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Protein

Intercellular adhesion molecule 1

Gene

ICAM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.2 Publications
(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins.2 Publications
(Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins.3 Publications
(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.1 Publication

GO - Molecular functioni

  • integrin binding Source: MGI
  • signaling receptor activity Source: ProtInc
  • transmembrane signaling receptor activity Source: ProtInc
  • virus receptor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processCell adhesion, Host-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-216083 Integrin cell surface interactions
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-877300 Interferon gamma signaling
SABIO-RKiP05362
SIGNORiP05362

Names & Taxonomyi

Protein namesi
Recommended name:
Intercellular adhesion molecule 1
Short name:
ICAM-1
Alternative name(s):
Major group rhinovirus receptor
CD_antigen: CD54
Gene namesi
Name:ICAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000090339.8
HGNCiHGNC:5344 ICAM1
MIMi147840 gene
neXtProtiNX_P05362

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 480ExtracellularSequence analysisAdd BLAST453
Transmembranei481 – 503HelicalSequence analysisAdd BLAST23
Topological domaini504 – 532CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3383
MalaCardsiICAM1
MIMi611162 phenotype
OpenTargetsiENSG00000090339
PharmGKBiPA29592

Chemistry databases

ChEMBLiCHEMBL3070
DrugBankiDB08818 Hyaluronic acid
DB00108 Natalizumab

Polymorphism and mutation databases

BioMutaiICAM1
DMDMi68067956

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Add BLAST27
ChainiPRO_000001478328 – 532Intercellular adhesion molecule 1Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 92Combined sources3 Publications
Disulfide bondi52 ↔ 96Combined sources3 Publications
Glycosylationi130N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi135 ↔ 186Combined sources3 Publications
Glycosylationi145N-linked (GlcNAc...) (complex) asparagine4 Publications1
Glycosylationi183N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi202N-linked (GlcNAc...) asparagine4 Publications1
Disulfide bondi237 ↔ 290Combined sources1 Publication
Glycosylationi267N-linked (GlcNAc...) asparagine4 Publications1
Glycosylationi296N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi332 ↔ 371Combined sources1 Publication
Glycosylationi385N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi403 ↔ 419Combined sources1 Publication
Glycosylationi406N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi431 ↔ 457Combined sources1 Publication
Modified residuei521PhosphothreonineCombined sources1
Modified residuei530PhosphothreonineCombined sources1

Post-translational modificationi

Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP05362
MaxQBiP05362
PaxDbiP05362
PeptideAtlasiP05362
PRIDEiP05362
ProteomicsDBi51830

PTM databases

GlyConnecti1423
iPTMnetiP05362
PhosphoSitePlusiP05362

Miscellaneous databases

PMAP-CutDBiP05362

Expressioni

Gene expression databases

BgeeiENSG00000090339 Expressed in 205 organ(s), highest expression level in lung
CleanExiHS_ICAM1
ExpressionAtlasiP05362 baseline and differential
GenevisibleiP05362 HS

Organism-specific databases

HPAiCAB002142
HPA002126
HPA004877

Interactioni

Subunit structurei

Homodimer (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF.Curated4 Publications
(Microbial infection) Interacts with major receptor group rhinovirus A-B capsid proteins (PubMed:1968231, PubMed:2538243).2 Publications
(Microbial infection) Interacts with Coxsackievirus A21 capsid proteins (PubMed:11160747, PubMed:16004874, PubMed:9539703).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ITGALP207012EBI-1035358,EBI-961214

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109610, 177 interactors
DIPiDIP-36658N
IntActiP05362, 12 interactors
MINTiP05362
STRINGi9606.ENSP00000264832

Chemistry databases

BindingDBiP05362

Structurei

Secondary structure

1532
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP05362
SMRiP05362
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05362

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 103Ig-like C2-type 1Add BLAST63
Domaini128 – 193Ig-like C2-type 2Add BLAST66
Domaini230 – 297Ig-like C2-type 3Add BLAST68
Domaini325 – 378Ig-like C2-type 4Add BLAST54
Domaini412 – 464Ig-like C2-type 5Add BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi152 – 154Cell attachment site; atypicalSequence analysis3

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPHM Eukaryota
ENOG410YQ1Q LUCA
GeneTreeiENSGT00530000063246
HOGENOMiHOG000059554
HOVERGENiHBG052074
InParanoidiP05362
KOiK06490
OMAiQTLRCQA
OrthoDBiEOG091G022Y
PhylomeDBiP05362
TreeFamiTF333745

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR003988 ICAM
IPR013768 ICAM_N
IPR003987 ICAM_VCAM_N
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF03921 ICAM_N, 1 hit
PRINTSiPR01473 ICAM
PR01472 ICAMVCAM1
SMARTiView protein in SMART
SM00409 IG, 3 hits
SUPFAMiSSF48726 SSF48726, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P05362-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPSSPRPAL PALLVLLGAL FPGPGNAQTS VSPSKVILPR GGSVLVTCST
60 70 80 90 100
SCDQPKLLGI ETPLPKKELL LPGNNRKVYE LSNVQEDSQP MCYSNCPDGQ
110 120 130 140 150
STAKTFLTVY WTPERVELAP LPSWQPVGKN LTLRCQVEGG APRANLTVVL
160 170 180 190 200
LRGEKELKRE PAVGEPAEVT TTVLVRRDHH GANFSCRTEL DLRPQGLELF
210 220 230 240 250
ENTSAPYQLQ TFVLPATPPQ LVSPRVLEVD TQGTVVCSLD GLFPVSEAQV
260 270 280 290 300
HLALGDQRLN PTVTYGNDSF SAKASVSVTA EDEGTQRLTC AVILGNQSQE
310 320 330 340 350
TLQTVTIYSF PAPNVILTKP EVSEGTEVTV KCEAHPRAKV TLNGVPAQPL
360 370 380 390 400
GPRAQLLLKA TPEDNGRSFS CSATLEVAGQ LIHKNQTREL RVLYGPRLDE
410 420 430 440 450
RDCPGNWTWP ENSQQTPMCQ AWGNPLPELK CLKDGTFPLP IGESVTVTRD
460 470 480 490 500
LEGTYLCRAR STQGEVTRKV TVNVLSPRYE IVIITVVAAA VIMGTAGLST
510 520 530
YLYNRQRKIK KYRLQQAQKG TPMKPNTQAT PP
Length:532
Mass (Da):57,825
Last modified:June 21, 2005 - v2
Checksum:i550089365A733AFB
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ESS4E7ESS4_HUMAN
Intercellular adhesion molecule 1
ICAM1
310Annotation score:
K7EKL8K7EKL8_HUMAN
Intercellular adhesion molecule 1
ICAM1
180Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9 – 10AL → PV in CAA40441 (PubMed:1983003).Curated2
Sequence conflicti17L → F in AAQ14902 (PubMed:15572059).Curated1
Sequence conflicti27A → V in AAQ14902 (PubMed:15572059).Curated1

Polymorphismi

Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria [MIMi:611162].1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04987934S → C. Corresponds to variant dbSNP:rs5491EnsemblClinVar.1
Natural variantiVAR_01020456K → M in Kilifi; at homozygosity it is associated with increased susceptibility to cerebral malaria. 3 PublicationsCorresponds to variant dbSNP:rs5491EnsemblClinVar.1
Natural variantiVAR_014651155K → N. Corresponds to variant dbSNP:rs5492Ensembl.1
Natural variantiVAR_014186241G → R3 PublicationsCorresponds to variant dbSNP:rs1799969Ensembl.1
Natural variantiVAR_014652315V → M. Corresponds to variant dbSNP:rs5495Ensembl.1
Natural variantiVAR_014653352P → L1 PublicationCorresponds to variant dbSNP:rs1801714Ensembl.1
Natural variantiVAR_014654397R → Q1 PublicationCorresponds to variant dbSNP:rs5497Ensembl.1
Natural variantiVAR_014187469K → E6 PublicationsCorresponds to variant dbSNP:rs5498Ensembl.1
Natural variantiVAR_016267478R → W1 PublicationCorresponds to variant dbSNP:rs5030400Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06990 mRNA Translation: CAA30051.1
J03132 mRNA Translation: AAA52709.1
M24283 mRNA Translation: AAA52708.1
X59286, X59287, X59288 Genomic DNA Translation: CAA41977.1
BT006854 mRNA Translation: AAP35500.1
AY225514 Genomic DNA Translation: AAO30128.1
AK312636 mRNA Translation: BAG35520.1
CH471106 Genomic DNA Translation: EAW84086.1
BC015969 mRNA Translation: AAH15969.1
X57151 Genomic DNA Translation: CAA40441.1
AF340039 mRNA Translation: AAQ14902.1
CCDSiCCDS12231.1
PIRiA29849
RefSeqiNP_000192.2, NM_000201.2
UniGeneiHs.643447

Genome annotation databases

EnsembliENST00000264832; ENSP00000264832; ENSG00000090339
GeneIDi3383
KEGGihsa:3383
UCSCiuc002mnq.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Wikipedia

Intercellular adhesion molecule entry

SeattleSNPs
Virus Particle ExploreR db

Icosahedral capsid structure

Functional Glycomics Gateway - Glycan Binding

ICAM-1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06990 mRNA Translation: CAA30051.1
J03132 mRNA Translation: AAA52709.1
M24283 mRNA Translation: AAA52708.1
X59286, X59287, X59288 Genomic DNA Translation: CAA41977.1
BT006854 mRNA Translation: AAP35500.1
AY225514 Genomic DNA Translation: AAO30128.1
AK312636 mRNA Translation: BAG35520.1
CH471106 Genomic DNA Translation: EAW84086.1
BC015969 mRNA Translation: AAH15969.1
X57151 Genomic DNA Translation: CAA40441.1
AF340039 mRNA Translation: AAQ14902.1
CCDSiCCDS12231.1
PIRiA29849
RefSeqiNP_000192.2, NM_000201.2
UniGeneiHs.643447

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D3Eelectron microscopy28.00I28-212[»]
1D3Ielectron microscopy26.00I28-212[»]
1D3LX-ray3.25A28-212[»]
1IAMX-ray2.10A28-212[»]
1IC1X-ray3.00A/B28-217[»]
1IJ4model-I44-109[»]
1MQ8X-ray3.30A/C28-318[»]
1P53X-ray3.06A/B212-477[»]
1Z7Zelectron microscopy8.00I28-477[»]
2OZ4X-ray2.70A213-477[»]
3TCXX-ray3.60A/C/E/G/I/K/M/O/Q/S/U/W/Y/a29-112[»]
5MZAX-ray2.78B28-212[»]
6EITelectron microscopy3.90428-112[»]
ProteinModelPortaliP05362
SMRiP05362
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109610, 177 interactors
DIPiDIP-36658N
IntActiP05362, 12 interactors
MINTiP05362
STRINGi9606.ENSP00000264832

Chemistry databases

BindingDBiP05362
ChEMBLiCHEMBL3070
DrugBankiDB08818 Hyaluronic acid
DB00108 Natalizumab

PTM databases

GlyConnecti1423
iPTMnetiP05362
PhosphoSitePlusiP05362

Polymorphism and mutation databases

BioMutaiICAM1
DMDMi68067956

Proteomic databases

EPDiP05362
MaxQBiP05362
PaxDbiP05362
PeptideAtlasiP05362
PRIDEiP05362
ProteomicsDBi51830

Protocols and materials databases

DNASUi3383
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264832; ENSP00000264832; ENSG00000090339
GeneIDi3383
KEGGihsa:3383
UCSCiuc002mnq.3 human

Organism-specific databases

CTDi3383
DisGeNETi3383
EuPathDBiHostDB:ENSG00000090339.8
GeneCardsiICAM1
HGNCiHGNC:5344 ICAM1
HPAiCAB002142
HPA002126
HPA004877
MalaCardsiICAM1
MIMi147840 gene
611162 phenotype
neXtProtiNX_P05362
OpenTargetsiENSG00000090339
PharmGKBiPA29592
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPHM Eukaryota
ENOG410YQ1Q LUCA
GeneTreeiENSGT00530000063246
HOGENOMiHOG000059554
HOVERGENiHBG052074
InParanoidiP05362
KOiK06490
OMAiQTLRCQA
OrthoDBiEOG091G022Y
PhylomeDBiP05362
TreeFamiTF333745

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-216083 Integrin cell surface interactions
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-877300 Interferon gamma signaling
SABIO-RKiP05362
SIGNORiP05362

Miscellaneous databases

ChiTaRSiICAM1 human
EvolutionaryTraceiP05362
GeneWikiiICAM-1
GenomeRNAii3383
PMAP-CutDBiP05362
PROiPR:P05362
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000090339 Expressed in 205 organ(s), highest expression level in lung
CleanExiHS_ICAM1
ExpressionAtlasiP05362 baseline and differential
GenevisibleiP05362 HS

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR003988 ICAM
IPR013768 ICAM_N
IPR003987 ICAM_VCAM_N
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF03921 ICAM_N, 1 hit
PRINTSiPR01473 ICAM
PR01472 ICAMVCAM1
SMARTiView protein in SMART
SM00409 IG, 3 hits
SUPFAMiSSF48726 SSF48726, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiICAM1_HUMAN
AccessioniPrimary (citable) accession number: P05362
Secondary accession number(s): B2R6M3, Q5NKV7, Q96B50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: June 21, 2005
Last modified: November 7, 2018
This is version 226 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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