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Protein

60S acidic ribosomal protein P0

Gene

RPLP0

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

GO - Molecular functioni

  • peptide binding Source: Ensembl
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S acidic ribosomal protein P0
Alternative name(s):
60S ribosomal protein L10E
Large ribosomal subunit protein uL101 Publication
Gene namesi
Name:RPLP0
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000089157.15
HGNCiHGNC:10371 RPLP0
MIMi180510 gene
neXtProtiNX_P05388

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6175
OpenTargetsiENSG00000089157
PharmGKBiPA34772

Polymorphism and mutation databases

BioMutaiRPLP0
DMDMi133041

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001547581 – 31760S acidic ribosomal protein P0Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphotyrosineBy similarity1
Modified residuei59PhosphothreonineCombined sources1
Cross-linki297Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki297Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei304PhosphoserineCombined sources1
Modified residuei307PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP05388
MaxQBiP05388
PaxDbiP05388
PeptideAtlasiP05388
PRIDEiP05388
ProteomicsDBi51833
TopDownProteomicsiP05388-1 [P05388-1]

2D gel databases

REPRODUCTION-2DPAGEiP05388

PTM databases

iPTMnetiP05388
PhosphoSitePlusiP05388
SwissPalmiP05388

Expressioni

Gene expression databases

BgeeiENSG00000089157 Expressed in 88 organ(s), highest expression level in left adrenal gland
CleanExiHS_RPLP0
ExpressionAtlasiP05388 baseline and differential
GenevisibleiP05388 HS

Organism-specific databases

HPAiHPA003512

Interactioni

Subunit structurei

P0 forms a pentameric complex by interaction with dimers of P1 and P2 (PubMed:3323886). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with APEX1 (PubMed:19188445). Interacts with FMR1 isoform 6 (PubMed:24658146).4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi112094, 218 interactors
CORUMiP05388
IntActiP05388, 55 interactors
MINTiP05388
STRINGi9606.ENSP00000339027

Structurei

3D structure databases

ProteinModelPortaliP05388
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0815 Eukaryota
COG0244 LUCA
GeneTreeiENSGT00390000017839
HOGENOMiHOG000210987
HOVERGENiHBG000711
InParanoidiP05388
KOiK02941
OMAiMAHVAEW
OrthoDBiEOG091G0F47
PhylomeDBiP05388
TreeFamiTF300849

Family and domain databases

InterProiView protein in InterPro
IPR030670 L10E_eukaryotes
IPR001790 Ribosomal_L10P
PfamiView protein in Pfam
PF00466 Ribosomal_L10, 1 hit
PIRSFiPIRSF039087 L10E, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P05388-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPREDRATWK SNYFLKIIQL LDDYPKCFIV GADNVGSKQM QQIRMSLRGK
60 70 80 90 100
AVVLMGKNTM MRKAIRGHLE NNPALEKLLP HIRGNVGFVF TKEDLTEIRD
110 120 130 140 150
MLLANKVPAA ARAGAIAPCE VTVPAQNTGL GPEKTSFFQA LGITTKISRG
160 170 180 190 200
TIEILSDVQL IKTGDKVGAS EATLLNMLNI SPFSFGLVIQ QVFDNGSIYN
210 220 230 240 250
PEVLDITEET LHSRFLEGVR NVASVCLQIG YPTVASVPHS IINGYKRVLA
260 270 280 290 300
LSVETDYTFP LAEKVKAFLA DPSAFVAAAP VAAATTAAPA AAAAPAKVEA
310
KEESEESDED MGFGLFD
Length:317
Mass (Da):34,274
Last modified:November 1, 1988 - v1
Checksum:i255AD25571C51199
GO
Isoform 2 (identifier: P05388-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-217: Missing.

Note: No experimental confirmation available.
Show »
Length:255
Mass (Da):27,436
Checksum:iB10D4073AAA5990A
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VWS0F8VWS0_HUMAN
60S acidic ribosomal protein P0
RPLP0
281Annotation score:
F8VPE8F8VPE8_HUMAN
60S acidic ribosomal protein P0
RPLP0
153Annotation score:
F8VWV4F8VWV4_HUMAN
60S acidic ribosomal protein P0
RPLP0
111Annotation score:
F8VW21F8VW21_HUMAN
60S acidic ribosomal protein P0
RPLP0
244Annotation score:
F8VU65F8VU65_HUMAN
60S acidic ribosomal protein P0
RPLP0
247Annotation score:
F8VS58F8VS58_HUMAN
60S acidic ribosomal protein P0
RPLP0
121Annotation score:
F8VQY6F8VQY6_HUMAN
60S acidic ribosomal protein P0
RPLP0
142Annotation score:
F8VRK7F8VRK7_HUMAN
60S acidic ribosomal protein P0
RPLP0
156Annotation score:
F8VZS0F8VZS0_HUMAN
60S acidic ribosomal protein P0
RPLP0
246Annotation score:
G3V210G3V210_HUMAN
60S acidic ribosomal protein P0
RPLP0 hCG_2016152
166Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti246K → E in AAH01127 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055867156 – 217Missing in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17885 mRNA Translation: AAA36470.1
AC004263 Genomic DNA Translation: AAC05176.1
BC000087 mRNA Translation: AAH00087.1
BC000345 mRNA Translation: AAH00345.1
BC000752 mRNA Translation: AAH00752.1
BC001127 mRNA Translation: AAH01127.1
BC001834 mRNA Translation: AAH01834.1
BC003655 mRNA Translation: AAH03655.1
BC005863 mRNA Translation: AAH05863.1
BC008092 mRNA Translation: AAH08092.1
BC008594 mRNA Translation: AAH08594.1
BC009867 mRNA Translation: AAH09867.1
BC015173 mRNA Translation: AAH15173.1
BC015690 mRNA Translation: AAH15690.1
BC107717 mRNA Translation: AAI07718.1
AB007187 Genomic DNA Translation: BAA25845.1
CCDSiCCDS9193.1 [P05388-1]
PIRiA27125 R5HUP0
RefSeqiNP_000993.1, NM_001002.3 [P05388-1]
NP_444505.1, NM_053275.3 [P05388-1]
UniGeneiHs.546285

Genome annotation databases

EnsembliENST00000228306; ENSP00000339027; ENSG00000089157 [P05388-1]
ENST00000313104; ENSP00000366471; ENSG00000089157 [P05388-2]
ENST00000392514; ENSP00000376299; ENSG00000089157 [P05388-1]
ENST00000551150; ENSP00000449328; ENSG00000089157 [P05388-1]
GeneIDi6175
KEGGihsa:6175
UCSCiuc001txp.4 human [P05388-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17885 mRNA Translation: AAA36470.1
AC004263 Genomic DNA Translation: AAC05176.1
BC000087 mRNA Translation: AAH00087.1
BC000345 mRNA Translation: AAH00345.1
BC000752 mRNA Translation: AAH00752.1
BC001127 mRNA Translation: AAH01127.1
BC001834 mRNA Translation: AAH01834.1
BC003655 mRNA Translation: AAH03655.1
BC005863 mRNA Translation: AAH05863.1
BC008092 mRNA Translation: AAH08092.1
BC008594 mRNA Translation: AAH08594.1
BC009867 mRNA Translation: AAH09867.1
BC015173 mRNA Translation: AAH15173.1
BC015690 mRNA Translation: AAH15690.1
BC107717 mRNA Translation: AAI07718.1
AB007187 Genomic DNA Translation: BAA25845.1
CCDSiCCDS9193.1 [P05388-1]
PIRiA27125 R5HUP0
RefSeqiNP_000993.1, NM_001002.3 [P05388-1]
NP_444505.1, NM_053275.3 [P05388-1]
UniGeneiHs.546285

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00q5-227[»]
4V6Xelectron microscopy5.00Cq1-317[»]
5AJ0electron microscopy3.50AK1-317[»]
ProteinModelPortaliP05388
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112094, 218 interactors
CORUMiP05388
IntActiP05388, 55 interactors
MINTiP05388
STRINGi9606.ENSP00000339027

PTM databases

iPTMnetiP05388
PhosphoSitePlusiP05388
SwissPalmiP05388

Polymorphism and mutation databases

BioMutaiRPLP0
DMDMi133041

2D gel databases

REPRODUCTION-2DPAGEiP05388

Proteomic databases

EPDiP05388
MaxQBiP05388
PaxDbiP05388
PeptideAtlasiP05388
PRIDEiP05388
ProteomicsDBi51833
TopDownProteomicsiP05388-1 [P05388-1]

Protocols and materials databases

DNASUi6175
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228306; ENSP00000339027; ENSG00000089157 [P05388-1]
ENST00000313104; ENSP00000366471; ENSG00000089157 [P05388-2]
ENST00000392514; ENSP00000376299; ENSG00000089157 [P05388-1]
ENST00000551150; ENSP00000449328; ENSG00000089157 [P05388-1]
GeneIDi6175
KEGGihsa:6175
UCSCiuc001txp.4 human [P05388-1]

Organism-specific databases

CTDi6175
DisGeNETi6175
EuPathDBiHostDB:ENSG00000089157.15
GeneCardsiRPLP0
HGNCiHGNC:10371 RPLP0
HPAiHPA003512
MIMi180510 gene
neXtProtiNX_P05388
OpenTargetsiENSG00000089157
PharmGKBiPA34772
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0815 Eukaryota
COG0244 LUCA
GeneTreeiENSGT00390000017839
HOGENOMiHOG000210987
HOVERGENiHBG000711
InParanoidiP05388
KOiK02941
OMAiMAHVAEW
OrthoDBiEOG091G0F47
PhylomeDBiP05388
TreeFamiTF300849

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRSiRPLP0 human
GeneWikiiRPLP0
GenomeRNAii6175
PROiPR:P05388
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000089157 Expressed in 88 organ(s), highest expression level in left adrenal gland
CleanExiHS_RPLP0
ExpressionAtlasiP05388 baseline and differential
GenevisibleiP05388 HS

Family and domain databases

InterProiView protein in InterPro
IPR030670 L10E_eukaryotes
IPR001790 Ribosomal_L10P
PfamiView protein in Pfam
PF00466 Ribosomal_L10, 1 hit
PIRSFiPIRSF039087 L10E, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRLA0_HUMAN
AccessioniPrimary (citable) accession number: P05388
Secondary accession number(s): Q3B7A4, Q9BVK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: October 10, 2018
This is version 207 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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