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Protein

Serum amyloid A-1 protein

Gene

Saa1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major acute phase protein.1 Publication

GO - Molecular functioni

  • chemoattractant activity Source: GO_Central
  • G protein-coupled receptor binding Source: MGI
  • heparin binding Source: UniProtKB-KW

GO - Biological processi

  • acute-phase response Source: UniProtKB-KW
  • cell chemotaxis Source: GO_Central
  • cholesterol metabolic process Source: MGI
  • response to bacterium Source: MGI

Keywordsi

Molecular functionHeparin-binding
Biological processAcute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A-1 protein
Gene namesi
Name:Saa1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:98221 Saa1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000003158820 – 122Serum amyloid A-1 proteinAdd BLAST103

Proteomic databases

PaxDbiP05366
PeptideAtlasiP05366
PRIDEiP05366

PTM databases

iPTMnetiP05366
PhosphoSitePlusiP05366

Expressioni

Tissue specificityi

Detected in blood plasma (at protein level). Detected in liver.2 Publications

Inductioni

By bacterial lipopolysaccharide.1 Publication

Gene expression databases

BgeeiENSMUSG00000074115 Expressed in 53 organ(s), highest expression level in colon
CleanExiMM_SAA1
ExpressionAtlasiP05366 baseline and differential
GenevisibleiP05366 MM

Interactioni

Subunit structurei

Homohexamer; dimer of trimers. Can form amyloid fibrils after partial proteolysis; the native, undenatured protein does not form amyloid fibrils (in vitro). Apolipoprotein of the HDL complex. Binds to heparin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119150

Structurei

3D structure databases

ProteinModelPortaliP05366
SMRiP05366
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 45Important for amyloid formationBy similarityAdd BLAST26

Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXU4 Eukaryota
ENOG410YSBK LUCA
GeneTreeiENSGT00390000004737
HOGENOMiHOG000126881
HOVERGENiHBG016327
InParanoidiP05366
KOiK17310
OMAiHEDTIAD
OrthoDBiEOG091G17YH
PhylomeDBiP05366
TreeFamiTF332544

Family and domain databases

InterProiView protein in InterPro
IPR000096 Serum_amyloid_A
PfamiView protein in Pfam
PF00277 SAA, 1 hit
PIRSFiPIRSF002472 Serum_amyloid_A, 1 hit
PRINTSiPR00306 SERUMAMYLOID
SMARTiView protein in SMART
SM00197 SAA, 1 hit
PROSITEiView protein in PROSITE
PS00992 SAA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05366-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLLTSLVFC SLLLGVCHGG FFSFVHEAFQ GAGDMWRAYT DMKEANWKNS
60 70 80 90 100
DKYFHARGNY DAAQRGPGGV WAAEKISDGR EAFQEFFGRG HEDTIADQEA
110 120
NRHGRSGKDP NYYRPPGLPD KY
Length:122
Mass (Da):13,770
Last modified:July 1, 1989 - v2
Checksum:i0AEF6D5F208EA4D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13521 Genomic DNA Translation: AAA40084.1
M11131 Genomic RNA Translation: AAA40083.1
CCDSiCCDS21284.1
PIRiA23843
RefSeqiNP_033143.1, NM_009117.3
XP_006540789.1, XM_006540726.3
UniGeneiMm.148800

Genome annotation databases

EnsembliENSMUST00000128088; ENSMUSP00000119150; ENSMUSG00000074115
GeneIDi20208
KEGGimmu:20208
UCSCiuc009gyz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13521 Genomic DNA Translation: AAA40084.1
M11131 Genomic RNA Translation: AAA40083.1
CCDSiCCDS21284.1
PIRiA23843
RefSeqiNP_033143.1, NM_009117.3
XP_006540789.1, XM_006540726.3
UniGeneiMm.148800

3D structure databases

ProteinModelPortaliP05366
SMRiP05366
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119150

PTM databases

iPTMnetiP05366
PhosphoSitePlusiP05366

Proteomic databases

PaxDbiP05366
PeptideAtlasiP05366
PRIDEiP05366

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000128088; ENSMUSP00000119150; ENSMUSG00000074115
GeneIDi20208
KEGGimmu:20208
UCSCiuc009gyz.1 mouse

Organism-specific databases

CTDi6288
MGIiMGI:98221 Saa1

Phylogenomic databases

eggNOGiENOG410IXU4 Eukaryota
ENOG410YSBK LUCA
GeneTreeiENSGT00390000004737
HOGENOMiHOG000126881
HOVERGENiHBG016327
InParanoidiP05366
KOiK17310
OMAiHEDTIAD
OrthoDBiEOG091G17YH
PhylomeDBiP05366
TreeFamiTF332544

Miscellaneous databases

PROiPR:P05366
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074115 Expressed in 53 organ(s), highest expression level in colon
CleanExiMM_SAA1
ExpressionAtlasiP05366 baseline and differential
GenevisibleiP05366 MM

Family and domain databases

InterProiView protein in InterPro
IPR000096 Serum_amyloid_A
PfamiView protein in Pfam
PF00277 SAA, 1 hit
PIRSFiPIRSF002472 Serum_amyloid_A, 1 hit
PRINTSiPR00306 SERUMAMYLOID
SMARTiView protein in SMART
SM00197 SAA, 1 hit
PROSITEiView protein in PROSITE
PS00992 SAA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSAA1_MOUSE
AccessioniPrimary (citable) accession number: P05366
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 1, 1989
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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