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Protein

60S acidic ribosomal protein P1

Gene

RPLP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the elongation step of protein synthesis.

GO - Molecular functioni

  • protein kinase activator activity Source: GO_Central
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S acidic ribosomal protein P1
Alternative name(s):
Large ribosomal subunit protein P11 Publication
Gene namesi
Name:RPLP1
Synonyms:RRP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000137818.11
HGNCiHGNC:10372 RPLP1
MIMi180520 gene
neXtProtiNX_P05386

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6176
OpenTargetsiENSG00000137818
PharmGKBiPA34775

Polymorphism and mutation databases

BioMutaiRPLP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001576862 – 11460S acidic ribosomal protein P1Add BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei101PhosphoserineCombined sources1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP05386
MaxQBiP05386
PaxDbiP05386
PeptideAtlasiP05386
PRIDEiP05386
ProteomicsDBi51831
TopDownProteomicsiP05386-1 [P05386-1]
P05386-2 [P05386-2]

PTM databases

iPTMnetiP05386
PhosphoSitePlusiP05386
SwissPalmiP05386

Expressioni

Gene expression databases

BgeeiENSG00000137818
CleanExiHS_RPLP1
HS_RRP1
ExpressionAtlasiP05386 baseline and differential
GenevisibleiP05386 HS

Organism-specific databases

HPAiHPA003368

Interactioni

Subunit structurei

Heterodimer with RPLP2 at the lateral ribosomal stalk of the large ribosomal subunit.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi112095, 130 interactors
CORUMiP05386
IntActiP05386, 60 interactors
MINTiP05386
STRINGi9606.ENSP00000346037

Structurei

Secondary structure

1114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 19Combined sources16
Helixi25 – 35Combined sources11
Helixi42 – 50Combined sources9
Turni51 – 53Combined sources3
Helixi56 – 60Combined sources5
Turni61 – 64Combined sources4

3D structure databases

ProteinModelPortaliP05386
SMRiP05386
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1762 Eukaryota
COG2058 LUCA
GeneTreeiENSGT00550000074698
HOGENOMiHOG000229898
HOVERGENiHBG002291
InParanoidiP05386
KOiK02942
OMAiQELLCTY
OrthoDBiEOG091G17EU
PhylomeDBiP05386
TreeFamiTF312932

Family and domain databases

Gene3Di1.10.10.1410, 1 hit
HAMAPiMF_01478 Ribosomal_L12_arch, 1 hit
InterProiView protein in InterPro
IPR038716 P1/P2_N_sf
IPR027534 Ribosomal_L12

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P05386-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASVSELACI YSALILHDDE VTVTEDKINA LIKAAGVNVE PFWPGLFAKA
60 70 80 90 100
LANVNIGSLI CNVGAGGPAP AAGAAPAGGP APSTAAAPAE EKKVEAKKEE
110
SEESDDDMGF GLFD
Length:114
Mass (Da):11,514
Last modified:November 1, 1988 - v1
Checksum:i4C282AB8DCA079C8
GO
Isoform 2 (identifier: P05386-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-49: Missing.

Note: No experimental confirmation available.
Show »
Length:89
Mass (Da):8,804
Checksum:iB84B9045B930348B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04524425 – 49Missing in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17886 mRNA Translation: AAA36471.1
AB061836 Genomic DNA Translation: BAB79474.1
AC027237 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77845.1
BC003369 mRNA Translation: AAH03369.1
BC007590 mRNA Translation: AAH07590.1
CD388103 mRNA No translation available.
CCDSiCCDS10233.1 [P05386-1]
CCDS10234.1 [P05386-2]
PIRiB27125 R6HUP1
RefSeqiNP_000994.1, NM_001003.2 [P05386-1]
NP_998890.1, NM_213725.1 [P05386-2]
UniGeneiHs.356502

Genome annotation databases

EnsembliENST00000260379; ENSP00000346037; ENSG00000137818 [P05386-1]
ENST00000357790; ENSP00000350437; ENSG00000137818 [P05386-2]
GeneIDi6176
KEGGihsa:6176
UCSCiuc002asd.2 human [P05386-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRLA1_HUMAN
AccessioniPrimary (citable) accession number: P05386
Secondary accession number(s): A6NIB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: July 18, 2018
This is version 194 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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