Annotation score: | ||
F8VRK7 | F8VRK7_HUMAN | 60S acidic ribosomal protein P0 | RPLP0 | 156 | Annotation score: | ||
F8VS58 | F8VS58_HUMAN | 60S acidic ribosomal protein P0 | RPLP0 | 121 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 246 | K → E in AAH01127 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055867 | 156 – 217 | Missing in isoform 2. 1 PublicationAdd BLAST | 62 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M17885 mRNA Translation: AAA36470.1 AC004263 Genomic DNA Translation: AAC05176.1 BC000087 mRNA Translation: AAH00087.1 BC000345 mRNA Translation: AAH00345.1 BC000752 mRNA Translation: AAH00752.1 BC001127 mRNA Translation: AAH01127.1 BC001834 mRNA Translation: AAH01834.1 BC003655 mRNA Translation: AAH03655.1 BC005863 mRNA Translation: AAH05863.1 BC008092 mRNA Translation: AAH08092.1 BC008594 mRNA Translation: AAH08594.1 BC009867 mRNA Translation: AAH09867.1 BC015173 mRNA Translation: AAH15173.1 BC015690 mRNA Translation: AAH15690.1 BC107717 mRNA Translation: AAI07718.1 AB007187 Genomic DNA Translation: BAA25845.1 |
CCDSi | CCDS9193.1 [P05388-1] |
PIRi | A27125 R5HUP0 |
RefSeqi | NP_000993.1, NM_001002.3 [P05388-1] NP_444505.1, NM_053275.3 [P05388-1] |
Genome annotation databases
Ensembli | ENST00000228306; ENSP00000339027; ENSG00000089157 [P05388-1] ENST00000313104; ENSP00000366471; ENSG00000089157 [P05388-2] ENST00000392514; ENSP00000376299; ENSG00000089157 [P05388-1] ENST00000551150; ENSP00000449328; ENSG00000089157 [P05388-1] |
GeneIDi | 6175 |
KEGGi | hsa:6175 |
UCSCi | uc001txp.4 human [P05388-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M17885 mRNA Translation: AAA36470.1 AC004263 Genomic DNA Translation: AAC05176.1 BC000087 mRNA Translation: AAH00087.1 BC000345 mRNA Translation: AAH00345.1 BC000752 mRNA Translation: AAH00752.1 BC001127 mRNA Translation: AAH01127.1 BC001834 mRNA Translation: AAH01834.1 BC003655 mRNA Translation: AAH03655.1 BC005863 mRNA Translation: AAH05863.1 BC008092 mRNA Translation: AAH08092.1 BC008594 mRNA Translation: AAH08594.1 BC009867 mRNA Translation: AAH09867.1 BC015173 mRNA Translation: AAH15173.1 BC015690 mRNA Translation: AAH15690.1 BC107717 mRNA Translation: AAI07718.1 AB007187 Genomic DNA Translation: BAA25845.1 |
CCDSi | CCDS9193.1 [P05388-1] |
PIRi | A27125 R5HUP0 |
RefSeqi | NP_000993.1, NM_001002.3 [P05388-1] NP_444505.1, NM_053275.3 [P05388-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4V6W | electron microscopy | 6.00 | q | 5-227 | [»] | |
4V6X | electron microscopy | 5.00 | Cq | 1-317 | [»] | |
5AJ0 | electron microscopy | 3.50 | AK | 1-317 | [»] | |
6OLG | electron microscopy | 3.40 | AK | 1-109 | [»] | |
SMRi | P05388 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 112094, 252 interactors |
CORUMi | P05388 |
IntActi | P05388, 80 interactors |
MINTi | P05388 |
STRINGi | 9606.ENSP00000449328 |
PTM databases
iPTMneti | P05388 |
PhosphoSitePlusi | P05388 |
SwissPalmi | P05388 |
Polymorphism and mutation databases
BioMutai | RPLP0 |
DMDMi | 133041 |
2D gel databases
REPRODUCTION-2DPAGEi | P05388 |
Proteomic databases
EPDi | P05388 |
jPOSTi | P05388 |
MassIVEi | P05388 |
MaxQBi | P05388 |
PaxDbi | P05388 |
PeptideAtlasi | P05388 |
PRIDEi | P05388 |
ProteomicsDBi | 51833 [P05388-1] 61651 |
TopDownProteomicsi | P05388-1 [P05388-1] |
Protocols and materials databases
DNASUi | 6175 |
Genome annotation databases
Ensembli | ENST00000228306; ENSP00000339027; ENSG00000089157 [P05388-1] ENST00000313104; ENSP00000366471; ENSG00000089157 [P05388-2] ENST00000392514; ENSP00000376299; ENSG00000089157 [P05388-1] ENST00000551150; ENSP00000449328; ENSG00000089157 [P05388-1] |
GeneIDi | 6175 |
KEGGi | hsa:6175 |
UCSCi | uc001txp.4 human [P05388-1] |
Organism-specific databases
CTDi | 6175 |
DisGeNETi | 6175 |
GeneCardsi | RPLP0 |
HGNCi | HGNC:10371 RPLP0 |
HPAi | HPA003512 |
MIMi | 180510 gene |
neXtProti | NX_P05388 |
OpenTargetsi | ENSG00000089157 |
PharmGKBi | PA34772 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0815 Eukaryota COG0244 LUCA |
GeneTreei | ENSGT00390000017839 |
HOGENOMi | HOG000210987 |
InParanoidi | P05388 |
KOi | K02941 |
OMAi | VWVPAGN |
OrthoDBi | 1102823at2759 |
PhylomeDBi | P05388 |
TreeFami | TF300849 |
Enzyme and pathway databases
Reactomei | R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902 Peptide chain elongation R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane R-HSA-192823 Viral mRNA Translation R-HSA-2408557 Selenocysteine synthesis R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689 Formation of a pool of free 40S subunits R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764 Eukaryotic Translation Termination R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
ChiTaRSi | RPLP0 human |
GeneWikii | RPLP0 |
GenomeRNAii | 6175 |
Pharosi | P05388 |
PROi | PR:P05388 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000089157 Expressed in 88 organ(s), highest expression level in left adrenal gland |
ExpressionAtlasi | P05388 baseline and differential |
Genevisiblei | P05388 HS |
Family and domain databases
InterProi | View protein in InterPro IPR030670 L10E_eukaryotes IPR001790 Ribosomal_L10P IPR040637 RL10P_insert |
Pfami | View protein in Pfam PF00466 Ribosomal_L10, 1 hit PF17777 RL10P_insert, 1 hit |
PIRSFi | PIRSF039087 L10E, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RLA0_HUMAN | |
Accessioni | P05388Primary (citable) accession number: P05388 Secondary accession number(s): Q3B7A4, Q9BVK4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | November 1, 1988 | |
Last modified: | November 13, 2019 | |
This is version 219 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Ribosomal proteins
Ribosomal proteins families and list of entries - SIMILARITY comments
Index of protein domains and families - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references