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UniProtKB - P05386 (RLA1_HUMAN)
Protein
60S acidic ribosomal protein P1
Gene
RPLP1
Organism
Homo sapiens (Human)
Status
Functioni
Plays an important role in the elongation step of protein synthesis.
GO - Molecular functioni
- protein kinase activator activity Source: GO_Central
- ribonucleoprotein complex binding Source: GO_Central
- structural constituent of ribosome Source: FlyBase
GO - Biological processi
- cytoplasmic translation Source: GO_Central
- regulation of translation Source: Ensembl
- translation Source: UniProtKB
- translational elongation Source: InterPro
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | P05386 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SignaLinki | P05386 |
SIGNORi | P05386 |
Names & Taxonomyi
Protein namesi | Recommended name: 60S acidic ribosomal protein P1Alternative name(s): Large ribosomal subunit protein P11 Publication |
Gene namesi | Name:RPLP1 Synonyms:RRP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10372, RPLP1 |
MIMi | 180520, gene |
neXtProti | NX_P05386 |
VEuPathDBi | HostDB:ENSG00000137818 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
- cytosolic large ribosomal subunit Source: GO_Central
- cytosolic ribosome Source: FlyBase
Other locations
- cytoplasm Source: ComplexPortal
- focal adhesion Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 6176 |
OpenTargetsi | ENSG00000137818 |
PharmGKBi | PA34775 |
Miscellaneous databases
Pharosi | P05386, Tbio |
Genetic variation databases
BioMutai | RPLP1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000157686 | 2 – 114 | 60S acidic ribosomal protein P1Add BLAST | 113 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 101 | PhosphoserineCombined sources1 Publication | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P05386 |
jPOSTi | P05386 |
MassIVEi | P05386 |
MaxQBi | P05386 |
PaxDbi | P05386 |
PeptideAtlasi | P05386 |
PRIDEi | P05386 |
ProteomicsDBi | 1259 51831 [P05386-1] |
TopDownProteomicsi | P05386-1 [P05386-1] P05386-2 [P05386-2] |
PTM databases
GlyGeni | P05386, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P05386 |
MetOSitei | P05386 |
PhosphoSitePlusi | P05386 |
SwissPalmi | P05386 |
Expressioni
Gene expression databases
Bgeei | ENSG00000137818, Expressed in uterus and 135 other tissues |
ExpressionAtlasi | P05386, baseline and differential |
Genevisiblei | P05386, HS |
Organism-specific databases
HPAi | ENSG00000137818, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer with RPLP2 at the lateral ribosomal stalk of the large ribosomal subunit.
1 PublicationBinary interactionsi
Protein-protein interaction databases
BioGRIDi | 112095, 232 interactors |
ComplexPortali | CPX-5183, 60S cytosolic large ribosomal subunit |
CORUMi | P05386 |
IntActi | P05386, 92 interactors |
MINTi | P05386 |
STRINGi | 9606.ENSP00000346037 |
Miscellaneous databases
RNActi | P05386, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P05386 |
BMRBi | P05386 |
SMRi | P05386 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 69 – 114 | DisorderedSequence analysisAdd BLAST | 46 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 90 – 104 | Basic and acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the eukaryotic ribosomal protein P1/P2 family.Curated
Phylogenomic databases
eggNOGi | KOG1762, Eukaryota |
GeneTreei | ENSGT00550000074698 |
HOGENOMi | CLU_114656_1_2_1 |
InParanoidi | P05386 |
OMAi | TDVEPIW |
PhylomeDBi | P05386 |
TreeFami | TF312932 |
Family and domain databases
DisProti | DP01253 |
Gene3Di | 1.10.10.1410, 1 hit |
HAMAPi | MF_01478, Ribosomal_L12_arch, 1 hit |
InterProi | View protein in InterPro IPR038716, P1/P2_N_sf IPR027534, Ribosomal_L12/P1/P2 |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P05386-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASVSELACI YSALILHDDE VTVTEDKINA LIKAAGVNVE PFWPGLFAKA
60 70 80 90 100
LANVNIGSLI CNVGAGGPAP AAGAAPAGGP APSTAAAPAE EKKVEAKKEE
110
SEESDDDMGF GLFD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YL57 | H0YL57_HUMAN | 60S acidic ribosomal protein P1 | RPLP1 | 54 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045244 | 25 – 49 | Missing in isoform 2. 1 PublicationAdd BLAST | 25 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M17886 mRNA Translation: AAA36471.1 AB061836 Genomic DNA Translation: BAB79474.1 AC027237 Genomic DNA No translation available. CH471082 Genomic DNA Translation: EAW77845.1 BC003369 mRNA Translation: AAH03369.1 BC007590 mRNA Translation: AAH07590.1 CD388103 mRNA No translation available. |
CCDSi | CCDS10233.1 [P05386-1] CCDS10234.1 [P05386-2] |
PIRi | B27125, R6HUP1 |
RefSeqi | NP_000994.1, NM_001003.2 [P05386-1] NP_998890.1, NM_213725.1 [P05386-2] |
Genome annotation databases
Ensembli | ENST00000260379.11; ENSP00000346037.5; ENSG00000137818.12 ENST00000357790.5; ENSP00000350437.5; ENSG00000137818.12 [P05386-2] |
GeneIDi | 6176 |
KEGGi | hsa:6176 |
MANE-Selecti | ENST00000260379.11; ENSP00000346037.5; NM_001003.3; NP_000994.1 |
UCSCi | uc002asd.2, human [P05386-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M17886 mRNA Translation: AAA36471.1 AB061836 Genomic DNA Translation: BAB79474.1 AC027237 Genomic DNA No translation available. CH471082 Genomic DNA Translation: EAW77845.1 BC003369 mRNA Translation: AAH03369.1 BC007590 mRNA Translation: AAH07590.1 CD388103 mRNA No translation available. |
CCDSi | CCDS10233.1 [P05386-1] CCDS10234.1 [P05386-2] |
PIRi | B27125, R6HUP1 |
RefSeqi | NP_000994.1, NM_001003.2 [P05386-1] NP_998890.1, NM_213725.1 [P05386-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2LBF | NMR | - | A | 1-69 | [»] | |
4BEH | NMR | - | A | 1-114 | [»] | |
4V6X | electron microscopy | 5.00 | Cs/Ct | 1-114 | [»] | |
AlphaFoldDBi | P05386 | |||||
BMRBi | P05386 | |||||
SMRi | P05386 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112095, 232 interactors |
ComplexPortali | CPX-5183, 60S cytosolic large ribosomal subunit |
CORUMi | P05386 |
IntActi | P05386, 92 interactors |
MINTi | P05386 |
STRINGi | 9606.ENSP00000346037 |
PTM databases
GlyGeni | P05386, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P05386 |
MetOSitei | P05386 |
PhosphoSitePlusi | P05386 |
SwissPalmi | P05386 |
Genetic variation databases
BioMutai | RPLP1 |
Proteomic databases
EPDi | P05386 |
jPOSTi | P05386 |
MassIVEi | P05386 |
MaxQBi | P05386 |
PaxDbi | P05386 |
PeptideAtlasi | P05386 |
PRIDEi | P05386 |
ProteomicsDBi | 1259 51831 [P05386-1] |
TopDownProteomicsi | P05386-1 [P05386-1] P05386-2 [P05386-2] |
Protocols and materials databases
Antibodypediai | 1247, 160 antibodies from 28 providers |
DNASUi | 6176 |
Genome annotation databases
Ensembli | ENST00000260379.11; ENSP00000346037.5; ENSG00000137818.12 ENST00000357790.5; ENSP00000350437.5; ENSG00000137818.12 [P05386-2] |
GeneIDi | 6176 |
KEGGi | hsa:6176 |
MANE-Selecti | ENST00000260379.11; ENSP00000346037.5; NM_001003.3; NP_000994.1 |
UCSCi | uc002asd.2, human [P05386-1] |
Organism-specific databases
CTDi | 6176 |
DisGeNETi | 6176 |
GeneCardsi | RPLP1 |
HGNCi | HGNC:10372, RPLP1 |
HPAi | ENSG00000137818, Low tissue specificity |
MIMi | 180520, gene |
neXtProti | NX_P05386 |
OpenTargetsi | ENSG00000137818 |
PharmGKBi | PA34775 |
VEuPathDBi | HostDB:ENSG00000137818 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1762, Eukaryota |
GeneTreei | ENSGT00550000074698 |
HOGENOMi | CLU_114656_1_2_1 |
InParanoidi | P05386 |
OMAi | TDVEPIW |
PhylomeDBi | P05386 |
TreeFami | TF312932 |
Enzyme and pathway databases
PathwayCommonsi | P05386 |
Reactomei | R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-156902, Peptide chain elongation R-HSA-1799339, SRP-dependent cotranslational protein targeting to membrane R-HSA-192823, Viral mRNA Translation R-HSA-2408557, Selenocysteine synthesis R-HSA-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-HSA-72689, Formation of a pool of free 40S subunits R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72764, Eukaryotic Translation Termination R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9633012, Response of EIF2AK4 (GCN2) to amino acid deficiency R-HSA-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
SignaLinki | P05386 |
SIGNORi | P05386 |
Miscellaneous databases
BioGRID-ORCSi | 6176, 790 hits in 1055 CRISPR screens |
ChiTaRSi | RPLP1, human |
GeneWikii | RPLP1 |
GenomeRNAii | 6176 |
Pharosi | P05386, Tbio |
PROi | PR:P05386 |
RNActi | P05386, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137818, Expressed in uterus and 135 other tissues |
ExpressionAtlasi | P05386, baseline and differential |
Genevisiblei | P05386, HS |
Family and domain databases
DisProti | DP01253 |
Gene3Di | 1.10.10.1410, 1 hit |
HAMAPi | MF_01478, Ribosomal_L12_arch, 1 hit |
InterProi | View protein in InterPro IPR038716, P1/P2_N_sf IPR027534, Ribosomal_L12/P1/P2 |
MobiDBi | Search... |
Entry informationi
Entry namei | RLA1_HUMAN | |
Accessioni | P05386Primary (citable) accession number: P05386 Secondary accession number(s): A6NIB2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | November 1, 1988 | |
Last modified: | May 25, 2022 | |
This is version 219 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families