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Protein

Serum amyloid A-2 protein

Gene

Saa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major acute phase reactant. Apolipoprotein of the HDL complex.

Miscellaneous

SAA2 is the preferred amyloid-forming precursor.

GO - Molecular functioni

  • chemoattractant activity Source: GO_Central
  • G protein-coupled receptor binding Source: MGI

GO - Biological processi

  • acute-phase response Source: UniProtKB-KW
  • cell chemotaxis Source: GO_Central
  • response to stilbenoid Source: UniProtKB

Keywordsi

Biological processAcute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A-2 protein
Cleaved into the following chain:
Alternative name(s):
Amyloid fibril protein AA
Gene namesi
Name:Saa2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:98222 Saa2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, HDL, Secreted

Pathology & Biotechi

Involvement in diseasei

Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000003158920 – 122Serum amyloid A-2 proteinAdd BLAST103
ChainiPRO_000003159020 – 92Amyloid protein AAdd BLAST73

Post-translational modificationi

This protein is the precursor of amyloid protein A, which is formed by the removal of residues from the C-terminal end.

Proteomic databases

MaxQBiP05367
PaxDbiP05367
PeptideAtlasiP05367
PRIDEiP05367

PTM databases

PhosphoSitePlusiP05367

Expressioni

Tissue specificityi

Expressed by the liver; secreted in plasma.

Inductioni

Upon cytokine stimulation.

Gene expression databases

BgeeiENSMUSG00000057465 Expressed in 124 organ(s), highest expression level in inguinal mammary gland
CleanExiMM_SAA2
ExpressionAtlasiP05367 baseline and differential
GenevisibleiP05367 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203062, 1 interactor
STRINGi10090.ENSMUSP00000075365

Structurei

3D structure databases

ProteinModelPortaliP05367
SMRiP05367
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXU4 Eukaryota
ENOG410YSBK LUCA
GeneTreeiENSGT00390000004737
HOGENOMiHOG000126881
HOVERGENiHBG016327
InParanoidiP05367
KOiK17310
OMAiHARGNFD
OrthoDBiEOG091G17YH
PhylomeDBiP05367
TreeFamiTF332544

Family and domain databases

InterProiView protein in InterPro
IPR000096 Serum_amyloid_A
PfamiView protein in Pfam
PF00277 SAA, 1 hit
PIRSFiPIRSF002472 Serum_amyloid_A, 1 hit
PRINTSiPR00306 SERUMAMYLOID
SMARTiView protein in SMART
SM00197 SAA, 1 hit
PROSITEiView protein in PROSITE
PS00992 SAA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P05367-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLLTSLVFC SLLLGVCHGG FFSFIGEAFQ GAGDMWRAYT DMKEAGWKDG
60 70 80 90 100
DKYFHARGNY DAAQRGPGGV WAAEKISDAR ESFQEFFGRG HEDTMADQEA
110 120
NRHGRSGKDP NYYRPPGLPA KY
Length:122
Mass (Da):13,622
Last modified:November 1, 1988 - v1
Checksum:i99E79D6FF97E96E0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GQV5A0A1B0GQV5_MOUSE
Serum amyloid A protein
Saa2
88Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti120A → D in strain: SJL/J. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13522 Genomic DNA Translation: AAA40086.1
M11130 mRNA Translation: AAA40085.1
M17791 Genomic DNA Translation: AAA40087.1
CCDSiCCDS21285.1
PIRiB23843
RefSeqiNP_035444.1, NM_011314.2
XP_006540790.1, XM_006540727.2
UniGeneiMm.200941

Genome annotation databases

EnsembliENSMUST00000075982; ENSMUSP00000075365; ENSMUSG00000057465
ENSMUST00000210769; ENSMUSP00000147751; ENSMUSG00000057465
GeneIDi20209
KEGGimmu:20209
UCSCiuc009gzb.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13522 Genomic DNA Translation: AAA40086.1
M11130 mRNA Translation: AAA40085.1
M17791 Genomic DNA Translation: AAA40087.1
CCDSiCCDS21285.1
PIRiB23843
RefSeqiNP_035444.1, NM_011314.2
XP_006540790.1, XM_006540727.2
UniGeneiMm.200941

3D structure databases

ProteinModelPortaliP05367
SMRiP05367
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203062, 1 interactor
STRINGi10090.ENSMUSP00000075365

PTM databases

PhosphoSitePlusiP05367

Proteomic databases

MaxQBiP05367
PaxDbiP05367
PeptideAtlasiP05367
PRIDEiP05367

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075982; ENSMUSP00000075365; ENSMUSG00000057465
ENSMUST00000210769; ENSMUSP00000147751; ENSMUSG00000057465
GeneIDi20209
KEGGimmu:20209
UCSCiuc009gzb.2 mouse

Organism-specific databases

CTDi6289
MGIiMGI:98222 Saa2

Phylogenomic databases

eggNOGiENOG410IXU4 Eukaryota
ENOG410YSBK LUCA
GeneTreeiENSGT00390000004737
HOGENOMiHOG000126881
HOVERGENiHBG016327
InParanoidiP05367
KOiK17310
OMAiHARGNFD
OrthoDBiEOG091G17YH
PhylomeDBiP05367
TreeFamiTF332544

Miscellaneous databases

PROiPR:P05367
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057465 Expressed in 124 organ(s), highest expression level in inguinal mammary gland
CleanExiMM_SAA2
ExpressionAtlasiP05367 baseline and differential
GenevisibleiP05367 MM

Family and domain databases

InterProiView protein in InterPro
IPR000096 Serum_amyloid_A
PfamiView protein in Pfam
PF00277 SAA, 1 hit
PIRSFiPIRSF002472 Serum_amyloid_A, 1 hit
PRINTSiPR00306 SERUMAMYLOID
SMARTiView protein in SMART
SM00197 SAA, 1 hit
PROSITEiView protein in PROSITE
PS00992 SAA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSAA2_MOUSE
AccessioniPrimary (citable) accession number: P05367
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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