Clusterin

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• amyloid-beta binding Source: RGD
• low-density lipoprotein particle receptor binding Source: RGD
• misfolded protein binding Source: UniProtKB
• protein-containing complex binding Source: RGD
• protein N-terminus binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.6

    "Clusterin interacts with SCLIP (SCG10-like protein) and promotes neurite outgrowth of PC12 cells."
    Kang S.W., Shin Y.J., Shim Y.J., Jeong S.Y., Park I.S., Min B.H.
    Exp. Cell Res. 309:305-315(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH STMN3, SUBCELLULAR LOCATION, FUNCTION.
• signaling receptor binding Source: RGD
• tau protein binding Source: RGD
• ubiquitin protein ligase binding Source: UniProtKB
• unfolded protein binding Source: UniProtKB

GO - Biological processⁱ

• aging Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Differential proteomics in the aging Noble rat ventral prostate."
    Lam Y.W., Tam N.N., Evans J.E., Green K.M., Zhang X., Ho S.M.
    Proteomics 8:2750-2763(2008) [PubMed] [Europe PMC] [Abstract]
• cell morphogenesis Source: Alzheimers_University_of_Toronto
• cellular response to growth factor stimulus Source: RGDInferred from expression patternⁱ
  • Ref.6

    "Clusterin interacts with SCLIP (SCG10-like protein) and promotes neurite outgrowth of PC12 cells."
    Kang S.W., Shin Y.J., Shim Y.J., Jeong S.Y., Park I.S., Min B.H.
    Exp. Cell Res. 309:305-315(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH STMN3, SUBCELLULAR LOCATION, FUNCTION.
• central nervous system myelin maintenance Source: Alzheimers_University_of_Toronto
• chaperone-mediated protein complex assembly Source: Alzheimers_University_of_Toronto
• chaperone-mediated protein folding Source: UniProtKB
• endocrine pancreas development Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Clusterin induces differentiation of pancreatic duct cells into insulin-secreting cells."
    Kim B.M., Kim S.Y., Lee S., Shin Y.J., Min B.H., Bendayan M., Park I.S.
    Diabetologia 49:311-320(2006) [PubMed] [Europe PMC] [Abstract]
• estrous cycle Source: RGDInferred from expression patternⁱ
  • "Estrous cycle regulation of mammary epithelial cell proliferation, differentiation, and death in the Sprague-Dawley rat: a model for investigating the role of estrous cycling in mammary carcinogenesis."
    Schedin P., Mitrenga T., Kaeck M.
    J Mammary Gland Biol Neoplasia 5:211-225(2000) [PubMed] [Europe PMC] [Abstract]
• immune complex clearance Source: UniProtKB
• intrinsic apoptotic signaling pathway Source: UniProtKB
• microglial cell activation Source: Alzheimers_University_of_Toronto
• microglial cell proliferation Source: Alzheimers_University_of_Toronto
• negative regulation of amyloid-beta formation Source: Alzheimers_University_of_Toronto
• negative regulation of amyloid fibril formation Source: UniProtKB
• negative regulation of apoptotic process Source: RGDInferred from mutant phenotypeⁱ
  • "Modulation of clusterin isoforms is associated with all-trans retinoic acid-induced proliferative arrest and apoptosis of intimal smooth muscle cells."
    Orlandi A., Pucci S., Ciucci A., Pichiorri F., Ferlosio A., Spagnoli L.G.
    Arterioscler Thromb Vasc Biol 25:348-353(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell death Source: RGD
• negative regulation of cellular response to thapsigargin Source: RGD
• negative regulation of cellular response to tunicamycin Source: RGD
• negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
• negative regulation of protein-containing complex assembly Source: BHF-UCL
• negative regulation of response to endoplasmic reticulum stress Source: RGD
• neuron projection morphogenesis Source: RGDInferred from mutant phenotypeⁱ
  • Ref.6

    "Clusterin interacts with SCLIP (SCG10-like protein) and promotes neurite outgrowth of PC12 cells."
    Kang S.W., Shin Y.J., Shim Y.J., Jeong S.Y., Park I.S., Min B.H.
    Exp. Cell Res. 309:305-315(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH STMN3, SUBCELLULAR LOCATION, FUNCTION.
• positive regulation of amyloid-beta formation Source: Alzheimers_University_of_Toronto
• positive regulation of apoptotic process Source: UniProtKB
• positive regulation of cell differentiation Source: RGDInferred from mutant phenotypeⁱ
  • "Clusterin induces differentiation of pancreatic duct cells into insulin-secreting cells."
    Kim B.M., Kim S.Y., Lee S., Shin Y.J., Min B.H., Bendayan M., Park I.S.
    Diabetologia 49:311-320(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: RGDInferred from mutant phenotypeⁱ
  • "Modulation of clusterin isoforms is associated with all-trans retinoic acid-induced proliferative arrest and apoptosis of intimal smooth muscle cells."
    Orlandi A., Pucci S., Ciucci A., Pichiorri F., Ferlosio A., Spagnoli L.G.
    Arterioscler Thromb Vasc Biol 25:348-353(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: ARUK-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Clusterin regulates beta-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway."
    Killick R., Ribe E.M., Al-Shawi R., Malik B., Hooper C., Fernandes C., Dobson R., Nolan P.M., Lourdusamy A., Furney S., Lin K., Breen G., Wroe R., To A.W., Leroy K., Causevic M., Usardi A., Robinson M.

    , Noble W., Williamson R., Lunnon K., Kellie S., Reynolds C.H., Bazenet C., Hodges A., Brion J.P., Stephenson J., Simons J.P., Lovestone S.
    Mol Psychiatry 19:88-98(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
• positive regulation of neurofibrillary tangle assembly Source: Alzheimers_University_of_Toronto
• positive regulation of neuron death Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Clusterin regulates beta-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway."
    Killick R., Ribe E.M., Al-Shawi R., Malik B., Hooper C., Fernandes C., Dobson R., Nolan P.M., Lourdusamy A., Furney S., Lin K., Breen G., Wroe R., To A.W., Leroy K., Causevic M., Usardi A., Robinson M.

    , Noble W., Williamson R., Lunnon K., Kellie S., Reynolds C.H., Bazenet C., Hodges A., Brion J.P., Stephenson J., Simons J.P., Lovestone S.
    Mol Psychiatry 19:88-98(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
• positive regulation of nitric oxide biosynthetic process Source: Alzheimers_University_of_Toronto
• positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
• positive regulation of protein-containing complex assembly Source: RGD
• positive regulation of receptor-mediated endocytosis Source: UniProtKB
• positive regulation of tau-protein kinase activity Source: Alzheimers_University_of_Toronto
• positive regulation of tumor necrosis factor production Source: Alzheimers_University_of_Toronto
• positive regulation of ubiquitin-dependent protein catabolic process Source: UniProtKB
• protein import Source: Alzheimers_University_of_Toronto
• protein stabilization Source: CAFA <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Clusterin, a binding protein with a molten globule-like region."
    Bailey R.W., Dunker A.K., Brown C.J., Garner E.C., Griswold M.D.
    Biochemistry 40:11828-11840(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of amyloid-beta clearance Source: Alzheimers_University_of_Toronto
• regulation of apoptotic process Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of cell population proliferation Source: UniProtKB
• regulation of neuronal signal transduction Source: Alzheimers_University_of_Toronto
• regulation of neuron death Source: Alzheimers_University_of_Toronto
• response to light stimulus Source: RGDInferred from expression patternⁱ
  • "Expression of multiple forms of clusterin during light-induced retinal degeneration."
    Wong P., Ulyanova T., Organisciak D.T., Bennett S., Lakins J., Arnold J.M., Kutty R.K., Tenniswood M., vanVeen T., Darrow R.M., Chader G.
    Curr Eye Res 23:157-165(2001) [PubMed] [Europe PMC] [Abstract]
• response to misfolded protein Source: UniProtKB
• response to potassium ion Source: RGDInferred from expression patternⁱ
  • "Delayed, but prolonged increases in astrocytic clusterin (ApoJ) mRNA expression following acute cortical spreading depression in the rat: evidence for a role of clusterin in ischemic tolerance."
    Wiggins A.K., Shen P.J., Gundlach A.L.
    Brain Res Mol Brain Res 114:20-30(2003) [PubMed] [Europe PMC] [Abstract]
• response to virus Source: RGD
• response to wounding Source: RGDInferred from expression patternⁱ
  • "Urinary clusterin levels in the rat correlate with the severity of tubular damage and may help to differentiate between glomerular and tubular injuries."
    Hidaka S., Kranzlin B., Gretz N., Witzgall R.
    Cell Tissue Res 310:289-296(2002) [PubMed] [Europe PMC] [Abstract]
• spermatogenesis Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• low-density lipoprotein particle receptor binding Source: RGD
• misfolded protein binding Source: UniProtKB
• protein N-terminus binding Source: RGDInferred from physical interactionⁱ
  • Ref.6

    "Clusterin interacts with SCLIP (SCG10-like protein) and promotes neurite outgrowth of PC12 cells."
    Kang S.W., Shin Y.J., Shim Y.J., Jeong S.Y., Park I.S., Min B.H.
    Exp. Cell Res. 309:305-315(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH STMN3, SUBCELLULAR LOCATION, FUNCTION.
• signaling receptor binding Source: RGD
• tau protein binding Source: RGD
• ubiquitin protein ligase binding Source: UniProtKB
• unfolded protein binding Source: UniProtKB

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Motif

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MKILLLCVAL LLTWDNGMVL GEQEFSDNEL QELSTQGSRY VNKEIQNAVQ 
        60         70         80         90        100
GVKHIKTLIE KTNAERKSLL NSLEEAKKKK EGALDDTRDS EMKLKAFPEV 
       110        120        130        140        150
CNETMMALWE ECKPCLKHTC MKFYARVCRS GSGLVGRQLE EFLNQSSPFY 
       160        170        180        190        200
FWMNGDRIDS LLESDRQQSQ VLDAMQDSFT RASGIIDTLF QDRFFTHEPQ 
       210        220        230        240        250
DIHHFSPMGF PHKRPHFLYP KSRLVRSLMP LSHYGPLSFH NMFQPFFDMI 
       260        270        280        290        300
HQAQQAMDVQ LHSPALQFPD VDFLKEGEDD PTVCKEIRHN STGCLKMKGQ 
       310        320        330        340        350
CEKCQEILSV DCSTNNPAQA NLRQELNDSL QVAERLTQQY NELLHSLQSK 
       360        370        380        390        400
MLNTSSLLEQ LNDQFTWVSQ LANLTQGDDQ YLRVSTVTTH SSDSEVPSRV 
       410        420        430        440 
TEVVVKLFDS DPITVVLPEE VSKDNPKFMD TVAEKALQEY RRKSRME    

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families