Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S acidic ribosomal protein P2

Gene

RPLP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the elongation step of protein synthesis.

GO - Molecular functioni

  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SIGNORiP05387

Names & Taxonomyi

Protein namesi
Recommended name:
60S acidic ribosomal protein P2
Alternative name(s):
Large ribosomal subunit protein P21 Publication
Renal carcinoma antigen NY-REN-44
Gene namesi
Name:RPLP2
Synonyms:D11S2243E, RPP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000177600.8
HGNCiHGNC:10377 RPLP2
MIMi180530 gene
neXtProtiNX_P05387

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6181
OpenTargetsiENSG00000177600
PharmGKBiPA34776

Protein family/group databases

Allergomei1276 Hom s P2

Polymorphism and mutation databases

BioMutaiRPLP2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001576401 – 11560S acidic ribosomal protein P2Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei21N6-acetyllysine; alternateCombined sources1
Modified residuei21N6-succinyllysine; alternateBy similarity1
Modified residuei79PhosphoserineCombined sources1
Modified residuei86PhosphoserineCombined sources1
Modified residuei102Phosphoserine1 Publication1
Modified residuei105PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP05387
PaxDbiP05387
PeptideAtlasiP05387
PRIDEiP05387
ProteomicsDBi51832
TopDownProteomicsiP05387

2D gel databases

SWISS-2DPAGEiP05387

PTM databases

iPTMnetiP05387
PhosphoSitePlusiP05387
SwissPalmiP05387

Expressioni

Gene expression databases

BgeeiENSG00000177600
CleanExiHS_RPLP2
ExpressionAtlasiP05387 baseline and differential
GenevisibleiP05387 HS

Organism-specific databases

HPAiHPA053635

Interactioni

Subunit structurei

Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RPLP1P053862EBI-352813,EBI-354582

Protein-protein interaction databases

BioGridi112096, 139 interactors
CORUMiP05387
IntActiP05387, 32 interactors
MINTiP05387
STRINGi9606.ENSP00000322419

Structurei

Secondary structure

1115
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1 – 3Combined sources3
Helixi4 – 13Combined sources10
Helixi20 – 28Combined sources9
Turni29 – 31Combined sources3
Helixi38 – 46Combined sources9
Helixi51 – 55Combined sources5
Beta strandi59 – 61Combined sources3
Beta strandi63 – 66Combined sources4
Turni91 – 94Combined sources4
Helixi112 – 114Combined sources3

3D structure databases

DisProtiDP00793
ProteinModelPortaliP05387
SMRiP05387
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05387

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3449 Eukaryota
COG2058 LUCA
GeneTreeiENSGT00550000074828
HOGENOMiHOG000229897
HOVERGENiHBG014761
InParanoidiP05387
KOiK02943
OMAiAFFNFTM
OrthoDBiEOG091G14BD
PhylomeDBiP05387
TreeFamiTF320650

Family and domain databases

Gene3Di1.10.10.1410, 1 hit
HAMAPiMF_01478 Ribosomal_L12_arch, 1 hit
InterProiView protein in InterPro
IPR038716 P1/P2_N_sf
IPR027534 Ribosomal_L12

Sequencei

Sequence statusi: Complete.

P05387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYVASYLLA ALGGNSSPSA KDIKKILDSV GIEADDDRLN KVISELNGKN
60 70 80 90 100
IEDVIAQGIG KLASVPAGGA VAVSAAPGSA APAAGSAPAA AEEKKDEKKE
110
ESEESDDDMG FGLFD
Length:115
Mass (Da):11,665
Last modified:November 1, 1988 - v1
Checksum:iB5ECFE2510A756BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17887 mRNA Translation: AAA36472.1
AB061837 Genomic DNA Translation: BAB79475.1
AK311954 mRNA Translation: BAG34894.1
CR542212 mRNA Translation: CAG47008.1
CR542248 mRNA Translation: CAG47044.1
AP006621 Genomic DNA No translation available.
CH471158 Genomic DNA Translation: EAX02393.1
BC005354 mRNA Translation: AAH05354.1
BC005920 mRNA Translation: AAH05920.1
BC007573 mRNA Translation: AAH07573.1
BC062314 mRNA Translation: AAH62314.1
CCDSiCCDS7717.1
PIRiC27125 R6HUP2
RefSeqiNP_000995.1, NM_001004.3
UniGeneiHs.437594

Genome annotation databases

EnsembliENST00000321153; ENSP00000322419; ENSG00000177600
ENST00000530797; ENSP00000431240; ENSG00000177600
GeneIDi6181
KEGGihsa:6181
UCSCiuc001lrq.2 human

Similar proteinsi

Entry informationi

Entry nameiRLA2_HUMAN
AccessioniPrimary (citable) accession number: P05387
Secondary accession number(s): Q6FG96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: July 18, 2018
This is version 202 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health