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Protein

Intercellular adhesion molecule 1

Gene

ICAM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.2 Publications
(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins.2 Publications
(Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins.3 Publications
(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • integrin binding Source: MGI
  • signaling receptor activity Source: ProtInc
  • transmembrane signaling receptor activity Source: ProtInc
  • virus receptor activity Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processCell adhesion, Host-virus interaction

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-216083 Integrin cell surface interactions
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-877300 Interferon gamma signaling

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P05362

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P05362

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Intercellular adhesion molecule 1
Short name:
ICAM-1
Alternative name(s):
Major group rhinovirus receptor
CD_antigen: CD54
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ICAM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000090339.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5344 ICAM1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
147840 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P05362

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 480ExtracellularSequence analysisAdd BLAST453
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei481 – 503HelicalSequence analysisAdd BLAST23
Topological domaini504 – 532CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3383

MalaCards human disease database

More...
MalaCardsi
ICAM1
MIMi611162 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000090339

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29592

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3070

Drug and drug target database

More...
DrugBanki
DB08818 Hyaluronic acid
DB00108 Natalizumab

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ICAM1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68067956

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Add BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001478328 – 532Intercellular adhesion molecule 1Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi48 ↔ 92Combined sources3 Publications
Disulfide bondi52 ↔ 96Combined sources3 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi130N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi135 ↔ 186Combined sources3 Publications
Glycosylationi145N-linked (GlcNAc...) (complex) asparagine4 Publications1
Glycosylationi183N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi202N-linked (GlcNAc...) asparagine4 Publications1
Disulfide bondi237 ↔ 290Combined sources1 Publication
Glycosylationi267N-linked (GlcNAc...) asparagine4 Publications1
Glycosylationi296N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi332 ↔ 371Combined sources1 Publication
Glycosylationi385N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi403 ↔ 419Combined sources1 Publication
Glycosylationi406N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi431 ↔ 457Combined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei521PhosphothreonineCombined sources1
Modified residuei530PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P05362

MaxQB - The MaxQuant DataBase

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MaxQBi
P05362

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P05362

PeptideAtlas

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PeptideAtlasi
P05362

PRoteomics IDEntifications database

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PRIDEi
P05362

ProteomicsDB human proteome resource

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ProteomicsDBi
51830

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1423

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P05362

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P05362

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P05362

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000090339 Expressed in 205 organ(s), highest expression level in lung

CleanEx database of gene expression profiles

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CleanExi
HS_ICAM1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P05362 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P05362 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002142
HPA002126
HPA004877

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF.Curated4 Publications
(Microbial infection) Interacts with major receptor group rhinovirus A-B capsid proteins (PubMed:1968231, PubMed:2538243).2 Publications
(Microbial infection) Interacts with Coxsackievirus A21 capsid proteins (PubMed:11160747, PubMed:16004874, PubMed:9539703).3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ITGALP207012EBI-1035358,EBI-961214

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109610, 178 interactors

Database of interacting proteins

More...
DIPi
DIP-36658N

Protein interaction database and analysis system

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IntActi
P05362, 12 interactors

Molecular INTeraction database

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MINTi
P05362

STRING: functional protein association networks

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STRINGi
9606.ENSP00000264832

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P05362

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1532
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P05362

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P05362

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P05362

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 103Ig-like C2-type 1Add BLAST63
Domaini128 – 193Ig-like C2-type 2Add BLAST66
Domaini230 – 297Ig-like C2-type 3Add BLAST68
Domaini325 – 378Ig-like C2-type 4Add BLAST54
Domaini412 – 464Ig-like C2-type 5Add BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi152 – 154Cell attachment site; atypicalSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IPHM Eukaryota
ENOG410YQ1Q LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000162311

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000059554

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052074

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P05362

KEGG Orthology (KO)

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KOi
K06490

Identification of Orthologs from Complete Genome Data

More...
OMAi
QTLRCQA

Database of Orthologous Groups

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OrthoDBi
EOG091G022Y

Database for complete collections of gene phylogenies

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PhylomeDBi
P05362

TreeFam database of animal gene trees

More...
TreeFami
TF333745

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003988 ICAM
IPR013768 ICAM_N
IPR003987 ICAM_VCAM_N
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03921 ICAM_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01473 ICAM
PR01472 ICAMVCAM1

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P05362-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPSSPRPAL PALLVLLGAL FPGPGNAQTS VSPSKVILPR GGSVLVTCST
60 70 80 90 100
SCDQPKLLGI ETPLPKKELL LPGNNRKVYE LSNVQEDSQP MCYSNCPDGQ
110 120 130 140 150
STAKTFLTVY WTPERVELAP LPSWQPVGKN LTLRCQVEGG APRANLTVVL
160 170 180 190 200
LRGEKELKRE PAVGEPAEVT TTVLVRRDHH GANFSCRTEL DLRPQGLELF
210 220 230 240 250
ENTSAPYQLQ TFVLPATPPQ LVSPRVLEVD TQGTVVCSLD GLFPVSEAQV
260 270 280 290 300
HLALGDQRLN PTVTYGNDSF SAKASVSVTA EDEGTQRLTC AVILGNQSQE
310 320 330 340 350
TLQTVTIYSF PAPNVILTKP EVSEGTEVTV KCEAHPRAKV TLNGVPAQPL
360 370 380 390 400
GPRAQLLLKA TPEDNGRSFS CSATLEVAGQ LIHKNQTREL RVLYGPRLDE
410 420 430 440 450
RDCPGNWTWP ENSQQTPMCQ AWGNPLPELK CLKDGTFPLP IGESVTVTRD
460 470 480 490 500
LEGTYLCRAR STQGEVTRKV TVNVLSPRYE IVIITVVAAA VIMGTAGLST
510 520 530
YLYNRQRKIK KYRLQQAQKG TPMKPNTQAT PP
Length:532
Mass (Da):57,825
Last modified:June 21, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i550089365A733AFB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ESS4E7ESS4_HUMAN
Intercellular adhesion molecule 1
ICAM1
310Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EKL8K7EKL8_HUMAN
Intercellular adhesion molecule 1
ICAM1
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9 – 10AL → PV in CAA40441 (PubMed:1983003).Curated2
Sequence conflicti17L → F in AAQ14902 (PubMed:15572059).Curated1
Sequence conflicti27A → V in AAQ14902 (PubMed:15572059).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria [MIMi:611162].1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04987934S → C. Corresponds to variant dbSNP:rs5491EnsemblClinVar.1
Natural variantiVAR_01020456K → M in Kilifi; at homozygosity it is associated with increased susceptibility to cerebral malaria. 3 PublicationsCorresponds to variant dbSNP:rs5491EnsemblClinVar.1
Natural variantiVAR_014651155K → N. Corresponds to variant dbSNP:rs5492Ensembl.1
Natural variantiVAR_014186241G → R3 PublicationsCorresponds to variant dbSNP:rs1799969Ensembl.1
Natural variantiVAR_014652315V → M. Corresponds to variant dbSNP:rs5495Ensembl.1
Natural variantiVAR_014653352P → L1 PublicationCorresponds to variant dbSNP:rs1801714Ensembl.1
Natural variantiVAR_014654397R → Q1 PublicationCorresponds to variant dbSNP:rs5497Ensembl.1
Natural variantiVAR_014187469K → E6 PublicationsCorresponds to variant dbSNP:rs5498Ensembl.1
Natural variantiVAR_016267478R → W1 PublicationCorresponds to variant dbSNP:rs5030400Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X06990 mRNA Translation: CAA30051.1
J03132 mRNA Translation: AAA52709.1
M24283 mRNA Translation: AAA52708.1
X59286, X59287, X59288 Genomic DNA Translation: CAA41977.1
BT006854 mRNA Translation: AAP35500.1
AY225514 Genomic DNA Translation: AAO30128.1
AK312636 mRNA Translation: BAG35520.1
CH471106 Genomic DNA Translation: EAW84086.1
BC015969 mRNA Translation: AAH15969.1
X57151 Genomic DNA Translation: CAA40441.1
AF340039 mRNA Translation: AAQ14902.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12231.1

Protein sequence database of the Protein Information Resource

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PIRi
A29849

NCBI Reference Sequences

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RefSeqi
NP_000192.2, NM_000201.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.643447

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000264832; ENSP00000264832; ENSG00000090339

Database of genes from NCBI RefSeq genomes

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GeneIDi
3383

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3383

UCSC genome browser

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UCSCi
uc002mnq.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Wikipedia

Intercellular adhesion molecule entry

SeattleSNPs
Virus Particle ExploreR db

Icosahedral capsid structure

Functional Glycomics Gateway - Glycan Binding

ICAM-1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06990 mRNA Translation: CAA30051.1
J03132 mRNA Translation: AAA52709.1
M24283 mRNA Translation: AAA52708.1
X59286, X59287, X59288 Genomic DNA Translation: CAA41977.1
BT006854 mRNA Translation: AAP35500.1
AY225514 Genomic DNA Translation: AAO30128.1
AK312636 mRNA Translation: BAG35520.1
CH471106 Genomic DNA Translation: EAW84086.1
BC015969 mRNA Translation: AAH15969.1
X57151 Genomic DNA Translation: CAA40441.1
AF340039 mRNA Translation: AAQ14902.1
CCDSiCCDS12231.1
PIRiA29849
RefSeqiNP_000192.2, NM_000201.2
UniGeneiHs.643447

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D3Eelectron microscopy28.00I28-212[»]
1D3Ielectron microscopy26.00I28-212[»]
1D3LX-ray3.25A28-212[»]
1IAMX-ray2.10A28-212[»]
1IC1X-ray3.00A/B28-217[»]
1IJ4model-I44-109[»]
1MQ8X-ray3.30A/C28-318[»]
1P53X-ray3.06A/B212-477[»]
1Z7Zelectron microscopy8.00I28-477[»]
2OZ4X-ray2.70A213-477[»]
3TCXX-ray3.60A/C/E/G/I/K/M/O/Q/S/U/W/Y/a29-112[»]
5MZAX-ray2.78B28-212[»]
6EITelectron microscopy3.90428-112[»]
ProteinModelPortaliP05362
SMRiP05362
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109610, 178 interactors
DIPiDIP-36658N
IntActiP05362, 12 interactors
MINTiP05362
STRINGi9606.ENSP00000264832

Chemistry databases

BindingDBiP05362
ChEMBLiCHEMBL3070
DrugBankiDB08818 Hyaluronic acid
DB00108 Natalizumab

PTM databases

GlyConnecti1423
iPTMnetiP05362
PhosphoSitePlusiP05362

Polymorphism and mutation databases

BioMutaiICAM1
DMDMi68067956

Proteomic databases

EPDiP05362
MaxQBiP05362
PaxDbiP05362
PeptideAtlasiP05362
PRIDEiP05362
ProteomicsDBi51830

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3383
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264832; ENSP00000264832; ENSG00000090339
GeneIDi3383
KEGGihsa:3383
UCSCiuc002mnq.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3383
DisGeNETi3383
EuPathDBiHostDB:ENSG00000090339.8

GeneCards: human genes, protein and diseases

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GeneCardsi
ICAM1
HGNCiHGNC:5344 ICAM1
HPAiCAB002142
HPA002126
HPA004877
MalaCardsiICAM1
MIMi147840 gene
611162 phenotype
neXtProtiNX_P05362
OpenTargetsiENSG00000090339
PharmGKBiPA29592

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IPHM Eukaryota
ENOG410YQ1Q LUCA
GeneTreeiENSGT00940000162311
HOGENOMiHOG000059554
HOVERGENiHBG052074
InParanoidiP05362
KOiK06490
OMAiQTLRCQA
OrthoDBiEOG091G022Y
PhylomeDBiP05362
TreeFamiTF333745

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-216083 Integrin cell surface interactions
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-877300 Interferon gamma signaling
SABIO-RKiP05362
SIGNORiP05362

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ICAM1 human
EvolutionaryTraceiP05362

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ICAM-1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3383
PMAP-CutDBiP05362

Protein Ontology

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PROi
PR:P05362

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000090339 Expressed in 205 organ(s), highest expression level in lung
CleanExiHS_ICAM1
ExpressionAtlasiP05362 baseline and differential
GenevisibleiP05362 HS

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR003988 ICAM
IPR013768 ICAM_N
IPR003987 ICAM_VCAM_N
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF03921 ICAM_N, 1 hit
PRINTSiPR01473 ICAM
PR01472 ICAMVCAM1
SMARTiView protein in SMART
SM00409 IG, 3 hits
SUPFAMiSSF48726 SSF48726, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiICAM1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05362
Secondary accession number(s): B2R6M3, Q5NKV7, Q96B50
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: June 21, 2005
Last modified: December 5, 2018
This is version 227 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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